+E Messenger RNA Biogenesis KO
#
Messenger RNA Biogenesis - Saccharomyces cerevisiae (budding yeast)
%
!
AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E YBR236C ABD1; mRNA (guanine-N7)-methyltransferase K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
E YBR160W CDC28; cyclin-dependent serine/threonine-protein kinase CDC28 K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]
E YDL108W KIN28; TFIIH complex serine/threonine-protein kinase subunit KIN28 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E YGL130W CEG1; mRNA guanylyltransferase K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
E YPL228W CET1; polynucleotide 5'-phosphatase K01098 CET1; polynucleotide 5'-triphosphatase [EC:3.6.1.74]
E YMR180C CTL1; polynucleotide 5'-phosphatase K01098 CET1; polynucleotide 5'-triphosphatase [EC:3.6.1.74]
D Cap binding complex
E YMR125W STO1; Sto1p K12882 NCBP1; nuclear cap-binding protein subunit 1
E YPL178W CBC2; nuclear cap-binding protein subunit CBC2 K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
D Pre-mRNA cleavage factor IIm (CFIIm)
E YOR250C CLP1; cleavage polyadenylation factor subunit CLP1 K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
E YDR228C PCF11; Pcf11p K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
D Cleavage and polyadenylation specificity factor (CPSF) complex
E YDR301W CFT1; cleavage/polyadenylation factor CFT1 K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1
E YLR115W CFT2; cleavage polyadenylation factor subunit CFT2 K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E YLR277C YSH1; cleavage polyadenylation factor subunit YSH1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E YOR179C SYC1; cleavage polyadenylation factor subunit SYC1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E YPR107C YTH1; cleavage polyadenylation factor RNA-binding subunit YTH1 K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E YJR093C FIP1; cleavage polyadenylation factor subunit FIP1 K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1
E YKL059C MPE1; cleavage polyadenylation factor subunit MPE1 K15541 MPE1; protein MPE1
E YNL317W PFS2; cleavage polyadenylation factor subunit PFS2 K15542 PFS2; polyadenylation factor subunit 2
E YKL018W SWD2; WD-repeat containing protein SWD2 K14962 WDR82; COMPASS component SWD2
E YDR195W REF2; RNA-processing protein REF2 K15543 REF2; RNA end formation protein 2
E YER133W GLC7; type 1 serine/threonine-protein phosphatase catalytic subunit GLC7 K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E YDR436W PPZ2; salt homeostasis regulator K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E YML016C PPZ1; salt homeostasis regulator K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E YPL179W PPQ1; protein-serine/threonine phosphatase K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E YNL222W SSU72; RNA polymerase II subunit A C-terminal domain phosphatase K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E YGL044C RNA15; Rna15p K14407 CSTF2; cleavage stimulation factor subunit 2
E YGR156W PTI1; cleavage polyadenylation factor subunit PTI1 K14407 CSTF2; cleavage stimulation factor subunit 2
E YMR061W RNA14; cleavage polyadenylation factor subunit RNA14 K14408 CSTF3; cleavage stimulation factor subunit 3
E YAL043C PTA1; RNA-processing protein PTA1 K06100 SYMPK; symplekin
D U7-dependent histone pre-mRNA processing factors
E YER029C SMB1; mRNA splicing protein SMB1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E YLR147C SMD3; mRNA splicing protein SMD3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E YOR159C SME1; mRNA splicing protein SME1 K11097 SNRPE; small nuclear ribonucleoprotein E
E YPR182W SMX3; mRNA splicing protein SMX3 K11098 SNRPF; small nuclear ribonucleoprotein F
E YFL017W-A SMX2; mRNA splicing protein SMX2 K11099 SNRPG; small nuclear ribonucleoprotein G
E YLR115W CFT2; cleavage polyadenylation factor subunit CFT2 K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E YLR277C YSH1; cleavage polyadenylation factor subunit YSH1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E YOR179C SYC1; cleavage polyadenylation factor subunit SYC1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E YGL044C RNA15; Rna15p K14407 CSTF2; cleavage stimulation factor subunit 2
E YGR156W PTI1; cleavage polyadenylation factor subunit PTI1 K14407 CSTF2; cleavage stimulation factor subunit 2
E YAL043C PTA1; RNA-processing protein PTA1 K06100 SYMPK; symplekin
D DRB sensitivity inducing factor (DSIF) complex
E YGR063C SPT4; transcription elongation factor SPT4 K15171 SUPT4H1; transcription elongation factor SPT4
E YML010W SPT5; transcription elongation factor SPT5 K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
E YGL192W IME4; mRNA (N6-adenosine)-methyltransferase K05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]
E YCL055W KAR4; Kar4p K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit
D Poly(A) addition factors
E YKR002W PAP1; polynucleotide adenylyltransferase PAP1 K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
D Negative regulators of mRNA 3' end processing
C Other processing factors
D YOR077W RTS2; Rts2p K13102 KIN; DNA/RNA-binding protein KIN17
D YGL122C NAB2; mRNA-binding protein NAB2 K23039 NAB2; nuclear polyadenylated RNA-binding protein NAB2
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E YDR381W YRA1; RNA-binding protein YRA1 K12881 THOC4; THO complex subunit 4
E YDL084W SUB2; ATP-dependent RNA helicase SUB2 K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
E YDR021W FAL1; ATP-dependent RNA helicase FAL1 K13025 EIF4A3; ATP-dependent RNA helicase [EC:3.6.4.13]
D TREX complex
E YNL139C THO2; Tho2p K12879 THOC2; THO complex subunit 2
E YNL253W TEX1; Tex1p K12880 THOC3; THO complex subunit 3
E YDR381W YRA1; RNA-binding protein YRA1 K12881 THOC4; THO complex subunit 4
E YDR138W HPR1; Hpr1p K18712 HPR1; THO complex subunit HPR1
E YHR167W THP2; Thp2p K18713 THP2; THO complex subunit THP2
E YML062C MFT1; Mft1p K18714 MFT1; THO complex subunit MFT1
D TREX-2 complex
E YOL072W THP1; Thp1p K23801 PCID2; nuclear mRNA export protein PCID2/THP1
E YDR363W-A SEM1; proteasome regulatory particle lid subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E YBR111W-A SUS1; Sus1p K11368 ENY2; enhancer of yellow 2 transcription factor
E YOR257W CDC31; centrin K16466 CETN3; centrin-3
E YDR159W SAC3; Sac3p K23719 SAC3; nuclear mRNA export protein SAC3
D Nuclear pore complex
E YKR095W MLP1; Mlp1p K09291 TPR; nucleoprotein TPR
E YIL149C MLP2; Mlp2p K09291 TPR; nucleoprotein TPR
E YER107C GLE2; RNA export factor GLE2 K14298 RAE1; mRNA export factor
E YLR208W SEC13; GTPase-activating protein SEC13 K14004 SEC13; protein transport protein SEC13
E YJR042W NUP85; Nup85p K14304 NUP85; nuclear pore complex protein Nup85
E YGR119C NUP57; FG-nucleoporin NUP57 K14308 NUP54; nuclear pore complex protein Nup54
E YJL041W NSP1; FG-nucleoporin NSP1 K14306 NUP62; nuclear pore complex protein Nup62
E YFR002W NIC96; linker nucleoporin NIC96 K14309 NUP93; nuclear pore complex protein Nup93
E YMR047C NUP116; FG-nucleoporin NUP116 K14297 NUP98; nuclear pore complex protein Nup98-Nup96
E YKL068W NUP100; FG-nucleoporin NUP100 K14297 NUP98; nuclear pore complex protein Nup98-Nup96
E YDL116W NUP84; Nup84p K14301 NUP107; nuclear pore complex protein Nup107
E YKR082W NUP133; Nup133p K14300 NUP133; nuclear pore complex protein Nup133
E YML103C NUP188; Nup188p K14311 NUP188; nuclear pore complex protein Nup188
E YBL079W NUP170; Nup170p K14312 NUP155; nuclear pore complex protein Nup155
E YER105C NUP157; Nup157p K14312 NUP155; nuclear pore complex protein Nup155
E YKL057C NUP120; Nup120p K14303 NUP160; nuclear pore complex protein Nup160
E YMR153W NUP53; FG-nucleoporin NUP53 K14313 NUP35; nuclear pore complex protein Nup53
E YJL039C NUP192; Nup192p K14310 NUP205; nuclear pore complex protein Nup205
E YGL172W NUP49; FG-nucleoporin NUP49 K14307 NUPL1; nucleoporin p58/p45
E YML031W NDC1; Ndc1p K14315 NDC1; nucleoporin NDC1
E YGL100W SEH1; Seh1p K14299 SEH1; nucleoporin SEH1
E YIL115C NUP159; FG-nucleoporin NUP159 K18715 NUP159; nucleoporin NUP159
E YDR192C NUP42; FG-nucleoporin NUP42 K18716 NUP42; nucleoporin NUP42
E YDL088C ASM4; FG-nucleoporin ASM4 K18717 ASM4; nucleoporin ASM4
E YAR002W NUP60; FG-nucleoporin NUP60 K18718 NUP60; nucleoporin NUP60
E YJL061W NUP82; linker nucleoporin NUP82 K18719 NUP82; nucleoporin NUP82
E YGL092W NUP145; nucleocytoplasmic transporter NUP145 K18720 NUP145; nucleoporin NUP145
E YOR098C NUP1; FG-nucleoporin NUP1 K18721 NUP1; nucleoporin NUP1
E YLR335W NUP2; nucleoporin NUP2 K18722 NUP2; nucleoporin NUP2
E YOR257W CDC31; centrin K16466 CETN3; centrin-3
E YDL207W GLE1; nucleoporin GLE1 K18723 GLE1; nucleoporin GLE1
E YPL169C MEX67; Mex67p K14284 NXF; nuclear RNA export factor
E YKL186C MTR2; Mtr2p K14543 MTR2; mRNA transport regulator MTR2
E YLR018C POM34; Pom34p K18724 POM34; nucleoporin POM34
E YMR129W POM152; Pom152p K18725 POM152; nucleoporin POM152
E YIL016W SNL1; Snl1p K14017 SNL1; HSP70 co-chaperone SNL1
D Ran-mediated transport factors
E YLR293C GSP1; Ran GTPase GSP1 K07936 RAN; GTP-binding nuclear protein Ran
E YOR185C GSP2; Ran GTPase GSP2 K07936 RAN; GTP-binding nuclear protein Ran
E YDL091C UBX3; Ubx3p K18726 FAF2; FAS-associated factor 2
E YDL126C CDC48; AAA family ATPase CDC48 K13525 VCP; transitional endoplasmic reticulum ATPase
E YGR218W CRM1; exportin CRM1 K14290 XPO1; exportin-1
E YMR235C RNA1; GTPase-activating protein RNA1 K14319 RANGAP1; Ran GTPase-activating protein 1
E YDR432W NPL3; mRNA-binding protein NPL3 K14651 TAF15; transcription initiation factor TFIID subunit 15
D eIF4F and regulatory proteins
E YOL139C CDC33; translation initiation factor eIF4E K03259 EIF4E; translation initiation factor 4E
E YJL138C TIF2; translation initiation factor eIF4A K03257 EIF4A; translation initiation factor 4A
E YKR059W TIF1; translation initiation factor eIF4A K03257 EIF4A; translation initiation factor 4A
E YGR162W TIF4631; translation initiation factor eIF4G K03260 EIF4G; translation initiation factor 4G
E YGL049C TIF4632; translation initiation factor eIF4G K03260 EIF4G; translation initiation factor 4G
E YPR163C TIF3; Tif3p K03258 EIF4B; translation initiation factor 4B
E YDR532C KRE28; Kre28p K05749 CYFIP; cytoplasmic FMR1 interacting protein
E YPL119C DBP1; putative DEAD-box ATP-dependent RNA helicase DBP1 K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
E YOR204W DED1; DEAD-box ATP-dependent RNA helicase DED1 K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
E YBR172C SMY2; Smy2p K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E YPL105C SYH1; Syh1p K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E YER165W PAB1; polyadenylate-binding protein K13126 PABPC; polyadenylate-binding protein
E YLR398C SKI2; SKI complex RNA helicase subunit SKI2 K12599 SKI2; antiviral helicase SKI2 [EC:3.6.4.13]
E YGR271W SLH1; putative RNA helicase K18664 SLH1; antiviral helicase SLH1 [EC:3.6.4.13]
E YER007C-A TMA20; translation machinery-associated protein 20 K07575 MCTS; malignant T-cell-amplified sequence
E YJR014W TMA22; Tma22p K24272 DENR; density-regulated protein
D APOBEC1-ACF complex
D Other transport factors
E YOL123W HRP1; Hrp1p K14411 MSI; RNA-binding protein Musashi
E YKR084C HBS1; ribosome dissociation factor GTPase HBS1 K14416 HBS1; elongation factor 1 alpha-like protein
E YNL001W DOM34; ribosome dissociation factor DOM34 K06965 PELO; protein pelota
E YIR001C SGN1; Sgn1p K14396 PABPN1; polyadenylate-binding protein 2
E YMR255W GFD1; Gfd1p K18731 GFD1; mRNA transport factor GFD1
E YOR046C DBP5; ATP-dependent RNA helicase DBP5 K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:3.6.4.13]
E YDR416W SYF1; mRNA splicing protein SYF1 K12867 SYF1; pre-mRNA-splicing factor SYF1
E YER063W THO1; Tho1p K18732 SARNP; SAP domain-containing ribonucleoprotein
E YGL097W SRM1; Ran guanyl-nucleotide exchange factor K11493 RCC1; regulator of chromosome condensation
E YPR045C THP3; Thp3p K23802 LENG8; SAC3 family protein LENG8/THP3
E YKL214C YRA2; Yra2p K23799 YRA2; RNA annealing protein YRA2
C Surveillance factors
D Surveillance complex
E YBR143C SUP45; translation termination factor eRF1 K03265 ETF1; peptide chain release factor subunit 1
E YDR172W SUP35; translation termination factor GTPase eRF3 K03267 ERF3; peptide chain release factor subunit 3
E YMR080C NAM7; ATP-dependent RNA helicase NAM7 K14326 UPF1; regulator of nonsense transcripts 1 [EC:3.6.4.13 5.6.2.3]
E YHR077C NMD2; Nmd2p K14327 UPF2; regulator of nonsense transcripts 2
E YGR072W UPF3; Upf3p K14328 UPF3; regulator of nonsense transcripts 3
D Protein phosphatase 2A
E YDL134C PPH21; phosphoprotein phosphatase 2A catalytic subunit PPH21 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E YDL188C PPH22; phosphoprotein phosphatase 2A catalytic subunit PPH22 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E YAL016W TPD3; protein phosphatase 2A structural subunit TPD3 K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
E YGL190C CDC55; protein phosphatase 2A regulatory subunit CDC55 K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
E YOR014W RTS1; protein phosphatase 2A regulatory subunit RTS1 K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
D Other surveillance factors
E YBR172C SMY2; Smy2p K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E YPL105C SYH1; Syh1p K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
C Factors involved in mRNA localization
D Cargo complex
E YKL130C SHE2; She2p K18736 SHE2; SWI5-dependent HO expression protein 2
E YBR130C SHE3; She3p K18737 SHE3; SWI5-dependent HO expression protein 3
E YDR496C PUF6; Puf6p K14844 PUF6; pumilio homology domain family member 6
E YBL032W HEK2; Hek2p K18738 HEK; heterogeneous nuclear rnp K-like protein
E YBR233W PBP2; Pbp2p K18738 HEK; heterogeneous nuclear rnp K-like protein
E YOR326W MYO2; myosin 2 K10357 MYO5; myosin V
E YAL029C MYO4; myosin 4 K10357 MYO5; myosin V
E YKL185W ASH1; DNA-binding transcription repressor ASH1 K18658 ASH1; transcriptional regulatory protein ASH1
D Factors that have mRNA localization signals
D Trans-acting binding proteins
E YPR080W TEF1; translation elongation factor EF-1 alpha K03231 EEF1A; elongation factor 1-alpha
E YBR118W TEF2; translation elongation factor EF-1 alpha K03231 EEF1A; elongation factor 1-alpha
E YPL048W CAM1; translation elongation factor EF1B gamma K03233 EEF1G; elongation factor 1-gamma
E YKL081W TEF4; translation elongation factor EF1B gamma K03233 EEF1G; elongation factor 1-gamma
E YGR201C uncharacterized protein K03233 EEF1G; elongation factor 1-gamma
D Other mRNA localization factors
E YDR532C KRE28; Kre28p K05749 CYFIP; cytoplasmic FMR1 interacting protein
E YDR293C SSD1; mRNA-binding translational repressor SSD1 K18748 SSD1; protein SSD1
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E YGL173C XRN1; chromatin-binding exonuclease XRN1 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E YOL139C CDC33; translation initiation factor eIF4E K03259 EIF4E; translation initiation factor 4E
E YMR080C NAM7; ATP-dependent RNA helicase NAM7 K14326 UPF1; regulator of nonsense transcripts 1 [EC:3.6.4.13 5.6.2.3]
E YPL119C DBP1; putative DEAD-box ATP-dependent RNA helicase DBP1 K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
E YOR204W DED1; DEAD-box ATP-dependent RNA helicase DED1 K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
E YDL160C DHH1; DExD/H-box ATP-dependent RNA helicase DHH1 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:3.6.4.13]
E YPR129W SCD6; Scd6p K18749 LSM14; protein LSM14
E YBR017C KAP104; Kap104p K18752 TNPO1; transportin-1
E YJL164C TPK1; cAMP-dependent protein kinase catalytic subunit TPK1 K04345 PKA; protein kinase A [EC:2.7.11.11]
E YPL203W TPK2; cAMP-dependent protein kinase catalytic subunit TPK2 K04345 PKA; protein kinase A [EC:2.7.11.11]
E YKL166C TPK3; cAMP-dependent protein kinase catalytic subunit TPK3 K04345 PKA; protein kinase A [EC:2.7.11.11]
E YCL037C SRO9; Sro9p K18757 LARP1; la-related protein 1
E YDR515W SLF1; Slf1p K18757 LARP1; la-related protein 1
D P-body specific factors
E YNL118C DCP2; decapping enzyme complex catalytic subunit K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E YOL149W DCP1; Dcp1p K12612 DCP1; mRNA-decapping enzyme subunit 1
E YJL124C LSM1; Lsm1p K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E YBL026W LSM2; Sm-like protein LSM2 K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E YLR438C-A LSM3; U4/U6-U5 snRNP complex subunit LSM3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E YER112W LSM4; U6 snRNA complex subunit LSM4 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E YER146W LSM5; RNA-binding protein LSM5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E YDR378C LSM6; U4/U6-U5 snRNP complex subunit LSM6 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E YNL147W LSM7; Sm-like protein LSM7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E YJR022W LSM8; U4/U6-U5 snRNP complex subunit LSM8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
E YOR326W MYO2; myosin 2 K10357 MYO5; myosin V
E YAL029C MYO4; myosin 4 K10357 MYO5; myosin V
E YML085C TUB1; alpha-tubulin TUB1 K07374 TUBA; tubulin alpha
E YML124C TUB3; alpha-tubulin TUB3 K07374 TUBA; tubulin alpha
E YCR093W CDC39; CCR4-NOT core subunit CDC39 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E YDL165W CDC36; CCR4-NOT core subunit CDC36 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E YIL038C NOT3; CCR4-NOT core subunit NOT3 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E YPR072W NOT5; CCR4-NOT core subunit NOT5 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E YER068W MOT2; CCR4-NOT core ubiquitin-protein ligase subunit MOT2 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E YAL021C CCR4; CCR4-NOT core exoribonuclease subunit CCR4 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E YNR052C POP2; CCR4-NOT core DEDD family RNase subunit POP2 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E YGL094C PAN2; poly(A)-specific ribonuclease K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E YKL025C PAN3; Pan3p K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
E YCR077C PAT1; Pat1p K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
E YER035W EDC2; Edc2p K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E YGL222C EDC1; Edc1p K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E YEL015W EDC3; Edc3p K12615 EDC3; enhancer of mRNA-decapping protein 3
E YHR077C NMD2; Nmd2p K14327 UPF2; regulator of nonsense transcripts 2
E YGR072W UPF3; Upf3p K14328 UPF3; regulator of nonsense transcripts 3
E YDR404C RPB7; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
E YDR374C PHO92; mRNA-binding phosphate metabolism regulator K20102 YTHDF; YTH domain-containing family protein
D Stress granule specific factors
E YNL016W PUB1; Pub1p K13201 TIA1; nucleolysin TIA-1/TIAR
E YER165W PAB1; polyadenylate-binding protein K13126 PABPC; polyadenylate-binding protein
E YGR054W uncharacterized protein K15026 EIF2A; translation initiation factor 2A
E YOR361C PRT1; translation initiation factor eIF3 core subunit B K03253 EIF3B; translation initiation factor 3 subunit B
E YJL138C TIF2; translation initiation factor eIF4A K03257 EIF4A; translation initiation factor 4A
E YKR059W TIF1; translation initiation factor eIF4A K03257 EIF4A; translation initiation factor 4A
E YDR021W FAL1; ATP-dependent RNA helicase FAL1 K13025 EIF4A3; ATP-dependent RNA helicase [EC:3.6.4.13]
E YPR163C TIF3; Tif3p K03258 EIF4B; translation initiation factor 4B
E YGR162W TIF4631; translation initiation factor eIF4G K03260 EIF4G; translation initiation factor 4G
E YGL049C TIF4632; translation initiation factor eIF4G K03260 EIF4G; translation initiation factor 4G
E YMR116C ASC1; guanine nucleotide-binding protein subunit beta K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
E YPL169C MEX67; Mex67p K14284 NXF; nuclear RNA export factor
E YNL021W HDA1; histone deacetylase HDA1 K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E YOL149W DCP1; Dcp1p K12612 DCP1; mRNA-decapping enzyme subunit 1
E YNL118C DCP2; decapping enzyme complex catalytic subunit K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E YDL160C DHH1; DExD/H-box ATP-dependent RNA helicase DHH1 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:3.6.4.13]
E YER035W EDC2; Edc2p K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E YGL222C EDC1; Edc1p K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E YEL015W EDC3; Edc3p K12615 EDC3; enhancer of mRNA-decapping protein 3
E YCR077C PAT1; Pat1p K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
D Lsm complex
E YJL124C LSM1; Lsm1p K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E YBL026W LSM2; Sm-like protein LSM2 K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E YLR438C-A LSM3; U4/U6-U5 snRNP complex subunit LSM3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E YER112W LSM4; U6 snRNA complex subunit LSM4 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E YER146W LSM5; RNA-binding protein LSM5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E YDR378C LSM6; U4/U6-U5 snRNP complex subunit LSM6 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E YNL147W LSM7; Sm-like protein LSM7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E YJR022W LSM8; U4/U6-U5 snRNP complex subunit LSM8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
D 5' exonucleases
E YGL173C XRN1; chromatin-binding exonuclease XRN1 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E YOR048C RAT1; ssRNA exonuclease RAT1 K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D Other 5'-3' decay factors
E YLR270W DCS1; 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
C 3'-5' decay
D Core exosome factors
E YNL232W CSL4; exosome non-catalytic core subunit CSL4 K07573 CSL4; exosome complex component CSL4
E YHR069C RRP4; exosome non-catalytic core subunit RRP4 K03679 RRP4; exosome complex component RRP4
E YOL142W RRP40; exosome non-catalytic core subunit RRP40 K03681 RRP40; exosome complex component RRP40
E YGR195W SKI6; exosome non-catalytic core subunit SKI6 K11600 RRP41; exosome complex component RRP41
E YGR095C RRP46; exosome non-catalytic core subunit RRP46 K12590 RRP46; exosome complex component RRP46
E YGR158C MTR3; exosome non-catalytic core subunit MTR3 K12587 MTR3; exosome complex component MTR3
E YDL111C RRP42; exosome non-catalytic core subunit RRP42 K12589 RRP42; exosome complex component RRP42
E YCR035C RRP43; exosome non-catalytic core subunit RRP43 K12586 RRP43; exosome complex component RRP43
E YDR280W RRP45; exosome non-catalytic core subunit RRP45 K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E YOL021C DIS3; exosome catalytic subunit DIS3 K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
E YOR001W RRP6; exosome nuclease subunit RRP6 K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]
E YHR081W LRP1; Lrp1p K12592 C1D; exosome complex protein LRP1
E YNR024W MPP6; Mpp6p K12594 MPP6; M-phase phosphoprotein 6, fungi type
E YOR076C SKI7; Ski7p K12595 SKI7; superkiller protein 7
D TRAMP complex
E YOL115W PAP2; non-canonical poly(A) polymerase PAP2 K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E YIL079C AIR1; TRAMP complex RNA-binding subunit K12597 AIR1_2; protein AIR1/2
E YDL175C AIR2; TRAMP complex RNA-binding subunit K12597 AIR1_2; protein AIR1/2
E YJL050W MTR4; ATP-dependent RNA helicase MTR4 K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:3.6.4.13]
E YNL299W TRF5; non-canonical poly(A) polymerase TRF5 K12596 TRF5; poly(A) RNA polymerase
D Ski complex
E YLR398C SKI2; SKI complex RNA helicase subunit SKI2 K12599 SKI2; antiviral helicase SKI2 [EC:3.6.4.13]
E YPR189W SKI3; SKI complex subunit tetratricopeptide repeat protein SKI3 K12600 SKI3; superkiller protein 3
E YGL213C SKI8; SKI complex subunit WD repeat protein SKI8 K12601 SKI8; superkiller protein 8
D Ccr4-NOT complex
E YAL021C CCR4; CCR4-NOT core exoribonuclease subunit CCR4 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E YCR093W CDC39; CCR4-NOT core subunit CDC39 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E YDL165W CDC36; CCR4-NOT core subunit CDC36 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E YIL038C NOT3; CCR4-NOT core subunit NOT3 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E YPR072W NOT5; CCR4-NOT core subunit NOT5 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E YER068W MOT2; CCR4-NOT core ubiquitin-protein ligase subunit MOT2 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E YNR052C POP2; CCR4-NOT core DEDD family RNase subunit POP2 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E YNL288W CAF40; CCR4-NOT core subunit CAF40 K12606 RCD1; CCR4-NOT transcription complex subunit 9
E YFL028C CAF16; putative ATP-binding cassette family ATPase CAF16 K12608 CAF16; CCR4-NOT complex subunit CAF16
E YNL278W CAF120; Caf120p K12609 CAF120; CCR4-NOT transcriptional complex subunit CAF120
E YLR187W SKG3; Skg3p K12609 CAF120; CCR4-NOT transcriptional complex subunit CAF120
D Pan complex
E YGL094C PAN2; poly(A)-specific ribonuclease K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E YKL025C PAN3; Pan3p K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
D Other 3'-5' decay factors
E YLR270W DCS1; 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
C Other degradation factors
D RNases
#
AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
E YMR239C RNT1; ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
E YLR059C REX2; Rex2p K13288 orn; oligoribonuclease [EC:3.1.-.-]
D Helicases
D Other RNA degradosome components
E YMR323W ERR3; phosphopyruvate hydratase ERR3 K01689 ENO; enolase [EC:4.2.1.11]
E YGR254W ENO1; phosphopyruvate hydratase ENO1 K01689 ENO; enolase [EC:4.2.1.11]
E YHR174W ENO2; phosphopyruvate hydratase ENO2 K01689 ENO; enolase [EC:4.2.1.11]
E YOR393W ERR1; phosphopyruvate hydratase ERR1 K01689 ENO; enolase [EC:4.2.1.11]
E YPL281C ERR2; phosphopyruvate hydratase ERR2 K01689 ENO; enolase [EC:4.2.1.11]
E YMR205C PFK2; 6-phosphofructokinase subunit beta K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
E YGR240C PFK1; 6-phosphofructokinase subunit alpha K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C Other RNA degradation factors
D Chaperones
E YJR045C SSC1; Hsp70 family ATPase SSC1 K04043 dnaK; molecular chaperone DnaK
E YLR369W SSQ1; Hsp70 family ATPase SSQ1 K04043 dnaK; molecular chaperone DnaK
E YEL030W ECM10; Hsp70 family ATPase ECM10 K04043 dnaK; molecular chaperone DnaK
E YLR259C HSP60; chaperone ATPase HSP60 K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
E YBR044C TCM62; Tcm62p K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E YHR069C RRP4; exosome non-catalytic core subunit RRP4 K03679 RRP4; exosome complex component RRP4
E YNL232W CSL4; exosome non-catalytic core subunit CSL4 K07573 CSL4; exosome complex component CSL4
D Cofactors
E YGR195W SKI6; exosome non-catalytic core subunit SKI6 K11600 RRP41; exosome complex component RRP41
E YDL111C RRP42; exosome non-catalytic core subunit RRP42 K12589 RRP42; exosome complex component RRP42
D Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: October 14, 2022