+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces spongiicola
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E DDQ41_09730 beta-ACP synthase K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E DDQ41_09735 ketosynthase chain-length factor K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
E DDQ41_09740 curamycin polyketide synthase K14669 whiEV; minimal PKS acyl carrier protein
E DDQ41_07365 polyketide cyclase K14670 whiEVI; aromatase
E DDQ41_09745 polyketide cyclase K14670 whiEVI; aromatase
E DDQ41_07340 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
E DDQ41_09750 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E DDQ41_07350 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E DDQ41_07355 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E DDQ41_07360 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
D Nonaketide PKS
E DDQ41_07350 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E DDQ41_07355 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E DDQ41_07360 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
D Decaketide PKS
E DDQ41_07350 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E DDQ41_07355 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E DDQ41_07360 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D DDQ41_26490 type III polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D DDQ41_16145 antibiotic synthesis protein MbtH K05375 mbtH; MbtH protein
D DDQ41_25575 MbtH family protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D DDQ41_28735 4'-phosphopantetheinyl transferase K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]
D DDQ41_25540 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D DDQ41_25540 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
D DDQ41_25540 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D DDQ41_25540 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D DDQ41_25540 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
C DDQ41_30995 4-hydroxybenzoyl-CoA thioesterase K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
B Oxygenase
C DDQ41_00860 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C DDQ41_21455 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C DDQ41_30005 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C DDQ41_30940 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C DDQ41_30925 Pyoverdin chromophore biosynthetic protein pvcC K21184 sgcC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]
C DDQ41_30650 hydrolase K21159 sgcF; epoxide hydrolase
C DDQ41_07345 cupin domain-containing protein K14673 whiEII; putative monooxygenase
C DDQ41_09725 protein in whiE locus K14673 whiEII; putative monooxygenase
C DDQ41_09715 monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C DDQ41_09755 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C DDQ41_28830 cyclodehydratase K14627 actVI3; dehydratase [EC:4.2.1.-]
C DDQ41_31030 enediyne biosynthesis protein K21160 sgcE2; enediyne biosynthesis protein E2
C DDQ41_31025 enediyne biosynthesis protein K21161 sgcE3; enediyne biosynthesis protein E3
C DDQ41_31020 RNA-binding protein K21162 sgcE4; enediyne biosynthesis protein E4
C DDQ41_31015 enediyne biosynthesis protein K21163 sgcE5; enediyne biosynthesis protein E5
C DDQ41_30985 cytochrome P450 K21164 sgcE7; enediyne biosynthesis protein E7
C DDQ41_30970 regulator K21165 sgcE8; enediyne biosynthesis protein E8
C DDQ41_30965 glucose-methanol-choline oxidoreductase K21166 sgcE9; enediyne biosynthesis protein E9
C DDQ41_30960 TIGR03084 family protein K21167 sgcE11; enediyne biosynthesis protein E11
C DDQ41_30920 hypothetical protein K21186 sgcC5; condensation enzyme
C DDQ41_30990 flavin reductase K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
B Aminotransferase
B Others
C DDQ41_20935 aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024