Target-based Classification of Drugs

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     Type
 G Protein-coupled receptors
 
 Ion channels
 
 Nuclear receptors
 
 Protein kinases
 
 Cytokines and receptors
 
 Cell surface molecules and ligands
 
 Transporters
 
 Enzymes
   Oxidoreductases (EC1)
     Dehydrogenases [EC:1.1.1.-]
     Dehydrogenases [EC:1.2.1.-]
     Dehydrogenases [EC:1.3.-.-]
     Amine oxidases [EC:1.4.3.-]
     Dihydrofolate reductase [EC:1.5.1.3]
       DHFR [HSA:1719 200895] [KO:K00287]
         D00142  Methotrexate (JP17/USP/INN) <JP/US>
         D02115  Methotrexate sodium <US>
         D07472  Pemetrexed (INN)
         D03828  Pemetrexed disodium (USAN)
         D06503  Pemetrexed sodium hydrate (JAN) <JP/US>
         D10596  Pemetrexed sodium hemipentahydrate (JAN)
         D05589  Pralatrexate (JAN/USAN/INN) <JP/US>
         D06238  Trimetrexate (USAN/INN)
         D06239  Trimetrexate glucuronate (USAN)
         D03942  Edatrexate (USAN/INN)
         D05500  Piritrexim isethionate (USAN)
         D05999  Talotrexin ammonium (USAN)
         D11352  Pemetrexed tromethamine (USAN)
 
 
 
 
 
 
 
 
 
 
 
 
 
     NAD(P)H dehydrogenase [EC:1.6.5.2]
     Peroxidase [EC:1.11.1.-]
     Peroxygenase [EC:1.11.2.-]
     Dioxygenases [EC:1.13.11.-]
     Prolyl 4-hydroxylase [EC:1.14.11.2]
     HIF hydroxylase [EC:1.14.11.29]
     Nitic oxide synthase [EC:1.14.13.39]
     Cytochrome P450 [EC:1.14.14.-]
     Other monooxygenases [EC:1.14.16.- 1.14.17.- 1.14.18.-]
     Prostaglandin synthase [EC:1.14.99.1]
     Superoxide dismutase [EC:1.15.1.1]
     Xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2]
     Ribonucleoside-diphosphate reductase [EC:1.17.4.1]
     Vitamin-K-epoxide reductase [EC:1.17.4.4]
     Thyroxine 5'-deiodinase [EC:1.21.99.4]
   Transferases (EC2)
     Methyltransferases [EC:2.1.1.-]
       COMT [HSA:1312] [KO:K00545]
       DNMT [HSA:1786 1788 1789] [KO:K00558 K17398 K17399]
       DNMT1 [HSA:1786] [KO:K00558]
       EZH [HSA:2145 2146] [KO:K17451 K11430]
       EZH2 [HSA:2146] [KO:K11430]
       TYMS [HSA:7298] [KO:K00560]
         D01064  Raltitrexed (JAN/USAN/INN)
         D07472  Pemetrexed (INN)
         D03828  Pemetrexed disodium (USAN)
         D06503  Pemetrexed sodium hydrate (JAN) <JP/US>
         D10596  Pemetrexed sodium hemipentahydrate (JAN)
         D00584  Fluorouracil (JP17/USP/INN) <JP/US>
         D07974  Fluorouracil sodium salt
         D01244  Tegafur (JP17/USAN/INN) <JP>
         D01784  Carmofur (JP17/INN)
         D01223  Capecitabine (JAN/USP/INN) <JP/US>
         D04197  Floxuridine (USP/INN) <US>
         D01309  Doxifluridine (JP17/INN) <JP>
         D04964  Metesind glucuronate (USAN)
         D10803  Plevitrexed (INN)
         D11352  Pemetrexed tromethamine (USAN)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
     Acyltransferases [EC:2.3.1.-]
     gamma-Glutamyltransferase [EC:2.3.2.2]
     E3 ubiquitin-protein ligase [EC:2.3.2.27]
     ATP citrate synthase [EC:2.3.3.8]
     Hexosyltransferases [EC:2.4.1.-]
     Pentosyltransferases [EC:2.4.2.-]
     Alkyl/Aryl transferases [EC:2.5.1.-]
     Aminotransferase [EC:2.6.1.-]
     Phosphotransferase [EC:2.7.1.-]
     DNA polymerase [EC:2.7.7.7]
     Reverse transcriptase [EC:2.7.7.49]
   Hydrolases (EC3)
   Lyases (EC4)
   Isomerases (EC5)
   Ligases (EC6)
     GART [EC:6.3.4.13 2.1.2.2 6.3.3.1]
       GART [HSA:2618] [KO:K11787]
         D07472  Pemetrexed (INN)
         D03828  Pemetrexed disodium (USAN)
         D06503  Pemetrexed sodium hydrate (JAN) <JP/US>
         D10596  Pemetrexed sodium hemipentahydrate (JAN)
         D04766  Lometrexol sodium (USAN)
         D05400  Pelitrexol (USAN/INN)
         D11352  Pemetrexed tromethamine (USAN)
 
 
 
 
 
 
 
     Carbamoyl-phosphate synthase [EC:6.3.4.16]
     Acetyl-CoA carboxylase [EC:6.4.1.2]
 
 Nucleic acids
 
 Not elsewhere classified

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Last updated: October 13, 2020

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