Target-based Classification of Drugs

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     Type
 G Protein-coupled receptors
 
 Ion channels
 
 Nuclear receptors
 
 Protein kinases
   Serine/threonine kinases
   Receptor serine/threonine kinases (RSTK)
   Receptor tyrosine kinases (RTK)
     EGFR family
     INSR family
     PDGFR family
       PDGFR [HSA:5156 5159] [KO:K04363 K05089]
         D08552  Sunitinib (INN)
         D06402  Sunitinib malate (JAN/USAN) <JP/US>
         D08953  Nilotinib (USAN/INN)
         D06413  Nilotinib hydrochloride hydrate (JAN) <JP/US>
         D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
         D10481  Nintedanib (USAN/INN)
         D10396  Nintedanib esylate (USAN) <JP/US>
         D05029  Midostaurin (JAN/USAN/INN) <US>
         D06678  Motesanib (USAN)
         D08503  Toceranib (USAN)
         D08544  Toceranib phosphate (USAN)
         D09635  Linifanib (USAN/INN)
         D10102  Crenolanib (USAN)
         D10103  Crenolanib besylate (USAN)
         D10423  Ilorasertib (USAN)
         D11140  Sitravatinib (USAN/INN)
         D11541  Sitravatinib malate (USAN)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
       PDGFRA [HSA:5156] [KO:K04363]
       PDGFRA* [HSA_VAR:5156v2] [HSA:5156] [KO:K04363]
       FIP1L1-PDGFRA [HSA:5156] [KO:K04363]
       PDGFRB [HSA:5159] [KO:K05089]
       KIT (CD117) [HSA:3815] [KO:K05091]
       KIT* (CD117) [HSA_VAR:3815v1] [HSA:3815] [KO:K05091]
       FLT3 (CD135) [HSA:2322] [KO:K05092]
       FLT3* (CD135) [HSA_VAR:2322v1 2322v2] [HSA:2322] [KO:K05092]
       FLT3* (CD135) [HSA_VAR:2322v2] [HSA:2322] [KO:K05092]
     FGFR family
       FGFR [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095]
       FGFR1 (CD331) [HSA:2260] [KO:K04362]
         D10138  Regorafenib (USAN/INN)
         D10137  Regorafenib hydrate (JAN) <JP/US>
         D10481  Nintedanib (USAN/INN)
         D10396  Nintedanib esylate (USAN) <JP/US>
         D08878  Brivanib alaninate (JAN/USAN/INN)
         D09589  Brivanib (USAN)
         D11589  Infigratinib (USAN/INN)
         D11611  Infigratinib phosphate (USAN)
         D11762  Lucitanib (USAN/INN)
         D11885  Surufatinib (USAN/INN)
 
 
 
 
 
 
 
 
 
 
       FGFR2 (CD332) [HSA:2263] [KO:K05093]
         D10481  Nintedanib (USAN/INN)
         D10396  Nintedanib esylate (USAN) <JP/US>
         D05338  Palifermin (USAN/INN) <US>
         D11589  Infigratinib (USAN/INN)
         D11611  Infigratinib phosphate (USAN)
         D11725  Futibatinib (JAN/USAN/INN)
         D11762  Lucitanib (USAN/INN)
 
 
 
 
 
 
 
       FGFR2* (CD332) [HSA_VAR:2263v2] [HSA:2263] [KO:K05093]
       FGFR3 (CD333) [HSA:2261] [KO:K05094]
         D10481  Nintedanib (USAN/INN)
         D10396  Nintedanib esylate (USAN) <JP/US>
         D08907  Dovitinib lactate (USAN)
         D11445  Vofatamab (USAN)
         D11589  Infigratinib (USAN/INN)
         D11611  Infigratinib phosphate (USAN)
 
 
 
Monoclonal antibody
 
 
       FGFR3* (CD333) [HSA_VAR:2261v2] [HSA:2261] [KO:K05094]
       FGFR4 [HSA:2264] [KO:K05095]
     VEGFR family
       VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
         D08552  Sunitinib (INN)
         D06402  Sunitinib malate (JAN/USAN) <JP/US>
         D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
         D03218  Axitinib (JAN/USAN) <JP/US>
         D10138  Regorafenib (USAN/INN)
         D10137  Regorafenib hydrate (JAN) <JP/US>
         D09919  Lenvatinib (USAN/INN) <US>
         D09920  Lenvatinib mesylate (USAN) <JP>
         D10481  Nintedanib (USAN/INN)
         D10396  Nintedanib esylate (USAN) <JP/US>
         D08881  Cediranib (USAN/INN)
         D08883  Cediranib maleate (JAN/USAN)
         D09683  Tivozanib (USAN/INN)
         D10190  Tivozanib hydrochloride (USAN)
         D06285  Vatalanib (USAN/INN)
         D06678  Motesanib (USAN)
         D08907  Dovitinib lactate (USAN)
         D08947  Motesanib diphosphate (USAN)
         D09635  Linifanib (USAN/INN)
         D09926  Icrucumab (USAN/INN)
         D10423  Ilorasertib (USAN)
         D11140  Sitravatinib (USAN/INN)
         D11541  Sitravatinib malate (USAN)
         D11713  Selpercatinib (JAN/USAN/INN) <US>
         D11762  Lucitanib (USAN/INN)
         D11885  Surufatinib (USAN/INN)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Monoclonal antibody
 
 
 
 
 
 
       VEGFR2 (KDR) [HSA:3791] [KO:K05098]
         D09371  Ramucirumab (USAN) <JP/US>
         D08552  Sunitinib (INN)
         D06402  Sunitinib malate (JAN/USAN) <JP/US>
         D08524  Sorafenib (USAN/INN)
         D06272  Sorafenib tosylate (USAN) <JP/US>
         D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
         D06407  Vandetanib (JAN/USAN/INN) <JP/US>
         D03218  Axitinib (JAN/USAN) <JP/US>
         D10138  Regorafenib (USAN/INN)
         D10137  Regorafenib hydrate (JAN) <JP/US>
         D10062  Cabozantinib (USAN)
         D10095  Cabozantinib s-malate (USAN) <JP/US>
         D09919  Lenvatinib (USAN/INN) <US>
         D09920  Lenvatinib mesylate (USAN) <JP>
         D10481  Nintedanib (USAN/INN)
         D10396  Nintedanib esylate (USAN) <JP/US>
         D08881  Cediranib (USAN/INN)
         D08883  Cediranib maleate (JAN/USAN)
         D09683  Tivozanib (USAN/INN)
         D10190  Tivozanib hydrochloride (USAN)
         D05029  Midostaurin (JAN/USAN/INN) <US>
         D05819  Semaxanib (USAN/INN)
         D06285  Vatalanib (USAN/INN)
         D06678  Motesanib (USAN)
         D08503  Toceranib (USAN)
         D08544  Toceranib phosphate (USAN)
         D08878  Brivanib alaninate (JAN/USAN/INN)
         D08907  Dovitinib lactate (USAN)
         D08947  Motesanib diphosphate (USAN)
         D09589  Brivanib (USAN)
         D09618  Foretinib (USAN/INN)
         D09635  Linifanib (USAN/INN)
         D09945  Pegdinetanib (USAN/INN)
         D10224  Golvatinib (USAN)
         D10465  Golvatinib tartrate (USAN)
         D10862  Altiratinib (USAN)
         D11140  Sitravatinib (USAN/INN)
         D11288  Rivoceranib (USAN/INN)
         D11289  Rivoceranib mesylate (USAN)
         D11541  Sitravatinib malate (USAN)
         D11762  Lucitanib (USAN/INN)
         D11772  Tesevatinib (USAN/INN)
         D11773  Tesevatinib tosylate (USAN)
         D11885  Surufatinib (USAN/INN)
Monoclonal antibody
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
       VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
         D08552  Sunitinib (INN)
         D06402  Sunitinib malate (JAN/USAN) <JP/US>
         D08524  Sorafenib (USAN/INN)
         D06272  Sorafenib tosylate (USAN) <JP/US>
         D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
         D03218  Axitinib (JAN/USAN) <JP/US>
         D10138  Regorafenib (USAN/INN)
         D10137  Regorafenib hydrate (JAN) <JP/US>
         D09919  Lenvatinib (USAN/INN) <US>
         D09920  Lenvatinib mesylate (USAN) <JP>
         D10481  Nintedanib (USAN/INN)
         D10396  Nintedanib esylate (USAN) <JP/US>
         D08881  Cediranib (USAN/INN)
         D08883  Cediranib maleate (JAN/USAN)
         D09683  Tivozanib (USAN/INN)
         D10190  Tivozanib hydrochloride (USAN)
         D06285  Vatalanib (USAN/INN)
         D06678  Motesanib (USAN)
         D08907  Dovitinib lactate (USAN)
         D08947  Motesanib diphosphate (USAN)
         D09635  Linifanib (USAN/INN)
         D11140  Sitravatinib (USAN/INN)
         D11541  Sitravatinib malate (USAN)
         D11713  Selpercatinib (JAN/USAN/INN) <US>
         D11762  Lucitanib (USAN/INN)
         D11772  Tesevatinib (USAN/INN)
         D11773  Tesevatinib tosylate (USAN)
         D11885  Surufatinib (USAN/INN)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
     MET family
     TRK family
     EPH family
     AXL family
     ALK family
     TIE family
     RET family
     CCK family
   Non-receptor tyrosine kinases
 
 Cytokines and receptors
 
 Cell surface molecules and ligands
 
 Transporters
 
 Enzymes
 
 Nucleic acids
 
 Not elsewhere classified

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Last updated: October 28, 2020

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