Chromosome and Associated Proteins - Canis lupus familiaris (dog)

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     KO 
 Eukaryotic type

   Sister chromatid cohesion proteins

   Meiosis-specific proteins

   Nucleosome assembly factors

   Histone modification proteins

     HATs (histone acetyltransferases)

     HAT complexes

     HDACs (histone deacetylases)

     HDAC complexes

     HMTs (histone methyltransferases)

       HKMTs (histone lysine methyltransferases)

         480128 ASH1L; histone-lysine N-methyltransferase ASH1L
         485073 DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
         474851 EHMT2; histone-lysine N-methyltransferase EHMT2 isoform X1
         491224 EHMT1; histone-lysine N-methyltransferase EHMT1 isoform X3
         480516 EZH1; histone-lysine N-methyltransferase EZH1
         475511 EZH2; histone-lysine N-methyltransferase EZH2 isoform X6
         479417 KMT2A; histone-lysine N-methyltransferase 2A isoform X14
         486558 KMT2D; histone-lysine N-methyltransferase 2D isoform X1
         611094 KMT2C; histone-lysine N-methyltransferase 2C isoform X37
         100688666 KMT2B; histone-lysine N-methyltransferase 2B
         475895 KMT2E; LOW QUALITY PROTEIN: inactive histone-lysine N-methyltransferase 2E isoform X5
         489094 NSD1; histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1
         479077 NSD2; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2
         475584 NSD3; histone-lysine N-methyltransferase NSD3 isoform X1
         100688431 PRDM2; PR domain zinc finger protein 2 isoform X1
         488148 MECOM; histone-lysine N-methyltransferase MECOM isoform X1
         100687856 PRDM6; putative histone-lysine N-methyltransferase PRDM6
         487823 PRDM8; LOW QUALITY PROTEIN: PR domain zinc finger protein 8
         489083 ZNF488; zinc finger protein 488 isoform X2
         119873358 PRDM12; PR domain zinc finger protein 12
         479582 PRDM16; histone-lysine N-methyltransferase PRDM16 isoform X1
         486257 SETD1B; histone-lysine N-methyltransferase SETD1B
         489916 SETD1A; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SETD1A isoform X2
         476643 SETD2; histone-lysine N-methyltransferase SETD2 isoform X1
         487747 SETD4; SET domain-containing protein 4 isoform X1
         487253 SETD6; N-lysine methyltransferase SETD6 isoform X1
         476079 SETD7; histone-lysine N-methyltransferase SETD7
         610615 KMT5A; N-lysine methyltransferase KMT5A isoform X1
         483186 SETDB1; histone-lysine N-methyltransferase SETDB1 isoform X3
         485441 SETDB2; histone-lysine N-methyltransferase SETDB2 isoform X1
         476549 SETMAR; histone-lysine N-methyltransferase SETMAR
         475758 SMYD1; histone-lysine N-methyltransferase SMYD1 isoform X2
         480026 SMYD2; N-lysine methyltransferase SMYD2
         480101 SMYD3; histone-lysine N-methyltransferase SMYD3 isoform X1
         491868 SUV39H1; histone-lysine N-methyltransferase SUV39H1 isoform X1
         477995 SUV39H2; histone-lysine N-methyltransferase SUV39H2 isoform X2
         483690 KMT5B; histone-lysine N-methyltransferase KMT5B isoform X1
         484295 KMT5C; histone-lysine N-methyltransferase KMT5C isoform X1

K06101 ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354] 
K11427 DOT1L; [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360] 
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355] 
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355] 
K17451 EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356] 
K11430 EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] 
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354] 
K09187 MLL2; [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354] 
K09188 MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354] 
K14959 MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354] 
K09189 MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354] 
K15588 NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357] 
K11424 WHSC1; [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357] 
K11425 WHSC1L1; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371] 
K11432 PRDM2; [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355] 
K04462 MECOM; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367] 
K20795 PRDM6; [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361] 
K20797 PRDM8; PR domain zinc finger protein 8 [EC:2.1.1.-] 
K20797 PRDM8; PR domain zinc finger protein 8 [EC:2.1.1.-] 
K24255 PRDM12; PR domain zinc finger protein 12 [EC:2.1.1.-] 
K22410 PRDM16; [histone H3]-lysine9 N-methyltransferase [EC:2.1.1.367] 
K11422 SETD1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354] 
K11422 SETD1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354] 
K11423 SETD2; [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359] 
K27277 SETD4; SET domain-containing protein 4 [EC:2.1.1.- 2.1.1.364] 
K05302 SETD6; N-lysine methyltransferase SETD6 [EC:2.1.1.-] 
K11431 SETD7; [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364] 
K11428 SETD8; [histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361] 
K11421 SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366] 
K18494 SETDB2; [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355] 
K11433 SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357] 
K11426 SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357] 
K11426 SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357] 
K11426 SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357] 
K11419 SUV39H; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355] 
K11419 SUV39H; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355] 
K11429 SUV420H; [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362] 
K11429 SUV420H; [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362] 

       PRMTs (protein arginine metyltransferases)

     HMT complexes

     Histone demethylases

     Polycomb repressive complex (PRC) and associated proteins

       Canonical PRC1 (PRC1.2/1.4)

       Noncanonical PRC1 (PRC1.1)

       Noncanonical PRC1 (PRC1.3/1.5)

       Noncanonical PRC1 (PRC1.6)

       PRC2.1

         480516 EZH1; histone-lysine N-methyltransferase EZH1
         475511 EZH2; histone-lysine N-methyltransferase EZH2 isoform X6
         476779 EED; polycomb protein EED isoform X1
         491158 SUZ12; polycomb protein SUZ12 isoform X2
         478149 RBBP4; histone-binding protein RBBP4 isoform X1
         119870425 histone-binding protein RBBP4-like
         480854 RBBP7; histone-binding protein RBBP7 isoform X1
         481741 PHF1; PHD finger protein 1 isoform X2
         479948 MTF2; metal-response element-binding transcription factor 2 isoform X4
         100688884 PHF19; uncharacterized protein PHF19 isoform X1
         608579 EPOP; elongin BC and Polycomb repressive complex 2-associated protein isoform X2
         486817 LCOR; LOW QUALITY PROTEIN: ligand-dependent corepressor isoform X1

K17451 EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356] 
K11430 EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] 
K11462 EED; polycomb protein EED 
K11463 SUZ12; polycomb protein SUZ12 
K10752 RBBP4; histone-binding protein RBBP4 
K10752 RBBP4; histone-binding protein RBBP4 
K11659 RBBP7; histone-binding protein RBBP7 
K11467 PHF1; PHD finger protein 1 
K11485 MTF2; metal regulatory transcription factor 2 
K11486 PHF19; PHD finger protein 19 
K26259 EPOP; elongin BC and Polycomb repressive complex 2-associated protein 
K26260 LCOR; ligand-dependent corepressor 

       PRC2.2

         480516 EZH1; histone-lysine N-methyltransferase EZH1
         475511 EZH2; histone-lysine N-methyltransferase EZH2 isoform X6
         476779 EED; polycomb protein EED isoform X1
         491158 SUZ12; polycomb protein SUZ12 isoform X2
         478149 RBBP4; histone-binding protein RBBP4 isoform X1
         119870425 histone-binding protein RBBP4-like
         480854 RBBP7; histone-binding protein RBBP7 isoform X1
         486656 AEBP2; zinc finger protein AEBP2 isoform X2
         478729 JARID2; protein Jumonji isoform X1

K17451 EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356] 
K11430 EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] 
K11462 EED; polycomb protein EED 
K11463 SUZ12; polycomb protein SUZ12 
K10752 RBBP4; histone-binding protein RBBP4 
K10752 RBBP4; histone-binding protein RBBP4 
K11659 RBBP7; histone-binding protein RBBP7 
K17452 AEBP2; zinc finger protein AEBP2 
K11478 JARID2; protein Jumonji 

       PR-DUB complex

       Other PRC associated proteins

     Sir proteins

     Other histone modification proteins

   Chromosome condensation proteins

   Centromeric chromatin formation proteins

   Heterochromatin formation proteins

   Gene silencing

   Centrosome formation proteins

   Sister chromatid separation proteins

   Chromatin remodeling factors

 





 Prokaryotic type













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Last updated: April 10, 2024