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KO |
 09100 Metabolism
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09120 Genetic Information Processing
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 09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
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 02020 Two-component system
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04010 MAPK signaling pathway [PATH:hsa04010]
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04013 MAPK signaling pathway - fly
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04016 MAPK signaling pathway - plant
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04011 MAPK signaling pathway - yeast
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04012 ErbB signaling pathway [PATH:hsa04012]
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04014 Ras signaling pathway [PATH:hsa04014]
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04015 Rap1 signaling pathway [PATH:hsa04015]
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04310 Wnt signaling pathway [PATH:hsa04310]
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04330 Notch signaling pathway [PATH:hsa04330]
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04340 Hedgehog signaling pathway [PATH:hsa04340]
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04341 Hedgehog signaling pathway - fly
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04350 TGF-beta signaling pathway [PATH:hsa04350]
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04390 Hippo signaling pathway [PATH:hsa04390]
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04391 Hippo signaling pathway - fly
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04392 Hippo signaling pathway - multiple species [PATH:hsa04392]
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04370 VEGF signaling pathway [PATH:hsa04370]
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04371 Apelin signaling pathway [PATH:hsa04371]
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04630 JAK-STAT signaling pathway [PATH:hsa04630]
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04064 NF-kappa B signaling pathway [PATH:hsa04064]
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04668 TNF signaling pathway [PATH:hsa04668]
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04066 HIF-1 signaling pathway [PATH:hsa04066]
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3569 IL6; interleukin 6
3570 IL6R; interleukin 6 receptor
6774 STAT3; signal transducer and activator of transcription 3
7099 TLR4; toll like receptor 4
3458 IFNG; interferon gamma
3459 IFNGR1; interferon gamma receptor 1
3460 IFNGR2; interferon gamma receptor 2
5970 RELA; RELA proto-oncogene, NF-kB subunit
4790 NFKB1; nuclear factor kappa B subunit 1
3630 INS; insulin
1950 EGF; epidermal growth factor
3479 IGF1; insulin like growth factor 1
3643 INSR; insulin receptor
1956 EGFR; epidermal growth factor receptor
3480 IGF1R; insulin like growth factor 1 receptor
2064 ERBB2; erb-b2 receptor tyrosine kinase 2
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
8569 MKNK1; MAPK interacting serine/threonine kinase 1
2872 MKNK2; MAPK interacting serine/threonine kinase 2
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
2475 MTOR; mechanistic target of rapamycin kinase
1978 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
1977 EIF4E; eukaryotic translation initiation factor 4E
9470 EIF4E2; eukaryotic translation initiation factor 4E family member 2
253314 EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
6194 RPS6; ribosomal protein S6
3091 HIF1A; hypoxia inducible factor 1 subunit alpha
7428 VHL; von Hippel-Lindau tumor suppressor
9978 RBX1; ring-box 1
6921 ELOC; elongin C
6923 ELOB; elongin B
8453 CUL2; cullin 2
54583 EGLN1; egl-9 family hypoxia inducible factor 1
112399 EGLN3; egl-9 family hypoxia inducible factor 3
112398 EGLN2; egl-9 family hypoxia inducible factor 2
405 ARNT; aryl hydrocarbon receptor nuclear translocator
1387 CREBBP; CREB binding protein
2033 EP300; E1A binding protein p300
1536 CYBB; cytochrome b-245 beta chain
5335 PLCG1; phospholipase C gamma 1
5336 PLCG2; phospholipase C gamma 2
5578 PRKCA; protein kinase C alpha
5579 PRKCB; protein kinase C beta
5582 PRKCG; protein kinase C gamma
815 CAMK2A; calcium/calmodulin dependent protein kinase II alpha
817 CAMK2D; calcium/calmodulin dependent protein kinase II delta
816 CAMK2B; calcium/calmodulin dependent protein kinase II beta
818 CAMK2G; calcium/calmodulin dependent protein kinase II gamma
7076 TIMP1; TIMP metallopeptidase inhibitor 1
4055 LTBR; lymphotoxin beta receptor
2056 EPO; erythropoietin
7018 TF; transferrin
7037 TFRC; transferrin receptor
7422 VEGFA; vascular endothelial growth factor A
2321 FLT1; fms related receptor tyrosine kinase 1
5054 SERPINE1; serpin family E member 1
284 ANGPT1; angiopoietin 1
285 ANGPT2; angiopoietin 2
51378 ANGPT4; angiopoietin 4
7010 TEK; TEK receptor tyrosine kinase
1906 EDN1; endothelin 1
4843 NOS2; nitric oxide synthase 2
4846 NOS3; nitric oxide synthase 3
3162 HMOX1; heme oxygenase 1
4878 NPPA; natriuretic peptide A
6513 SLC2A1; solute carrier family 2 member 1
5163 PDK1; pyruvate dehydrogenase kinase 1
3101 HK3; hexokinase 3
3098 HK1; hexokinase 1
3099 HK2; hexokinase 2
80201 HKDC1; hexokinase domain containing 1
5213 PFKM; phosphofructokinase, muscle
5214 PFKP; phosphofructokinase, platelet
5211 PFKL; phosphofructokinase, liver type
2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase
230 ALDOC; aldolase, fructose-bisphosphate C
226 ALDOA; aldolase, fructose-bisphosphate A
229 ALDOB; aldolase, fructose-bisphosphate B
2027 ENO3; enolase 3
2026 ENO2; enolase 2
2023 ENO1; enolase 1
387712 ENO4; enolase 4
5232 PGK2; phosphoglycerate kinase 2
5230 PGK1; phosphoglycerate kinase 1
5209 PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
160287 LDHAL6A; lactate dehydrogenase A like 6A
92483 LDHAL6B; lactate dehydrogenase A like 6B
3939 LDHA; lactate dehydrogenase A
3945 LDHB; lactate dehydrogenase B
3948 LDHC; lactate dehydrogenase C
596 BCL2; BCL2 apoptosis regulator
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
1027 CDKN1B; cyclin dependent kinase inhibitor 1B
5161 PDHA2; pyruvate dehydrogenase E1 subunit alpha 2
5160 PDHA1; pyruvate dehydrogenase E1 subunit alpha 1
5162 PDHB; pyruvate dehydrogenase E1 subunit beta
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K05405 IL6; interleukin 6
K05055 IL6R; interleukin 6 receptor
K04692 STAT3; signal transducer and activator of transcription 3
K10160 TLR4; toll-like receptor 4
K04687 IFNG; interferon gamma
K05132 IFNGR1; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K04735 RELA; transcription factor p65
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04526 INS; insulin
K04357 EGF; epidermal growth factor
K05459 IGF1; insulin-like growth factor 1
K04527 INSR; insulin receptor [EC:2.7.10.1]
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04372 MKNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
K04372 MKNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K02991 RP-S6e; small subunit ribosomal protein S6e
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03872 ELOC; elongin-C
K03873 ELOB; elongin-B
K03870 CUL2; cullin 2
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K21421 NOX2; NADPH oxidase 2 [EC:1.-.-.-]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K16451 TIMP1; metalloproteinase inhibitor 1
K03159 TNFRSF3; lymphotoxin beta receptor TNFR superfamily member 3
K05437 EPO; erythropoietin
K14736 TF; transferrin
K06503 TFRC; transferrin receptor
K05448 VEGFA; vascular endothelial growth factor A
K05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K03982 SERPINE1; plasminogen activator inhibitor 1
K05465 ANGPT1; angiopoietin 1
K05466 ANGPT2; angiopoietin 2
K05467 ANGPT4; angiopoietin 4
K05121 TEK; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
K16366 EDN1; endothelin-1
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242 NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
K00510 HMOX1; heme oxygenase 1 [EC:1.14.14.18]
K12334 NPPA; natriuretic peptide A
K07299 SLC2A1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K12077 PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]
K00844 HK; hexokinase [EC:2.7.1.1]
K00844 HK; hexokinase [EC:2.7.1.1]
K00844 HK; hexokinase [EC:2.7.1.1]
K00844 HK; hexokinase [EC:2.7.1.1]
K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]
K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
K01689 ENO; enolase [EC:4.2.1.11]
K01689 ENO; enolase [EC:4.2.1.11]
K01689 ENO; enolase [EC:4.2.1.11]
K01689 ENO; enolase [EC:4.2.1.11]
K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
K01103 PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]
K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
K02161 BCL2; apoptosis regulator Bcl-2
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K00161 PDHA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00161 PDHA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162 PDHB; pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
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04068 FoxO signaling pathway [PATH:hsa04068]
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04020 Calcium signaling pathway [PATH:hsa04020]
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04070 Phosphatidylinositol signaling system [PATH:hsa04070]
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04072 Phospholipase D signaling pathway [PATH:hsa04072]
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04071 Sphingolipid signaling pathway [PATH:hsa04071]
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04024 cAMP signaling pathway [PATH:hsa04024]
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04022 cGMP-PKG signaling pathway [PATH:hsa04022]
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04151 PI3K-Akt signaling pathway [PATH:hsa04151]
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04152 AMPK signaling pathway [PATH:hsa04152]
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04150 mTOR signaling pathway [PATH:hsa04150]
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04075 Plant hormone signal transduction
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09133 Signaling molecules and interaction
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09140 Cellular Processes
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09150 Organismal Systems
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09160 Human Diseases
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09161 Cancer: overview
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05200 Pathways in cancer [PATH:hsa05200]
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1630 DCC; DCC netrin 1 receptor
836 CASP3; caspase 3
842 CASP9; caspase 9
26060 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
999 CDH1; cadherin 1
1499 CTNNB1; catenin beta 1
29119 CTNNA3; catenin alpha 3
1495 CTNNA1; catenin alpha 1
1496 CTNNA2; catenin alpha 2
8312 AXIN1; axin 1
8313 AXIN2; axin 2
324 APC; APC regulator of WNT signaling pathway
10297 APC2; APC regulator of WNT signaling pathway 2
2932 GSK3B; glycogen synthase kinase 3 beta
6932 TCF7; transcription factor 7
83439 TCF7L1; transcription factor 7 like 1
6934 TCF7L2; transcription factor 7 like 2
51176 LEF1; lymphoid enhancer binding factor 1
332 BIRC5; baculoviral IAP repeat containing 5
4609 MYC; MYC proto-oncogene, bHLH transcription factor
595 CCND1; cyclin D1
7471 WNT1; Wnt family member 1
7472 WNT2; Wnt family member 2
7482 WNT2B; Wnt family member 2B
7473 WNT3; Wnt family member 3
89780 WNT3A; Wnt family member 3A
54361 WNT4; Wnt family member 4
7474 WNT5A; Wnt family member 5A
81029 WNT5B; Wnt family member 5B
7475 WNT6; Wnt family member 6
7476 WNT7A; Wnt family member 7A
7477 WNT7B; Wnt family member 7B
7478 WNT8A; Wnt family member 8A
7479 WNT8B; Wnt family member 8B
7483 WNT9A; Wnt family member 9A
7484 WNT9B; Wnt family member 9B
7480 WNT10B; Wnt family member 10B
80326 WNT10A; Wnt family member 10A
7481 WNT11; Wnt family member 11
51384 WNT16; Wnt family member 16
8321 FZD1; frizzled class receptor 1
8324 FZD7; frizzled class receptor 7
2535 FZD2; frizzled class receptor 2
7976 FZD3; frizzled class receptor 3
8322 FZD4; frizzled class receptor 4
7855 FZD5; frizzled class receptor 5
8325 FZD8; frizzled class receptor 8
8323 FZD6; frizzled class receptor 6
11211 FZD10; frizzled class receptor 10
8326 FZD9; frizzled class receptor 9
4041 LRP5; LDL receptor related protein 5
4040 LRP6; LDL receptor related protein 6
1857 DVL3; dishevelled segment polarity protein 3
1856 DVL2; dishevelled segment polarity protein 2
1855 DVL1; dishevelled segment polarity protein 1
10023 FRAT1; FRAT regulator of WNT signaling pathway 1
23401 FRAT2; FRAT regulator of WNT signaling pathway 2
2147 F2; coagulation factor II, thrombin
183 AGT; angiotensinogen
2149 F2R; coagulation factor II thrombin receptor
9002 F2RL3; F2R like thrombin or trypsin receptor 3
1902 LPAR1; lysophosphatidic acid receptor 1
9170 LPAR2; lysophosphatidic acid receptor 2
23566 LPAR3; lysophosphatidic acid receptor 3
2846 LPAR4; lysophosphatidic acid receptor 4
57121 LPAR5; lysophosphatidic acid receptor 5
10161 LPAR6; lysophosphatidic acid receptor 6
185 AGTR1; angiotensin II receptor type 1
2768 GNA12; G protein subunit alpha 12
10672 GNA13; G protein subunit alpha 13
23365 ARHGEF12; Rho guanine nucleotide exchange factor 12
9826 ARHGEF11; Rho guanine nucleotide exchange factor 11
9138 ARHGEF1; Rho guanine nucleotide exchange factor 1
57449 PLEKHG5; pleckstrin homology and RhoGEF domain containing G5
387 RHOA; ras homolog family member A
6093 ROCK1; Rho associated coiled-coil containing protein kinase 1
9475 ROCK2; Rho associated coiled-coil containing protein kinase 2
6387 CXCL12; C-X-C motif chemokine ligand 12
7852 CXCR4; C-X-C motif chemokine receptor 4
2770 GNAI1; G protein subunit alpha i1
2773 GNAI3; G protein subunit alpha i3
2771 GNAI2; G protein subunit alpha i2
5731 PTGER1; prostaglandin E receptor 1
5732 PTGER2; prostaglandin E receptor 2
5733 PTGER3; prostaglandin E receptor 3
5734 PTGER4; prostaglandin E receptor 4
2778 GNAS; GNAS complex locus
107 ADCY1; adenylate cyclase 1
108 ADCY2; adenylate cyclase 2
109 ADCY3; adenylate cyclase 3
196883 ADCY4; adenylate cyclase 4
111 ADCY5; adenylate cyclase 5
112 ADCY6; adenylate cyclase 6
113 ADCY7; adenylate cyclase 7
114 ADCY8; adenylate cyclase 8
115 ADCY9; adenylate cyclase 9
5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma
2782 GNB1; G protein subunit beta 1
2783 GNB2; G protein subunit beta 2
2784 GNB3; G protein subunit beta 3
59345 GNB4; G protein subunit beta 4
10681 GNB5; G protein subunit beta 5
54331 GNG2; G protein subunit gamma 2
2785 GNG3; G protein subunit gamma 3
2786 GNG4; G protein subunit gamma 4
2787 GNG5; G protein subunit gamma 5
2788 GNG7; G protein subunit gamma 7
94235 GNG8; G protein subunit gamma 8
2790 GNG10; G protein subunit gamma 10
2791 GNG11; G protein subunit gamma 11
55970 GNG12; G protein subunit gamma 12
51764 GNG13; G protein subunit gamma 13
2792 GNGT1; G protein subunit gamma transducin 1
2793 GNGT2; G protein subunit gamma transducin 2
1284 COL4A2; collagen type IV alpha 2 chain
1286 COL4A4; collagen type IV alpha 4 chain
1288 COL4A6; collagen type IV alpha 6 chain
1282 COL4A1; collagen type IV alpha 1 chain
1287 COL4A5; collagen type IV alpha 5 chain
1285 COL4A3; collagen type IV alpha 3 chain
284217 LAMA1; laminin subunit alpha 1
3908 LAMA2; laminin subunit alpha 2
3909 LAMA3; laminin subunit alpha 3
3911 LAMA5; laminin subunit alpha 5
3910 LAMA4; laminin subunit alpha 4
3912 LAMB1; laminin subunit beta 1
3913 LAMB2; laminin subunit beta 2
3914 LAMB3; laminin subunit beta 3
22798 LAMB4; laminin subunit beta 4
3915 LAMC1; laminin subunit gamma 1
3918 LAMC2; laminin subunit gamma 2
10319 LAMC3; laminin subunit gamma 3
2335 FN1; fibronectin 1
3673 ITGA2; integrin subunit alpha 2
3674 ITGA2B; integrin subunit alpha 2b
3675 ITGA3; integrin subunit alpha 3
3655 ITGA6; integrin subunit alpha 6
3685 ITGAV; integrin subunit alpha V
3688 ITGB1; integrin subunit beta 1
5747 PTK2; protein tyrosine kinase 2
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5728 PTEN; phosphatase and tensin homolog
4824 NKX3-1; NK3 homeobox 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
4790 NFKB1; nuclear factor kappa B subunit 1
4791 NFKB2; nuclear factor kappa B subunit 2
5970 RELA; RELA proto-oncogene, NF-kB subunit
5743 PTGS2; prostaglandin-endoperoxide synthase 2
4843 NOS2; nitric oxide synthase 2
596 BCL2; BCL2 apoptosis regulator
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
331 XIAP; X-linked inhibitor of apoptosis
79444 BIRC7; baculoviral IAP repeat containing 7
598 BCL2L1; BCL2 like 1
7185 TRAF1; TNF receptor associated factor 1
7186 TRAF2; TNF receptor associated factor 2
7187 TRAF3; TNF receptor associated factor 3
9618 TRAF4; TNF receptor associated factor 4
7188 TRAF5; TNF receptor associated factor 5
7189 TRAF6; TNF receptor associated factor 6
2475 MTOR; mechanistic target of rapamycin kinase
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
572 BAD; BCL2 associated agonist of cell death
2308 FOXO1; forkhead box O1
4193 MDM2; MDM2 proto-oncogene
7157 TP53; tumor protein p53
1027 CDKN1B; cyclin dependent kinase inhibitor 1B
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
613 BCR; BCR activator of RhoGEF and GTPase
25 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
1398 CRK; CRK proto-oncogene, adaptor protein
1399 CRKL; CRK like proto-oncogene, adaptor protein
867 CBL; Cbl proto-oncogene
6776 STAT5A; signal transducer and activator of transcription 5A
6777 STAT5B; signal transducer and activator of transcription 5B
5292 PIM1; Pim-1 proto-oncogene, serine/threonine kinase
11040 PIM2; Pim-2 proto-oncogene, serine/threonine kinase
3827 KNG1; kininogen 1
1906 EDN1; endothelin 1
623 BDKRB1; bradykinin receptor B1
624 BDKRB2; bradykinin receptor B2
1909 EDNRA; endothelin receptor type A
1910 EDNRB; endothelin receptor type B
2776 GNAQ; G protein subunit alpha q
2767 GNA11; G protein subunit alpha 11
23236 PLCB1; phospholipase C beta 1
5330 PLCB2; phospholipase C beta 2
5331 PLCB3; phospholipase C beta 3
5332 PLCB4; phospholipase C beta 4
5578 PRKCA; protein kinase C alpha
5579 PRKCB; protein kinase C beta
5582 PRKCG; protein kinase C gamma
3558 IL2; interleukin 2
3562 IL3; interleukin 3
3565 IL4; interleukin 4
3567 IL5; interleukin 5
3569 IL6; interleukin 6
3574 IL7; interleukin 7
3592 IL12A; interleukin 12A
3593 IL12B; interleukin 12B
3596 IL13; interleukin 13
3600 IL15; interleukin 15
51561 IL23A; interleukin 23 subunit alpha
2056 EPO; erythropoietin
3439 IFNA1; interferon alpha 1
3440 IFNA2; interferon alpha 2
3441 IFNA4; interferon alpha 4
3442 IFNA5; interferon alpha 5
3443 IFNA6; interferon alpha 6
3444 IFNA7; interferon alpha 7
3445 IFNA8; interferon alpha 8
3446 IFNA10; interferon alpha 10
3447 IFNA13; interferon alpha 13
3448 IFNA14; interferon alpha 14
3449 IFNA16; interferon alpha 16
3451 IFNA17; interferon alpha 17
3452 IFNA21; interferon alpha 21
3458 IFNG; interferon gamma
3559 IL2RA; interleukin 2 receptor subunit alpha
3560 IL2RB; interleukin 2 receptor subunit beta
3561 IL2RG; interleukin 2 receptor subunit gamma
3563 IL3RA; interleukin 3 receptor subunit alpha
3566 IL4R; interleukin 4 receptor
1439 CSF2RB; colony stimulating factor 2 receptor subunit beta
3568 IL5RA; interleukin 5 receptor subunit alpha
3570 IL6R; interleukin 6 receptor
3572 IL6ST; interleukin 6 signal transducer
3575 IL7R; interleukin 7 receptor
3594 IL12RB1; interleukin 12 receptor subunit beta 1
3595 IL12RB2; interleukin 12 receptor subunit beta 2
3597 IL13RA1; interleukin 13 receptor subunit alpha 1
3601 IL15RA; interleukin 15 receptor subunit alpha
149233 IL23R; interleukin 23 receptor
2057 EPOR; erythropoietin receptor
3454 IFNAR1; interferon alpha and beta receptor subunit 1
3455 IFNAR2; interferon alpha and beta receptor subunit 2
3459 IFNGR1; interferon gamma receptor 1
3460 IFNGR2; interferon gamma receptor 2
27436 EML4; EMAP like 4
238 ALK; ALK receptor tyrosine kinase
10125 RASGRP1; RAS guanyl releasing protein 1
10235 RASGRP2; RAS guanyl releasing protein 2
25780 RASGRP3; RAS guanyl releasing protein 3
115727 RASGRP4; RAS guanyl releasing protein 4
3716 JAK1; Janus kinase 1
3717 JAK2; Janus kinase 2
3718 JAK3; Janus kinase 3
6774 STAT3; signal transducer and activator of transcription 3
6772 STAT1; signal transducer and activator of transcription 1
6773 STAT2; signal transducer and activator of transcription 2
6775 STAT4; signal transducer and activator of transcription 4
6778 STAT6; signal transducer and activator of transcription 6
7422 VEGFA; vascular endothelial growth factor A
7423 VEGFB; vascular endothelial growth factor B
5228 PGF; placental growth factor
7424 VEGFC; vascular endothelial growth factor C
2277 VEGFD; vascular endothelial growth factor D
7039 TGFA; transforming growth factor alpha
1950 EGF; epidermal growth factor
1956 EGFR; epidermal growth factor receptor
2064 ERBB2; erb-b2 receptor tyrosine kinase 2
5154 PDGFA; platelet derived growth factor subunit A
5155 PDGFB; platelet derived growth factor subunit B
5156 PDGFRA; platelet derived growth factor receptor alpha
5159 PDGFRB; platelet derived growth factor receptor beta
3479 IGF1; insulin like growth factor 1
3481 IGF2; insulin like growth factor 2
3480 IGF1R; insulin like growth factor 1 receptor
4254 KITLG; KIT ligand
3815 KIT; KIT proto-oncogene, receptor tyrosine kinase
2323 FLT3LG; fms related receptor tyrosine kinase 3 ligand
2322 FLT3; fms related receptor tyrosine kinase 3
3082 HGF; hepatocyte growth factor
4233 MET; MET proto-oncogene, receptor tyrosine kinase
2246 FGF1; fibroblast growth factor 1
2247 FGF2; fibroblast growth factor 2
2248 FGF3; fibroblast growth factor 3
2249 FGF4; fibroblast growth factor 4
8822 FGF17; fibroblast growth factor 17
2251 FGF6; fibroblast growth factor 6
2252 FGF7; fibroblast growth factor 7
2253 FGF8; fibroblast growth factor 8
2254 FGF9; fibroblast growth factor 9
2255 FGF10; fibroblast growth factor 10
8823 FGF16; fibroblast growth factor 16
2250 FGF5; fibroblast growth factor 5
8817 FGF18; fibroblast growth factor 18
26281 FGF20; fibroblast growth factor 20
27006 FGF22; fibroblast growth factor 22
9965 FGF19; fibroblast growth factor 19
26291 FGF21; fibroblast growth factor 21
8074 FGF23; fibroblast growth factor 23
2260 FGFR1; fibroblast growth factor receptor 1
2263 FGFR2; fibroblast growth factor receptor 2
2261 FGFR3; fibroblast growth factor receptor 3
2264 FGFR4; fibroblast growth factor receptor 4
2885 GRB2; growth factor receptor bound protein 2
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
369 ARAF; A-Raf proto-oncogene, serine/threonine kinase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
2113 ETS1; ETS proto-oncogene 1, transcription factor
4312 MMP1; matrix metallopeptidase 1
4313 MMP2; matrix metallopeptidase 2
4318 MMP9; matrix metallopeptidase 9
3576 CXCL8; C-X-C motif chemokine ligand 8
1019 CDK4; cyclin dependent kinase 4
9252 RPS6KA5; ribosomal protein S6 kinase A5
5979 RET; ret proto-oncogene
8030 CCDC6; coiled-coil domain containing 6
8031 NCOA4; nuclear receptor coactivator 4
4914 NTRK1; neurotrophic receptor tyrosine kinase 1
7170 TPM3; tropomyosin 3
7175 TPR; translocated promoter region, nuclear basket protein
10342 TFG; trafficking from ER to golgi regulator
11186 RASSF1; Ras association domain family member 1
83593 RASSF5; Ras association domain family member 5
6789 STK4; serine/threonine kinase 4
1612 DAPK1; death associated protein kinase 1
1613 DAPK3; death associated protein kinase 3
23604 DAPK2; death associated protein kinase 2
5335 PLCG1; phospholipase C gamma 1
5336 PLCG2; phospholipase C gamma 2
2002 ELK1; ETS transcription factor ELK1
810 CALML3; calmodulin like 3
805 CALM2; calmodulin 2
808 CALM3; calmodulin 3
801 CALM1; calmodulin 1
163688 CALML6; calmodulin like 6
51806 CALML5; calmodulin like 5
91860 CALML4; calmodulin like 4
815 CAMK2A; calcium/calmodulin dependent protein kinase II alpha
817 CAMK2D; calcium/calmodulin dependent protein kinase II delta
816 CAMK2B; calcium/calmodulin dependent protein kinase II beta
818 CAMK2G; calcium/calmodulin dependent protein kinase II gamma
5900 RALGDS; ral guanine nucleotide dissociation stimulator
5898 RALA; RAS like proto-oncogene A
5899 RALB; RAS like proto-oncogene B
10928 RALBP1; ralA binding protein 1
998 CDC42; cell division cycle 42
5879 RAC1; Rac family small GTPase 1
5880 RAC2; Rac family small GTPase 2
5881 RAC3; Rac family small GTPase 3
5337 PLD1; phospholipase D1
5338 PLD2; phospholipase D2
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
7849 PAX8; paired box 8
5468 PPARG; peroxisome proliferator activated receptor gamma
6256 RXRA; retinoid X receptor alpha
6257 RXRB; retinoid X receptor beta
6258 RXRG; retinoid X receptor gamma
5915 RARB; retinoic acid receptor beta
2099 ESR1; estrogen receptor 1
2100 ESR2; estrogen receptor 2
8648 NCOA1; nuclear receptor coactivator 1
8202 NCOA3; nuclear receptor coactivator 3
6667 SP1; Sp1 transcription factor
5467 PPARD; peroxisome proliferator activated receptor delta
3728 JUP; junction plakoglobin
7704 ZBTB16; zinc finger and BTB domain containing 16
5914 RARA; retinoic acid receptor alpha
890 CCNA2; cyclin A2
8900 CCNA1; cyclin A1
5371 PML; PML nuclear body scaffold
861 RUNX1; RUNX family transcription factor 1
862 RUNX1T1; RUNX1 partner transcriptional co-repressor 1
6688 SPI1; Spi-1 proto-oncogene
1050 CEBPA; CCAAT enhancer binding protein alpha
1438 CSF2RA; colony stimulating factor 2 receptor subunit alpha
1441 CSF3R; colony stimulating factor 3 receptor
1436 CSF1R; colony stimulating factor 1 receptor
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
1869 E2F1; E2F transcription factor 1
1870 E2F2; E2F transcription factor 2
1871 E2F3; E2F transcription factor 3
4149 MAX; MYC associated factor X
7709 ZBTB17; zinc finger and BTB domain containing 17
1030 CDKN2B; cyclin dependent kinase inhibitor 2B
1021 CDK6; cyclin dependent kinase 6
894 CCND2; cyclin D2
896 CCND3; cyclin D3
1163 CKS1B; CDC28 protein kinase regulatory subunit 1B
1164 CKS2; CDC28 protein kinase regulatory subunit 2
6500 SKP1; S-phase kinase associated protein 1
8454 CUL1; cullin 1
9978 RBX1; ring-box 1
6502 SKP2; S-phase kinase associated protein 2
1017 CDK2; cyclin dependent kinase 2
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
5925 RB1; RB transcriptional corepressor 1
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
1643 DDB2; damage specific DNA binding protein 2
51426 POLK; DNA polymerase kappa
7015 TERT; telomerase reverse transcriptase
7012 TERC; telomerase RNA component
4286 MITF; melanocyte inducing transcription factor
7040 TGFB1; transforming growth factor beta 1
7042 TGFB2; transforming growth factor beta 2
7043 TGFB3; transforming growth factor beta 3
7046 TGFBR1; transforming growth factor beta receptor 1
7048 TGFBR2; transforming growth factor beta receptor 2
4087 SMAD2; SMAD family member 2
4088 SMAD3; SMAD family member 3
4089 SMAD4; SMAD family member 4
2122 MECOM; MDS1 and EVI1 complex locus
1487 CTBP1; C-terminal binding protein 1
1488 CTBP2; C-terminal binding protein 2
3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
4292 MLH1; mutL homolog 1
4436 MSH2; mutS homolog 2
4437 MSH3; mutS homolog 3
2956 MSH6; mutS homolog 6
675 BRCA2; BRCA2 DNA repair associated
5888 RAD51; RAD51 recombinase
356 FASLG; Fas ligand
355 FAS; Fas cell surface death receptor
8772 FADD; Fas associated via death domain
841 CASP8; caspase 8
637 BID; BH3 interacting domain death agonist
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113 BBC3; BCL2 binding component 3
10018 BCL2L11; BCL2 like 11
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
840 CASP7; caspase 7
9817 KEAP1; kelch like ECH associated protein 1
4780 NFE2L2; nuclear factor, erythroid 2 like 2
3162 HMOX1; heme oxygenase 1
1728 NQO1; NAD(P)H quinone dehydrogenase 1
221357 GSTA5; glutathione S-transferase alpha 5
2939 GSTA2; glutathione S-transferase alpha 2
2941 GSTA4; glutathione S-transferase alpha 4
119391 GSTO2; glutathione S-transferase omega 2
2948 GSTM4; glutathione S-transferase mu 4
2953 GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
2952 GSTT1; glutathione S-transferase theta 1
2947 GSTM3; glutathione S-transferase mu 3
4257 MGST1; microsomal glutathione S-transferase 1
4259 MGST3; microsomal glutathione S-transferase 3
2944 GSTM1; glutathione S-transferase mu 1
2949 GSTM5; glutathione S-transferase mu 5
4258 MGST2; microsomal glutathione S-transferase 2
2938 GSTA1; glutathione S-transferase alpha 1
2946 GSTM2; glutathione S-transferase mu 2
2940 GSTA3; glutathione S-transferase alpha 3
9446 GSTO1; glutathione S-transferase omega 1
653689 GSTT2B; glutathione S-transferase theta 2B
2950 GSTP1; glutathione S-transferase pi 1
7296 TXNRD1; thioredoxin reductase 1
114112 TXNRD3; thioredoxin reductase 3
10587 TXNRD2; thioredoxin reductase 2
7428 VHL; von Hippel-Lindau tumor suppressor
6921 ELOC; elongin C
6923 ELOB; elongin B
8453 CUL2; cullin 2
54583 EGLN1; egl-9 family hypoxia inducible factor 1
112399 EGLN3; egl-9 family hypoxia inducible factor 3
112398 EGLN2; egl-9 family hypoxia inducible factor 2
2271 FH; fumarate hydratase
3091 HIF1A; hypoxia inducible factor 1 subunit alpha
2034 EPAS1; endothelial PAS domain protein 1
405 ARNT; aryl hydrocarbon receptor nuclear translocator
9915 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
1387 CREBBP; CREB binding protein
2033 EP300; E1A binding protein p300
6513 SLC2A1; solute carrier family 2 member 1
182 JAG1; jagged canonical Notch ligand 1
3714 JAG2; jagged canonical Notch ligand 2
10683 DLL3; delta like canonical Notch ligand 3
28514 DLL1; delta like canonical Notch ligand 1
54567 DLL4; delta like canonical Notch ligand 4
4851 NOTCH1; notch receptor 1
4853 NOTCH2; notch receptor 2
4854 NOTCH3; notch receptor 3
4855 NOTCH4; notch receptor 4
3280 HES1; hes family bHLH transcription factor 1
388585 HES5; hes family bHLH transcription factor 5
26508 HEYL; hes related family bHLH transcription factor with YRPW motif like
23462 HEY1; hes related family bHLH transcription factor with YRPW motif 1
23493 HEY2; hes related family bHLH transcription factor with YRPW motif 2
2324 FLT4; fms related receptor tyrosine kinase 4
6469 SHH; sonic hedgehog signaling molecule
5727 PTCH1; patched 1
6608 SMO; smoothened, frizzled class receptor
374654 KIF7; kinesin family member 7
51684 SUFU; SUFU negative regulator of hedgehog signaling
2735 GLI1; GLI family zinc finger 1
2736 GLI2; GLI family zinc finger 2
2737 GLI3; GLI family zinc finger 3
650 BMP2; bone morphogenetic protein 2
652 BMP4; bone morphogenetic protein 4
64399 HHIP; hedgehog interacting protein
8643 PTCH2; patched 2
367 AR; androgen receptor
3320 HSP90AA1; heat shock protein 90 alpha family class A member 1
3326 HSP90AB1; heat shock protein 90 alpha family class B member 1
7184 HSP90B1; heat shock protein 90 beta family member 1
354 KLK3; kallikrein related peptidase 3
|
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08733 APPL1; DCC-interacting protein 13 alpha
K05689 CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02085 APC; adenomatosis polyposis coli protein
K02085 APC; adenomatosis polyposis coli protein
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; G1/S-specific cyclin-D1
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7; frizzled 1/7
K02432 FZD1_7; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4; frizzled 4
K02375 FZD5_8; frizzled 5/8
K02375 FZD5_8; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02842 FZD9_10; frizzled 9/10
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K03069 FRAT1; frequently rearranged in advanced T-cell lymphomas 1
K03096 FRAT2; frequently rearranged in advanced T-cell lymphomas 2
K01313 F2; coagulation factor II (thrombin) [EC:3.4.21.5]
K09821 AGT; angiotensinogen
K03914 F2R; coagulation factor II (thrombin) receptor
K04236 F2RL3; coagulation factor II (thrombin) receptor-like 3
K04289 LPAR1; lysophosphatidic acid receptor 1
K04291 LPAR2; lysophosphatidic acid receptor 2
K04294 LPAR3; lysophosphatidic acid receptor 3
K04275 LPAR4; lysophosphatidic acid receptor 4
K08390 LPAR5; lysophosphatidic acid receptor 5
K04273 LPAR6; lysophosphatidic acid receptor 6
K04166 AGTR1; angiotensin II receptor type 1
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
K07532 ARHGEF12; Rho guanine nucleotide exchange factor 12
K12331 ARHGEF11; Rho guanine nucleotide exchange factor 11
K12330 ARHGEF1; Rho guanine nucleotide exchange factor 1
K19464 PLEKHG5; pleckstrin homology domain-containing family G member 5
K04513 RHOA; Ras homolog gene family, member A
K04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
K10031 CXCL12; C-X-C motif chemokine 12
K04189 CXCR4; C-X-C chemokine receptor type 4
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04258 PTGER1; prostaglandin E receptor 1
K04259 PTGER2; prostaglandin E receptor 2
K04260 PTGER3; prostaglandin E receptor 3
K04261 PTGER4; prostaglandin E receptor 4
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04536 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538 GNB4; guanine nucleotide-binding protein subunit beta-4
K04539 GNB5; guanine nucleotide-binding protein subunit beta-5
K07826 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K05637 LAMA1_2; laminin, alpha 1/2
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09348 NKX3-1; homeobox protein Nkx-3.1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161 BCL2; apoptosis regulator Bcl-2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K07201 FOXO1; forkhead box protein O1
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451 TP53; tumor protein p53
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K08878 BCR1; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK; C-crk adapter molecule crk
K04438 CRK; C-crk adapter molecule crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K04702 PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
K08806 PIM2; proto-oncogene serine/threonine-protein kinase Pim-2 [EC:2.7.11.1]
K03898 KNG; kininogen
K16366 EDN1; endothelin-1
K03915 BDKRB1; bradykinin receptor B1
K03916 BDKRB2; bradykinin receptor B2
K04197 EDNRA; endothelin receptor type A
K04198 EDNRB; endothelin receptor type B
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04635 GNA11; guanine nucleotide-binding protein subunit alpha-11
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K05429 IL2; interleukin 2
K04736 IL3; interleukin 3
K05430 IL4; interleukin 4
K05428 IL5; interleukin 5
K05405 IL6; interleukin 6
K05431 IL7; interleukin 7
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K05435 IL13; interleukin 13
K05433 IL15; interleukin 15
K05426 IL23A; interleukin 23 subunit alpha
K05437 EPO; erythropoietin
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K04687 IFNG; interferon gamma
K05068 IL2RA; interleukin 2 receptor alpha
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K04737 IL3RA; interleukin 3 receptor alpha
K05071 IL4R; interleukin 4 receptor
K04738 CSF2RB; cytokine receptor common subunit beta
K05067 IL5RA. CD125; interleukin 5 receptor alpha
K05055 IL6R; interleukin 6 receptor
K05060 IL6ST; interleukin 6 signal transducer
K05072 IL7R; interleukin 7 receptor
K05063 IL12RB1; interleukin 12 receptor beta-1
K05064 IL12RB2; interleukin 12 receptor beta-2
K05076 IL13RA1; interleukin 13 receptor alpha-1
K05074 IL15RA; interleukin 15 receptor alpha
K05065 IL23R; interleukin 23 receptor
K05079 EPOR; erythropoietin receptor
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05132 IFNGR1; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K15420 EML4; echinoderm microtubule-associated protein-like 4
K05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K11222 STAT4; signal transducer and activator of transcription 4
K11225 STAT6; signal transducer and activator of transcription 6
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K05449 VEGFC_D; vascular endothelial growth factor C/D
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359 PDGFA; platelet-derived growth factor subunit A
K17386 PDGFB; platelet-derived growth factor subunit B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K13769 IGF2; insulin-like growth factor 2
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461 KITLG; KIT ligand
K05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K18496 FGF1; fibroblast growth factor 1
K18497 FGF2; fibroblast growth factor 2
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K22603 FGF19; fibroblast growth factor 19
K22429 FGF21; fibroblast growth factor 21
K22428 FGF23; fibroblast growth factor 23
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K02678 ETS1; C-ets-1
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030 IL8; interleukin 8
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6; coiled-coil domain-containing protein 6
K09289 NCOA4; nuclear receptor coactivator 4
K03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5; Ras association domain-containing protein 5
K04411 STK4; serine/threonine kinase 4
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04375 ELK1; ETS domain-containing protein Elk-1
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K08524 RXRA; retinoid X receptor alpha
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K08528 RARB; retinoic acid receptor beta
K08550 ESR1; estrogen receptor alpha
K08551 ESR2; estrogen receptor beta
K09101 NCOA1; nuclear receptor coactivator 1 [EC:2.3.1.48]
K11256 NCOA3; nuclear receptor coactivator 3 [EC:2.3.1.48]
K04684 SP1; transcription factor Sp1
K04504 NR1C2; peroxisome proliferator-activated receptor delta
K10056 JUP; junction plakoglobin
K10055 ZBTB16; zinc finger and BTB domain-containing protein 16
K08527 RARA; retinoic acid receptor alpha
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K10054 PML; probable transcription factor PML
K08367 RUNX1; runt-related transcription factor 1
K10053 RUNX1T1; CBFA2/RNUX1 translocation partner 1
K09438 SPI1; transcription factor PU.1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K05066 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor alpha
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K04453 MAX; Max protein
K10500 ZBTB17; zinc finger and BTB domain-containing protein 17
K04685 CDKN2B; cyclin-dependent kinase inhibitor 2B
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03094 SKP1; S-phase kinase-associated protein 1
K03347 CUL1; cullin 1
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K06618 RB1; retinoblastoma-associated protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
K22183 TERC; telomerase RNA component
K09455 MITF; microphthalmia-associated transcription factor
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 MECOM; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
K04496 CTBP; C-terminal binding protein
K04496 CTBP; C-terminal binding protein
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K08775 BRCA2; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K16341 BCL2L11; Bcl-2-like protein 11
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K10456 KLHL19; kelch-like protein 19
K05638 NFE2L2; nuclear factor erythroid 2-related factor 2
K00510 HMOX1; heme oxygenase 1 [EC:1.14.14.18]
K00355 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 ELOC; elongin-C
K03873 ELOB; elongin-B
K03870 CUL2; cullin 2
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A; hypoxia-inducible factor 2 alpha
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K06052 JAG1; jagged-1
K21635 JAG2; jagged-2
K06051 DLL; delta
K06051 DLL; delta
K06051 DLL; delta
K02599 NOTCH1; Notch 1
K20994 NOTCH2; Notch 2
K20995 NOTCH3; Notch 3
K20996 NOTCH4; Notch 4
K06054 HES1; hairy and enhancer of split 1
K06055 HES5; hairy and enhancer of split 5
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K11988 SHH; sonic hedgehog
K06225 PTCH1; patched 1
K06226 SMO; smoothened
K18806 KIF7; kinesin family member 7
K06229 SUFU; suppressor of fused
K16797 GLI1; zinc finger protein GLI1
K16798 GLI2; zinc finger protein GLI2
K06230 GLI3; zinc finger protein GLI3
K21283 BMP2; bone morphogenetic protein 2
K04662 BMP4; bone morphogenetic protein 4
K06231 HHIP; hedgehog interacting protein
K11101 PTCH2; patched 2
K08557 AR; androgen receptor
K04079 HSP90A; molecular chaperone HtpG
K04079 HSP90A; molecular chaperone HtpG
K09487 HSP90B; heat shock protein 90kDa beta
K01351 KLK3; semenogelase [EC:3.4.21.77]
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05202 Transcriptional misregulation in cancer [PATH:hsa05202]
|
05206 MicroRNAs in cancer [PATH:hsa05206]
|
05205 Proteoglycans in cancer [PATH:hsa05205]
|
05204 Chemical carcinogenesis [PATH:hsa05204]
|
05203 Viral carcinogenesis [PATH:hsa05203]
|
05230 Central carbon metabolism in cancer [PATH:hsa05230]
|
05231 Choline metabolism in cancer [PATH:hsa05231]
|
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:hsa05235]
|
|
|
09162 Cancer: specific types
|
05210 Colorectal cancer [PATH:hsa05210]
|
05212 Pancreatic cancer [PATH:hsa05212]
|
05225 Hepatocellular carcinoma [PATH:hsa05225]
|
05226 Gastric cancer [PATH:hsa05226]
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05214 Glioma [PATH:hsa05214]
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05216 Thyroid cancer [PATH:hsa05216]
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05221 Acute myeloid leukemia [PATH:hsa05221]
|
05220 Chronic myeloid leukemia [PATH:hsa05220]
|
05217 Basal cell carcinoma [PATH:hsa05217]
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05218 Melanoma [PATH:hsa05218]
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05211 Renal cell carcinoma [PATH:hsa05211]
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3091 HIF1A; hypoxia inducible factor 1 subunit alpha
2034 EPAS1; endothelial PAS domain protein 1
54583 EGLN1; egl-9 family hypoxia inducible factor 1
112399 EGLN3; egl-9 family hypoxia inducible factor 3
112398 EGLN2; egl-9 family hypoxia inducible factor 2
7428 VHL; von Hippel-Lindau tumor suppressor
6921 ELOC; elongin C
6923 ELOB; elongin B
9978 RBX1; ring-box 1
8453 CUL2; cullin 2
405 ARNT; aryl hydrocarbon receptor nuclear translocator
9915 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
1387 CREBBP; CREB binding protein
2033 EP300; E1A binding protein p300
6513 SLC2A1; solute carrier family 2 member 1
7422 VEGFA; vascular endothelial growth factor A
7040 TGFB1; transforming growth factor beta 1
7042 TGFB2; transforming growth factor beta 2
7043 TGFB3; transforming growth factor beta 3
5155 PDGFB; platelet derived growth factor subunit B
7039 TGFA; transforming growth factor alpha
3082 HGF; hepatocyte growth factor
4233 MET; MET proto-oncogene, receptor tyrosine kinase
2549 GAB1; GRB2 associated binding protein 1
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
572 BAD; BCL2 associated agonist of cell death
1398 CRK; CRK proto-oncogene, adaptor protein
1399 CRKL; CRK like proto-oncogene, adaptor protein
2889 RAPGEF1; Rap guanine nucleotide exchange factor 1
5906 RAP1A; RAP1A, member of RAS oncogene family
5908 RAP1B; RAP1B, member of RAS oncogene family
5781 PTPN11; protein tyrosine phosphatase non-receptor type 11
2885 GRB2; growth factor receptor bound protein 2
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
369 ARAF; A-Raf proto-oncogene, serine/threonine kinase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
2113 ETS1; ETS proto-oncogene 1, transcription factor
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
5879 RAC1; Rac family small GTPase 1
998 CDC42; cell division cycle 42
5058 PAK1; p21 (RAC1) activated kinase 1
5062 PAK2; p21 (RAC1) activated kinase 2
5063 PAK3; p21 (RAC1) activated kinase 3
10298 PAK4; p21 (RAC1) activated kinase 4
57144 PAK5; p21 (RAC1) activated kinase 5
56924 PAK6; p21 (RAC1) activated kinase 6
106821730 BUB1B-PAK6; BUB1B-PAK6 readthrough
5546 PRCC; proline rich mitotic checkpoint control factor
7030 TFE3; transcription factor binding to IGHM enhancer 3
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
2271 FH; fumarate hydratase
201163 FLCN; folliculin
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K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A; hypoxia-inducible factor 2 alpha
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 ELOC; elongin-C
K03873 ELOB; elongin-B
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03870 CUL2; cullin 2
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K05448 VEGFA; vascular endothelial growth factor A
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K17386 PDGFB; platelet-derived growth factor subunit B
K08774 TGFA; transforming growth factor, alpha
K05460 HGF; hepatocyte growth factor
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K09593 GAB1; GRB2-associated-binding protein 1
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K04438 CRK; C-crk adapter molecule crk
K04438 CRK; C-crk adapter molecule crk
K06277 RAPGEF1; Rap guanine nucleotide exchange factor 1
K04353 RAP1A; Ras-related protein Rap-1A
K07836 RAP1B; Ras-related protein Rap-1B
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K02678 ETS1; C-ets-1
K04448 JUN; transcription factor AP-1
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04393 CDC42; cell division control protein 42
K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]
K05733 PAK3; p21-activated kinase 3 [EC:2.7.11.1]
K05734 PAK4; p21-activated kinase 4 [EC:2.7.11.1]
K05736 PAK5; p21-activated kinase 5 [EC:2.7.11.1]
K05735 PAK6; p21-activated kinase 6 [EC:2.7.11.1]
K05735 PAK6; p21-activated kinase 6 [EC:2.7.11.1]
K13105 PRCC; proline-rich protein PRCC
K09105 TFE3; transcription factor E3
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
K09594 FLCN; folliculin
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05219 Bladder cancer [PATH:hsa05219]
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05215 Prostate cancer [PATH:hsa05215]
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05213 Endometrial cancer [PATH:hsa05213]
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05224 Breast cancer [PATH:hsa05224]
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05222 Small cell lung cancer [PATH:hsa05222]
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05223 Non-small cell lung cancer [PATH:hsa05223]
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09163 Immune disease
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09164 Neurodegenerative disease
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09165 Substance dependence
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09166 Cardiovascular disease
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09167 Endocrine and metabolic disease
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09171 Infectious disease: bacterial
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09172 Infectious disease: viral
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09174 Infectious disease: parasitic
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09175 Drug resistance: antimicrobial
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09176 Drug resistance: antineoplastic
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Homo sapiens (human)