KEGG Orthology (KO) - Homo sapiens (human)

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     KO
 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
   09141 Transport and catabolism
 
   09143 Cell growth and death
     04110 Cell cycle [PATH:hsa04110]
     04111 Cell cycle - yeast
     04112 Cell cycle - Caulobacter
     04113 Meiosis - yeast
     04114 Oocyte meiosis [PATH:hsa04114]
     04210 Apoptosis [PATH:hsa04210]
     04214 Apoptosis - fly
     04215 Apoptosis - multiple species [PATH:hsa04215]
     04216 Ferroptosis [PATH:hsa04216]
     04217 Necroptosis [PATH:hsa04217]
     04115 p53 signaling pathway [PATH:hsa04115]
       472 ATM; ATM serine/threonine kinase
       11200 CHEK2; checkpoint kinase 2
       545 ATR; ATR serine/threonine kinase
       1111 CHEK1; checkpoint kinase 1
       92344 GORAB; golgin, RAB6 interacting
       1029 CDKN2A; cyclin dependent kinase inhibitor 2A
       4193 MDM2; MDM2 proto-oncogene
       4194 MDM4; MDM4 regulator of p53
       7157 TP53; tumor protein p53
       1026 CDKN1A; cyclin dependent kinase inhibitor 1A
       595 CCND1; cyclin D1
       894 CCND2; cyclin D2
       896 CCND3; cyclin D3
       1019 CDK4; cyclin dependent kinase 4
       1021 CDK6; cyclin dependent kinase 6
       898 CCNE1; cyclin E1
       9134 CCNE2; cyclin E2
       1017 CDK2; cyclin dependent kinase 2
       2810 SFN; stratifin
       56475 RPRM; reprimo, TP53 dependent G2 arrest mediator homolog
       891 CCNB1; cyclin B1
       9133 CCNB2; cyclin B2
       983 CDK1; cyclin dependent kinase 1
       1647 GADD45A; growth arrest and DNA damage inducible alpha
       4616 GADD45B; growth arrest and DNA damage inducible beta
       10912 GADD45G; growth arrest and DNA damage inducible gamma
       51512 GTSE1; G2 and S-phase expressed 1
       355 FAS; Fas cell surface death receptor
       55367 PIDD1; p53-induced death domain protein 1
       8797 TNFRSF10A; TNF receptor superfamily member 10a
       8795 TNFRSF10B; TNF receptor superfamily member 10b
       841 CASP8; caspase 8
       637 BID; BH3 interacting domain death agonist
       581 BAX; BCL2 associated X, apoptosis regulator
       5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
       27113 BBC3; BCL2 binding component 3
       63970 TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1
       10572 SIVA1; SIVA1 apoptosis inducing factor
       598 BCL2L1; BCL2 like 1
       596 BCL2; BCL2 apoptosis regulator
       9540 TP53I3; tumor protein p53 inducible protein 3
       9538 EI24; EI24 autophagy associated transmembrane protein
       51246 SHISA5; shisa family member 5
       64065 PERP; p53 apoptosis effector related to PMP22
       64393 ZMAT3; zinc finger matrin-type 3
       6477 SIAH1; siah E3 ubiquitin protein ligase 1
       54205 CYCS; cytochrome c, somatic
       317 APAF1; apoptotic peptidase activating factor 1
       842 CASP9; caspase 9
       836 CASP3; caspase 3
       84883 AIFM2; apoptosis inducing factor mitochondria associated 2
       3486 IGFBP3; insulin like growth factor binding protein 3
       3479 IGF1; insulin like growth factor 1
       5054 SERPINE1; serpin family E member 1
       575 ADGRB1; adhesion G protein-coupled receptor B1
       3732 CD82; CD82 molecule
       7057 THBS1; thrombospondin 1
       5268 SERPINB5; serpin family B member 5
       1643 DDB2; damage specific DNA binding protein 2
       50484 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B
       6241 RRM2; ribonucleotide reductase regulatory subunit M2
       27244 SESN1; sestrin 1
       143686 SESN3; sestrin 3
       83667 SESN2; sestrin 2
       5728 PTEN; phosphatase and tensin homolog
       7249 TSC2; TSC complex subunit 2
       55240 STEAP3; STEAP3 metalloreductase
       64326 COP1; COP1 E3 ubiquitin ligase
       25898 RCHY1; ring finger and CHY zinc finger domain containing 1
       900 CCNG1; cyclin G1
       901 CCNG2; cyclin G2
       8493 PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D
       7161 TP73; tumor protein p73
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K19748 GORAB; RAB6-interacting golgin
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K10127 MDM4; protein Mdm4
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06644 SFN; stratifin
K10128 RPRM; reprimo, TP53-dependent G2 arrest mediator candidate
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K10129 GTSE1; G-2 and S-phase expressed protein 1
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K13773 TP53AIP1; p53-regulated apoptosis-inducing protein 1
K22744 SIVA1; apoptosis regulatory protein Siva
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K10133 TP53I3; tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10134 EI24; etoposide-induced 2.4 mRNA
K10135 SCOTIN; scotin
K10136 PERP; TP53 apoptosis effector
K10137 ZMAT3; zinc finger, matrin type 3
K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K22745 AIFM2; apoptosis-inducing factor 2
K10138 IGFBP3; insulin-like growth factor-binding protein 3
K05459 IGF1; insulin-like growth factor 1
K03982 SERPINE1; plasminogen activator inhibitor 1
K04596 ADGRB1; adhesion G protein-coupled receptor B1
K06509 KAI1; CD82 antigen
K16857 THBS1; thrombospondin 1
K10139 SERPINB5; serpin B5
K10140 DDB2; DNA damage-binding protein 2
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K07207 TSC2; tuberous sclerosis 2
K10142 STEAP3; metalloreductase STEAP3 [EC:1.16.1.-]
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K10145 CCNG1; cyclin G1
K10146 CCNG2; cyclin G2
K10147 PPM1D; protein phosphatase 1D [EC:3.1.3.16]
K10148 TP73; tumor protein p73
     04218 Cellular senescence [PATH:hsa04218]
 
   09144 Cellular community - eukaryotes
 
   09145 Cellular community - prokaryotes
 
   09142 Cell motility
 
 09150 Organismal Systems
 
   09151 Immune system
 
   09152 Endocrine system
 
   09153 Circulatory system
 
   09154 Digestive system
 
   09155 Excretory system
 
   09156 Nervous system
 
   09157 Sensory system
 
   09158 Development and regeneration
 
   09149 Aging
     04211 Longevity regulating pathway [PATH:hsa04211]
       3630 INS; insulin
       3643 INSR; insulin receptor
       3479 IGF1; insulin like growth factor 1
       3480 IGF1R; insulin like growth factor 1 receptor
       3667 IRS1; insulin receptor substrate 1
       8660 IRS2; insulin receptor substrate 2
       8471 IRS4; insulin receptor substrate 4
       3265 HRAS; HRas proto-oncogene, GTPase
       3845 KRAS; KRAS proto-oncogene, GTPase
       4893 NRAS; NRAS proto-oncogene, GTPase
       5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
       5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
       5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
       5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
       5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
       8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
       207 AKT1; AKT serine/threonine kinase 1
       208 AKT2; AKT serine/threonine kinase 2
       10000 AKT3; AKT serine/threonine kinase 3
       107 ADCY1; adenylate cyclase 1
       108 ADCY2; adenylate cyclase 2
       109 ADCY3; adenylate cyclase 3
       196883 ADCY4; adenylate cyclase 4
       111 ADCY5; adenylate cyclase 5
       112 ADCY6; adenylate cyclase 6
       113 ADCY7; adenylate cyclase 7
       114 ADCY8; adenylate cyclase 8
       115 ADCY9; adenylate cyclase 9
       5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
       5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta
       5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma
       1385 CREB1; cAMP responsive element binding protein 1
       1386 ATF2; activating transcription factor 2
       10488 CREB3; cAMP responsive element binding protein 3
       90993 CREB3L1; cAMP responsive element binding protein 3 like 1
       64764 CREB3L2; cAMP responsive element binding protein 3 like 2
       84699 CREB3L3; cAMP responsive element binding protein 3 like 3
       148327 CREB3L4; cAMP responsive element binding protein 3 like 4
       468 ATF4; activating transcription factor 4
       9586 CREB5; cAMP responsive element binding protein 5
       1388 ATF6B; activating transcription factor 6 beta
       10919 EHMT2; euchromatic histone lysine methyltransferase 2
       79813 EHMT1; euchromatic histone lysine methyltransferase 1
       2308 FOXO1; forkhead box O1
       2309 FOXO3; forkhead box O3
       6648 SOD2; superoxide dismutase 2
       847 CAT; catalase
       9474 ATG5; autophagy related 5
       9365 KL; klotho
       7248 TSC1; TSC complex subunit 1
       7249 TSC2; TSC complex subunit 2
       6009 RHEB; Ras homolog, mTORC1 binding
       2475 MTOR; mechanistic target of rapamycin kinase
       57521 RPTOR; regulatory associated protein of MTOR complex 1
       84335 AKT1S1; AKT1 substrate 1
       8408 ULK1; unc-51 like autophagy activating kinase 1
       9776 ATG13; autophagy related 13
       9821 RB1CC1; RB1 inducible coiled-coil 1
       60673 ATG101; autophagy related 101
       6198 RPS6KB1; ribosomal protein S6 kinase B1
       6199 RPS6KB2; ribosomal protein S6 kinase B2
       1978 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       1977 EIF4E; eukaryotic translation initiation factor 4E
       9470 EIF4E2; eukaryotic translation initiation factor 4E family member 2
       253314 EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
       9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
       51094 ADIPOR1; adiponectin receptor 1
       79602 ADIPOR2; adiponectin receptor 2
       26060 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
       10645 CAMKK2; calcium/calmodulin dependent protein kinase kinase 2
       5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
       5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
       5564 PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1
       5565 PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2
       5571 PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1
       53632 PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3
       51422 PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2
       23411 SIRT1; sirtuin 1
       581 BAX; BCL2 associated X, apoptosis regulator
       7157 TP53; tumor protein p53
       4790 NFKB1; nuclear factor kappa B subunit 1
       5970 RELA; RELA proto-oncogene, NF-kB subunit
       5468 PPARG; peroxisome proliferator activated receptor gamma
       10891 PPARGC1A; PPARG coactivator 1 alpha
       6794 STK11; serine/threonine kinase 11
       27244 SESN1; sestrin 1
       143686 SESN3; sestrin 3
       83667 SESN2; sestrin 2
       814 CAMK4; calcium/calmodulin dependent protein kinase IV
K04526 INS; insulin
K04527 INSR; insulin receptor [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17446 IRS4; insulin receptor substrate 4
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K04450 ATF2; cyclic AMP-dependent transcription factor ATF-2
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
K09047 CREB5; cyclic AMP-responsive element-binding protein 5
K09049 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K07201 FOXO1; forkhead box protein O1
K09408 FOXO3; forkhead box protein O3
K04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
K03781 katE; catalase [EC:1.11.1.6]
K08339 ATG5; autophagy-related protein 5
K14756 KL; klotho [EC:3.2.1.31]
K07206 TSC1; tuberous sclerosis 1
K07207 TSC2; tuberous sclerosis 2
K07208 RHEB; Ras homolog enriched in brain
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07204 RAPTOR; regulatory associated protein of mTOR
K16184 AKT1S1; proline-rich AKT1 substrate 1
K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K08331 ATG13; autophagy-related protein 13
K17589 RB1CC1; RB1-inducible coiled-coil protein 1
K19730 ATG101; autophagy-related protein 101
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K07296 ADIPOQ; adiponectin
K07297 ADIPOR; adiponectin receptor
K07297 ADIPOR; adiponectin receptor
K08733 APPL1; DCC-interacting protein 13 alpha
K07359 CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K11411 SIRT1; NAD+-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K02159 BAX; apoptosis regulator BAX
K04451 TP53; tumor protein p53
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K07202 PPARGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K05869 CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
     04212 Longevity regulating pathway - worm
     04213 Longevity regulating pathway - multiple species [PATH:hsa04213]
 
   09159 Environmental adaptation
 
 09160 Human Diseases
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

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Last updated: January 26, 2021