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KO |
 09100 Metabolism
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 09101 Carbohydrate metabolism
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09102 Energy metabolism
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09103 Lipid metabolism
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09104 Nucleotide metabolism
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00230 Purine metabolism [PATH:hsa00230]
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 53343 NUDT9; nudix hydrolase 9
56985 ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
11164 NUDT5; nudix hydrolase 5
5236 PGM1; phosphoglucomutase 1
55276 PGM2; phosphoglucomutase 2
221823 PRPS1L1; phosphoribosyl pyrophosphate synthetase 1 like 1
5634 PRPS2; phosphoribosyl pyrophosphate synthetase 2
5631 PRPS1; phosphoribosyl pyrophosphate synthetase 1
5471 PPAT; phosphoribosyl pyrophosphate amidotransferase
2618 GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
5198 PFAS; phosphoribosylformylglycinamidine synthase
10606 PAICS; phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
158 ADSL; adenylosuccinate lyase
471 ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
353 APRT; adenine phosphoribosyltransferase
22978 NT5C2; 5'-nucleotidase, cytosolic II
84618 NT5C1A; 5'-nucleotidase, cytosolic IA
93034 NT5C1B; 5'-nucleotidase, cytosolic IB
30833 NT5C; 5', 3'-nucleotidase, cytosolic
56953 NT5M; 5',3'-nucleotidase, mitochondrial
100526794 NT5C1B-RDH14; NT5C1B-RDH14 readthrough
4907 NT5E; 5'-nucleotidase ecto
51251 NT5C3A; 5'-nucleotidase, cytosolic IIIA
115024 NT5C3B; 5'-nucleotidase, cytosolic IIIB
4860 PNP; purine nucleoside phosphorylase
3251 HPRT1; hypoxanthine phosphoribosyltransferase 1
3614 IMPDH1; inosine monophosphate dehydrogenase 1
3615 IMPDH2; inosine monophosphate dehydrogenase 2
10201 NME6; NME/NM23 nucleoside diphosphate kinase 6
29922 NME7; NME/NM23 family member 7
4831 NME2; NME/NM23 nucleoside diphosphate kinase 2
4833 NME4; NME/NM23 nucleoside diphosphate kinase 4
4830 NME1; NME/NM23 nucleoside diphosphate kinase 1
4832 NME3; NME/NM23 nucleoside diphosphate kinase 3
654364 NME1-NME2; NME1-NME2 readthrough
221264 AK9; adenylate kinase 9
956 ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3
377841 ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8
953 ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1
124583 CANT1; calcium activated nucleotidase 1
9583 ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4
957 ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
955 ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6
131870 NUDT16; nudix hydrolase 16
3704 ITPA; inosine triphosphatase
7498 XDH; xanthine dehydrogenase
318 NUDT2; nudix hydrolase 2
8833 GMPS; guanine monophosphate synthase
2766 GMPR; guanosine monophosphate reductase
51292 GMPR2; guanosine monophosphate reductase 2
9615 GDA; guanine deaminase
2987 GUK1; guanylate kinase 1
5315 PKM; pyruvate kinase M1/2
5313 PKLR; pyruvate kinase L/R
6240 RRM1; ribonucleotide reductase catalytic subunit M1
50484 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B
6241 RRM2; ribonucleotide reductase regulatory subunit M2
1716 DGUOK; deoxyguanosine kinase
374659 HDDC3; HD domain containing 3
58497 PRUNE1; prune exopolyphosphatase 1
107 ADCY1; adenylate cyclase 1
108 ADCY2; adenylate cyclase 2
109 ADCY3; adenylate cyclase 3
196883 ADCY4; adenylate cyclase 4
111 ADCY5; adenylate cyclase 5
112 ADCY6; adenylate cyclase 6
113 ADCY7; adenylate cyclase 7
114 ADCY8; adenylate cyclase 8
115 ADCY9; adenylate cyclase 9
55811 ADCY10; adenylate cyclase 10
2977 GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2
2982 GUCY1A1; guanylate cyclase 1 soluble subunit alpha 1
2983 GUCY1B1; guanylate cyclase 1 soluble subunit beta 1
2984 GUCY2C; guanylate cyclase 2C
3000 GUCY2D; guanylate cyclase 2D, retinal
2986 GUCY2F; guanylate cyclase 2F, retinal
4881 NPR1; natriuretic peptide receptor 1
4882 NPR2; natriuretic peptide receptor 2
5136 PDE1A; phosphodiesterase 1A
5153 PDE1B; phosphodiesterase 1B
5137 PDE1C; phosphodiesterase 1C
5138 PDE2A; phosphodiesterase 2A
5139 PDE3A; phosphodiesterase 3A
5140 PDE3B; phosphodiesterase 3B
8654 PDE5A; phosphodiesterase 5A
5145 PDE6A; phosphodiesterase 6A
5158 PDE6B; phosphodiesterase 6B
5146 PDE6C; phosphodiesterase 6C
5147 PDE6D; phosphodiesterase 6D
5148 PDE6G; phosphodiesterase 6G
5149 PDE6H; phosphodiesterase 6H
5152 PDE9A; phosphodiesterase 9A
10846 PDE10A; phosphodiesterase 10A
50940 PDE11A; phosphodiesterase 11A
122622 ADSS1; adenylosuccinate synthase 1
159 ADSS2; adenylosuccinate synthase 2
271 AMPD2; adenosine monophosphate deaminase 2
272 AMPD3; adenosine monophosphate deaminase 3
270 AMPD1; adenosine monophosphate deaminase 1
132 ADK; adenosine kinase
1633 DCK; deoxycytidine kinase
100 ADA; adenosine deaminase
51816 ADA2; adenosine deaminase 2
122481 AK7; adenylate kinase 7
205 AK4; adenylate kinase 4
26289 AK5; adenylate kinase 5
204 AK2; adenylate kinase 2
203 AK1; adenylate kinase 1
390877 adenylate kinase isoenzyme 1-like
158067 AK8; adenylate kinase 8
102157402 AK6; adenylate kinase 6
50808 AK3; adenylate kinase 3
954 ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2
84284 NTPCR; nucleoside-triphosphatase, cancer-related
5141 PDE4A; phosphodiesterase 4A
5142 PDE4B; phosphodiesterase 4B
5143 PDE4C; phosphodiesterase 4C
5144 PDE4D; phosphodiesterase 4D
5150 PDE7A; phosphodiesterase 7A
27115 PDE7B; phosphodiesterase 7B
8622 PDE8B; phosphodiesterase 8B
5151 PDE8A; phosphodiesterase 8A
2272 FHIT; fragile histidine triad diadenosine triphosphatase
22875 ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase 4
9060 PAPSS2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2
9061 PAPSS1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1
5167 ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1
5169 ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3
646625 URAD; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
55821 ALLC; allantoicase
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K13988 NUDT9; ADP-ribose pyrophosphatase [EC:3.6.1.13]
K01517 ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.13 3.6.1.16 3.6.1.53]
K13987 NUDT5; ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase [EC:3.6.1.13 3.6.1.58 2.7.7.96]
K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
K15779 PGM2; phosphoglucomutase / phosphopentomutase [EC:5.4.2.2 5.4.2.7]
K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
K11787 GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]
K01587 PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6]
K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]
K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
K19970 NT5E; 5'-nucleotidase [EC:3.1.3.5]
K24242 NT5C3; cytosolic 5'-nucleotidase 3 [EC:3.1.3.5 3.1.3.-]
K24242 NT5C3; cytosolic 5'-nucleotidase 3 [EC:3.1.3.5 3.1.3.-]
K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
K00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]
K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
K18533 AK9; adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6]
K01510 ENTPD1_3_8; apyrase [EC:3.6.1.5]
K01510 ENTPD1_3_8; apyrase [EC:3.6.1.5]
K01510 ENTPD1_3_8; apyrase [EC:3.6.1.5]
K12304 CANT1; soluble calcium-activated nucleotidase 1 [EC:3.6.1.6]
K12305 ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6]
K01511 ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6]
K01511 ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6]
K16855 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]
K01519 ITPA; inosine triphosphate pyrophosphatase [EC:3.6.1.-]
K00106 XDH; xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2]
K01518 NUDT2; bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17]
K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
K00364 E1.7.1.7; GMP reductase [EC:1.7.1.7]
K00364 E1.7.1.7; GMP reductase [EC:1.7.1.7]
K01487 E3.5.4.3; guanine deaminase [EC:3.5.4.3]
K00942 E2.7.4.8; guanylate kinase [EC:2.7.4.8]
K00873 PK; pyruvate kinase [EC:2.7.1.40]
K12406 PKLR; pyruvate kinase isozymes R/L [EC:2.7.1.40]
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K00904 DGUOK; deoxyguanosine kinase [EC:2.7.1.113]
K21138 HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [EC:3.1.7.2]
K01514 PRUNE; exopolyphosphatase [EC:3.6.1.11]
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K11265 ADCY10; adenylate cyclase 10 [EC:4.6.1.1]
K12318 GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
K12318 GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
K12319 GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
K12320 GUCY2C; heat-stable enterotoxin receptor [EC:4.6.1.2]
K12321 GUCY2D_E; guanylate cyclase 2D/E [EC:4.6.1.2]
K12322 GUCY2F; guanylate cyclase 2F [EC:4.6.1.2]
K12323 ANPRA; atrial natriuretic peptide receptor A [EC:4.6.1.2]
K12324 ANPRB; atrial natriuretic peptide receptor B [EC:4.6.1.2]
K13755 PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
K13755 PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
K13755 PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
K18283 PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
K19021 PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [EC:3.1.4.17]
K13296 PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17]
K13762 PDE5; cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35]
K08718 PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:3.1.4.35]
K13756 PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [EC:3.1.4.35]
K13757 PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [EC:3.1.4.35]
K13758 PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
K13759 PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
K13760 PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
K13761 PDE9; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 [EC:3.1.4.35]
K18438 PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35]
K13298 PDE11; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 [EC:3.1.4.17 3.1.4.35]
K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
K01490 AMPD; AMP deaminase [EC:3.5.4.6]
K01490 AMPD; AMP deaminase [EC:3.5.4.6]
K01490 AMPD; AMP deaminase [EC:3.5.4.6]
K00856 E2.7.1.20; adenosine kinase [EC:2.7.1.20]
K00893 DCK; deoxycitidine kinase [EC:2.7.1.74]
K01488 add; adenosine deaminase [EC:3.5.4.4]
K19572 CECR1; adenosine deaminase CECR1 [EC:3.5.4.4]
K00939 adk; adenylate kinase [EC:2.7.4.3]
K00939 adk; adenylate kinase [EC:2.7.4.3]
K00939 adk; adenylate kinase [EC:2.7.4.3]
K00939 adk; adenylate kinase [EC:2.7.4.3]
K00939 adk; adenylate kinase [EC:2.7.4.3]
K00939 adk; adenylate kinase [EC:2.7.4.3]
K00939 adk; adenylate kinase [EC:2.7.4.3]
K18532 AK6; adenylate kinase [EC:2.7.4.3]
K00944 AK3; nucleoside-triphosphate--adenylate kinase [EC:2.7.4.10]
K01509 ENTPD2; adenosinetriphosphatase [EC:3.6.1.-]
K06928 NTPCR; nucleoside-triphosphatase [EC:3.6.1.15]
K13293 PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]
K13293 PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]
K13293 PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]
K13293 PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]
K18436 PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53]
K18436 PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53]
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53]
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53]
K01522 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
K18424 ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase family member 4 [EC:3.6.1.29]
K13811 PAPSS; 3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.7.4 2.7.1.25]
K13811 PAPSS; 3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.7.4 2.7.1.25]
K01513 ENPP1_3; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]
K01513 ENPP1_3; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]
K13485 PRHOXNB; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:4.1.1.97]
K01477 alc; allantoicase [EC:3.5.3.4]
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00240 Pyrimidine metabolism [PATH:hsa00240]
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09105 Amino acid metabolism
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09106 Metabolism of other amino acids
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09107 Glycan biosynthesis and metabolism
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09108 Metabolism of cofactors and vitamins
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09109 Metabolism of terpenoids and polyketides
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09110 Biosynthesis of other secondary metabolites
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09111 Xenobiotics biodegradation and metabolism
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09112 Not included in regular maps
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09120 Genetic Information Processing
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09130 Environmental Information Processing
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09140 Cellular Processes
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09150 Organismal Systems
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09160 Human Diseases
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09161 Cancer: overview
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09162 Cancer: specific types
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05210 Colorectal cancer [PATH:hsa05210]
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05212 Pancreatic cancer [PATH:hsa05212]
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05225 Hepatocellular carcinoma [PATH:hsa05225]
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05226 Gastric cancer [PATH:hsa05226]
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05214 Glioma [PATH:hsa05214]
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05216 Thyroid cancer [PATH:hsa05216]
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05221 Acute myeloid leukemia [PATH:hsa05221]
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05220 Chronic myeloid leukemia [PATH:hsa05220]
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05217 Basal cell carcinoma [PATH:hsa05217]
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05218 Melanoma [PATH:hsa05218]
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05211 Renal cell carcinoma [PATH:hsa05211]
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05219 Bladder cancer [PATH:hsa05219]
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05215 Prostate cancer [PATH:hsa05215]
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05213 Endometrial cancer [PATH:hsa05213]
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05224 Breast cancer [PATH:hsa05224]
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05222 Small cell lung cancer [PATH:hsa05222]
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2272 FHIT; fragile histidine triad diadenosine triphosphatase
5915 RARB; retinoic acid receptor beta
6256 RXRA; retinoid X receptor alpha
6257 RXRB; retinoid X receptor beta
6258 RXRG; retinoid X receptor gamma
7157 TP53; tumor protein p53
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
1643 DDB2; damage specific DNA binding protein 2
51426 POLK; DNA polymerase kappa
596 BCL2; BCL2 apoptosis regulator
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
836 CASP3; caspase 3
4609 MYC; MYC proto-oncogene, bHLH transcription factor
4149 MAX; MYC associated factor X
7709 ZBTB17; zinc finger and BTB domain containing 17
1030 CDKN2B; cyclin dependent kinase inhibitor 2B
1019 CDK4; cyclin dependent kinase 4
1021 CDK6; cyclin dependent kinase 6
595 CCND1; cyclin D1
1163 CKS1B; CDC28 protein kinase regulatory subunit 1B
1164 CKS2; CDC28 protein kinase regulatory subunit 2
6502 SKP2; S-phase kinase associated protein 2
1027 CDKN1B; cyclin dependent kinase inhibitor 1B
1017 CDK2; cyclin dependent kinase 2
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
5925 RB1; RB transcriptional corepressor 1
1869 E2F1; E2F transcription factor 1
1870 E2F2; E2F transcription factor 2
1871 E2F3; E2F transcription factor 3
1284 COL4A2; collagen type IV alpha 2 chain
1286 COL4A4; collagen type IV alpha 4 chain
1288 COL4A6; collagen type IV alpha 6 chain
1282 COL4A1; collagen type IV alpha 1 chain
1287 COL4A5; collagen type IV alpha 5 chain
1285 COL4A3; collagen type IV alpha 3 chain
284217 LAMA1; laminin subunit alpha 1
3908 LAMA2; laminin subunit alpha 2
3909 LAMA3; laminin subunit alpha 3
3911 LAMA5; laminin subunit alpha 5
3910 LAMA4; laminin subunit alpha 4
3912 LAMB1; laminin subunit beta 1
3913 LAMB2; laminin subunit beta 2
3914 LAMB3; laminin subunit beta 3
22798 LAMB4; laminin subunit beta 4
3915 LAMC1; laminin subunit gamma 1
3918 LAMC2; laminin subunit gamma 2
10319 LAMC3; laminin subunit gamma 3
2335 FN1; fibronectin 1
3673 ITGA2; integrin subunit alpha 2
3674 ITGA2B; integrin subunit alpha 2b
3675 ITGA3; integrin subunit alpha 3
3655 ITGA6; integrin subunit alpha 6
3685 ITGAV; integrin subunit alpha V
3688 ITGB1; integrin subunit beta 1
5747 PTK2; protein tyrosine kinase 2
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5728 PTEN; phosphatase and tensin homolog
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
331 XIAP; X-linked inhibitor of apoptosis
79444 BIRC7; baculoviral IAP repeat containing 7
598 BCL2L1; BCL2 like 1
7185 TRAF1; TNF receptor associated factor 1
7186 TRAF2; TNF receptor associated factor 2
7187 TRAF3; TNF receptor associated factor 3
9618 TRAF4; TNF receptor associated factor 4
7188 TRAF5; TNF receptor associated factor 5
7189 TRAF6; TNF receptor associated factor 6
5743 PTGS2; prostaglandin-endoperoxide synthase 2
4843 NOS2; nitric oxide synthase 2
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K01522 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
K08528 RARB; retinoic acid receptor beta
K08524 RXRA; retinoid X receptor alpha
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K02161 BCL2; apoptosis regulator Bcl-2
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04377 MYC; Myc proto-oncogene protein
K04453 MAX; Max protein
K10500 ZBTB17; zinc finger and BTB domain-containing protein 17
K04685 CDKN2B; cyclin-dependent kinase inhibitor 2B
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K04503 CCND1; G1/S-specific cyclin-D1
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K06618 RB1; retinoblastoma-associated protein
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K05637 LAMA1_2; laminin, alpha 1/2
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
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05223 Non-small cell lung cancer [PATH:hsa05223]
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2272 FHIT; fragile histidine triad diadenosine triphosphatase
5915 RARB; retinoic acid receptor beta
6256 RXRA; retinoid X receptor alpha
6257 RXRB; retinoid X receptor beta
6258 RXRG; retinoid X receptor gamma
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
1019 CDK4; cyclin dependent kinase 4
1021 CDK6; cyclin dependent kinase 6
595 CCND1; cyclin D1
5925 RB1; RB transcriptional corepressor 1
1869 E2F1; E2F transcription factor 1
1870 E2F2; E2F transcription factor 2
1871 E2F3; E2F transcription factor 3
3845 KRAS; KRAS proto-oncogene, GTPase
11186 RASSF1; Ras association domain family member 1
83593 RASSF5; Ras association domain family member 5
6789 STK4; serine/threonine kinase 4
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
572 BAD; BCL2 associated agonist of cell death
842 CASP9; caspase 9
2309 FOXO3; forkhead box O3
1950 EGF; epidermal growth factor
7039 TGFA; transforming growth factor alpha
1956 EGFR; epidermal growth factor receptor
2064 ERBB2; erb-b2 receptor tyrosine kinase 2
3082 HGF; hepatocyte growth factor
4233 MET; MET proto-oncogene, receptor tyrosine kinase
2885 GRB2; growth factor receptor bound protein 2
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265 HRAS; HRas proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
369 ARAF; A-Raf proto-oncogene, serine/threonine kinase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
5335 PLCG1; phospholipase C gamma 1
5336 PLCG2; phospholipase C gamma 2
5578 PRKCA; protein kinase C alpha
5579 PRKCB; protein kinase C beta
5582 PRKCG; protein kinase C gamma
7157 TP53; tumor protein p53
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
1643 DDB2; damage specific DNA binding protein 2
51426 POLK; DNA polymerase kappa
3798 KIF5A; kinesin family member 5A
3799 KIF5B; kinesin family member 5B
3800 KIF5C; kinesin family member 5C
5979 RET; ret proto-oncogene
27436 EML4; EMAP like 4
238 ALK; ALK receptor tyrosine kinase
3718 JAK3; Janus kinase 3
6774 STAT3; signal transducer and activator of transcription 3
6776 STAT5A; signal transducer and activator of transcription 5A
6777 STAT5B; signal transducer and activator of transcription 5B
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K01522 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
K08528 RARB; retinoic acid receptor beta
K08524 RXRA; retinoid X receptor alpha
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K04503 CCND1; G1/S-specific cyclin-D1
K06618 RB1; retinoblastoma-associated protein
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K07827 KRAS; GTPase KRas
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5; Ras association domain-containing protein 5
K04411 STK4; serine/threonine kinase 4
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K09408 FOXO3; forkhead box protein O3
K04357 EGF; epidermal growth factor
K08774 TGFA; transforming growth factor, alpha
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K10396 KIF5; kinesin family member 5
K10396 KIF5; kinesin family member 5
K10396 KIF5; kinesin family member 5
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K15420 EML4; echinoderm microtubule-associated protein-like 4
K05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
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09163 Immune disease
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09164 Neurodegenerative disease
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09165 Substance dependence
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09166 Cardiovascular disease
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09167 Endocrine and metabolic disease
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09171 Infectious disease: bacterial
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09172 Infectious disease: viral
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09174 Infectious disease: parasitic
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09175 Drug resistance: antimicrobial
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09176 Drug resistance: antineoplastic
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Homo sapiens (human)