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KO |
 09100 Metabolism
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09120 Genetic Information Processing
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 09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
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 02020 Two-component system
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04010 MAPK signaling pathway [PATH:hsa04010]
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04013 MAPK signaling pathway - fly
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04016 MAPK signaling pathway - plant
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04011 MAPK signaling pathway - yeast
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04012 ErbB signaling pathway [PATH:hsa04012]
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04014 Ras signaling pathway [PATH:hsa04014]
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04015 Rap1 signaling pathway [PATH:hsa04015]
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04310 Wnt signaling pathway [PATH:hsa04310]
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04330 Notch signaling pathway [PATH:hsa04330]
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04340 Hedgehog signaling pathway [PATH:hsa04340]
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04341 Hedgehog signaling pathway - fly
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04350 TGF-beta signaling pathway [PATH:hsa04350]
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04390 Hippo signaling pathway [PATH:hsa04390]
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04391 Hippo signaling pathway - fly
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04392 Hippo signaling pathway - multiple species [PATH:hsa04392]
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04370 VEGF signaling pathway [PATH:hsa04370]
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04371 Apelin signaling pathway [PATH:hsa04371]
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04630 JAK-STAT signaling pathway [PATH:hsa04630]
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04064 NF-kappa B signaling pathway [PATH:hsa04064]
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04668 TNF signaling pathway [PATH:hsa04668]
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04066 HIF-1 signaling pathway [PATH:hsa04066]
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04068 FoxO signaling pathway [PATH:hsa04068]
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04020 Calcium signaling pathway [PATH:hsa04020]
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04070 Phosphatidylinositol signaling system [PATH:hsa04070]
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04072 Phospholipase D signaling pathway [PATH:hsa04072]
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04071 Sphingolipid signaling pathway [PATH:hsa04071]
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04024 cAMP signaling pathway [PATH:hsa04024]
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04022 cGMP-PKG signaling pathway [PATH:hsa04022]
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04151 PI3K-Akt signaling pathway [PATH:hsa04151]
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04152 AMPK signaling pathway [PATH:hsa04152]
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6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7
6794 STK11; serine/threonine kinase 11
51719 CAB39; calcium binding protein 39
81617 CAB39L; calcium binding protein 39 like
92335 STRADA; STE20 related adaptor alpha
55437 STRADB; STE20 related adaptor beta
3952 LEP; leptin
3953 LEPR; leptin receptor
10645 CAMKK2; calcium/calmodulin dependent protein kinase kinase 2
148 ADRA1A; adrenoceptor alpha 1A
9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
51094 ADIPOR1; adiponectin receptor 1
79602 ADIPOR2; adiponectin receptor 2
5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
5564 PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1
5565 PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2
5571 PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1
53632 PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3
51422 PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2
5207 PFKFB1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
5208 PFKFB2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
5209 PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
5210 PFKFB4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
2203 FBP1; fructose-bisphosphatase 1
8789 FBP2; fructose-bisphosphatase 2
5213 PFKM; phosphofructokinase, muscle
5214 PFKP; phosphofructokinase, platelet
5211 PFKL; phosphofructokinase, liver type
3172 HNF4A; hepatocyte nuclear factor 4 alpha
2538 G6PC1; glucose-6-phosphatase catalytic subunit 1
57818 G6PC2; glucose-6-phosphatase catalytic subunit 2
92579 G6PC3; glucose-6-phosphatase catalytic subunit 3
5105 PCK1; phosphoenolpyruvate carboxykinase 1
5106 PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial
200186 CRTC2; CREB regulated transcription coactivator 2
1385 CREB1; cAMP responsive element binding protein 1
10488 CREB3; cAMP responsive element binding protein 3
90993 CREB3L1; cAMP responsive element binding protein 3 like 1
64764 CREB3L2; cAMP responsive element binding protein 3 like 2
84699 CREB3L3; cAMP responsive element binding protein 3 like 3
148327 CREB3L4; cAMP responsive element binding protein 3 like 4
9586 CREB5; cAMP responsive element binding protein 5
10891 PPARGC1A; PPARG coactivator 1 alpha
1994 ELAVL1; ELAV like RNA binding protein 1
595 CCND1; cyclin D1
890 CCNA2; cyclin A2
8900 CCNA1; cyclin A1
29904 EEF2K; eukaryotic elongation factor 2 kinase
1938 EEF2; eukaryotic translation elongation factor 2
2308 FOXO1; forkhead box O1
2309 FOXO3; forkhead box O3
23411 SIRT1; sirtuin 1
6517 SLC2A4; solute carrier family 2 member 4
2998 GYS2; glycogen synthase 2
2997 GYS1; glycogen synthase 1
3991 LIPE; lipase E, hormone sensitive type
3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase
6720 SREBF1; sterol regulatory element binding transcription factor 1
2194 FASN; fatty acid synthase
31 ACACA; acetyl-CoA carboxylase alpha
6319 SCD; stearoyl-CoA desaturase
79966 SCD5; stearoyl-CoA desaturase 5
32 ACACB; acetyl-CoA carboxylase beta
23417 MLYCD; malonyl-CoA decarboxylase
1374 CPT1A; carnitine palmitoyltransferase 1A
1375 CPT1B; carnitine palmitoyltransferase 1B
126129 CPT1C; carnitine palmitoyltransferase 1C
5515 PPP2CA; protein phosphatase 2 catalytic subunit alpha
5516 PPP2CB; protein phosphatase 2 catalytic subunit beta
5519 PPP2R1B; protein phosphatase 2 scaffold subunit Abeta
5518 PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha
5520 PPP2R2A; protein phosphatase 2 regulatory subunit Balpha
5521 PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta
5522 PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma
55844 PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta
28227 PPP2R3B; protein phosphatase 2 regulatory subunit B''beta
55012 PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma
5523 PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha
5526 PPP2R5B; protein phosphatase 2 regulatory subunit B'beta
5527 PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma
5528 PPP2R5D; protein phosphatase 2 regulatory subunit B'delta
5529 PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon
5525 PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha
23216 TBC1D1; TBC1 domain family member 1
5862 RAB2A; RAB2A, member RAS oncogene family
4218 RAB8A; RAB8A, member RAS oncogene family
10890 RAB10; RAB10, member RAS oncogene family
9230 RAB11B; RAB11B, member RAS oncogene family
51552 RAB14; RAB14, member RAS oncogene family
1080 CFTR; CF transmembrane conductance regulator
948 CD36; CD36 molecule
3479 IGF1; insulin like growth factor 1
3480 IGF1R; insulin like growth factor 1 receptor
3630 INS; insulin
3643 INSR; insulin receptor
3667 IRS1; insulin receptor substrate 1
8660 IRS2; insulin receptor substrate 2
8471 IRS4; insulin receptor substrate 4
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
7249 TSC2; TSC complex subunit 2
7248 TSC1; TSC complex subunit 1
6009 RHEB; Ras homolog, mTORC1 binding
2475 MTOR; mechanistic target of rapamycin kinase
57521 RPTOR; regulatory associated protein of MTOR complex 1
84335 AKT1S1; AKT1 substrate 1
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
1978 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
5468 PPARG; peroxisome proliferator activated receptor gamma
8408 ULK1; unc-51 like autophagy activating kinase 1
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K04427 MAP3K7; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K08272 CAB39; calcium binding protein 39
K08272 CAB39; calcium binding protein 39
K08271 STRADA; STE20-related kinase adapter protein alpha
K17532 STRADB; STE20-related kinase adapter protein beta
K05424 LEP; leptin
K05062 LEPR; leptin receptor
K07359 CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]
K04135 ADRA1A; adrenergic receptor alpha-1A
K07296 ADIPOQ; adiponectin
K07297 ADIPOR; adiponectin receptor
K07297 ADIPOR; adiponectin receptor
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K19028 PFKFB1; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 [EC:2.7.1.105 3.1.3.46]
K19029 PFKFB2; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 2 [EC:2.7.1.105 3.1.3.46]
K01103 PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]
K19030 PFKFB4; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 4 [EC:2.7.1.105 3.1.3.46]
K03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11]
K03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11]
K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
K07292 NR2A1; hepatocyte nuclear factor 4-alpha
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K16333 CRTC2; CREB-regulated transcription coactivator 2
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09047 CREB5; cyclic AMP-responsive element-binding protein 5
K07202 PPARGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
K13088 ELAVL1; ELAV-like protein 1
K04503 CCND1; G1/S-specific cyclin-D1
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K08292 EEF2K; elongation factor 2 kinase [EC:2.7.11.20]
K03234 EEF2; elongation factor 2
K07201 FOXO1; forkhead box protein O1
K09408 FOXO3; forkhead box protein O3
K11411 SIRT1; NAD+-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K07191 SLC2A4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
K00693 GYS; glycogen synthase [EC:2.4.1.11]
K00693 GYS; glycogen synthase [EC:2.4.1.11]
K07188 LIPE; hormone-sensitive lipase [EC:3.1.1.79]
K00021 HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
K07197 SREBP1; sterol regulatory element-binding transcription factor 1
K00665 FASN; fatty acid synthase, animal type [EC:2.3.1.85]
K11262 ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
K01946 ACACB; acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01578 MLYCD; malonyl-CoA decarboxylase [EC:4.1.1.9]
K08765 CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
K19523 CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21]
K19524 CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K18341 TBC1D1; TBC1 domain family member 1
K07877 RAB2A; Ras-related protein Rab-2A
K07901 RAB8A; Ras-related protein Rab-8A
K07903 RAB10; Ras-related protein Rab-10
K07905 RAB11B; Ras-related protein Rab-11B
K07881 RAB14; Ras-related protein Rab-14
K05031 CFTR; cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
K06259 CD36; CD36 antigen
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04526 INS; insulin
K04527 INSR; insulin receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17446 IRS4; insulin receptor substrate 4
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K07207 TSC2; tuberous sclerosis 2
K07206 TSC1; tuberous sclerosis 1
K07208 RHEB; Ras homolog enriched in brain
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07204 RAPTOR; regulatory associated protein of mTOR
K16184 AKT1S1; proline-rich AKT1 substrate 1
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
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04150 mTOR signaling pathway [PATH:hsa04150]
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04075 Plant hormone signal transduction
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09133 Signaling molecules and interaction
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09140 Cellular Processes
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09150 Organismal Systems
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09151 Immune system
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09152 Endocrine system
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04911 Insulin secretion [PATH:hsa04911]
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04910 Insulin signaling pathway [PATH:hsa04910]
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04922 Glucagon signaling pathway [PATH:hsa04922]
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04923 Regulation of lipolysis in adipocytes [PATH:hsa04923]
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04920 Adipocytokine signaling pathway [PATH:hsa04920]
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7124 TNF; tumor necrosis factor
7132 TNFRSF1A; TNF receptor superfamily member 1A
8717 TRADD; TNFRSF1A associated via death domain
7133 TNFRSF1B; TNF receptor superfamily member 1B
7186 TRAF2; TNF receptor associated factor 2
2475 MTOR; mechanistic target of rapamycin kinase
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
4793 NFKBIB; NFKB inhibitor beta
4794 NFKBIE; NFKB inhibitor epsilon
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
9021 SOCS3; suppressor of cytokine signaling 3
3667 IRS1; insulin receptor substrate 1
8660 IRS2; insulin receptor substrate 2
8471 IRS4; insulin receptor substrate 4
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
948 CD36; CD36 molecule
23305 ACSL6; acyl-CoA synthetase long chain family member 6
2182 ACSL4; acyl-CoA synthetase long chain family member 4
2180 ACSL1; acyl-CoA synthetase long chain family member 1
51703 ACSL5; acyl-CoA synthetase long chain family member 5
2181 ACSL3; acyl-CoA synthetase long chain family member 3
23205 ACSBG1; acyl-CoA synthetase bubblegum family member 1
81616 ACSBG2; acyl-CoA synthetase bubblegum family member 2
5588 PRKCQ; protein kinase C theta
3952 LEP; leptin
3953 LEPR; leptin receptor
3717 JAK2; Janus kinase 2
6774 STAT3; signal transducer and activator of transcription 3
5443 POMC; proopiomelanocortin
5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
5564 PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1
5565 PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2
5571 PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1
53632 PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3
51422 PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2
181 AGRP; agouti related neuropeptide
4852 NPY; neuropeptide Y
10891 PPARGC1A; PPARG coactivator 1 alpha
5105 PCK1; phosphoenolpyruvate carboxykinase 1
5106 PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial
2538 G6PC1; glucose-6-phosphatase catalytic subunit 1
57818 G6PC2; glucose-6-phosphatase catalytic subunit 2
92579 G6PC3; glucose-6-phosphatase catalytic subunit 3
5781 PTPN11; protein tyrosine phosphatase non-receptor type 11
5465 PPARA; peroxisome proliferator activated receptor alpha
6256 RXRA; retinoid X receptor alpha
6257 RXRB; retinoid X receptor beta
6258 RXRG; retinoid X receptor gamma
9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
51094 ADIPOR1; adiponectin receptor 1
79602 ADIPOR2; adiponectin receptor 2
6794 STK11; serine/threonine kinase 11
10645 CAMKK2; calcium/calmodulin dependent protein kinase kinase 2
32 ACACB; acetyl-CoA carboxylase beta
1374 CPT1A; carnitine palmitoyltransferase 1A
1375 CPT1B; carnitine palmitoyltransferase 1B
126129 CPT1C; carnitine palmitoyltransferase 1C
6513 SLC2A1; solute carrier family 2 member 1
6517 SLC2A4; solute carrier family 2 member 4
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K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K05141 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02581 NFKBIB; NF-kappa-B inhibitor beta
K05872 NFKBIE; NF-kappa-B inhibitor epsilon
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K04696 SOCS3; suppressor of cytokine signaling 3
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17446 IRS4; insulin receptor substrate 4
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K06259 CD36; CD36 antigen
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]
K05424 LEP; leptin
K05062 LEPR; leptin receptor
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K05228 POMC; proopiomelanocortin
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K05231 AGRP; agouti related protein
K05232 NPY; neuropeptide Y
K07202 PPARGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K07294 NR1C1; peroxisome proliferator-activated receptor alpha
K08524 RXRA; retinoid X receptor alpha
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K07296 ADIPOQ; adiponectin
K07297 ADIPOR; adiponectin receptor
K07297 ADIPOR; adiponectin receptor
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K07359 CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]
K01946 ACACB; acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K08765 CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
K19523 CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21]
K19524 CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
K07299 SLC2A1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K07191 SLC2A4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
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03320 PPAR signaling pathway [PATH:hsa03320]
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04929 GnRH secretion [PATH:hsa04929]
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04912 GnRH signaling pathway [PATH:hsa04912]
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04913 Ovarian steroidogenesis [PATH:hsa04913]
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04915 Estrogen signaling pathway [PATH:hsa04915]
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04914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
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04917 Prolactin signaling pathway [PATH:hsa04917]
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04921 Oxytocin signaling pathway [PATH:hsa04921]
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04926 Relaxin signaling pathway [PATH:hsa04926]
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04935 Growth hormone synthesis, secretion and action [PATH:hsa04935]
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04918 Thyroid hormone synthesis [PATH:hsa04918]
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04919 Thyroid hormone signaling pathway [PATH:hsa04919]
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04928 Parathyroid hormone synthesis, secretion and action [PATH:hsa04928]
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04916 Melanogenesis [PATH:hsa04916]
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04924 Renin secretion [PATH:hsa04924]
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04614 Renin-angiotensin system [PATH:hsa04614]
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04925 Aldosterone synthesis and secretion [PATH:hsa04925]
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04927 Cortisol synthesis and secretion [PATH:hsa04927]
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09153 Circulatory system
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09154 Digestive system
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09155 Excretory system
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09156 Nervous system
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09157 Sensory system
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09158 Development and regeneration
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09149 Aging
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04211 Longevity regulating pathway [PATH:hsa04211]
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3630 INS; insulin
3643 INSR; insulin receptor
3479 IGF1; insulin like growth factor 1
3480 IGF1R; insulin like growth factor 1 receptor
3667 IRS1; insulin receptor substrate 1
8660 IRS2; insulin receptor substrate 2
8471 IRS4; insulin receptor substrate 4
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
107 ADCY1; adenylate cyclase 1
108 ADCY2; adenylate cyclase 2
109 ADCY3; adenylate cyclase 3
196883 ADCY4; adenylate cyclase 4
111 ADCY5; adenylate cyclase 5
112 ADCY6; adenylate cyclase 6
113 ADCY7; adenylate cyclase 7
114 ADCY8; adenylate cyclase 8
115 ADCY9; adenylate cyclase 9
5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma
1385 CREB1; cAMP responsive element binding protein 1
1386 ATF2; activating transcription factor 2
10488 CREB3; cAMP responsive element binding protein 3
90993 CREB3L1; cAMP responsive element binding protein 3 like 1
64764 CREB3L2; cAMP responsive element binding protein 3 like 2
84699 CREB3L3; cAMP responsive element binding protein 3 like 3
148327 CREB3L4; cAMP responsive element binding protein 3 like 4
468 ATF4; activating transcription factor 4
9586 CREB5; cAMP responsive element binding protein 5
1388 ATF6B; activating transcription factor 6 beta
10919 EHMT2; euchromatic histone lysine methyltransferase 2
79813 EHMT1; euchromatic histone lysine methyltransferase 1
2308 FOXO1; forkhead box O1
2309 FOXO3; forkhead box O3
6648 SOD2; superoxide dismutase 2
847 CAT; catalase
9474 ATG5; autophagy related 5
9365 KL; klotho
7248 TSC1; TSC complex subunit 1
7249 TSC2; TSC complex subunit 2
6009 RHEB; Ras homolog, mTORC1 binding
2475 MTOR; mechanistic target of rapamycin kinase
57521 RPTOR; regulatory associated protein of MTOR complex 1
84335 AKT1S1; AKT1 substrate 1
8408 ULK1; unc-51 like autophagy activating kinase 1
9776 ATG13; autophagy related 13
9821 RB1CC1; RB1 inducible coiled-coil 1
60673 ATG101; autophagy related 101
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
1978 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
1977 EIF4E; eukaryotic translation initiation factor 4E
9470 EIF4E2; eukaryotic translation initiation factor 4E family member 2
253314 EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
51094 ADIPOR1; adiponectin receptor 1
79602 ADIPOR2; adiponectin receptor 2
26060 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
10645 CAMKK2; calcium/calmodulin dependent protein kinase kinase 2
5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
5564 PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1
5565 PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2
5571 PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1
53632 PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3
51422 PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2
23411 SIRT1; sirtuin 1
581 BAX; BCL2 associated X, apoptosis regulator
7157 TP53; tumor protein p53
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
5468 PPARG; peroxisome proliferator activated receptor gamma
10891 PPARGC1A; PPARG coactivator 1 alpha
6794 STK11; serine/threonine kinase 11
27244 SESN1; sestrin 1
143686 SESN3; sestrin 3
83667 SESN2; sestrin 2
814 CAMK4; calcium/calmodulin dependent protein kinase IV
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K04526 INS; insulin
K04527 INSR; insulin receptor [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17446 IRS4; insulin receptor substrate 4
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K04450 ATF2; cyclic AMP-dependent transcription factor ATF-2
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
K09047 CREB5; cyclic AMP-responsive element-binding protein 5
K09049 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K07201 FOXO1; forkhead box protein O1
K09408 FOXO3; forkhead box protein O3
K04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
K03781 katE; catalase [EC:1.11.1.6]
K08339 ATG5; autophagy-related protein 5
K14756 KL; klotho [EC:3.2.1.31]
K07206 TSC1; tuberous sclerosis 1
K07207 TSC2; tuberous sclerosis 2
K07208 RHEB; Ras homolog enriched in brain
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07204 RAPTOR; regulatory associated protein of mTOR
K16184 AKT1S1; proline-rich AKT1 substrate 1
K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K08331 ATG13; autophagy-related protein 13
K17589 RB1CC1; RB1-inducible coiled-coil protein 1
K19730 ATG101; autophagy-related protein 101
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K07296 ADIPOQ; adiponectin
K07297 ADIPOR; adiponectin receptor
K07297 ADIPOR; adiponectin receptor
K08733 APPL1; DCC-interacting protein 13 alpha
K07359 CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K11411 SIRT1; NAD+-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K02159 BAX; apoptosis regulator BAX
K04451 TP53; tumor protein p53
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K07202 PPARGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K05869 CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
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04212 Longevity regulating pathway - worm
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04213 Longevity regulating pathway - multiple species [PATH:hsa04213]
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09159 Environmental adaptation
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09160 Human Diseases
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09161 Cancer: overview
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09162 Cancer: specific types
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09163 Immune disease
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09164 Neurodegenerative disease
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09165 Substance dependence
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09166 Cardiovascular disease
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09167 Endocrine and metabolic disease
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04930 Type II diabetes mellitus [PATH:hsa04930]
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04940 Type I diabetes mellitus [PATH:hsa04940]
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04950 Maturity onset diabetes of the young [PATH:hsa04950]
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04932 Non-alcoholic fatty liver disease [PATH:hsa04932]
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3569 IL6; interleukin 6
3570 IL6R; interleukin 6 receptor
9021 SOCS3; suppressor of cytokine signaling 3
7124 TNF; tumor necrosis factor
7132 TNFRSF1A; TNF receptor superfamily member 1A
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
3630 INS; insulin
3643 INSR; insulin receptor
3667 IRS1; insulin receptor substrate 1
8660 IRS2; insulin receptor substrate 2
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
2931 GSK3A; glycogen synthase kinase 3 alpha
2932 GSK3B; glycogen synthase kinase 3 beta
10062 NR1H3; nuclear receptor subfamily 1 group H member 3
6256 RXRA; retinoid X receptor alpha
6720 SREBF1; sterol regulatory element binding transcription factor 1
6945 MLX; MAX dimerization protein MLX
22877 MLXIP; MLX interacting protein
51085 MLXIPL; MLX interacting protein like
5313 PKLR; pyruvate kinase L/R
3952 LEP; leptin
3953 LEPR; leptin receptor
9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
51094 ADIPOR1; adiponectin receptor 1
79602 ADIPOR2; adiponectin receptor 2
5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
5564 PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1
5565 PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2
5571 PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1
53632 PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3
51422 PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2
5465 PPARA; peroxisome proliferator activated receptor alpha
998 CDC42; cell division cycle 42
5879 RAC1; Rac family small GTPase 1
4296 MAP3K11; mitogen-activated protein kinase kinase kinase 11
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
83737 ITCH; itchy E3 ubiquitin protein ligase
2081 ERN1; endoplasmic reticulum to nucleus signaling 1
7186 TRAF2; TNF receptor associated factor 2
4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
3552 IL1A; interleukin 1 alpha
3553 IL1B; interleukin 1 beta
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
7494 XBP1; X-box binding protein 1
1050 CEBPA; CCAAT enhancer binding protein alpha
1571 CYP2E1; cytochrome P450 family 2 subfamily E member 1
356 FASLG; Fas ligand
3576 CXCL8; C-X-C motif chemokine ligand 8
7040 TGFB1; transforming growth factor beta 1
9451 EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
1965 EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
468 ATF4; activating transcription factor 4
1649 DDIT3; DNA damage inducible transcript 3
10018 BCL2L11; BCL2 like 11
581 BAX; BCL2 associated X, apoptosis regulator
355 FAS; Fas cell surface death receptor
841 CASP8; caspase 8
637 BID; BH3 interacting domain death agonist
54205 CYCS; cytochrome c, somatic
836 CASP3; caspase 3
840 CASP7; caspase 7
4723 NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1
4729 NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2
4731 NDUFV3; NADH:ubiquinone oxidoreductase subunit V3
4694 NDUFA1; NADH:ubiquinone oxidoreductase subunit A1
4695 NDUFA2; NADH:ubiquinone oxidoreductase subunit A2
4696 NDUFA3; NADH:ubiquinone oxidoreductase subunit A3
4697 NDUFA4; NDUFA4 mitochondrial complex associated
56901 NDUFA4L2; NDUFA4 mitochondrial complex associated like 2
4698 NDUFA5; NADH:ubiquinone oxidoreductase subunit A5
4700 NDUFA6; NADH:ubiquinone oxidoreductase subunit A6
4701 NDUFA7; NADH:ubiquinone oxidoreductase subunit A7
4702 NDUFA8; NADH:ubiquinone oxidoreductase subunit A8
4704 NDUFA9; NADH:ubiquinone oxidoreductase subunit A9
4705 NDUFA10; NADH:ubiquinone oxidoreductase subunit A10
4706 NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1
126328 NDUFA11; NADH:ubiquinone oxidoreductase subunit A11
55967 NDUFA12; NADH:ubiquinone oxidoreductase subunit A12
51079 NDUFA13; NADH:ubiquinone oxidoreductase subunit A13
4707 NDUFB1; NADH:ubiquinone oxidoreductase subunit B1
4708 NDUFB2; NADH:ubiquinone oxidoreductase subunit B2
4709 NDUFB3; NADH:ubiquinone oxidoreductase subunit B3
4710 NDUFB4; NADH:ubiquinone oxidoreductase subunit B4
4711 NDUFB5; NADH:ubiquinone oxidoreductase subunit B5
4712 NDUFB6; NADH:ubiquinone oxidoreductase subunit B6
4713 NDUFB7; NADH:ubiquinone oxidoreductase subunit B7
4714 NDUFB8; NADH:ubiquinone oxidoreductase subunit B8
4715 NDUFB9; NADH:ubiquinone oxidoreductase subunit B9
4716 NDUFB10; NADH:ubiquinone oxidoreductase subunit B10
54539 NDUFB11; NADH:ubiquinone oxidoreductase subunit B11
4719 NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1
4720 NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2
4722 NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3
4724 NDUFS4; NADH:ubiquinone oxidoreductase subunit S4
4725 NDUFS5; NADH:ubiquinone oxidoreductase subunit S5
4726 NDUFS6; NADH:ubiquinone oxidoreductase subunit S6
374291 NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7
4728 NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8
4717 NDUFC1; NADH:ubiquinone oxidoreductase subunit C1
4718 NDUFC2; NADH:ubiquinone oxidoreductase subunit C2
100532726 NDUFC2-KCTD14; NDUFC2-KCTD14 readthrough
6389 SDHA; succinate dehydrogenase complex flavoprotein subunit A
6390 SDHB; succinate dehydrogenase complex iron sulfur subunit B
6391 SDHC; succinate dehydrogenase complex subunit C
6392 SDHD; succinate dehydrogenase complex subunit D
7386 UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
4519 CYTB; cytochrome b
1537 CYC1; cytochrome c1
7384 UQCRC1; ubiquinol-cytochrome c reductase core protein 1
7385 UQCRC2; ubiquinol-cytochrome c reductase core protein 2
7388 UQCRH; ubiquinol-cytochrome c reductase hinge protein
440567 UQCRHL; ubiquinol-cytochrome c reductase hinge protein like
7381 UQCRB; ubiquinol-cytochrome c reductase binding protein
27089 UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII
29796 UQCR10; ubiquinol-cytochrome c reductase, complex III subunit X
10975 UQCR11; ubiquinol-cytochrome c reductase, complex III subunit XI
4514 COX3; cytochrome c oxidase subunit III
4512 COX1; cytochrome c oxidase subunit I
4513 COX2; cytochrome c oxidase subunit II
84701 COX4I2; cytochrome c oxidase subunit 4I2
1327 COX4I1; cytochrome c oxidase subunit 4I1
9377 COX5A; cytochrome c oxidase subunit 5A
1329 COX5B; cytochrome c oxidase subunit 5B
1337 COX6A1; cytochrome c oxidase subunit 6A1
1339 COX6A2; cytochrome c oxidase subunit 6A2
1340 COX6B1; cytochrome c oxidase subunit 6B1
125965 COX6B2; cytochrome c oxidase subunit 6B2
1345 COX6C; cytochrome c oxidase subunit 6C
1346 COX7A1; cytochrome c oxidase subunit 7A1
1347 COX7A2; cytochrome c oxidase subunit 7A2
9167 COX7A2L; cytochrome c oxidase subunit 7A2 like
1349 COX7B; cytochrome c oxidase subunit 7B
170712 COX7B2; cytochrome c oxidase subunit 7B2
1350 COX7C; cytochrome c oxidase subunit 7C
341947 COX8C; cytochrome c oxidase subunit 8C
1351 COX8A; cytochrome c oxidase subunit 8A
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K05405 IL6; interleukin 6
K05055 IL6R; interleukin 6 receptor
K04696 SOCS3; suppressor of cytokine signaling 3
K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K04526 INS; insulin
K04527 INSR; insulin receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K08822 GSK3A; glycogen synthase kinase 3 alpha [EC:2.7.11.26]
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K08536 NR1H3; liver X receptor alpha
K08524 RXRA; retinoid X receptor alpha
K07197 SREBP1; sterol regulatory element-binding transcription factor 1
K09113 MLX; MAX-like protein X
K09113 MLX; MAX-like protein X
K09113 MLX; MAX-like protein X
K12406 PKLR; pyruvate kinase isozymes R/L [EC:2.7.1.40]
K05424 LEP; leptin
K05062 LEPR; leptin receptor
K07296 ADIPOQ; adiponectin
K07297 ADIPOR; adiponectin receptor
K07297 ADIPOR; adiponectin receptor
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07294 NR1C1; peroxisome proliferator-activated receptor alpha
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04419 MAP3K11; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K05632 ITCH; E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04379 FOS; proto-oncogene protein c-fos
K04448 JUN; transcription factor AP-1
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K09027 XBP1; X box-binding protein 1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K07415 CYP2E1; cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K10030 IL8; interleukin 8
K13375 TGFB1; transforming growth factor beta-1
K08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K03237 EIF2S1; translation initiation factor 2 subunit 1
K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
K04452 DDIT3; DNA damage-inducible transcript 3
K16341 BCL2L11; Bcl-2-like protein 11
K02159 BAX; apoptosis regulator BAX
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K08738 CYC; cytochrome c
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K03942 NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945 NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946 NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947 NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03948 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949 NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950 NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951 NDUFA7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952 NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953 NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954 NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955 NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956 NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K11352 NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353 NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K03957 NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958 NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959 NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960 NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961 NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962 NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963 NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964 NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965 NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966 NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K11351 NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K03934 NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935 NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936 NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937 NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939 NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941 NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03967 NDUFC1; NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968 NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2
K03968 NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2
K00234 SDHA; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235 SDHB; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236 SDHC; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237 SDHD; succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00411 UQCRFS1; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit
K00413 CYC1; ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414 QCR1; ubiquinol-cytochrome c reductase core subunit 1
K00415 QCR2; ubiquinol-cytochrome c reductase core subunit 2
K00416 QCR6; ubiquinol-cytochrome c reductase subunit 6
K00416 QCR6; ubiquinol-cytochrome c reductase subunit 6
K00417 QCR7; ubiquinol-cytochrome c reductase subunit 7
K00418 QCR8; ubiquinol-cytochrome c reductase subunit 8
K00419 QCR9; ubiquinol-cytochrome c reductase subunit 9
K00420 QCR10; ubiquinol-cytochrome c reductase subunit 10
K02262 COX3; cytochrome c oxidase subunit 3
K02256 COX1; cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02261 COX2; cytochrome c oxidase subunit 2
K02263 COX4; cytochrome c oxidase subunit 4
K02263 COX4; cytochrome c oxidase subunit 4
K02264 COX5A; cytochrome c oxidase subunit 5a
K02265 COX5B; cytochrome c oxidase subunit 5b
K02266 COX6A; cytochrome c oxidase subunit 6a
K02266 COX6A; cytochrome c oxidase subunit 6a
K02267 COX6B; cytochrome c oxidase subunit 6b
K02267 COX6B; cytochrome c oxidase subunit 6b
K02268 COX6C; cytochrome c oxidase subunit 6c
K02270 COX7A; cytochrome c oxidase subunit 7a
K02270 COX7A; cytochrome c oxidase subunit 7a
K02270 COX7A; cytochrome c oxidase subunit 7a
K02271 COX7B; cytochrome c oxidase subunit 7b
K02271 COX7B; cytochrome c oxidase subunit 7b
K02272 COX7C; cytochrome c oxidase subunit 7c
K02273 COX8; cytochrome c oxidase subunit 8
K02273 COX8; cytochrome c oxidase subunit 8
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04931 Insulin resistance [PATH:hsa04931]
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04933 AGE-RAGE signaling pathway in diabetic complications [PATH:hsa04933]
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04934 Cushing syndrome [PATH:hsa04934]
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09171 Infectious disease: bacterial
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09172 Infectious disease: viral
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09174 Infectious disease: parasitic
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09175 Drug resistance: antimicrobial
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09176 Drug resistance: antineoplastic
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Homo sapiens (human)