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KO |
 09100 Metabolism
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09120 Genetic Information Processing
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 09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
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 02020 Two-component system
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04010 MAPK signaling pathway [PATH:hsa04010]
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04013 MAPK signaling pathway - fly
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04016 MAPK signaling pathway - plant
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04011 MAPK signaling pathway - yeast
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04012 ErbB signaling pathway [PATH:hsa04012]
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04014 Ras signaling pathway [PATH:hsa04014]
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04015 Rap1 signaling pathway [PATH:hsa04015]
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04310 Wnt signaling pathway [PATH:hsa04310]
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04330 Notch signaling pathway [PATH:hsa04330]
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04340 Hedgehog signaling pathway [PATH:hsa04340]
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04341 Hedgehog signaling pathway - fly
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04350 TGF-beta signaling pathway [PATH:hsa04350]
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04390 Hippo signaling pathway [PATH:hsa04390]
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04391 Hippo signaling pathway - fly
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04392 Hippo signaling pathway - multiple species [PATH:hsa04392]
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04370 VEGF signaling pathway [PATH:hsa04370]
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04371 Apelin signaling pathway [PATH:hsa04371]
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04630 JAK-STAT signaling pathway [PATH:hsa04630]
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04064 NF-kappa B signaling pathway [PATH:hsa04064]
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04668 TNF signaling pathway [PATH:hsa04668]
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04066 HIF-1 signaling pathway [PATH:hsa04066]
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04068 FoxO signaling pathway [PATH:hsa04068]
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04020 Calcium signaling pathway [PATH:hsa04020]
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04070 Phosphatidylinositol signaling system [PATH:hsa04070]
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04072 Phospholipase D signaling pathway [PATH:hsa04072]
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04071 Sphingolipid signaling pathway [PATH:hsa04071]
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04024 cAMP signaling pathway [PATH:hsa04024]
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04022 cGMP-PKG signaling pathway [PATH:hsa04022]
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04151 PI3K-Akt signaling pathway [PATH:hsa04151]
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04152 AMPK signaling pathway [PATH:hsa04152]
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04150 mTOR signaling pathway [PATH:hsa04150]
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8140 SLC7A5; solute carrier family 7 member 5
6520 SLC3A2; solute carrier family 3 member 2
153129 SLC38A9; solute carrier family 38 member 9
523 ATP6V1A; ATPase H+ transporting V1 subunit A
525 ATP6V1B1; ATPase H+ transporting V1 subunit B1
526 ATP6V1B2; ATPase H+ transporting V1 subunit B2
245973 ATP6V1C2; ATPase H+ transporting V1 subunit C2
528 ATP6V1C1; ATPase H+ transporting V1 subunit C1
51382 ATP6V1D; ATPase H+ transporting V1 subunit D
90423 ATP6V1E2; ATPase H+ transporting V1 subunit E2
529 ATP6V1E1; ATPase H+ transporting V1 subunit E1
9296 ATP6V1F; ATPase H+ transporting V1 subunit F
9550 ATP6V1G1; ATPase H+ transporting V1 subunit G1
127124 ATP6V1G3; ATPase H+ transporting V1 subunit G3
534 ATP6V1G2; ATPase H+ transporting V1 subunit G2
51606 ATP6V1H; ATPase H+ transporting V1 subunit H
55004 LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
28956 LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
8649 LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
389541 LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
10542 LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
201163 FLCN; folliculin
96459 FNIP1; folliculin interacting protein 1
57600 FNIP2; folliculin interacting protein 2
10670 RRAGA; Ras related GTP binding A
10325 RRAGB; Ras related GTP binding B
64121 RRAGC; Ras related GTP binding C
58528 RRAGD; Ras related GTP binding D
83667 SESN2; sestrin 2
652968 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1
729438 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2
54468 MIOS; meiosis regulator for oocyte development
81929 SEH1L; SEH1 like nucleoporin
84219 WDR24; WD repeat domain 24
79726 WDR59; WD repeat domain 59
6396 SEC13; SEC13 homolog, nuclear pore and COPII coat complex component
9681 DEPDC5; DEP domain containing 5, GATOR1 subcomplex subunit
10641 NPRL2; NPR2 like, GATOR1 complex subunit
8131 NPRL3; NPR3 like, GATOR1 complex subunit
6502 SKP2; S-phase kinase associated protein 2
220441 RNF152; ring finger protein 152
57521 RPTOR; regulatory associated protein of MTOR complex 1
84335 AKT1S1; AKT1 substrate 1
2475 MTOR; mechanistic target of rapamycin kinase
64798 DEPTOR; DEP domain containing MTOR interacting protein
64223 MLST8; MTOR associated protein, LST8 homolog
9894 TELO2; telomere maintenance 2
9675 TTI1; TELO2 interacting protein 1
6249 CLIP1; CAP-Gly domain containing linker protein 1
2887 GRB10; growth factor receptor bound protein 10
23175 LPIN1; lipin 1
64900 LPIN3; lipin 3
9663 LPIN2; lipin 2
8408 ULK1; unc-51 like autophagy activating kinase 1
9706 ULK2; unc-51 like autophagy activating kinase 2
1978 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
1977 EIF4E; eukaryotic translation initiation factor 4E
9470 EIF4E2; eukaryotic translation initiation factor 4E family member 2
253314 EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
1975 EIF4B; eukaryotic translation initiation factor 4B
6194 RPS6; ribosomal protein S6
92335 STRADA; STE20 related adaptor alpha
55437 STRADB; STE20 related adaptor beta
6794 STK11; serine/threonine kinase 11
51719 CAB39; calcium binding protein 39
81617 CAB39L; calcium binding protein 39 like
5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
7248 TSC1; TSC complex subunit 1
7249 TSC2; TSC complex subunit 2
51256 TBC1D7; TBC1 domain family member 7
107080638 TBC1D7-LOC100130357 readthrough
6009 RHEB; Ras homolog, mTORC1 binding
54541 DDIT4; DNA damage inducible transcript 4
7471 WNT1; Wnt family member 1
7472 WNT2; Wnt family member 2
7482 WNT2B; Wnt family member 2B
7473 WNT3; Wnt family member 3
89780 WNT3A; Wnt family member 3A
54361 WNT4; Wnt family member 4
7474 WNT5A; Wnt family member 5A
81029 WNT5B; Wnt family member 5B
7475 WNT6; Wnt family member 6
7476 WNT7A; Wnt family member 7A
7477 WNT7B; Wnt family member 7B
7478 WNT8A; Wnt family member 8A
7479 WNT8B; Wnt family member 8B
7483 WNT9A; Wnt family member 9A
7484 WNT9B; Wnt family member 9B
7480 WNT10B; Wnt family member 10B
80326 WNT10A; Wnt family member 10A
7481 WNT11; Wnt family member 11
51384 WNT16; Wnt family member 16
8321 FZD1; frizzled class receptor 1
8324 FZD7; frizzled class receptor 7
2535 FZD2; frizzled class receptor 2
7976 FZD3; frizzled class receptor 3
8322 FZD4; frizzled class receptor 4
7855 FZD5; frizzled class receptor 5
8325 FZD8; frizzled class receptor 8
8323 FZD6; frizzled class receptor 6
11211 FZD10; frizzled class receptor 10
8326 FZD9; frizzled class receptor 9
4041 LRP5; LDL receptor related protein 5
4040 LRP6; LDL receptor related protein 6
1857 DVL3; dishevelled segment polarity protein 3
1856 DVL2; dishevelled segment polarity protein 2
1855 DVL1; dishevelled segment polarity protein 1
2932 GSK3B; glycogen synthase kinase 3 beta
7124 TNF; tumor necrosis factor
7132 TNFRSF1A; TNF receptor superfamily member 1A
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
3630 INS; insulin
3479 IGF1; insulin like growth factor 1
3643 INSR; insulin receptor
3480 IGF1R; insulin like growth factor 1 receptor
2885 GRB2; growth factor receptor bound protein 2
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
6197 RPS6KA3; ribosomal protein S6 kinase A3
6195 RPS6KA1; ribosomal protein S6 kinase A1
6196 RPS6KA2; ribosomal protein S6 kinase A2
27330 RPS6KA6; ribosomal protein S6 kinase A6
3667 IRS1; insulin receptor substrate 1
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5728 PTEN; phosphatase and tensin homolog
5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
79109 MAPKAP1; MAPK associated protein 1
253260 RICTOR; RPTOR independent companion of MTOR complex 2
55615 PRR5; proline rich 5
387 RHOA; ras homolog family member A
5578 PRKCA; protein kinase C alpha
5579 PRKCB; protein kinase C beta
5582 PRKCG; protein kinase C gamma
6446 SGK1; serum/glucocorticoid regulated kinase 1
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K13780 SLC7A5; solute carrier family 7 (L-type amino acid transporter), member 5
K06519 SLC3A2; solute carrier family 3, member 2
K14995 SLC38A9; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9
K02145 ATPeV1A; V-type H+-transporting ATPase subunit A [EC:7.1.2.2]
K02147 ATPeV1B; V-type H+-transporting ATPase subunit B
K02147 ATPeV1B; V-type H+-transporting ATPase subunit B
K02148 ATPeV1C; V-type H+-transporting ATPase subunit C
K02148 ATPeV1C; V-type H+-transporting ATPase subunit C
K02149 ATPeV1D; V-type H+-transporting ATPase subunit D
K02150 ATPeV1E; V-type H+-transporting ATPase subunit E
K02150 ATPeV1E; V-type H+-transporting ATPase subunit E
K02151 ATPeV1F; V-type H+-transporting ATPase subunit F
K02152 ATPeV1G; V-type H+-transporting ATPase subunit G
K02152 ATPeV1G; V-type H+-transporting ATPase subunit G
K02152 ATPeV1G; V-type H+-transporting ATPase subunit G
K02144 ATPeV1H; V-type H+-transporting ATPase subunit H
K20397 LAMTOR1; ragulator complex protein LAMTOR1
K20398 LAMTOR2; ragulator complex protein LAMTOR2
K04370 LAMTOR3; ragulator complex protein LAMTOR3
K20399 LAMTOR4; ragulator complex protein LAMTOR4
K16344 LAMTOR5; ragulator complex protein LAMTOR5
K09594 FLCN; folliculin
K20400 FNIP1; folliculin-interacting protein 1
K20401 FNIP2; folliculin-interacting protein 2
K16185 RRAGA_B; Ras-related GTP-binding protein A/B
K16185 RRAGA_B; Ras-related GTP-binding protein A/B
K16186 RRAGC_D; Ras-related GTP-binding protein C/D
K16186 RRAGC_D; Ras-related GTP-binding protein C/D
K20394 SESN2; sestrin 2
K23080 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1
K23081 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2
K20407 MIOS; WD repeat-containing protein mio
K14299 SEH1; nucleoporin SEH1
K20408 WDR24; WD repeat-containing protein 24
K20409 WDR59; WD repeat-containing protein 59
K14004 SEC13; protein transport protein SEC13
K20404 DEPDC5; DEP domain-containing protein 5
K20405 NPRL2; nitrogen permease regulator 2-like protein
K20406 NPRL3; nitrogen permease regulator 3-like protein
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]
K07204 RAPTOR; regulatory associated protein of mTOR
K16184 AKT1S1; proline-rich AKT1 substrate 1
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K20402 DEPTOR; DEP domain-containing mTOR-interacting protein
K08266 MLST8; target of rapamycin complex subunit LST8
K11137 TELO2; telomere length regulation protein
K20403 TTI1; TELO2-interacting protein 1
K10421 CLIP1; CAP-Gly domain-containing linker protein 1
K20064 GRB10; growth factor receptor-bound protein 10
K15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]
K15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]
K15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]
K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K03258 EIF4B; translation initiation factor 4B
K02991 RP-S6e; small subunit ribosomal protein S6e
K08271 STRADA; STE20-related kinase adapter protein alpha
K17532 STRADB; STE20-related kinase adapter protein beta
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K08272 CAB39; calcium binding protein 39
K08272 CAB39; calcium binding protein 39
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07206 TSC1; tuberous sclerosis 1
K07207 TSC2; tuberous sclerosis 2
K20396 TBC1D7; TBC1 domain family member 7
K20396 TBC1D7; TBC1 domain family member 7
K07208 RHEB; Ras homolog enriched in brain
K08270 DDIT4; DNA-damage-inducible transcript 4
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7; frizzled 1/7
K02432 FZD1_7; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4; frizzled 4
K02375 FZD5_8; frizzled 5/8
K02375 FZD5_8; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02842 FZD9_10; frizzled 9/10
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04526 INS; insulin
K05459 IGF1; insulin-like growth factor 1
K04527 INSR; insulin receptor [EC:2.7.10.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K16172 IRS1; insulin receptor substrate 1
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1
K08267 RICTOR; rapamycin-insensitive companion of mTOR
K20411 PRR5; proline-rich protein 5
K04513 RHOA; Ras homolog gene family, member A
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K13302 SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
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04075 Plant hormone signal transduction
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09133 Signaling molecules and interaction
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09140 Cellular Processes
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09141 Transport and catabolism
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09143 Cell growth and death
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04110 Cell cycle [PATH:hsa04110]
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04111 Cell cycle - yeast
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04112 Cell cycle - Caulobacter
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04113 Meiosis - yeast
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04114 Oocyte meiosis [PATH:hsa04114]
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04210 Apoptosis [PATH:hsa04210]
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04214 Apoptosis - fly
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04215 Apoptosis - multiple species [PATH:hsa04215]
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04216 Ferroptosis [PATH:hsa04216]
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04217 Necroptosis [PATH:hsa04217]
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04115 p53 signaling pathway [PATH:hsa04115]
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472 ATM; ATM serine/threonine kinase
11200 CHEK2; checkpoint kinase 2
545 ATR; ATR serine/threonine kinase
1111 CHEK1; checkpoint kinase 1
92344 GORAB; golgin, RAB6 interacting
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
4193 MDM2; MDM2 proto-oncogene
4194 MDM4; MDM4 regulator of p53
7157 TP53; tumor protein p53
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
595 CCND1; cyclin D1
894 CCND2; cyclin D2
896 CCND3; cyclin D3
1019 CDK4; cyclin dependent kinase 4
1021 CDK6; cyclin dependent kinase 6
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
1017 CDK2; cyclin dependent kinase 2
2810 SFN; stratifin
56475 RPRM; reprimo, TP53 dependent G2 arrest mediator homolog
891 CCNB1; cyclin B1
9133 CCNB2; cyclin B2
983 CDK1; cyclin dependent kinase 1
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
51512 GTSE1; G2 and S-phase expressed 1
355 FAS; Fas cell surface death receptor
55367 PIDD1; p53-induced death domain protein 1
8797 TNFRSF10A; TNF receptor superfamily member 10a
8795 TNFRSF10B; TNF receptor superfamily member 10b
841 CASP8; caspase 8
637 BID; BH3 interacting domain death agonist
581 BAX; BCL2 associated X, apoptosis regulator
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113 BBC3; BCL2 binding component 3
63970 TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1
10572 SIVA1; SIVA1 apoptosis inducing factor
598 BCL2L1; BCL2 like 1
596 BCL2; BCL2 apoptosis regulator
9540 TP53I3; tumor protein p53 inducible protein 3
9538 EI24; EI24 autophagy associated transmembrane protein
51246 SHISA5; shisa family member 5
64065 PERP; p53 apoptosis effector related to PMP22
64393 ZMAT3; zinc finger matrin-type 3
6477 SIAH1; siah E3 ubiquitin protein ligase 1
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
836 CASP3; caspase 3
84883 AIFM2; apoptosis inducing factor mitochondria associated 2
3486 IGFBP3; insulin like growth factor binding protein 3
3479 IGF1; insulin like growth factor 1
5054 SERPINE1; serpin family E member 1
575 ADGRB1; adhesion G protein-coupled receptor B1
3732 CD82; CD82 molecule
7057 THBS1; thrombospondin 1
5268 SERPINB5; serpin family B member 5
1643 DDB2; damage specific DNA binding protein 2
50484 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B
6241 RRM2; ribonucleotide reductase regulatory subunit M2
27244 SESN1; sestrin 1
143686 SESN3; sestrin 3
83667 SESN2; sestrin 2
5728 PTEN; phosphatase and tensin homolog
7249 TSC2; TSC complex subunit 2
55240 STEAP3; STEAP3 metalloreductase
64326 COP1; COP1 E3 ubiquitin ligase
25898 RCHY1; ring finger and CHY zinc finger domain containing 1
900 CCNG1; cyclin G1
901 CCNG2; cyclin G2
8493 PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D
7161 TP73; tumor protein p73
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K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K19748 GORAB; RAB6-interacting golgin
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K10127 MDM4; protein Mdm4
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06644 SFN; stratifin
K10128 RPRM; reprimo, TP53-dependent G2 arrest mediator candidate
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K10129 GTSE1; G-2 and S-phase expressed protein 1
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K13773 TP53AIP1; p53-regulated apoptosis-inducing protein 1
K22744 SIVA1; apoptosis regulatory protein Siva
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K10133 TP53I3; tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10134 EI24; etoposide-induced 2.4 mRNA
K10135 SCOTIN; scotin
K10136 PERP; TP53 apoptosis effector
K10137 ZMAT3; zinc finger, matrin type 3
K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K22745 AIFM2; apoptosis-inducing factor 2
K10138 IGFBP3; insulin-like growth factor-binding protein 3
K05459 IGF1; insulin-like growth factor 1
K03982 SERPINE1; plasminogen activator inhibitor 1
K04596 ADGRB1; adhesion G protein-coupled receptor B1
K06509 KAI1; CD82 antigen
K16857 THBS1; thrombospondin 1
K10139 SERPINB5; serpin B5
K10140 DDB2; DNA damage-binding protein 2
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K07207 TSC2; tuberous sclerosis 2
K10142 STEAP3; metalloreductase STEAP3 [EC:1.16.1.-]
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K10145 CCNG1; cyclin G1
K10146 CCNG2; cyclin G2
K10147 PPM1D; protein phosphatase 1D [EC:3.1.3.16]
K10148 TP73; tumor protein p73
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04218 Cellular senescence [PATH:hsa04218]
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09144 Cellular community - eukaryotes
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09145 Cellular community - prokaryotes
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09142 Cell motility
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09150 Organismal Systems
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09151 Immune system
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09152 Endocrine system
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09153 Circulatory system
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09154 Digestive system
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09155 Excretory system
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09156 Nervous system
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09157 Sensory system
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09158 Development and regeneration
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09149 Aging
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04211 Longevity regulating pathway [PATH:hsa04211]
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3630 INS; insulin
3643 INSR; insulin receptor
3479 IGF1; insulin like growth factor 1
3480 IGF1R; insulin like growth factor 1 receptor
3667 IRS1; insulin receptor substrate 1
8660 IRS2; insulin receptor substrate 2
8471 IRS4; insulin receptor substrate 4
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
107 ADCY1; adenylate cyclase 1
108 ADCY2; adenylate cyclase 2
109 ADCY3; adenylate cyclase 3
196883 ADCY4; adenylate cyclase 4
111 ADCY5; adenylate cyclase 5
112 ADCY6; adenylate cyclase 6
113 ADCY7; adenylate cyclase 7
114 ADCY8; adenylate cyclase 8
115 ADCY9; adenylate cyclase 9
5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma
1385 CREB1; cAMP responsive element binding protein 1
1386 ATF2; activating transcription factor 2
10488 CREB3; cAMP responsive element binding protein 3
90993 CREB3L1; cAMP responsive element binding protein 3 like 1
64764 CREB3L2; cAMP responsive element binding protein 3 like 2
84699 CREB3L3; cAMP responsive element binding protein 3 like 3
148327 CREB3L4; cAMP responsive element binding protein 3 like 4
468 ATF4; activating transcription factor 4
9586 CREB5; cAMP responsive element binding protein 5
1388 ATF6B; activating transcription factor 6 beta
10919 EHMT2; euchromatic histone lysine methyltransferase 2
79813 EHMT1; euchromatic histone lysine methyltransferase 1
2308 FOXO1; forkhead box O1
2309 FOXO3; forkhead box O3
6648 SOD2; superoxide dismutase 2
847 CAT; catalase
9474 ATG5; autophagy related 5
9365 KL; klotho
7248 TSC1; TSC complex subunit 1
7249 TSC2; TSC complex subunit 2
6009 RHEB; Ras homolog, mTORC1 binding
2475 MTOR; mechanistic target of rapamycin kinase
57521 RPTOR; regulatory associated protein of MTOR complex 1
84335 AKT1S1; AKT1 substrate 1
8408 ULK1; unc-51 like autophagy activating kinase 1
9776 ATG13; autophagy related 13
9821 RB1CC1; RB1 inducible coiled-coil 1
60673 ATG101; autophagy related 101
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
1978 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
1977 EIF4E; eukaryotic translation initiation factor 4E
9470 EIF4E2; eukaryotic translation initiation factor 4E family member 2
253314 EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
51094 ADIPOR1; adiponectin receptor 1
79602 ADIPOR2; adiponectin receptor 2
26060 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
10645 CAMKK2; calcium/calmodulin dependent protein kinase kinase 2
5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
5564 PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1
5565 PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2
5571 PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1
53632 PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3
51422 PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2
23411 SIRT1; sirtuin 1
581 BAX; BCL2 associated X, apoptosis regulator
7157 TP53; tumor protein p53
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
5468 PPARG; peroxisome proliferator activated receptor gamma
10891 PPARGC1A; PPARG coactivator 1 alpha
6794 STK11; serine/threonine kinase 11
27244 SESN1; sestrin 1
143686 SESN3; sestrin 3
83667 SESN2; sestrin 2
814 CAMK4; calcium/calmodulin dependent protein kinase IV
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K04526 INS; insulin
K04527 INSR; insulin receptor [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17446 IRS4; insulin receptor substrate 4
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K04450 ATF2; cyclic AMP-dependent transcription factor ATF-2
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
K09047 CREB5; cyclic AMP-responsive element-binding protein 5
K09049 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K07201 FOXO1; forkhead box protein O1
K09408 FOXO3; forkhead box protein O3
K04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
K03781 katE; catalase [EC:1.11.1.6]
K08339 ATG5; autophagy-related protein 5
K14756 KL; klotho [EC:3.2.1.31]
K07206 TSC1; tuberous sclerosis 1
K07207 TSC2; tuberous sclerosis 2
K07208 RHEB; Ras homolog enriched in brain
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07204 RAPTOR; regulatory associated protein of mTOR
K16184 AKT1S1; proline-rich AKT1 substrate 1
K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K08331 ATG13; autophagy-related protein 13
K17589 RB1CC1; RB1-inducible coiled-coil protein 1
K19730 ATG101; autophagy-related protein 101
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K07296 ADIPOQ; adiponectin
K07297 ADIPOR; adiponectin receptor
K07297 ADIPOR; adiponectin receptor
K08733 APPL1; DCC-interacting protein 13 alpha
K07359 CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K11411 SIRT1; NAD+-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K02159 BAX; apoptosis regulator BAX
K04451 TP53; tumor protein p53
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K07202 PPARGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K05869 CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
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04212 Longevity regulating pathway - worm
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04213 Longevity regulating pathway - multiple species [PATH:hsa04213]
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09159 Environmental adaptation
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09160 Human Diseases
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Homo sapiens (human)