1. Oxidoreductases

 2. Transferases

 3. Hydrolases

 4. Lyases

 5. Isomerases

 6. Ligases

   6.1  Forming carbon-oxygen bonds

   6.2  Forming carbon-sulfur bonds

     6.2.1  Acid-thiol ligases

       6.2.1.1  acetate---CoA ligase

       6.2.1.2  medium-chain acyl-CoA ligase

       6.2.1.3  long-chain-fatty-acid---CoA ligase

       6.2.1.4  succinate---CoA ligase (GDP-forming)

       6.2.1.5  succinate---CoA ligase (ADP-forming)

       6.2.1.6  glutarate---CoA ligase

       6.2.1.7  cholate---CoA ligase

       6.2.1.8  oxalate---CoA ligase

       6.2.1.9  malate---CoA ligase

       6.2.1.10  carboxylic acid---CoA ligase (GDP-forming)

       6.2.1.11  biotin---CoA ligase

       6.2.1.12  4-coumarate---CoA ligase

       6.2.1.13  acetate---CoA ligase (ADP-forming)

       6.2.1.14  6-carboxyhexanoate---CoA ligase

       6.2.1.15  arachidonate---CoA ligase

       6.2.1.16  acetoacetate---CoA ligase

       6.2.1.17  propionate---CoA ligase

       6.2.1.18  citrate---CoA ligase

       6.2.1.19  long-chain-fatty-acid---protein ligase

       6.2.1.20  long-chain-fatty-acid---[acyl-carrier-protein] ligase

       6.2.1.22  [citrate (pro-3S)-lyase] ligase

       6.2.1.23  dicarboxylate---CoA ligase

       6.2.1.24  phytanate---CoA ligase

       6.2.1.25  benzoate---CoA ligase

       6.2.1.26  o-succinylbenzoate---CoA ligase

       6.2.1.27  4-hydroxybenzoate---CoA ligase

       6.2.1.28  3alpha,7alpha-dihydroxy-5beta-cholestanate---CoA ligase

       6.2.1.30  phenylacetate---CoA ligase

       6.2.1.31  2-furoate---CoA ligase

       6.2.1.32  anthranilate---CoA ligase

       6.2.1.33  4-chlorobenzoate---CoA ligase

       6.2.1.34  trans-feruloyl-CoA synthase

       6.2.1.35  acetate---[acyl-carrier protein] ligase

       6.2.1.36  3-hydroxypropionyl-CoA synthase

       6.2.1.37  3-hydroxybenzoate---CoA ligase

       6.2.1.38  (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase

       6.2.1.39  [butirosin acyl-carrier protein]---L-glutamate ligase

       6.2.1.40  4-hydroxybutyrate---CoA ligase (AMP-forming)

       6.2.1.41  3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase

       6.2.1.42  3-oxocholest-4-en-26-oate---CoA ligase

       6.2.1.43  2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase

       6.2.1.44  3-(methylthio)propionyl---CoA ligase

       6.2.1.45  E1 ubiquitin-activating enzyme

       6.2.1.46  L-allo-isoleucine---holo-[CmaA peptidyl-carrier protein] ligase

       6.2.1.47  medium-chain-fatty-acid---[acyl-carrier-protein] ligase

       6.2.1.48  carnitine---CoA ligase

       6.2.1.49  long-chain fatty acid adenylyltransferase FadD28

       6.2.1.50  4-hydroxybenzoate adenylyltransferase FadD22

       6.2.1.51  4-hydroxyphenylalkanoate adenylyltransferase FadD29

       6.2.1.52  L-firefly luciferin---CoA ligase

       6.2.1.53  L-proline---[L-prolyl-carrier protein] ligase

       6.2.1.54  D-alanine---[D-alanyl-carrier protein] ligase

       6.2.1.55  E1 SAMP-activating enzyme

       6.2.1.56  4-hydroxybutyrate---CoA ligase (ADP-forming)

       6.2.1.57  long-chain fatty acid adenylase/transferase FadD23

       6.2.1.58  isophthalate---CoA ligase

       6.2.1.59  long-chain fatty acid adenylase/transferase FadD26

       6.2.1.60  marinolic acid---CoA ligase

       6.2.1.61  salicylate---[aryl-carrier protein] ligase

       6.2.1.62  3,4-dihydroxybenzoate---[aryl-carrier protein] ligase

       6.2.1.63  L-arginine---[L-arginyl-carrier protein] ligase

       6.2.1.64  E1 NEDD8-activating enzyme

       6.2.1.65  salicylate---CoA ligase

       6.2.1.-  

     6.2.2  Amide---thiol ligases

   6.3  Forming carbon-nitrogen bonds

   6.4  Forming carbon-carbon bonds

   6.5  Forming phosphoric-ester bonds

   6.6  Forming nitrogen-D-metal bonds

   6.-  

 7. Translocases