Chromosome and Associated Proteins - Homo sapiens (human)

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     KO
 Eukaryotic type
   Sister chromatid cohesion proteins
   Meiosis-specific sister chromatid cohesion proteins
   Nucleosome assembly factors
   Histone modification proteins
     HATs (histone acetyltransferases)
     HAT complexes
     HDACs (histone deacetylases)
     HDAC complexes
     HMTs (histone methyltransferases)
       HKMTs (histone lysine methyltransferases)
         55870 ASH1L; ASH1 like histone lysine methyltransferase
         84444 DOT1L; DOT1 like histone lysine methyltransferase
         10919 EHMT2; euchromatic histone lysine methyltransferase 2
         79813 EHMT1; euchromatic histone lysine methyltransferase 1
         2145 EZH1; enhancer of zeste 1 polycomb repressive complex 2 subunit
         2146 EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit
         4297 KMT2A; lysine methyltransferase 2A
         8085 KMT2D; lysine methyltransferase 2D
         58508 KMT2C; lysine methyltransferase 2C
         9757 KMT2B; lysine methyltransferase 2B
         55904 KMT2E; lysine methyltransferase 2E (inactive)
         64324 NSD1; nuclear receptor binding SET domain protein 1
         7468 NSD2; nuclear receptor binding SET domain protein 2
         54904 NSD3; nuclear receptor binding SET domain protein 3
         7799 PRDM2; PR/SET domain 2
         2122 MECOM; MDS1 and EVI1 complex locus
         93166 PRDM6; PR/SET domain 6
         56979 PRDM9; PR/SET domain 9
         11105 PRDM7; PR/SET domain 7
         56978 PRDM8; PR/SET domain 8
         59335 PRDM12; PR/SET domain 12
         63976 PRDM16; PR/SET domain 16
         23067 SETD1B; SET domain containing 1B, histone lysine methyltransferase
         9739 SETD1A; SET domain containing 1A, histone lysine methyltransferase
         29072 SETD2; SET domain containing 2, histone lysine methyltransferase
         79918 SETD6; SET domain containing 6, protein lysine methyltransferase
         80854 SETD7; SET domain containing 7, histone lysine methyltransferase
         387893 KMT5A; lysine methyltransferase 5A
         9869 SETDB1; SET domain bifurcated histone lysine methyltransferase 1
         83852 SETDB2; SET domain bifurcated histone lysine methyltransferase 2
         6419 SETMAR; SET domain and mariner transposase fusion gene
         56950 SMYD2; SET and MYND domain containing 2
         64754 SMYD3; SET and MYND domain containing 3
         150572 SMYD1; SET and MYND domain containing 1
         6839 SUV39H1; suppressor of variegation 3-9 homolog 1
         79723 SUV39H2; suppressor of variegation 3-9 homolog 2
         84787 KMT5C; lysine methyltransferase 5C
         51111 KMT5B; lysine methyltransferase 5B
K06101 ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354] 
K11427 DOT1L; [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360] 
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355] 
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355] 
K17451 EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356] 
K11430 EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] 
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354] 
K09187 MLL2; [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354] 
K09188 MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354] 
K14959 MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354] 
K09189 MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354] 
K15588 NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357] 
K11424 WHSC1; [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357] 
K11425 WHSC1L1; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371] 
K11432 PRDM2; [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355] 
K04462 MECOM; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367] 
K20795 PRDM6; [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361] 
K20796 PRDM7_9; [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354] 
K20796 PRDM7_9; [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354] 
K20797 PRDM8; PR domain zinc finger protein 8 [EC:2.1.1.-] 
K24255 PRDM12; PR domain zinc finger protein 12 [EC:2.1.1.-] 
K22410 PRDM16; [histone H3]-lysine9 N-methyltransferase [EC:2.1.1.367] 
K11422 SETD1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354] 
K11422 SETD1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354] 
K11423 SETD2; [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359] 
K05302 SETD6; N-lysine methyltransferase SETD6 [EC:2.1.1.-] 
K11431 SETD7; [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364] 
K11428 SETD8; [histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361] 
K11421 SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366] 
K18494 SETDB2; [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355] 
K11433 SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357] 
K11426 SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357] 
K11426 SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357] 
K11426 SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357] 
K11419 SUV39H; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355] 
K11419 SUV39H; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355] 
K11429 SUV420H; [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362] 
K11429 SUV420H; [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362] 
       PRMTs (protein arginine metyltransferases)
     HMT complexes
     Histone demethylases
     Polycomb group proteins
       PRC1 (polycomb repressive complex 1)
       PRC2-EZH1 complex
       PRC2-EZH2 complex
         2146 EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit
         8726 EED; embryonic ectoderm development
         23512 SUZ12; SUZ12 polycomb repressive complex 2 subunit
         5928 RBBP4; RB binding protein 4, chromatin remodeling factor
         121536 AEBP2; AE binding protein 2
K11430 EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] 
K11462 EED; polycomb protein EED 
K11463 SUZ12; polycomb protein SUZ12 
K10752 RBBP4; histone-binding protein RBBP4 
K17452 AEBP2; zinc finger protein AEBP2 
       AUTS2-polycomb complex
       Other polycomb group proteins
     Sir proteins
     Other histone modification proteins
   Chromosome condensation proteins
   Centromeric chromatin formation proteins
   Heterochromatin formation proteins
   Gene silencing
   Centrosome formation and ciliogenesis proteins
   Sister chromatid separation proteins
   Chromatin remodeling factors
 
 Prokaryotic type

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Last updated: January 12, 2021