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KO |
Eukaryotic type
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Sister chromatid cohesion proteins
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Meiosis-specific proteins
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Nucleosome assembly factors
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Histone modification proteins
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HATs (histone acetyltransferases)
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HAT complexes
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HDACs (histone deacetylases)
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Class I HDACs
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3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
8841 HDAC3; histone deacetylase 3
55869 HDAC8; histone deacetylase 8
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K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11404 HDAC3; histone deacetylase 3 [EC:3.5.1.98]
K11405 HDAC8; histone deacetylase 8 [EC:3.5.1.98]
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Class II HDACs
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SIRTs (sirtuins, class III HDACs)
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Class IV HDACs
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HDAC complexes
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Sin3A-HDAC complex
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3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
25942 SIN3A; SIN3 transcription regulator family member A
5928 RBBP4; RB binding protein 4, chromatin remodeling factor
5931 RBBP7; RB binding protein 7, chromatin remodeling factor
64426 SUDS3; SDS3 homolog, SIN3A corepressor complex component
8819 SAP30; Sin3A associated protein 30
79685 SAP30L; SAP30 like
10284 SAP18; Sin3A associated protein 18
79595 SAP130; Sin3A associated protein 130
100316904 SAP25; Sin3A associated protein 25
5926 ARID4A; AT-rich interaction domain 4A
51742 ARID4B; AT-rich interaction domain 4B
25855 BRMS1; BRMS1 transcriptional repressor and anoikis regulator
84312 BRMS1L; BRMS1 like transcriptional repressor
3621 ING1; inhibitor of growth family member 1
3622 ING2; inhibitor of growth family member 2
58516 SINHCAF; SIN3-HDAC complex associated factor
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K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11644 SIN3A; paired amphipathic helix protein Sin3a
K10752 RBBP4; histone-binding protein RBBP4
K11659 RBBP7; histone-binding protein RBBP7
K19201 SUDS3; Sin3 histone deacetylase corepressor complex component SDS3
K19202 SAP30; histone deacetylase complex subunit SAP30
K19202 SAP30; histone deacetylase complex subunit SAP30
K14324 SAP18; histone deacetylase complex subunit SAP18
K19192 SAP130; histone deacetylase complex subunit SAP130
K19193 SAP25; histone deacetylase complex subunit SAP25
K19194 ARID4A; AT-rich interactive domain-containing protein 4A
K19195 ARID4B; AT-rich interactive domain-containing protein 4B
K19196 BRMS1; breast cancer metastasis-suppressor 1 and related proteins
K19196 BRMS1; breast cancer metastasis-suppressor 1 and related proteins
K19197 ING1; inhibitor of growth protein 1
K19198 ING2; inhibitor of growth protein 2
K26090 SINHCAF; SIN3-HDAC complex-associated factor
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BRAF-HDAC complex
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3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
10362 HMG20B; high mobility group 20B
23028 KDM1A; lysine demethylase 1A
23186 RCOR1; REST corepressor 1
51317 PHF21A; PHD finger protein 21A
9203 ZMYM3; zinc finger MYM-type containing 3
9202 ZMYM4; zinc finger MYM-type containing 4
7750 ZMYM2; zinc finger MYM-type containing 2
7764 ZNF217; zinc finger protein 217
23199 GSE1; Gse1 coiled-coil protein
2969 GTF2I; general transcription factor IIi
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K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K24650 HMG20B; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
K11450 KDM1A; [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase [EC:1.14.99.66]
K11829 RCOR1; REST corepressor 1
K24651 PHF21A; PHD finger protein 21A
K24675 ZMYM2_3_4; zinc finger MYM-type protein 2/3/4
K24675 ZMYM2_3_4; zinc finger MYM-type protein 2/3/4
K24675 ZMYM2_3_4; zinc finger MYM-type protein 2/3/4
K27275 ZNF217; zinc finger protein 217
K27276 GSE1; genetic suppressor element 1
K03121 TFII-I; transcription initiation factor TFII-I
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REST complex
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5978 REST; RE1 silencing transcription factor
25942 SIN3A; SIN3 transcription regulator family member A
23309 SIN3B; SIN3 transcription regulator family member B
3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
23186 RCOR1; REST corepressor 1
283248 RCOR2; REST corepressor 2
55758 RCOR3; REST corepressor 3
23028 KDM1A; lysine demethylase 1A
6595 SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
6597 SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
10919 EHMT2; euchromatic histone lysine methyltransferase 2
79813 EHMT1; euchromatic histone lysine methyltransferase 1
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K09222 REST; RE1-silencing transcription factor
K11644 SIN3A; paired amphipathic helix protein Sin3a
K23213 SIN3B; paired amphipathic helix protein Sin3b
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11829 RCOR1; REST corepressor 1
K26242 RCOR2_3; REST corepressor 2/3
K26242 RCOR2_3; REST corepressor 2/3
K11450 KDM1A; [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase [EC:1.14.99.66]
K11647 SMARCA2_4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 [EC:5.6.2.-]
K11647 SMARCA2_4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 [EC:5.6.2.-]
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
K11420 EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
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SHIP complex
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3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
3635 INPP5D; inositol polyphosphate-5-phosphatase D
3306 HSPA2; heat shock protein family A (Hsp70) member 2
146212 KCTD19; potassium channel tetramerization domain containing 19
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K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K03084 SHIP1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K26598 HSPA2; heat shock 70kDa protein 2
K26581 KCTD19; BTB/POZ domain-containing protein KCTD19
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MiDAC complex
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3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
91748 MIDEAS; mitotic deacetylase associated SANT domain protein
116092 DNTTIP1; deoxynucleotidyltransferase terminal interacting protein 1
55809 TRERF1; transcriptional regulating factor 1
84215 ZNF541; zinc finger protein 541
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K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K26582 MIDEAS; mitotic deacetylase-associated SANT domain protein
K08707 DNTTIP1; deoxynucleotidyltransferase terminal-interacting protein 1
K26583 TRERF1; transcriptional-regulating factor 1
K26584 ZNF541; zinc finger protein 541
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SMART complex
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Other HDAC associated proteins
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HMTs (histone methyltransferases)
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HMT complexes
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Histone demethylases
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Polycomb repressive complex (PRC) and associated proteins
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Canonical PRC1 (PRC1.2/1.4)
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Noncanonical PRC1 (PRC1.1)
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Noncanonical PRC1 (PRC1.3/1.5)
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Noncanonical PRC1 (PRC1.6)
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6045 RNF2; ring finger protein 2
6015 RING1; ring finger protein 1
84108 PCGF6; polycomb group ring finger 6
23429 RYBP; RING1 and YY1 binding protein
10138 YAF2; YY1 associated factor 2
1876 E2F6; E2F transcription factor 6
7027 TFDP1; transcription factor Dp-1
4149 MAX; MYC associated factor X
23269 MGA; MAX dimerization protein MGA
26013 L3MBTL1; L3MBTL histone methyl-lysine binding protein 1
84456 L3MBTL3; L3MBTL histone methyl-lysine binding protein 3
83746 L3MBTL2; L3MBTL histone methyl-lysine binding protein 2
91133 L3MBTL4; L3MBTL histone methyl-lysine binding protein 4
11335 CBX3; chromobox 3
11091 WDR5; WD repeat domain 5
54554 WDR5B; WD repeat domain 5B
3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
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K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K11470 PCGF6; polycomb group RING finger protein 6
K11469 RYBP; RING1 and YY1-binding protein
K11468 YAF2; YY1-associated factor 2
K09390 E2F6; transcription factor E2F6
K04683 TFDP1; transcription factor Dp-1
K04453 MAX; Max protein
K23399 MGA; MAX gene-associated protein
K24387 L3MBTL; lethal(3)malignant brain tumor-like protein
K24387 L3MBTL; lethal(3)malignant brain tumor-like protein
K24387 L3MBTL; lethal(3)malignant brain tumor-like protein
K24387 L3MBTL; lethal(3)malignant brain tumor-like protein
K11586 CBX3; chromobox protein 3
K14963 WDR5; COMPASS component SWD3
K14963 WDR5; COMPASS component SWD3
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
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PRC2.1
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PRC2.2
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PR-DUB complex
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Other PRC associated proteins
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Sir proteins
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Other histone modification proteins
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Chromosome condensation proteins
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Centromeric chromatin formation proteins
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Heterochromatin formation proteins
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HP1 (heterochromatin protein 1)
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MBPs (metylated DNA binding proteins)
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Other heterochromatin formation proteins
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546 ATRX; ATRX chromatin remodeler
1786 DNMT1; DNA methyltransferase 1
1788 DNMT3A; DNA methyltransferase 3 alpha
1789 DNMT3B; DNA methyltransferase 3 beta
29947 DNMT3L; DNA methyltransferase 3 like
3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
25942 SIN3A; SIN3 transcription regulator family member A
1107 CHD3; chromodomain helicase DNA binding protein 3
1108 CHD4; chromodomain helicase DNA binding protein 4
5928 RBBP4; RB binding protein 4, chromatin remodeling factor
55729 ATF7IP; activating transcription factor 7 interacting protein
80063 ATF7IP2; activating transcription factor 7 interacting protein 2
9869 SETDB1; SET domain bifurcated histone lysine methyltransferase 1
83852 SETDB2; SET domain bifurcated histone lysine methyltransferase 2
6839 SUV39H1; SUV39H1 histone lysine methyltransferase
79723 SUV39H2; SUV39H2 histone lysine methyltransferase
3930 LBR; lamin B receptor
57167 SALL4; spalt like transcription factor 4
6299 SALL1; spalt like transcription factor 1
6297 SALL2; spalt like transcription factor 2
27164 SALL3; spalt like transcription factor 3
54737 MPHOSPH8; M-phase phosphoprotein 8
51535 PPHLN1; periphilin 1
23272 TASOR; transcription activation suppressor
23394 ADNP; activity dependent neuroprotector homeobox
27245 AHDC1; AT-hook DNA binding motif containing 1
283489 CHAMP1; chromosome alignment maintaining phosphoprotein 1
23126 POGZ; pogo transposable element derived with ZNF domain
23347 SMCHD1; structural maintenance of chromosomes flexible hinge domain containing 1
55791 LRIF1; ligand dependent nuclear receptor interacting factor 1
100506736 SLFN12L; schlafen family member 12 like
55106 SLFN12; schlafen family member 12
79968 WDR76; WD repeat domain 76
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K10779 ATRX; transcriptional regulator ATRX
K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
K17400 DNMT3L; DNA (cytosine-5)-methyltransferase 3-like
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11644 SIN3A; paired amphipathic helix protein Sin3a
K11642 CHD3; chromodomain-helicase-DNA-binding protein 3 [EC:5.6.2.-]
K11643 CHD4; chromodomain-helicase-DNA-binding protein 4 [EC:5.6.2.-]
K10752 RBBP4; histone-binding protein RBBP4
K25802 ATF7IP; activating transcription factor 7-interacting protein
K25802 ATF7IP; activating transcription factor 7-interacting protein
K11421 SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]
K18494 SETDB2; [histone H3]-lysine9 N-trimethyltransferase SETDB2 [EC:2.1.1.355]
K11419 SUV39H; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]
K11419 SUV39H; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]
K19532 LBR; Delta14-sterol reductase (lamin-B receptor) [EC:1.3.1.70]
K19871 SALL; sal-like protein
K19871 SALL; sal-like protein
K19871 SALL; sal-like protein
K19871 SALL; sal-like protein
K21871 MPHOSPH8; M-phase phosphoprotein 8
K21872 PPHLN1; periphilin-1
K21873 FAM208A; protein TASOR
K22591 ADNP; activity-dependent neuroprotector homeobox protein
K22592 AHDC1; AT-hook DNA-binding motif-containing protein 1
K22593 CHAMP1; chromosome alignment-maintaining phosphoprotein 1
K22594 POGZ; pogo transposable element with ZNF domain
K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
K23220 LRIF1; ligand-dependent nuclear receptor-interacting factor 1
K24457 SLFN12; schlafen family member 12
K24457 SLFN12; schlafen family member 12
K24755 WDR76; WD repeat-containing protein 76
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Gene silencing
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Centrosome formation proteins
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Sister chromatid separation proteins
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Chromatin remodeling factors
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BAF complex
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PBAF complex
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GBAF(ncBAF) complex
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CHRAC complex
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RSF complex
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WICH complex
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B-WICH complex
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NORC complex
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BRF complex
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NuRD complex
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3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
1107 CHD3; chromodomain helicase DNA binding protein 3
1108 CHD4; chromodomain helicase DNA binding protein 4
5928 RBBP4; RB binding protein 4, chromatin remodeling factor
5931 RBBP7; RB binding protein 7, chromatin remodeling factor
9219 MTA2; metastasis associated 1 family member 2
9112 MTA1; metastasis associated 1
57504 MTA3; metastasis associated 1 family member 3
53615 MBD3; methyl-CpG binding domain protein 3
54815 GATAD2A; GATA zinc finger domain containing 2A
57459 GATAD2B; GATA zinc finger domain containing 2B
84295 PHF6; PHD finger protein 6
8099 CDK2AP1; cyclin dependent kinase 2 associated protein 1
10263 CDK2AP2; cyclin dependent kinase 2 associated protein 2
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K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11642 CHD3; chromodomain-helicase-DNA-binding protein 3 [EC:5.6.2.-]
K11643 CHD4; chromodomain-helicase-DNA-binding protein 4 [EC:5.6.2.-]
K10752 RBBP4; histone-binding protein RBBP4
K11659 RBBP7; histone-binding protein RBBP7
K11660 MTA; metastasis-associated protein MTA
K11660 MTA; metastasis-associated protein MTA
K11660 MTA; metastasis-associated protein MTA
K11591 MBD3; methyl-CpG-binding domain protein 3
K23194 GATAD2; transcriptional repressor p66
K23194 GATAD2; transcriptional repressor p66
K23310 PHF6; PHD finger protein 6
K26454 CDK2AP1; cyclin-dependent kinase 2-associated protein 1
K26455 CDK2AP2; cyclin-dependent kinase 2-associated protein 2
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NuRF complex
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NuRF complex (fruit fly)
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CERF complex
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SRCAP complex
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INO80 complex
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INO80 complex (yeast)
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RSC complex
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SWI/SNF complex
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SWR1 complex
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ASTRA complex
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Other chromatin remodeling factors
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Prokaryotic type
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