Ubiquitin System - Homo sapiens (human)

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     KO
 Ubiquitins and ubiquitin-like proteins
 
 Ubiquitin-activating enzymes (E1)
 
 Ubiquitin-conjugating enzymes (E2)
 
 Ubiquitin ligases (E3)
   HECT type E3
   U-box type E3
   Single Ring-finger type E3
   Atypical E3
   UBL E3 ligases
   Multi subunit Ring-finger type E3
     SCF complex
     ECV complex
     Cul3 complex
       Ring finger protein
       Cullin
       Adoptor and target recognizing subunit (BTB)
         57626 KLHL1; kelch like family member 1
         56062 KLHL4; kelch like family member 4
         51088 KLHL5; kelch like family member 5
         11275 KLHL2; kelch like family member 2
         26249 KLHL3; kelch like family member 3
         89857 KLHL6; kelch like family member 6
         55975 KLHL7; kelch like family member 7
         57563 KLHL8; kelch like family member 8
         55958 KLHL9; kelch like family member 9
         90293 KLHL13; kelch like family member 13
         317719 KLHL10; kelch like family member 10
         55175 KLHL11; kelch like family member 11
         59349 KLHL12; kelch like family member 12
         57565 KLHL14; kelch like family member 14
         80311 KLHL15; kelch like family member 15
         8139 GAN; gigaxonin
         339451 KLHL17; kelch like family member 17
         23276 KLHL18; kelch like family member 18
         9817 KEAP1; kelch like ECH associated protein 1
         27252 KLHL20; kelch like family member 20
         9903 KLHL21; kelch like family member 21
         84861 KLHL22; kelch like family member 22
         151230 KLHL23; kelch like family member 23
         100526832 PHOSPHO2-KLHL23; PHOSPHO2-KLHL23 readthrough
         54800 KLHL24; kelch like family member 24
         283212 KLHL35; kelch like family member 35
         64410 KLHL25; kelch like family member 25
         8507 ENC1; ectodermal-neural cortex 1
         55295 KLHL26; kelch like family member 26
         3652 IPP; intracisternal A particle-promoted polypeptide
         54813 KLHL28; kelch like family member 28
         114818 KLHL29; kelch like family member 29
         377007 KLHL30; kelch like family member 30
         401265 KLHL31; kelch like family member 31
         114792 KLHL32; kelch like family member 32
         123103 KLHL33; kelch like family member 33
         257240 KLHL34; kelch like family member 34
         79786 KLHL36; kelch like family member 36
         340359 KLHL38; kelch like family member 38
         25948 KBTBD2; kelch repeat and BTB domain containing 2
         143879 KBTBD3; kelch repeat and BTB domain containing 3
         55709 KBTBD4; kelch repeat and BTB domain containing 4
         131377 KLHL40; kelch like family member 40
         10324 KLHL41; kelch like family member 41
         89890 KBTBD6; kelch repeat and BTB domain containing 6
         84078 KBTBD7; kelch repeat and BTB domain containing 7
         84541 KBTBD8; kelch repeat and BTB domain containing 8
         9920 KBTBD11; kelch repeat and BTB domain containing 11
         166348 KBTBD12; kelch repeat and BTB domain containing 12
         390594 KBTBD13; kelch repeat and BTB domain containing 13
         53339 BTBD1; BTB domain containing 1
         55643 BTBD2; BTB domain containing 2
         90135 BTBD6; BTB domain containing 6
         22903 BTBD3; BTB domain containing 3
         55727 BTBD7; BTB domain containing 7
         284697 BTBD8; BTB domain containing 8
         114781 BTBD9; BTB domain containing 9
         84280 BTBD10; BTB domain containing 10
         121551 BTBD11; BTB domain containing 11
         84464 SLX4; SLX4 structure-specific endonuclease subunit
         64395 GMCL1; germ cell-less 1, spermatogenesis associated
         64396 GMCL2; germ cell-less 2, spermatogenesis associated
         138151 NACC2; NACC family member 2
         112939 NACC1; nucleus accumbens associated 1
         118663 BTBD16; BTB domain containing 16
         22890 ZBTB1; zinc finger and BTB domain containing 1
         57621 ZBTB2; zinc finger and BTB domain containing 2
         79842 ZBTB3; zinc finger and BTB domain containing 3
         57659 ZBTB4; zinc finger and BTB domain containing 4
         9925 ZBTB5; zinc finger and BTB domain containing 5
         10773 ZBTB6; zinc finger and BTB domain containing 6
         201501 ZBTB7C; zinc finger and BTB domain containing 7C
         51341 ZBTB7A; zinc finger and BTB domain containing 7A
         51043 ZBTB7B; zinc finger and BTB domain containing 7B
         653121 ZBTB8A; zinc finger and BTB domain containing 8A
         728116 ZBTB8B; zinc finger and BTB domain containing 8B
         221504 ZBTB9; zinc finger and BTB domain containing 9
         65986 ZBTB10; zinc finger and BTB domain containing 10
         27107 ZBTB11; zinc finger and BTB domain containing 11
         221527 ZBTB12; zinc finger and BTB domain containing 12
         7704 ZBTB16; zinc finger and BTB domain containing 16
         7709 ZBTB17; zinc finger and BTB domain containing 17
         26137 ZBTB20; zinc finger and BTB domain containing 20
         9278 ZBTB22; zinc finger and BTB domain containing 22
         9841 ZBTB24; zinc finger and BTB domain containing 24
         7597 ZBTB25; zinc finger and BTB domain containing 25
         57684 ZBTB26; zinc finger and BTB domain containing 26
         27033 ZBTB32; zinc finger and BTB domain containing 32
         10009 ZBTB33; zinc finger and BTB domain containing 33
         403341 ZBTB34; zinc finger and BTB domain containing 34
         84614 ZBTB37; zinc finger and BTB domain containing 37
         253461 ZBTB38; zinc finger and BTB domain containing 38
         9880 ZBTB39; zinc finger and BTB domain containing 39
         9923 ZBTB40; zinc finger and BTB domain containing 40
         360023 ZBTB41; zinc finger and BTB domain containing 41
         23099 ZBTB43; zinc finger and BTB domain containing 43
         29068 ZBTB44; zinc finger and BTB domain containing 44
         84878 ZBTB45; zinc finger and BTB domain containing 45
         140685 ZBTB46; zinc finger and BTB domain containing 46
         92999 ZBTB47; zinc finger and BTB domain containing 47
         3104 ZBTB48; zinc finger and BTB domain containing 48
         80325 ABTB1; ankyrin repeat and BTB domain containing 1
         25841 ABTB2; ankyrin repeat and BTB domain containing 2
         23221 RHOBTB2; Rho related BTB domain containing 2
         9886 RHOBTB1; Rho related BTB domain containing 1
         22836 RHOBTB3; Rho related BTB domain containing 3
         7126 TNFAIP1; TNF alpha induced protein 1
         83892 KCTD10; potassium channel tetramerization domain containing 10
         253980 KCTD13; potassium channel tetramerization domain containing 13
         284252 KCTD1; potassium channel tetramerization domain containing 1
         79047 KCTD15; potassium channel tetramerization domain containing 15
         23510 KCTD2; potassium channel tetramerization domain containing 2
         54442 KCTD5; potassium channel tetramerization domain containing 5
         79734 KCTD17; potassium channel tetramerization domain containing 17
         51133 KCTD3; potassium channel tetramerization domain containing 3
         200845 KCTD6; potassium channel tetramerization domain containing 6
         154881 KCTD7; potassium channel tetramerization domain containing 7
         65987 KCTD14; potassium channel tetramerization domain containing 14
         115207 KCTD12; potassium channel tetramerization domain containing 12
         386617 KCTD8; potassium channel tetramerization domain containing 8
         57528 KCTD16; potassium channel tetramerization domain containing 16
         54793 KCTD9; potassium channel tetramerization domain containing 9
         147040 KCTD11; potassium channel tetramerization domain containing 11
         130535 KCTD18; potassium channel tetramerization domain containing 18
         283219 KCTD21; potassium channel tetramerization domain containing 21
         56616 DIABLO; diablo IAP-binding mitochondrial protein
         8405 SPOP; speckle type BTB/POZ protein
         339745 SPOPL; speckle type BTB/POZ protein like
         8216 LZTR1; leucine zipper like transcription regulator 1
K10442 KLHL1_4_5; kelch-like protein 1/4/5 
K10442 KLHL1_4_5; kelch-like protein 1/4/5 
K10442 KLHL1_4_5; kelch-like protein 1/4/5 
K10443 KLHL2_3; kelch-like protein 2/3 
K10443 KLHL2_3; kelch-like protein 2/3 
K10444 KLHL6; kelch-like protein 6 
K10445 KLHL7; kelch-like protein 7 
K10446 KLHL8; kelch-like protein 8 
K10447 KLHL9_13; kelch-like protein 9/13 
K10447 KLHL9_13; kelch-like protein 9/13 
K10448 KLHL10; kelch-like protein 10 
K10449 KLHL11; kelch-like protein 11 
K10450 KLHL12; kelch-like protein 12 
K10451 KLHL14; kelch-like protein 14 
K10452 KLHL15; kelch-like protein 15 
K10453 KLHL16; kelch-like protein 16 (gigaxonin) 
K10454 KLHL17; kelch-like protein 17 (actinfilin) 
K10455 KLHL18; kelch-like protein 18 
K10456 KLHL19; kelch-like protein 19 
K10457 KLHL20; kelch-like protein 20 
K10458 KLHL21; kelch-like protein 21 
K10459 KLHL22; kelch-like protein 22 
K10460 KLHL23; kelch-like protein 23 
K10460 KLHL23; kelch-like protein 23 
K10461 KLHL24_35; kelch-like protein 24/35 
K10461 KLHL24_35; kelch-like protein 24/35 
K10462 KLHL25_37; kelch-like protein 25/37 (ectoderm-neural cortex protein) 
K10462 KLHL25_37; kelch-like protein 25/37 (ectoderm-neural cortex protein) 
K10463 KLHL26; kelch-like protein 26 
K13956 IPP; actin-binding protein IPP 
K10464 KLHL28; kelch-like protein 28 
K10465 KLHL29; kelch-like protein 29 
K10466 KLHL30; kelch-like protein 30 
K10467 KLHL31; kelch-like protein 31 
K10468 KLHL32; kelch-like protein 32 
K13957 KLHL33; kelch-like protein 33 
K10469 KLHL34; kelch-like protein 34 
K13958 KLHL36; kelch-like protein 36 
K13959 KLHL38; kelch-like protein 38 
K10470 KBTBD2; kelch repeat and BTB domain-containing protein 2 
K10471 KBTBD3; kelch repeat and BTB domain-containing protein 3 
K10472 KBTBD4; kelch repeat and BTB domain-containing protein 4 
K10473 KBTBD5_10; kelch repeat and BTB domain-containing protein 5/10 
K10473 KBTBD5_10; kelch repeat and BTB domain-containing protein 5/10 
K10474 KBTBD6_7; kelch repeat and BTB domain-containing protein 6/7 
K10474 KBTBD6_7; kelch repeat and BTB domain-containing protein 6/7 
K10475 KBTBD8; kelch repeat and BTB domain-containing protein 8 
K10476 KBTBD11; kelch repeat and BTB domain-containing protein 11 
K21912 KBTBD12; kelch repeat and BTB domain-containing protein 12 
K21913 KBTBD13; kelch repeat and BTB domain-containing protein 13 
K10477 BTBD1_2; BTB/POZ domain-containing protein 1/2 
K10477 BTBD1_2; BTB/POZ domain-containing protein 1/2 
K10478 BTBD3_6; BTB/POZ domain-containing protein 3/6 
K10478 BTBD3_6; BTB/POZ domain-containing protein 3/6 
K10479 BTBD7; BTB/POZ domain-containing protein 7 
K10480 BTBD8; BTB/POZ domain-containing protein 8 
K10481 BTBD9; BTB/POZ domain-containing protein 9 
K10482 BTBD10; BTB/POZ domain-containing protein 10 
K10483 BTBD11; BTB/POZ domain-containing protein 11 
K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) 
K10485 BTBD13; BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1) 
K10485 BTBD13; BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1) 
K10486 BTBD14; BTB/POZ domain-containing protein 14 
K10486 BTBD14; BTB/POZ domain-containing protein 14 
K10487 BTBD16; BTB/POZ domain-containing protein 16 
K10488 ZBTB1; zinc finger and BTB domain-containing protein 1 
K10489 ZBTB2; zinc finger and BTB domain-containing protein 2 
K10490 ZBTB3; zinc finger and BTB domain-containing protein 3 
K10491 ZBTB4; zinc finger and BTB domain-containing protein 4 
K10492 ZBTB5; zinc finger and BTB domain-containing protein 5 
K10493 ZBTB6; zinc finger and BTB domain-containing protein 6 
K10494 ZBTB7; zinc finger and BTB domain-containing protein 7 
K10494 ZBTB7; zinc finger and BTB domain-containing protein 7 
K10494 ZBTB7; zinc finger and BTB domain-containing protein 7 
K10495 ZBTB8; zinc finger and BTB domain-containing protein 8 
K10495 ZBTB8; zinc finger and BTB domain-containing protein 8 
K10496 ZBTB9; zinc finger and BTB domain-containing protein 9 
K10497 ZBTB10; zinc finger and BTB domain-containing protein 10 
K10498 ZBTB11; zinc finger and BTB domain-containing protein 11 
K10499 ZBTB12; zinc finger and BTB domain-containing protein 12 
K10055 ZBTB16; zinc finger and BTB domain-containing protein 16 
K10500 ZBTB17; zinc finger and BTB domain-containing protein 17 
K10501 ZBTB20; zinc finger and BTB domain-containing protein 20 
K10502 ZBTB22; zinc finger and BTB domain-containing protein 22 
K10503 ZBTB24; zinc finger and BTB domain-containing protein 24 
K10504 ZBTB25; zinc finger and BTB domain-containing protein 25 
K10505 ZBTB26; zinc finger and BTB domain-containing protein 26 
K10506 ZBTB32; zinc finger and BTB domain-containing protein 32 
K10507 ZBTB33; zinc finger and BTB domain-containing protein 33 
K10508 ZBTB34; zinc finger and BTB domain-containing protein 34 
K10509 ZBTB37; zinc finger and BTB domain-containing protein 37 
K10510 ZBTB38; zinc finger and BTB domain-containing protein 38 
K10511 ZBTB39; zinc finger and BTB domain-containing protein 39 
K10512 ZBTB40; zinc finger and BTB domain-containing protein 40 
K10513 ZBTB41; zinc finger and BTB domain-containing protein 41 
K10514 ZBTB43; zinc finger and BTB domain-containing protein 43 
K10515 ZBTB44; zinc finger and BTB domain-containing protein 44 
K10516 ZBTB45; zinc finger and BTB domain-containing protein 45 
K10517 ZBTB46; zinc finger and BTB domain-containing protein 46 
K10518 ZBTB47; zinc finger and BTB domain-containing protein 47 
K10519 ZBTB48; zinc finger and BTB domain-containing protein 48 
K10520 ABTB1; ankyrin repeat and BTB/POZ domain-containing protein 1 
K10521 ABTB2; ankyrin repeat and BTB/POZ domain-containing protein 2 
K07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1/2 
K07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1/2 
K07869 RHOBTB3; Rho-related BTB domain-containing protein 3 
K15074 BACURD; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 
K15074 BACURD; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 
K15074 BACURD; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 
K21754 KCTD1_15; BTB/POZ domain-containing protein KCTD1/15 
K21754 KCTD1_15; BTB/POZ domain-containing protein KCTD1/15 
K21914 KCTD2_5_17; BTB/POZ domain-containing protein KCTD2/5/17 
K21914 KCTD2_5_17; BTB/POZ domain-containing protein KCTD2/5/17 
K21914 KCTD2_5_17; BTB/POZ domain-containing protein KCTD2/5/17 
K21915 KCTD3; BTB/POZ domain-containing protein KCTD3 
K21916 KCTD6; BTB/POZ domain-containing protein KCTD6 
K21917 KCTD7_14; BTB/POZ domain-containing protein KCTD7/14 
K21917 KCTD7_14; BTB/POZ domain-containing protein KCTD7/14 
K21918 KCTD8_12_16; BTB/POZ domain-containing protein KCTD8/12/16 
K21918 KCTD8_12_16; BTB/POZ domain-containing protein KCTD8/12/16 
K21918 KCTD8_12_16; BTB/POZ domain-containing protein KCTD8/12/16 
K21919 KCTD9; BTB/POZ domain-containing protein KCTD9 
K21920 KCTD11; BTB/POZ domain-containing protein KCTD11 [EC:2.3.2.27] 
K21921 KCTD18; BTB/POZ domain-containing protein KCTD18 
K21922 KCTD21; BTB/POZ domain-containing protein KCTD21 
K10522 DIABLO; diablo 
K10523 SPOP; speckle-type POZ protein 
K10523 SPOP; speckle-type POZ protein 
K23330 LZTR1; leucine-zipper-like transcriptional regulator 1 
     Cul4 complex
     ECS complex
     Cul7 complex
     Cul9 complex
     APC/C
     BRCC complex
     KPC complex
     LUBAC complex
     CTLH complex
     ERAD complex
     SLX5-SLX8 complex
     Multi subunit type E3 associated proteins
 
 Deubiquitinating enzyme (DUB)

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Last updated: September 3, 2020