KEGG Networks

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     Indent
 06200 Cancer network
   06201 Signaling network
     06210 MAPK (ERK) signaling
       N00001  EGF-EGFR-RAS-ERK signaling pathway
       N00276  EGF-overexpression to RAS-ERK signaling pathway
       N00229  TGFA-EGFR-RAS-ERK signaling pathway
       N00230  TGFA-overexpression to RAS-ERK signaling pathway
       N00277  EREG-EGFR-RAS-ERK signaling pathway
       N00278  EREG-overexpression to RAS-ERK signaling pathway
       N00279  AREG-EGFR-RAS-ERK signaling pathway
       N00280  AREG-overexpression to RAS-ERK signaling pathway
       N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
       N00006  Amplified EGFR to RAS-ERK signaling pathway
       N00041  EGFR-overexpression to RAS-ERK signaling pathway
       N00021  EGF-ERBB2-RAS-ERK signaling pathway
       N00022  ERBB2-overexpression to RAS-ERK signaling pathway
       N00252  Amplified ERBB2 to RAS-ERK signaling pathway
       N00015  PDGF-PDGFR-RAS-ERK signaling pathway
       N00016  PDGF-overexpression to RAS-ERK signaling pathway
       N00018  Amplified PDGFR to RAS-ERK signaling pathway
       N00215  KITLG-KIT-RAS-ERK signaling pathway
       N00003  Mutation-activated KIT to RAS-ERK signaling pathway
       N00019  FGF-FGFR-RAS-ERK signaling pathway
       N00020  Amplified FGFR1 to RAS-ERK signaling pathway
       N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
       N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
       N00004  Duplication-activated FLT3 to RAS-ERK signaling pathway
       N00233  IGF2-IGF1R-RAS-ERK signaling pathway
       N00235  IGF2-overexpression to RAS-ERK signaling pathway
       N00237  IGF1R-overexpression to RAS-ERK signaling pathway
       N00216  HGF-MET-RAS-ERK signaling pathway
       N00246  HGF-overexpression to RAS-ERK signaling pathway
       N00005  Mutation-activated MET to RAS-ERK signaling pathway
       N00259  Amplified MET to RAS-ERK signaling pathway
       N00248  MET-overexpression to RAS-ERK signaling pathway
       N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
       N00009  TRK fusion kinase to RAS-ERK signaling pathway
       N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
       N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
       N00160  KSHV K1 to RAS-ERK signaling pathway
       N00077  HRAS-overexpression to RAS-ERK signaling pathway
       N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
       N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
       N00013  Mutation-activated BRAF to ERK signaling pathway
       N00023  EGF-EGFR-PLCG-ERK signaling pathway
       N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
       N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
 
 
 
 
 
 
 
 
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1
     06211 MAPK (JNK) signaling
       N00188  IL1-IL1R-JNK signaling pathway
       N00189  KSHV K15 to JNK signaling pathway
 
6
     06212 MAPK (p38) signaling
       N00186  IL1-IL1R-p38 signaling pathway
       N00187  KSHV Kaposin B to p38 signaling pathway
 
8
     06213 Other RAS signaling
       N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
       N00097  Loss of RASSF1 to EGF-EGFR-RAS-RASSF1 signaling pathway
       N00103  EGF-EGFR-RAS-RalGDS signaling pathway
       N00104  Mutation-activated KRAS to RalGDS signaling pathway
 
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4
     06214 PI3K signaling
       N00033  EGF-EGFR-PI3K signaling pathway
       N00281  EGF-overexpression to PI3K signaling pathway
       N00231  TGFA-EGFR-PI3K signaling pathway
       N00232  TGFA-overexpression to PI3K signaling pathway
       N00282  EREG-EGFR-PI3K signaling pathway
       N00283  EREG-overexpression to PI3K signaling pathway
       N00284  AREG-EGFR-PI3K signaling pathway
       N00285  AREG-overexpression to PI3K signaling pathway
       N00036  Mutation-activated EGFR to PI3K signaling pathway
       N00035  Amplified EGFR to PI3K signaling pathway
       N00042  EGFR-overexpression to PI3K signaling pathway
       N00034  ERBB2-overexpression to PI3K signaling pathway
       N00253  Amplified ERBB2 to PI3K signaling pathway
       N00039  PDGF-PDGFR-PI3K signaling pathway
       N00040  Amplified PDGFR to PI3K signaling pathway
       N00045  KITLG-KIT-PI3K signaling pathway
       N00046  Mutation-activated KIT to PI3K signaling pathway
       N00037  FGF-FGFR-PI3K signaling pathway
       N00038  Amplified FGFR1 to PI3K signaling pathway
       N00182  IGF-IGFR-PI3K-NFKB signaling pathway
       N00179  KSHV K1 to PI3K-NFKB signaling pathway
       N00234  IGF2-IGF1R-PI3K signaling pathway
       N00236  IGF2-overexpression to PI3K signaling pathway
       N00238  IGF1R-overexpression to PI3K signaling pathway
       N00047  EML4-ALK fusion kinase to PI3K signaling pathway
       N00043  HGF-MET-PI3K signaling pathway
       N00247  HGF-overexpression to PI3K signaling pathway
       N00044  Mutation-activated MET to PI3K signaling pathway
       N00260  Amplified MET to PI3K signaling pathway
       N00249  MET-overexpression to PI3K signaling pathway
       N00048  BCR-ABL fusion kinase to PI3K signaling pathway
       N00049  Mutation-activated PI3K to PI3K signaling pathway
       N00050  Amplified PI3K to PI3K signaling pathway
       N00220  PTEN-PI3K-AKT signaling pathway
       N00051  Deleted PTEN to PI3K signaling pathway
       N00052  Mutation-inactivated PTEN to PI3K signaling pathway
       N00082  Loss of NKX3-1 to PI3K signaling pathway
       N00030  EGF-EGFR-RAS-PI3K signaling pathway
       N00159  KSHV K1 to PI3K signaling pathway
       N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
       N00031  Duplication-activated FLT3 to RAS-PI3K signaling pathway
       N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
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3
4
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4
2
2
3
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     06215 WNT signaling
       N00056  Wnt signaling pathway
       N00059  FZD7-overexpression to Wnt signaling pathway
       N00060  LRP6-overexpression to Wnt signaling pathway
       N00175  KSHV LANA to Wnt signaling pathway
       N00242  Mutation-inactivated AXIN to Wnt signaling pathway
       N00057  Mutation-inactivated APC to Wnt signaling pathway
       N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
       N00061  CDH1-reduced expression to Wnt signaling pathway
       N00257  Loss of CDH1 to Wnt signaling pathway
       N00258  Mutation-inactivated CDH1 to Wnt signaling pathway
 
 
 
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     06216 NOTCH signaling
       N00086  Notch signaling pathway
       N00087  NOTCH-overexpression to Notch signaling pathway
 
 
     06217 HH signaling
       N00062  Hedgehog signaling pathway
       N00010  Mutation-inactivated PTCH1 to Hedgehog signaling pathway
       N00017  Mutation-activated SMO to Hedgehog signaling pathway
 
1
2
     06218 TGFB signaling
       N00063  TGF-beta signaling pathway
       N00241  TGFBR2-reduced expression to TGF-beta signaling pathway
       N00064  Mutation-inactivated TGFBR2 to TGF-beta signaling pathway
       N00256  TGFBR1-reduced expression to TGF-beta signaling pathway
       N00106  AML1-EVI1 fusion to TGF-beta signaling pathway
       N00107  EVI-1 overexpression to TGF-beta signaling pathway
       N00065  Mutation-inactivated SMAD2 to TGF-beta signaling pathway
 
1
1
1
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     06219 JAK-STAT signaling
       N00053  Cytokine-Jak-STAT signaling pathway
       N00181  KSHV vIL-6 to Jak-STAT signaling pathway
       N00105  EML4-ALK fusion kinase to Jak-STAT signaling pathway
       N00055  BCR-ABL fusion kinase to Jak-STAT signaling pathway
       N00219  FLT3LG-FLT3-STAT5 signaling pathway
       N00054  Duplication-activated FLT3 to Jak-STAT signaling pathway
       N00094  EGF-Jak-STAT signaling pathway
       N00095  ERBB2-overexpression to EGF-Jak-STAT signaling pathway
 
 
1
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     06220 Calcium signaling
       N00026  EGF-EGFR-PLCG-CAMK signaling pathway
       N00027  Amplified EGFR to PLCG-CAMK signaling pathway
       N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
       N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
       N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
       N00180  KSHV K1 to PLCG-calcineurin signaling pathway
       N00172  KSHV K15 to PLCG-calcineurin signaling pathway
       N00227  TGFA-EGFR-PLCG-PKC signaling pathway
       N00228  TGFA-overexpression to PLCG-PKC signaling pathway
 
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     06221 TLR signaling
       N00148  TLR3-IRF7 signaling pathway
       N00162  KSHV vIRF3 to TLR3-IRF7 signaling pathway
       N00163  KSHV KIE1/2 to TLR3-IRF7 signaling pathway
       N00149  TLR3-IRF3 signaling pathway
       N00161  KSHV vIRF1/2 to TLR3-IRF3 signaling pathway
 
3
3
 
3
     06222 IFN signaling
       N00150  Type I IFN signaling pathway
       N00261  KSHV vIRF2 to IFN signaling pathway
 
2
     06223 TNF-NFKB signaling
       N00151  TNF-NFKB signaling pathway  TNF-NFKB signaling pathway
       N00174  KSHV vFLIP to TNF-NFKB signaling pathway
       N00173  KSHV K15 to NFKB signaling pathway
       N00171  KSHV vFLIP to NFKB signaling pathway
 
1
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2
     06224 CXCR signaling
       N00152  CXCR-GNB/G-ERK signaling pathway
       N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
       N00153  CXCR-GNB/G-PI3K-JNK signaling pathway
       N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
       N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
       N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
 
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1
     06225 HIF-1 signaling
       N00079  HIF-1 signaling pathway
       N00080  Loss of VHL to HIF-1 signaling pathway
       N00081  Mutation-inactivated VHL to HIF-1 signaling pathway
1
 
 
     06226 KEAP1-NRF2 signaling
       N00243  KEAP1-NRF2 signaling pathway
       N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
       N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
 
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1
     06227 NR signaling
       N00083  Androgen receptor signaling pathway
       N00084  Amplified AR to androgen receptor signaling pathway
       N00085  Mutation-activated AR to androgen receptor signaling pathway
       N00286  Nuclear-initiated estrogen signaling pathway
       N00287  ESR1-positive to nuclear-initiated estrogen signaling pathway
 
 
 
 
 
     06229 MHC presentation
       N00363  Antigen processing and presentation by MHC class I molecules
       N00184  KSHV MIR1/2 to MHC1-endocytosis
       N00185  KSHV MIR2 to cell surface molecule-endocytosis
 
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2
     06228 Autophagy
       N00155  Autophagy-vesicle nucleation
       N00177  KSHV vBCL2 to autophagy-vesicle nucleation
       N00156  Autophagy-vesicle elongation
       N00176  KSHV vFLIP to autophagy-vesicle elongation
 
 
1
 
     06230 Cell cycle G1/S
       N00066  p21-Cell cycle G1/S
       N00067  Deleted p14(ARF) to p21-cell cycle G1/S
       N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
       N00068  Amplified MDM2 to p21-cell cycle G1/S
       N00167  KSHV vIRF1/3 to p21-cell cycle G1/S
       N00169  KSHV LANA to p21-cell cycle G1/S
       N00069  p16-Cell cycle G1/S
       N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
       N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
       N00168  KSHV vCyclin to cell cycle G1/S
       N00072  Amplified CDK4 to cell cycle G1/S
       N00073  Mutation-activated CDK4 to cell cycle G1/S
       N00275  Amplified CCND1 to cell cycle G1/S
       N00170  KSHV LANA to cell cycle G1/S
       N00074  Loss of RB1 to cell cycle G1/S
       N00075  Mutation-inactivated RB1 to cell cycle G1/S
       N00090  p15-Cell cycle G1/S
       N00088  Amplified MYC to p15-cell cycle G1/S
       N00089  Amplified MYC to cell cycle G1/S
       N00091  p27-Cell cycle G1/S
       N00092  Amplified MYC to p27-cell cycle G1/S
       N00093  Loss of CDKN1B to p27-cell cycle G1/S
       N00254  CDKN1B-reduced expression to p27-cell cycle G1/S
       N00255  Amplified CCNE to cell cycle G1/S
 
 
 
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     06231 Apoptosis
       N00145  Extrinsic apoptotic pathway
       N00146  Crosstalk between extrinsic and intrinsic apoptotic pathways
       N00166  KSHV vFLIP to crosstalk between extrinsic and intrinsic apoptotic pathways
       N00164  KSHV vBCL2 to crosstalk between extrinsic and intrinsic apoptotic pathways
       N00165  KSHV vIAP to crosstalk between extrinsic and intrinsic apoptotic pathways
       N00098  Intrinsic apoptotic pathway
       N00100  BCL2-overexpression to intrinsic apoptotic pathway
       N00099  Mutation-inactivated BAX to apoptotic pathway
       N00101  DCC-apoptotic pathway
       N00102  Loss of DCC to DCC-apoptotic pathway
 
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     06232 Telomerase activity
       N00239  Telomerase activity
       N00240  TERT-overexpression to telomerase activity
 
 
   06202 Transcription
     06240 All cancer types
       N00115  Mutation-inactivated TP53 to transcription
 
     06241 Leukemia and lymphoma
       N00116  Mutation-inactivated RUNX1 to transcription
       N00111  AML1-ETO fusion to CEBPA-mediated transcription
       N00112  AML1-ETO fusion to PU.1-mediated transcription
       N00108  AML1-ETO fusion to transcriptional activtion
       N00109  PML-RARA fusion to transcriptional activtion
       N00113  PML-RARA fusion to transcriptional repression
       N00110  PLZF-RARA fusion to transcriptional activtion
       N00114  PLZF-RARA fusion to transcriptional repression
       N00117  E2A-PBX1 fusion to transcriptional activation
       N00118  TEL-AML1 fusion to transcriptional repression
       N00119  MLL-AF4 fusion to transcriptional activation
       N00120  MLL-ENL fusion to transcriptional activation
       N00144  TLX1 rearrangement to transcriptional repression
       N00121  LMO2-rearrangement to transcriptional activation
       N00122  LMO2-rearrangement to transcriptional repression
       N00123  Amplified REL to transcription
       N00124  IGH-MAF fusion to transcriptional activation
       N00125  IGH-MMSET fusion to transcriptional activation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
     06242 Carcinoma
       N00250  CDX2-overexpression to transcriptional activation
       N00251  CDX2-overexpression to transcriptional repression
       N00126  PAX8-PPARG fusion to PPARG-mediated transcription
       N00127  PRCC-TFE3 fusion to transcriptional activation
       N00128  TMPRSS2-ERG fusion to transcriptional activation
       N00129  TMPRSS2-ERG fusion to transcriptional repression
       N00130  TMPRSS2-ETV5 fusion to transcriptional activation
 
 
 
 
 
 
 
     06243 Sarcoma
       N00133  EWSR1-FLI1 fusion to transcriptional activation
       N00134  EWSR1-FLI1 fusion to transcriptional repression
       N00135  EWSR1-ERG fusion to transcriptional activation
       N00136  EWSR1-ATF1 fusion to transcriptional activation
       N00137  EWSR1-WT1 fusion to transcriptional activation
       N00138  EWSR1-NR4A3
       N00139  FUS-DDIT3 fusion to CEBPB-mediated transcription
       N00140  FUS-DDIT3 fusion to NFKB-mediated transcription
       N00141  PAX3-FOXO1 fusion to transcriptional activation
       N00142  SYT-SSX fusion to transcriptional repression
       N00143  ASPL-TFE3 fusion to transcriptional activation
 
 
 
 
 
 
 
 
 
 
 
     06244 Other
       N00131  Amplified MYCN to transcriptional activation
       N00132  Amplified MYCN to transcriptional repression
 
 
 
 06300 Endocrine network
 
 06100 Virus network

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Last updated: November 20, 2018