KEGG Orthology (KO)

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 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
 09160 Human Diseases
 
   09161 Cancer: overview
 
   09162 Cancer: specific types
 
   09163 Immune disease
 
   09164 Neurodegenerative disease
 
   09165 Substance dependence
 
   09166 Cardiovascular disease
 
   09167 Endocrine and metabolic disease
 
   09171 Infectious disease: bacterial
     05110 Vibrio cholerae infection [PATH:ko05110]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
       K13285  sipB, ipaB, bipB; invasin B
       K06256  CD44; CD44 antigen
       K13286  sipC, ipaC, bipC; invasin C
       K13287  sipD, ipaD, bipD; invasin D
       K06484  ITGA5, CD49e; integrin alpha 5
       K05719  ITGB1, CD29; integrin beta 1
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K04438  CRK, CRKII; C-crk adapter molecule crk
       K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
       K06106  CTTN, EMS1; cortactin
       K05760  PXN; paxillin
       K12366  ELMO1, CED12; engulfment and cell motility protein 1
       K18985  ELMO2, CED12A; engulfment and cell motility protein 2
       K13708  DOCK1; dedicator of cytokinesis protein 1
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K05753  WASF1; WAS protein family, member 1
       K05748  WASF2; WAS protein family, member 2
       K17260  ACTR2, ARP2; actin-related protein 2
       K18584  ACTR3, ARP3; actin-related protein 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K05692  ACTB_G1; actin beta/gamma 1
       K04513  RHOA; Ras homolog gene family, member A
       K05740  DIAPH1; diaphanous 1
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K10351  MYL2; myosin regulatory light chain 2
       K12753  MYL5; myosin regulatory light chain 5
       K12754  MYL7; myosin regulatory light chain 7
       K12755  MYL9; myosin regulatory light chain 9
       K12756  MYL10; myosin regulatory light chain 10
       K12757  MYL12; myosin regulatory light chain 12
       K12758  MYLPF; fast skeletal myosin light chain 2
       K05699  ACTN1_4; actinin alpha 1/4
       K06272  ILK; integrin-linked kinase [EC:2.7.11.1]
       K06271  TLN; talin
       K05700  VCL; vinculin
       K04393  CDC42; cell division control protein 42
       K13284  sipA, ipaA; invasin A
       K13793  ospE, espO; secreted effector OspE
       K13790  icsB, bopA; virulence protein IcsB
       K13743  ipgB2; protein IpgB2
       K13742  ipgB1; protein IpgB1
       K12679  icsA, virG; outer membrane protein IcsA
       K23612  WASL; neural Wiskott-Aldrich syndrome protein
       K05759  PFN; profilin
       K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K18441  CYTH; cytohesin
       K07941  ARF6; ADP-ribosylation factor 6
       K07937  ARF1_2; ADP-ribosylation factor 1/2
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07201  FOXO1; forkhead box protein O1
       K09408  FOXO3; forkhead box protein O3
       K12358  FOXO4; forkhead box protein O4
       K17847  FOXO6; forkhead box protein O6
       K08822  GSK3A; glycogen synthase kinase 3 alpha [EC:2.7.11.26]
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K05857  PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K05861  PLCZ; phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K04281  CAST; calpastatin
       K01367  CAPN1; calpain-1 [EC:3.4.22.52]
       K03853  CAPN2; calpain-2 [EC:3.4.22.53]
       K08583  CAPNS1, CAPN4; calpain, small subunit 1
       K04728  ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
       K04451  TP53, P53; tumor protein p53
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K02161  BCL2; apoptosis regulator Bcl-2
       K12785  espG, virA; LEE-encoded effector EspG
       K07345  fimA; major type 1 subunit fimbrin (pilin)
       K00844  HK; hexokinase [EC:2.7.1.1]
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K02159  BAX; apoptosis regulator BAX
       K08738  CYC; cytochrome c
       K15464  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
       K05864  PPID, CYPD; peptidyl-prolyl isomerase D [EC:5.2.1.8]
       K04394  CASP4, CASP11; caspase 4 [EC:3.4.22.57 3.4.22.64]
       K04519  IL1B; interleukin 1 beta
       K05482  IL18, IL1F4; interleukin 18
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K09849  TRAF5; TNF receptor-associated factor 5
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K10030  IL8, CXCL8; interleukin 8
       K23826  TIFA; TRAF-interacting protein with FHA domain-containing protein A
       K04386  IL1R1, CD121a; interleukin 1 receptor type I
       K04391  CD14; monocyte differentiation antigen CD14
       K10160  TLR4, CD284; toll-like receptor 4
       K02406  fliC, hag; flagellin
       K10168  TLR5; toll-like receptor 5
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K06068  PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
       K18050  PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
       K18052  PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]
       K07369  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
       K07368  BCL10; B-cell CLL/lymphoma 10
       K08727  NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
       K12791  ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K23827  ospI; glutamine deamidase
       K10704  UBE2V; ubiquitin-conjugating enzyme E2 variant
       K10580  UBE2N, BLU, UBC13; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
       K23828  ipaH1.4_2.5; E3 ubiquitin-protein ligase IpaH1.4/2.5 [EC:2.3.2.27]
       K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]
       K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]
       K20894  SHARPIN; shank-associated RH domain-interacting protein
       K23654  nleE, ospZ; T3SS secreted effector NleE
       K23829  TNIP1, ABIN1; TNFAIP3-interacting protein 1
       K13791  ipaH9.8; invasion plasmid antigen
       K13792  ospG; secreted effector OspG
       K06689  UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
       K03868  RBX1, ROC1; RING-box protein 1 [EC:2.3.2.32]
       K03347  CUL1, CDC53; cullin 1
       K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
       K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
       K23830  ipaH4.5; E3 ubiquitin-protein ligase IpaH4.5 [EC:2.3.2.27]
       K23831  ipaH0722; E3 ubiquitin-protein ligase IpaH0722 [EC:2.3.2.27]
       K17834  MB21D1; cyclic GMP-AMP synthase [EC:2.7.7.86]
       K12654  TMEM173, MITA; transmembrane protein 173
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K05411  IRF3; interferon regulatory factor 3
       K05415  IFNB; interferon beta
       K23832  ipaJ; cysteine protease IpaJ [EC:3.4.22.-]
       K12836  U2AF1; splicing factor U2AF 35 kDa subunit
       K12499  CCL5; C-C motif chemokine 5
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04445  RPS6KA5, MSK1; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
       K11253  H3; histone H3
       K11586  CBX3, HP1G; chromobox protein 3
       K13450  ospF, mkaD, spvC; phosphothreonine lyase [EC:4.2.3.-]
       K08334  BECN, VPS30, ATG6; beclin
       K17889  ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
       K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K16185  RRAGA_B; Ras-related GTP-binding protein A/B
       K16186  RRAGC_D; Ras-related GTP-binding protein C/D
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K07204  RAPTOR; regulatory associated protein of mTOR
       K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
       K17890  ATG16L1; autophagy-related protein 16-1
       K08339  ATG5; autophagy-related protein 5
       K08336  ATG12; ubiquitin-like protein ATG12
       K08341  GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
       K03990  C3; complement component 3
       K14381  SQSTM1; sequestosome 1
       K21348  CALCOCO2, NDP52; calcium-binding and coiled-coil domain-containing protein 2
       K02927  RP-L40e, RPL40, UBA52; ubiquitin-large subunit ribosomal protein L40e
       K02977  RP-S27Ae, RPS27A, UBA80; ubiquitin-small subunit ribosomal protein S27Ae
       K04551  UBB; ubiquitin B
       K08770  UBC; ubiquitin C
       K16942  SEPT2; septin 2
       K16938  SEPT3_9_12; septin 3/9/12
       K16939  SEPT6_8_11; septin 6/8/11
       K16944  SEPT7, CDC3; septin 7
       K17908  WIPI1_2, ATG18; autophagy-related protein 18
       K17988  TECPR1; tectonin beta-propeller repeat-containing protein 1
       K20121  FNBP1; formin-binding protein 1
       K13520  icsP, sopA; outer membrane protease [EC:3.4.23.-]
       K23833  ospC; secreted effector OspC
       K11006  stxA; shiga toxin subunit A
       K11007  stxB; shiga toxin subunit B
       K11011  set1A; enterotoxin Set1A
       K11012  set1B; enterotoxin Set1B
       K23345  GLMN; glomulin
       K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
       K22487  prgJ; type III secretion system protein
       K12807  NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
       K03221  yscF, sctF, ssaG, prgI; type III secretion protein F
       K12805  NLRC4, CARD12; NLR family CARD domain-containing protein 4
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K23834  ipaH7.8; E3 ubiquitin-protein ligase IpaH7.8 [EC:2.3.2.27]
     05135 Yersinia infection [PATH:ko05135]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
 
   09172 Infectious disease: viral
 
   09174 Infectious disease: parasitic
 
   09175 Drug resistance: antimicrobial
 
   09176 Drug resistance: antineoplastic
 
 09180 Brite Hierarchies
 
   09181 Protein families: metabolism
 
   09182 Protein families: genetic information processing
 
   09183 Protein families: signaling and cellular processes
     02000 Transporters [BR:ko02000]
     02044 Secretion system [BR:ko02044]
     02042 Bacterial toxins [BR:ko02042]
       K00776  tox; NAD-diphthamide ADP-ribosyltransferase [EC:2.4.2.36]
       K10928  ctxA; cholera enterotoxin subunit A [EC:2.4.2.36]
       K10929  ctxB; cholera enterotoxin subunit B
       K11020  toxA; exotoxin A [EC:2.4.2.-]
       K16635  exoS; exoenzyme S
       K16636  exoT; exoenzyme T
       K11023  ptxA, artA, pltA; pertussis toxin subunit 1 [EC:2.4.2.-]
       K11024  ptxB; pertussis toxin subunit 2
       K11025  ptxC; pertussis toxin subunit 3
       K11026  ptxD; pertussis toxin subunit 4
       K11027  ptxE; pertussis toxin subunit 5
       K19298  subB, artB, pltB; subtilase cytotoxin, subunit B
       K11044  spyA; C3 family ADP-ribosyltransferase [EC:2.4.2.-]
       K06011  boNT; botulinum neurotoxin [EC:3.4.24.69]
       K16623  ntnH; botulinum neurotoxin type non-toxic component
       K16624  ha-33; main hemagglutinin component
       K16625  ha-17; hemagglutinin component HA-17
       K16626  ha-70; hemagglutinin components HA-22/23/53
       K08644  tetX; tentoxilysin [EC:3.4.24.68]
       K08645  lef; anthrax lethal toxin endopeptidase [EC:3.4.24.83]
       K11030  pagA; protective antigen
       K11029  cyaA; anthrax edema toxin adenylate cyclase [EC:4.6.1.1]
       K22944  cyaA; bifunctional hemolysin/adenylate cyclase [EC:4.6.1.1]
       K16637  K16637, exoY; adenylate cyclase ExoY
       K10954  zot; zona occludens toxin
       K11006  stxA; shiga toxin subunit A
       K11007  stxB; shiga toxin subunit B
       K19297  subA; subtilase cytotoxin, subunit A
       K11008  cnf1; cytotoxic necrotizing factor 1
       K11011  set1A; enterotoxin Set1A
       K11012  set1B; enterotoxin Set1B
       K11028  vacA; vacuolating cytotoxin
       K11013  cdtA; cytolethal distending toxin subunit A
       K11014  cdtB; cytolethal distending toxin subunit B
       K11015  cdtC; cytolethal distending toxin subunit C
       K11041  eta; exfoliative toxin A/B
       K11063  tcdAB; toxin A/B
       K19615  fitD, mcf; insecticidal toxin
       K11021  tccC; insecticidal toxin complex protein TccC
       K16883  sta; heat-stable enterotoxin STa/STI
       K16884  stb; heat-stable enterotoxin STb/STII
       K10948  hlyA; hemolysin
       K11031  slo; thiol-activated cytolysin
       K11032  hlyII; hemolysin II
       K11038  hlg, luk; leukocidin/hemolysin toxin family protein
       K11058  cpe; enterotoxin Cpe
       K10953  rtxA; RTX toxin RtxA
       K11005  hlyA; hemolysin A
       K11022  rtxA1, rtxA; structural toxin protein (hemagglutinin/hemolysin) RtxA
       K03699  tlyC; putative hemolysin
       K10952  ace; accessory cholera enterotoxin
       K11016  shlA, hhdA, hpmA; hemolysin
       K11017  shlB, hhdB, hpmB; hemolysin activation/secretion protein
       K11019  tdh; thermostable direct hemolysin
       K11033  nheA; non-hemolytic enterotoxin A
       K11034  nheBC; non-hemolytic enterotoxin B/C
       K11035  hblAB; hemolysin BL binding component
       K11036  hblC; hemolysin BL lytic component L2
       K11037  hblD; hemolysin BL lytic component L1
       K11039  hld; delta-hemolysin
       K11045  cfa; cAMP factor
       K11046  sagA; streptolysin S associated protein
       K11052  cylE; CylE protein
       K11068  hlyIII; hemolysin III
       K11139  hlyE, clyA, sheA; hemolysin E
       K01114  plc; phospholipase C [EC:3.1.4.3]
       K16619  plc, cpa; phospholipase C / alpha-toxin [EC:3.1.4.3]
       K11018  tlh; thermolabile hemolysin
       K16638  exoU; exoenzyme U
       K11010  ympA; superantigen YpmA
       K11040  se; staphylococcal enterotoxin
       K11043  tst; toxic shock syndrome toxin-1
       K23550  nanH; sialidase [EC:3.2.1.18]
       K01197  hya; hyaluronoglucosaminidase [EC:3.2.1.35]
       K01387  colA; microbial collagenase [EC:3.4.24.3]
       K08587  cloSI; clostripain [EC:3.4.22.8]
       K11009  ymt; murine toxin
       K10814  hcnA; hydrogen cyanide synthase HcnA [EC:1.4.99.5]
       K10815  hcnB; hydrogen cyanide synthase HcnB [EC:1.4.99.5]
       K10816  hcnC; hydrogen cyanide synthase HcnC [EC:1.4.99.5]
       K11057  cpb2; beta2-toxin
       K11059  entA; probable enterotoxin A
       K11060  entB; probable enterotoxin B
       K11061  entC; probable enterotoxin C
       K11062  entD; probable enterotoxin D
       K15126  bteA; type III secretion system cytotoxic effector protein
       K11042  ssl1; superantigen-like protein 1
       K23587  ssl5_11; superantigen-like protein 5/11
       K23586  ssl7, set1; superantigen-like protein 7
     02022 Two-component system [BR:ko02022]
     02035 Bacterial motility proteins [BR:ko02035]
     04812 Cytoskeleton proteins [BR:ko04812]
     04147 Exosome [BR:ko04147]
     02048 Prokaryotic defense system [BR:ko02048]
     04030 G protein-coupled receptors [BR:ko04030]
     04050 Cytokine receptors [BR:ko04050]
     04054 Pattern recognition receptors [BR:ko04054]
     03310 Nuclear receptors [BR:ko03310]
     04040 Ion channels [BR:ko04040]
     04031 GTP-binding proteins [BR:ko04031]
     04052 Cytokines and growth factors [BR:ko04052]
     04515 Cell adhesion molecules [BR:ko04515]
     04090 CD molecules [BR:ko04090]
     00535 Proteoglycans [BR:ko00535]
     00536 Glycosaminoglycan binding proteins [BR:ko00536]
     00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
     04091 Lectins [BR:ko04091]
     01504 Antimicrobial resistance genes [BR:ko01504]
     03200 Viral proteins [BR:ko03200]
     04990 Domain-containing proteins not elsewhere classified [BR:ko04990]
 
   09184 RNA family
 
 09190 Not Included in Pathway or Brite

[ KO | BRITE | KEGG2 | KEGG ]
Last updated: November 26, 2020