KEGG Orthology (KO)

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 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
 09160 Human Diseases
 
   09161 Cancer: overview
 
   09162 Cancer: specific types
 
   09163 Immune disease
 
   09164 Neurodegenerative disease
 
   09165 Substance dependence
 
   09166 Cardiovascular disease
 
   09167 Endocrine and metabolic disease
 
   09171 Infectious disease: bacterial
     05110 Vibrio cholerae infection [PATH:ko05110]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
       K11006  stxA; shiga toxin subunit A
       K11007  stxB; shiga toxin subunit B
       K06856  IGH; immunoglobulin heavy chain
       K23648  espJ; T3SS secreted effector ADP-ribosyltransferase EspJ
       K08893  HCK; hemopoietic cell kinase [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
       K18441  CYTH; cytohesin
       K07941  ARF6; ADP-ribosylation factor 6
       K07937  ARF1; ADP-ribosylation factor 1
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K05750  NCKAP1, NAP125; NCK-associated protein 1
       K05749  CYFIP; cytoplasmic FMR1 interacting protein
       K23649  ABI1; abl interactor 1
       K05752  C3ORF10, HSPC300; chromosome 3 open reading frame 10
       K05753  WASF1; WAS protein family, member 1
       K05748  WASF2; WAS protein family, member 2
       K06083  WASF3; WAS protein family, member 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K05692  ACTB_G1; actin beta/gamma 1
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K04513  RHOA; Ras homolog gene family, member A
       K04393  CDC42; cell division control protein 42
       K12785  espG, virA; LEE-encoded effector EspG
       K12788  espH; LEE-encoded effector EspH
       K10356  MYO1; myosin I
       K10357  MYO5; myosin V
       K10358  MYO6; myosin VI
       K12559  MYO10; myosin X
       K10352  MYH; myosin heavy chain
       K23650  espB; LEE-encoded effector EspB
       K23651  espT; T3SS secreted effector EspT
       K23652  espW; T3SS secreted effector EspW
       K12787  map; LEE-encoded effector Map
       K23612  WASL; neural Wiskott-Aldrich syndrome protein
       K13365  SLC9A3R1, NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1
       K08007  VIL2; villin 2 (ezrin)
       K01313  F2; coagulation factor II (thrombin) [EC:3.4.21.5]
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K12331  ARHGEF11; Rho guanine nucleotide exchange factor 11
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K20690  ARHGEF25; Rho guanine nucleotide exchange factor 25
       K12809  espG2; T3SS secreted effector EspG-like protein
       K07374  TUBA; tubulin alpha
       K07375  TUBB; tubulin beta
       K12791  ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2
       K23653  espM; T3SS effector EspM
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K12790  eae; intimin
       K12784  tir; translocated intimin receptor
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K20127  BAIAP2L1, IRTKS; BAI1-associated protein 2-like protein 1
       K05627  BAIAP2, IRSP53; BAI1-associated protein 2
       K12789  tccP; Tir-cytoskeleton coupling protein
       K07365  NCK1; NCK adaptor protein 1
       K19862  NCK2, GRB4; NCK adaptor protein 2
       K19475  WIPF; WAS/WASL-interacting protein
       K06106  CTTN, EMS1; cortactin
       K11294  NCL, NSR1; nucleolin
       K05719  ITGB1, CD29; integrin beta 1
       K12810  bfpA; major structural subunit of bundle-forming pilus
       K04519  IL1B; interleukin 1 beta
       K04386  IL1R1, CD121a; interleukin 1 receptor type I
       K10160  TLR4, CD284; toll-like receptor 4
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K10168  TLR5; toll-like receptor 5
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K00134  GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K02985  RP-S3e, RPS3; small subunit ribosomal protein S3e
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K05405  IL6; interleukin 6
       K10030  IL8, CXCL8; interleukin 8
       K23654  nleE, ospZ; T3SS secreted effector NleE
       K16042  nleH; non-LEE-encoded effector NleH
       K23655  nleC; T3SS secreted effector NleC
       K23656  nleD; T3SS secreted effector NleD
       K23657  nleB; T3SS secreted effector NleB
       K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
       K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K21889  TMBIM6, BI1, TEGT; Bax inhibitor 1
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K02159  BAX; apoptosis regulator BAX
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04397  CASP7; caspase 7 [EC:3.4.22.60]
       K06185  ABCF2; ATP-binding cassette, subfamily F, member 2
       K23658  nleF; T3SS secreted effector NleF
       K23659  espZ; LEE-encoded effector EspZ
       K23660  cif; cell inhibiting factor
       K12786  espF; LEE-encoded effector EspF
       K03221  yscF, sctF, ssaG, prgI; type III secretion protein F
       K22487  prgJ; type III secretion system protein
       K23661  escI; type III secretion system protein
       K12807  NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
       K22265  NLRP4; NACHT, LRR and PYD domains-containing protein 4
       K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K04394  CASP4, CASP11; caspase 4 [EC:3.4.22.57 3.4.22.64]
       K05482  IL18, IL1F4; interleukin 18
       K16041  nleA; non-LEE-encoded effector NleA
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
       K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
       K07874  RAB1A; Ras-related protein Rab-1A
       K14007  SEC24; protein transport protein SEC24
       K20352  TMED10, ERV25; p24 family protein delta-1
       K06088  OCLN; occludin
       K06087  CLDN; claudin
       K05701  TJP1, ZO1; tight junction protein 1
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05135 Yersinia infection [PATH:ko05135]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
 
   09172 Infectious disease: viral
 
   09174 Infectious disease: parasitic
 
   09175 Drug resistance: antimicrobial
 
   09176 Drug resistance: antineoplastic
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

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Last updated: April 5, 2020