KEGG Orthology (KO)

[ Brite menu | Organism menu | Download htext | Download json ]
    

1st Level  2nd Level  3rd Level  4th Level 

 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
   09151 Immune system
     04640 Hematopoietic cell lineage [PATH:ko04640]
     04610 Complement and coagulation cascades [PATH:ko04610]
     04611 Platelet activation [PATH:ko04611]
     04620 Toll-like receptor signaling pathway [PATH:ko04620]
     04624 Toll and Imd signaling pathway [PATH:ko04624]
     04621 NOD-like receptor signaling pathway [PATH:ko04621]
       K08727  NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04519  IL1B; interleukin 1 beta
       K05482  IL18, IL1F4; interleukin 18
       K05405  IL6; interleukin 6
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K10030  IL8, CXCL8; interleukin 8
       K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K12499  CCL5; C-C motif chemokine 5
       K13916  CAMP, LL37; cathelicidin antimicrobial peptide
       K05230  DEFA; defensin, alpha
       K21100  DEFB4; beta-defensin 4
       K23126  DEFB103; beta-defensin 103
       K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K17890  ATG16L1; autophagy-related protein 16-1
       K08339  ATG5; autophagy-related protein 5
       K08336  ATG12; ubiquitin-like protein ATG12
       K08341  GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
       K12795  SUGT1, SGT1; suppressor of G2 allele of SKP1
       K20894  SHARPIN; shank-associated RH domain-interacting protein
       K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]
       K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
       K12797  CARD6; caspase recruitment domain-containing protein 6
       K12792  TRIP6; thyroid receptor-interacting protein 6
       K12796  ERBIN, ERBB2IP; erbb2-interacting protein
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K09849  TRAF5; TNF receptor-associated factor 5
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K12794  CARD9; caspase recruitment domain-containing protein 9
       K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]
       K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
       K03174  TRAF3; TNF receptor-associated factor 3
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K12650  TANK; TRAF family member-associated NF-kappa-B activator
       K05411  IRF3; interferon regulatory factor 3
       K09447  IRF7; interferon regulatory factor 7
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K12653  NLRX1; NLR family member X1
       K08645  lef; anthrax lethal toxin endopeptidase [EC:3.4.24.83]
       K11030  pagA; protective antigen
       K20909  ANTXR; anthrax toxin receptor
       K12798  NLRP1, CARD7; NACHT, LRR and PYD domains-containing protein 1
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K02161  BCL2; apoptosis regulator Bcl-2
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K01363  CTSB; cathepsin B [EC:3.4.22.1]
       K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
       K03443  PANX1; pannexin 1
       K05220  P2RX7; P2X purinoceptor 7
       K04977  TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]
       K04982  TRPM7, CHAK1; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1]
       K04971  TRPV2; transient receptor potential cation channel subfamily V member 2
       K04612  CASR; calcium-sensing receptor
       K04622  GPRC6A; G protein-coupled receptor family C group 6 member A
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K15040  VDAC2; voltage-dependent anion channel protein 2
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K20858  MCU; calcium uniporter protein, mitochondrial
       K14216  OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]
       K01165  RNASEL; ribonuclease L
       K17820  DHX33; ATP-dependent RNA helicase DHX33 [EC:3.6.4.13]
       K21356  MFN1; mitofusin 1 [EC:3.6.5.-]
       K06030  MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
       K17065  DNM1L; dynamin 1-like protein [EC:3.6.5.5]
       K03462  NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
       K21421  NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
       K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
       K20910  TXNIP; thioredoxin-interacting protein
       K03671  trxA; thioredoxin 1
       K20876  NEK7; NIMA (never in mitosis gene a)-related kinase 7 [EC:2.7.11.1]
       K11864  BRCC3, BRCC36; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
       K04079  HSP90A, htpG; molecular chaperone HtpG
       K12801  CARD8, CARDINAL; caspase recruitment domain-containing protein 8
       K12802  PYDC1; pyrin domain-containing protein 1
       K20911  PYDC2, POP2; pyrin domain-containing protein 2
       K12803  MEFV; pyrin
       K12804  PSTPIP1; proline-serine-threonine phosphatase interacting protein 1
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02373  FADD; FAS-associated death domain protein
       K04741  CASP12; caspase 12 [EC:3.4.22.-]
       K12806  CARD16_17_18; caspase recruitment domain-containing protein 16/17/18
       K20863  NLRP6, NALP6; NACHT, LRR and PYD domains-containing protein 6
       K20864  NLRP7, NALP7; NACHT, LRR and PYD domains-containing protein 7
       K08598  yopJ; YopJ protease family
       K20865  NLRP12; NACHT, LRR and PYD domains-containing protein 12
       K02406  fliC; flagellin
       K12807  NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
       K12805  NLRC4, CARD12; NLR family CARD domain-containing protein 4
       K06068  PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
       K20897  GBP2; guanylate-binding protein 2
       K20898  GBP5; guanylate-binding protein 5
       K12966  AIM2; absent in melanoma 2
       K20914  IFI16; gamma-interferon-inducible protein 16
       K20915  TP53BP1, P202; tumor suppressor p53-binding protein 1
       K20916  POP3; pyrin domain-only protein 3
       K04513  RHOA; Ras homolog gene family, member A
       K06071  PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]
       K23691  PKN2; serine/threonine-protein kinase N2 [EC:2.7.11.13]
       K06630  YWHAE; 14-3-3 protein epsilon
       K20899  GBP1_3_4_7; guanylate-binding protein 1/3/4/7
       K04395  CASP5; caspase 5 [EC:3.4.22.58]
       K04394  CASP4, CASP11; caspase 4 [EC:3.4.22.57 3.4.22.64]
       K20917  GSDMD; gasdermin-D
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K10160  TLR4, CD284; toll-like receptor 4
       K05842  TRIF; toll-like receptor adapter molecule 1
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K12654  TMEM173, MITA; transmembrane protein 173
     04622 RIG-I-like receptor signaling pathway [PATH:ko04622]
     04623 Cytosolic DNA-sensing pathway [PATH:ko04623]
     04625 C-type lectin receptor signaling pathway [PATH:ko04625]
       K10074  CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A
       K14957  LSP1; lymphocyte-specific protein 1
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07831  MRAS; Ras-related protein M-Ras
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04735  RELA; transcription factor p65
       K09253  RELB; transcription factor RelB
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K04519  IL1B; interleukin 1 beta
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02183  CALM; calmodulin
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K05429  IL2; interleukin 2
       K05443  IL10, CSIF; interleukin 10
       K12496  EGR2; early growth response protein 2
       K12497  EGR3; early growth response protein 3
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K06068  PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K12794  CARD9; caspase recruitment domain-containing protein 9
       K07368  BCL10; B-cell CLL/lymphoma 10
       K07369  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K05405  IL6; interleukin 6
       K05426  IL23A; interleukin 23 subunit alpha
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K22517  CBLB; E3 ubiquitin-protein ligase CBL-B [EC:2.3.2.27]
       K17514  CLEC6A, DECTIN2; C-type lectin domain family 6 member A
       K07983  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma
       K06563  CLEC4M, DC-SIGN2, CD209, CD299; C-type lectin domain family 4 member M
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K04513  RHOA; Ras homolog gene family, member A
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K14958  KSR1; kinase suppressor of Ras 1
       K08862  PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K11220  STAT1; signal transducer and activator of transcription 1
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K11221  STAT2; signal transducer and activator of transcription 2
       K05492  IL17D, IL27; interleukin 17D
       K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]
       K09258  BCL3; B-cell CLL/lymphoma protein 3
       K21083  CCL17; C-C motif chemokine 17
       K21095  CCL22; C-C motif chemokine 22
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K10059  CLEC4E, MINCLE; C-type lectin domain family 4 member E
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K09444  IRF1; interferon regulatory factor 1
       K10058  CLEC4D, MCL, CD368; C-type lectin domain family 4 member D
       K10070  CLEC1B; C-type lectin domain family 1 member B
     04650 Natural killer cell mediated cytotoxicity [PATH:ko04650]
     04612 Antigen processing and presentation [PATH:ko04612]
     04660 T cell receptor signaling pathway [PATH:ko04660]
     04658 Th1 and Th2 cell differentiation [PATH:ko04658]
     04659 Th17 cell differentiation [PATH:ko04659]
     04657 IL-17 signaling pathway [PATH:ko04657]
     04662 B cell receptor signaling pathway [PATH:ko04662]
     04664 Fc epsilon RI signaling pathway [PATH:ko04664]
     04666 Fc gamma R-mediated phagocytosis [PATH:ko04666]
     04670 Leukocyte transendothelial migration [PATH:ko04670]
     04672 Intestinal immune network for IgA production [PATH:ko04672]
     04062 Chemokine signaling pathway [PATH:ko04062]
 
   09152 Endocrine system
 
   09153 Circulatory system
 
   09154 Digestive system
 
   09155 Excretory system
 
   09156 Nervous system
 
   09157 Sensory system
 
   09158 Development and regeneration
 
   09149 Aging
 
   09159 Environmental adaptation
 
 09160 Human Diseases
 
   09161 Cancer: overview
 
   09162 Cancer: specific types
 
   09163 Immune disease
 
   09164 Neurodegenerative disease
 
   09165 Substance dependence
 
   09166 Cardiovascular disease
 
   09167 Endocrine and metabolic disease
 
   09171 Infectious disease: bacterial
     05110 Vibrio cholerae infection [PATH:ko05110]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05135 Yersinia infection [PATH:ko05135]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04400  CASP10; caspase 10 [EC:3.4.22.63]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04726  BID; BH3 interacting domain death agonist
       K02159  BAX; apoptosis regulator BAX
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02084  APAF1; apoptotic protease-activating factor
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K02158  BAD; Bcl-2-antagonist of cell death
       K02161  BCL2; apoptosis regulator Bcl-2
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K08060  CIITA; MHC class II transactivator [EC:2.7.11.1]
       K08061  RFX5; regulatory factor X 5
       K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
       K08063  RFXAP; regulatory factor X-associated protein
       K08064  NFYA; nuclear transcription factor Y, alpha
       K08065  NFYB; nuclear transcription Y subunit beta
       K08066  NFYC; nuclear transcription factor Y, gamma
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K06752  MHC2; MHC class II antigen
       K06505  CD74, DHLAG; CD74 antigen
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K05443  IL10, CSIF; interleukin 10
       K05134  IL10RA, CD210A; interleukin 10 receptor alpha
       K05135  IL10RB, CD210B; interleukin 10 receptor beta
       K01368  CTSS; cathepsin S [EC:3.4.22.27]
       K10059  CLEC4E, MINCLE; C-type lectin domain family 4 member E
       K07983  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma
       K10074  CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K12794  CARD9; caspase recruitment domain-containing protein 9
       K07369  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
       K07368  BCL10; B-cell CLL/lymphoma 10
       K14952  namH; UDP-MurNAc hydroxylase
       K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K14953  lpqH; ipoprotein LpqH
       K14954  lprG; lipoprotein LprG
       K14955  lprA; lipoprotein LprA
       K02040  pstS; phosphate transport system substrate-binding protein
       K04043  dnaK, HSPA9; molecular chaperone DnaK
       K04077  groEL, HSPD1; chaperonin GroEL
       K14956  esxA, esat6; 6 kDa early secretory antigenic target
       K05399  LBP; lipopolysaccharide-binding protein
       K10159  TLR2, CD282; toll-like receptor 2
       K05398  TLR1, CD281; toll-like receptor 1
       K10169  TLR6, CD286; toll-like receptor 6
       K10160  TLR4, CD284; toll-like receptor 4
       K04391  CD14; monocyte differentiation antigen CD14
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04731  IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K05405  IL6; interleukin 6
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K05482  IL18, IL1F4; interleukin 18
       K05426  IL23A; interleukin 23 subunit alpha
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K10048  CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
       K10049  CEBPG; CCAAT/enhancer binding protein (C/EBP), gamma
       K10161  TLR9, CD289; toll-like receptor 9
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K06563  CLEC4M, DC-SIGN2, CD209, CD299; C-type lectin domain family 4 member M
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K04513  RHOA; Ras homolog gene family, member A
       K14957  LSP1; lymphocyte-specific protein 1
       K08862  PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
       K14958  KSR1; kinase suppressor of Ras 1
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
       K08539  VDR, NR1I1; vitamin D3 receptor
       K13916  CAMP, LL37; cathelicidin antimicrobial peptide
       K03990  C3; complement component 3
       K04011  CR1, CD35; complement component (3b/4b) receptor 1
       K06462  ITGAX, CD11c; integrin alpha X
       K06464  ITGB2, CD18; integrin beta 2
       K06461  ITGAM, CD11b; integrin alpha M
       K06560  MRC, CD206, CD280; mannose receptor, C type
       K04718  SPHK; sphingosine kinase [EC:2.7.1.91]
       K02183  CALM; calmodulin
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K12478  EEA1; early endosome antigen 1
       K07897  RAB7A; Ras-related protein Rab-7A
       K01379  CTSD; cathepsin D [EC:3.4.23.5]
       K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
       K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
       K02144  ATPeV1H; V-type H+-transporting ATPase subunit H
       K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
       K02155  ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit
       K03661  ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit
       K06528  LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
       K21302  sapM; phosphatidylinositol-3-phosphatase [EC:3.1.3.64]
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K13882  CORO1A; coronin-1A
       K14949  pknG; serine/threonine-protein kinase PknG [EC:2.7.11.1]
       K06856  IGH; immunoglobulin heavy chain
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
 
   09172 Infectious disease: viral
     05166 Human T-cell leukemia virus 1 infection [PATH:ko05166]
     05170 Human immunodeficiency virus 1 infection [PATH:ko05170]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex virus 1 infection [PATH:ko05168]
       K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
       K05477  TNFSF14, LIGHT, CD258; tumor necrosis factor ligand superfamily member 14
       K05152  TNFRSF14, HVEM, CD270; tumor necrosis factor receptor superfamily member 14
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K09849  TRAF5; TNF receptor-associated factor 5
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K19264  gD; Simplexvirus envelope glycoprotein D
       K06081  PVRL1, CD111; poliovirus receptor-related protein 1
       K19255  gB; Herpesviridae envelope glycoprotein B
       K19256  gC; Simplexvirus envelope glycoprotein C
       K15411  PILRA; paired immunoglobulin-like type 2 receptor alpha
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K19434  gH, UL22; Simplexvirus envelope glycoprotein H
       K19435  gL, UL1; Simplexvirus envelope glycoprotein L
       K06484  ITGA5, CD49e; integrin alpha 5
       K06493  ITGB3, CD61; integrin beta 3
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K12794  CARD9; caspase recruitment domain-containing protein 9
       K05411  IRF3; interferon regulatory factor 3
       K05415  IFNB; interferon beta
       K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
       K04451  TP53, P53; tumor protein p53
       K03990  C3; complement component 3
       K03994  C5; complement component 5
       K15412  CFP; complement factor properdin
       K10159  TLR2, CD282; toll-like receptor 2
       K10161  TLR9, CD289; toll-like receptor 9
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K09447  IRF7; interferon regulatory factor 7
       K05401  TLR3, CD283; toll-like receptor 3
       K19439  US3; Simplexvirus serine/threonine-protein kinase US3 [EC:2.7.11.1]
       K05842  TRIF; toll-like receptor adapter molecule 1
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K04519  IL1B; interleukin 1 beta
       K12499  CCL5; C-C motif chemokine 5
       K05405  IL6; interleukin 6
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K19438  US11; HSV1 RNA-binding protein
       K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.4.13]
       K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
       K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
       K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase [EC:3.4.19.12 3.4.22.-]
       K03174  TRAF3; TNF receptor-associated factor 3
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K19437  RL1; HSV1 neurovirulence factor ICP34.5
       K05414  IFNA; interferon alpha
       K17834  MB21D1; cyclic GMP-AMP synthase [EC:2.7.7.86]
       K19447  UL41; Simplexvirus virion host shutoff protein [EC:3.1.27.-]
       K12654  TMEM173, MITA; transmembrane protein 173
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
       K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
       K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
       K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
       K03237  EIF2S1; translation initiation factor 2 subunit 1
       K03239  EIF2B1; translation initiation factor eIF-2B subunit alpha
       K03754  EIF2B2; translation initiation factor eIF-2B subunit beta
       K03241  EIF2B3; translation initiation factor eIF-2B subunit gamma
       K03680  EIF2B4; translation initiation factor eIF-2B subunit delta
       K03240  EIF2B5; translation initiation factor eIF-2B subunit epsilon
       K14216  OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]
       K01165  RNASEL; ribonuclease L
       K19444  UL48; Simplexvirus tegument protein VP16
       K14966  HCFC; host cell factor
       K09364  POU2F, OTF; POU domain transcription factor, class 2
       K19445  ICP4, RS1; Simplexvirus major viral transcription factor ICP4
       K19441  US1; Simplexvirus transcriptional regulator ICP22
       K19443  UL54; Simplexvirus mRNA export factor
       K19446  US12; HSV1 ICP47 protein
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K19440  UL13; Simplexvirus serine/threonine-protein kinase UL13 [EC:2.7.11.1]
       K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K09228  KRAB; KRAB domain-containing zinc finger protein
       K06731  BST2, CD317; bone marrow stromal cell antigen 2
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K02308  DAXX; death-associated protein 6
       K15413  SP100; nuclear autoantigen Sp-100
       K10054  PML, TRIM19; probable transcription factor PML
       K05653  ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2
       K05654  ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3
       K08058  TAPBP; TAP binding protein (tapasin)
       K08056  PDIA3, GRP58; protein disulfide-isomerase A3 [EC:5.3.4.1]
       K08057  CALR; calreticulin
       K06751  MHC1; MHC class I antigen
       K08055  B2M; beta-2-microglobulin
       K06752  MHC2; MHC class II antigen
       K06505  CD74, DHLAG; CD74 antigen
       K23212  UL46; HSV tegument protein VP11/12
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07206  TSC1; tuberous sclerosis 1
       K07207  TSC2; tuberous sclerosis 2
       K07208  RHEB; Ras homolog enriched in brain
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K15409  SRPK1; serine/threonine-protein kinase SRPK1 [EC:2.7.11.1]
       K12890  SFRS1, ASF, SF2; splicing factor, arginine/serine-rich 1
       K12891  SFRS2; splicing factor, arginine/serine-rich 2
       K12892  SFRS3; splicing factor, arginine/serine-rich 3
       K12893  SFRS4_5_6; splicing factor, arginine/serine-rich 4/5/6
       K12896  SFRS7; splicing factor, arginine/serine-rich 7
       K21123  SFRS9; splicing factor, arginine/serine-rich 9
       K14284  NXF, TAP, MEX67; nuclear RNA export factor
       K12881  THOC4, ALY; THO complex subunit 4
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02373  FADD; FAS-associated death domain protein
       K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit [EC:1.17.4.1]
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04726  BID; BH3 interacting domain death agonist
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K02158  BAD; Bcl-2-antagonist of cell death
       K02161  BCL2; apoptosis regulator Bcl-2
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K08738  CYC; cytochrome c
       K02084  APAF1; apoptotic protease-activating factor
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
     05163 Human cytomegalovirus infection [PATH:ko05163]
     05167 Kaposi sarcoma-associated herpesvirus infection [PATH:ko05167]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05165 Human papillomavirus infection [PATH:ko05165]
 
   09174 Infectious disease: parasitic
 
   09175 Drug resistance: antimicrobial
 
   09176 Drug resistance: antineoplastic
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

[ KO | BRITE | KEGG2 | KEGG ]
Last updated: April 2, 2020