KEGG Orthology (KO)

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 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
   09151 Immune system
     04640 Hematopoietic cell lineage [PATH:ko04640]
     04610 Complement and coagulation cascades [PATH:ko04610]
     04611 Platelet activation [PATH:ko04611]
     04620 Toll-like receptor signaling pathway [PATH:ko04620]
     04624 Toll and Imd signaling pathway [PATH:ko04624]
     04621 NOD-like receptor signaling pathway [PATH:ko04621]
       K08727  NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04519  IL1B; interleukin 1 beta
       K05482  IL18, IL1F4; interleukin 18
       K05405  IL6; interleukin 6
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K10030  IL8, CXCL8; interleukin 8
       K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K12499  CCL5; C-C motif chemokine 5
       K13916  CAMP, LL37; cathelicidin antimicrobial peptide
       K05230  DEFA; defensin, alpha
       K21100  DEFB4; beta-defensin 4
       K23126  DEFB103; beta-defensin 103
       K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K17890  ATG16L1; autophagy-related protein 16-1
       K08339  ATG5; autophagy-related protein 5
       K08336  ATG12; ubiquitin-like protein ATG12
       K08341  GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
       K12795  SUGT1, SGT1; suppressor of G2 allele of SKP1
       K20894  SHARPIN; shank-associated RH domain-interacting protein
       K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]
       K11974  RNF31, HOIP; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
       K12797  CARD6; caspase recruitment domain-containing protein 6
       K12792  TRIP6; thyroid receptor-interacting protein 6
       K12796  ERBIN, ERBB2IP; erbb2-interacting protein
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K09849  TRAF5; TNF receptor-associated factor 5
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K12794  CARD9; caspase recruitment domain-containing protein 9
       K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]
       K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
       K03174  TRAF3; TNF receptor-associated factor 3
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K12650  TANK; TRAF family member-associated NF-kappa-B activator
       K05411  IRF3; interferon regulatory factor 3
       K09447  IRF7; interferon regulatory factor 7
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K12653  NLRX1; NLR family member X1
       K08645  lef; anthrax lethal toxin endopeptidase [EC:3.4.24.83]
       K11030  pagA; protective antigen
       K20909  ANTXR; anthrax toxin receptor
       K12798  NLRP1, CARD7; NACHT, LRR and PYD domains-containing protein 1
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K02161  BCL2; apoptosis regulator Bcl-2
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K01363  CTSB; cathepsin B [EC:3.4.22.1]
       K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
       K03443  PANX1; pannexin 1
       K05220  P2RX7; P2X purinoceptor 7
       K04977  TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]
       K04982  TRPM7, CHAK1; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1]
       K04971  TRPV2; transient receptor potential cation channel subfamily V member 2
       K04612  CASR; calcium-sensing receptor
       K04622  GPRC6A; G protein-coupled receptor family C group 6 member A
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K15040  VDAC2; voltage-dependent anion channel protein 2
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K20858  MCU; calcium uniporter protein, mitochondrial
       K14216  OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]
       K01165  RNASEL; ribonuclease L
       K17820  DHX33; ATP-dependent RNA helicase DHX33 [EC:3.6.4.13]
       K21356  MFN1; mitofusin 1 [EC:3.6.5.-]
       K06030  MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
       K17065  DNM1L; dynamin 1-like protein [EC:3.6.5.5]
       K03462  NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
       K21421  NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
       K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
       K20910  TXNIP; thioredoxin-interacting protein
       K03671  trxA; thioredoxin 1
       K20876  NEK7; NIMA (never in mitosis gene a)-related kinase 7 [EC:2.7.11.1]
       K11864  BRCC3, BRCC36; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
       K04079  HSP90A, htpG; molecular chaperone HtpG
       K12801  CARD8, CARDINAL; caspase recruitment domain-containing protein 8
       K12802  PYDC1; pyrin domain-containing protein 1
       K20911  PYDC2, POP2; pyrin domain-containing protein 2
       K12803  MEFV; pyrin
       K12804  PSTPIP1; proline-serine-threonine phosphatase interacting protein 1
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02373  FADD; FAS-associated death domain protein
       K04741  CASP12; caspase 12 [EC:3.4.22.-]
       K12806  CARD16_17_18; caspase recruitment domain-containing protein 16/17/18
       K20863  NLRP6, NALP6; NACHT, LRR and PYD domains-containing protein 6
       K20864  NLRP7, NALP7; NACHT, LRR and PYD domains-containing protein 7
       K08598  yopJ; YopJ protease family
       K20865  NLRP12; NACHT, LRR and PYD domains-containing protein 12
       K02406  fliC, hag; flagellin
       K12807  NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
       K12805  NLRC4, CARD12; NLR family CARD domain-containing protein 4
       K06068  PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
       K20897  GBP2; guanylate-binding protein 2
       K20898  GBP5; guanylate-binding protein 5
       K12966  AIM2; absent in melanoma 2
       K20914  IFI16; gamma-interferon-inducible protein 16
       K20915  TP53BP1, P202; tumor suppressor p53-binding protein 1
       K20916  POP3; pyrin domain-only protein 3
       K04513  RHOA; Ras homolog gene family, member A
       K06071  PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]
       K23691  PKN2; serine/threonine-protein kinase N2 [EC:2.7.11.13]
       K06630  YWHAE; 14-3-3 protein epsilon
       K20899  GBP1_3_4_7; guanylate-binding protein 1/3/4/7
       K04395  CASP5; caspase 5 [EC:3.4.22.58]
       K04394  CASP4, CASP11; caspase 4 [EC:3.4.22.57 3.4.22.64]
       K20917  GSDMD; gasdermin-D
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K10160  TLR4, CD284; toll-like receptor 4
       K05842  TRIF; toll-like receptor adapter molecule 1
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K12654  TMEM173, MITA; transmembrane protein 173
     04622 RIG-I-like receptor signaling pathway [PATH:ko04622]
     04623 Cytosolic DNA-sensing pathway [PATH:ko04623]
       K03018  RPC1, POLR3A; DNA-directed RNA polymerase III subunit RPC1 [EC:2.7.7.6]
       K03021  RPC2, POLR3B; DNA-directed RNA polymerase III subunit RPC2 [EC:2.7.7.6]
       K03023  RPC3, POLR3C; DNA-directed RNA polymerase III subunit RPC3
       K03026  RPC4, POLR3D; DNA-directed RNA polymerase III subunit RPC4
       K14721  RPC5, POLR3E; DNA-directed RNA polymerase III subunit RPC5
       K03027  RPC40, POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1
       K03019  RPC11, POLR3K; DNA-directed RNA polymerase III subunit RPC11
       K03020  RPC19, POLR1D; DNA-directed RNA polymerases I and III subunit RPAC2
       K03022  RPC8, POLR3H; DNA-directed RNA polymerase III subunit RPC8
       K03024  RPC7, POLR3G; DNA-directed RNA polymerase III subunit RPC7
       K03025  RPC6, POLR3F; DNA-directed RNA polymerase III subunit RPC6
       K03013  RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1
       K03014  RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2
       K03016  RPB8, POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3
       K03009  RPB12, POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4
       K03007  RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5
       K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.4.13]
       K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K05405  IL6; interleukin 6
       K17834  MB21D1; cyclic GMP-AMP synthase [EC:2.7.7.86]
       K12654  TMEM173, MITA; transmembrane protein 173
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K05411  IRF3; interferon regulatory factor 3
       K09447  IRF7; interferon regulatory factor 7
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K12965  ZBP1, DAI; Z-DNA binding protein 1
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K12964  CCL4; C-C motif chemokine 4
       K12499  CCL5; C-C motif chemokine 5
       K12671  CXCL10, IP10; C-X-C motif chemokine 10
       K12966  AIM2; absent in melanoma 2
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K04519  IL1B; interleukin 1 beta
       K05482  IL18, IL1F4; interleukin 18
       K12967  IL33; interleukin 33
       K10790  TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
       K12968  ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37]
       K12969  E3L; Vaccinia virus protein E3
       K12970  M45; Murid betaherpesvirus 1 ribonucleoside-diphosphate reductase [EC:1.17.4.1]
       K12971  IFI202; interferon-activable protein 202
     04625 C-type lectin receptor signaling pathway [PATH:ko04625]
     04650 Natural killer cell mediated cytotoxicity [PATH:ko04650]
     04612 Antigen processing and presentation [PATH:ko04612]
     04660 T cell receptor signaling pathway [PATH:ko04660]
     04658 Th1 and Th2 cell differentiation [PATH:ko04658]
     04659 Th17 cell differentiation [PATH:ko04659]
     04657 IL-17 signaling pathway [PATH:ko04657]
     04662 B cell receptor signaling pathway [PATH:ko04662]
     04664 Fc epsilon RI signaling pathway [PATH:ko04664]
     04666 Fc gamma R-mediated phagocytosis [PATH:ko04666]
     04670 Leukocyte transendothelial migration [PATH:ko04670]
     04672 Intestinal immune network for IgA production [PATH:ko04672]
     04062 Chemokine signaling pathway [PATH:ko04062]
 
   09152 Endocrine system
 
   09153 Circulatory system
 
   09154 Digestive system
 
   09155 Excretory system
 
   09156 Nervous system
 
   09157 Sensory system
 
   09158 Development and regeneration
 
   09149 Aging
 
   09159 Environmental adaptation
 
 09160 Human Diseases
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

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Last updated: January 15, 2021