KEGG Orthology (KO)

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 09100 Metabolism
 
   09101 Carbohydrate metabolism
 
   09102 Energy metabolism
 
   09103 Lipid metabolism
     00061 Fatty acid biosynthesis [PATH:ko00061]
     00062 Fatty acid elongation [PATH:ko00062]
     00071 Fatty acid degradation [PATH:ko00071]
     00073 Cutin, suberine and wax biosynthesis [PATH:ko00073]
     00100 Steroid biosynthesis [PATH:ko00100]
     00120 Primary bile acid biosynthesis [PATH:ko00120]
     00121 Secondary bile acid biosynthesis [PATH:ko00121]
     00140 Steroid hormone biosynthesis [PATH:ko00140]
     00561 Glycerolipid metabolism [PATH:ko00561]
     00564 Glycerophospholipid metabolism [PATH:ko00564]
       K00006  GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
       K00057  gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
       K00105  E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21]
       K00111  glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]
       K00112  glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3]
       K00113  glpC; glycerol-3-phosphate dehydrogenase subunit C
       K00629  GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]
       K13506  GPAT3_4, AGPAT9, AGPAT6; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]
       K13507  GAT; glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.15 2.3.1.42]
       K00630  ATS1; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
       K13508  GPAT; glycerol-3-phosphate acyltransferase [EC:2.3.1.15 2.3.1.198]
       K00631  plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
       K08591  plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
       K00655  plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
       K13509  AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51]
       K13523  AGPAT3_4; lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]
       K19007  AGPAT5; lysophosphatidiate acyltransferase [EC:2.3.1.51]
       K13513  LCLAT1, AGPAT8; lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]
       K13517  MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]
       K13519  LPT1, ALE1; lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-]
       K14674  TGL4; TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
       K22831  LOA1; 1-acylglycerol-3-phosphate O-acyltransferase [EC:2.3.1.51]
       K00649  GNPAT; glyceronephosphate O-acyltransferase [EC:2.3.1.42]
       K06123  AYR1; 1-acylglycerone phosphate reductase [EC:1.1.1.101]
       K00980  tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]
       K01517  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.13 3.6.1.16 3.6.1.53]
       K01080  PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]
       K15728  LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]
       K18693  DPP1, DPPL, PLPP4_5; diacylglycerol diphosphate phosphatase / phosphatidate phosphatase [EC:3.6.1.75 3.1.3.4]
       K00901  dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]
       K07029  dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107]
       K16368  DGK1; diacylglycerol kinase (CTP) [EC:2.7.1.174]
       K00994  CHPT1, CPT1; diacylglycerol cholinephosphotransferase [EC:2.7.8.2]
       K13644  CEPT1; choline/ethanolamine phosphotransferase [EC:2.7.8.1 2.7.8.2]
       K01114  plc; phospholipase C [EC:3.1.4.3]
       K16619  plc, cpa; phospholipase C / alpha-toxin [EC:3.1.4.3]
       K18694  PGC1; phosphatidylglycerol phospholipase C [EC:3.1.4.-]
       K01115  PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
       K16860  PLD3_4; phospholipase D3/4 [EC:3.1.4.4]
       K17717  pld; phospholipase D [EC:3.1.4.4]
       K00650  LCAT; lecithin-cholesterol acyltransferase [EC:2.3.1.43]
       K01047  PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4]
       K14621  PLB1, PLB; phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5]
       K16817  PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
       K01058  pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
       K13510  LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]
       K13512  LPCAT4, AGPAT7; lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]
       K13515  LPCAT3, MBOAT5; lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-]
       K16818  DAD1; phospholipase A1 [EC:3.1.1.32]
       K22389  LCAT3; phospholipase A1 [EC:3.1.1.32]
       K06900  capV; cGAMP-activated phospholipase [EC:3.1.1.32 3.1.1.-]
       K06128  LYPLA1; lysophospholipase I [EC:3.1.1.5]
       K06129  LYPLA3; lysophospholipase III [EC:3.1.1.5]
       K06130  LYPLA2; lysophospholipase II [EC:3.1.1.5]
       K13333  PLB; lysophospholipase [EC:3.1.1.5]
       K01048  pldB; lysophospholipase [EC:3.1.1.5]
       K14676  NTE, NRE; lysophospholipid hydrolase [EC:3.1.1.5]
       K18695  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2]
       K18696  GDE1; glycerophosphodiester phosphodiesterase [EC:3.1.4.46]
       K01126  E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]
       K00623  CHAT; choline O-acetyltransferase [EC:2.3.1.6]
       K01049  ACHE; acetylcholinesterase [EC:3.1.1.7]
       K00866  CKI1; choline kinase [EC:2.7.1.32]
       K14156  CHK; choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]
       K06124  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75]
       K00968  PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15]
       K00993  EPT1; ethanolaminephosphotransferase [EC:2.7.8.1]
       K05939  aas; acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20]
       K25193  SDC; serine decarboxylase [EC:4.1.1.-]
       K00894  ETNK, EKI; ethanolamine kinase [EC:2.7.1.82]
       K00967  PCYT2; ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14]
       K05929  E2.1.1.103, NMT; phosphoethanolamine N-methyltransferase [EC:2.1.1.103]
       K04019  eutA; ethanolamine utilization protein EutA
       K03735  eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]
       K03736  eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]
       K14286  AGXT2L1, ETNPPL; ethanolamine-phosphate phospho-lyase [EC:4.2.3.2]
       K00551  PEMT; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71]
       K16369  CHO2; phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17]
       K00550  PLMT; phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.71]
       K00570  pmtA; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71]
       K01521  cdh; CDP-diacylglycerol pyrophosphatase [EC:3.6.1.26]
       K00981  E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]
       K01004  pcs; phosphatidylcholine synthase [EC:2.7.8.24]
       K00998  pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
       K17103  CHO1, pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
       K13618  PLA1A; phosphatidylserine sn-1 acylhydrolase [EC:3.1.1.111]
       K08729  PTDSS1; phosphatidylserine synthase 1 [EC:2.7.8.-]
       K08730  PTDSS2; phosphatidylserine synthase 2 [EC:2.7.8.29]
       K01613  psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]
       K00995  pgsA, PGS1; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]
       K01094  GEP4; phosphatidylglycerophosphatase GEP4 [EC:3.1.3.27]
       K01095  pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]
       K01096  pgpB; phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27]
       K18697  pgpC; phosphatidylglycerophosphatase C [EC:3.1.3.27]
       K06131  clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]
       K06132  clsC; cardiolipin synthase C [EC:2.7.8.-]
       K08744  CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41]
       K13511  TAZ; monolysocardiolipin acyltransferase [EC:2.3.1.-]
       K13535  CLD1; cardiolipin-specific phospholipase [EC:3.1.1.-]
       K13514  LPGAT1; lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]
       K00999  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]
       K13516  MBOAT7; lysophospholipid acyltransferase 7 [EC:2.3.1.-]
       K13621  BTA1; betaine lipid synthase
       K13622  btaA; S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase
       K13623  btaB; S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase
       K00096  araM, egsA; glycerol-1-phosphate dehydrogenase [NAD(P)+] [EC:1.1.1.261]
       K17104  E2.5.1.41; phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41]
       K17105  E2.5.1.42; geranylgeranylglycerol-phosphate geranylgeranyltransferase [EC:2.5.1.42]
       K19664  carS; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67]
       K19665  pssA; archaetidylserine synthase [EC:2.7.8.38]
       K17830  GGR; digeranylgeranylglycerophospholipid reductase [EC:1.3.1.101 1.3.7.11]
       K07094  pcrB; heptaprenylglyceryl phosphate synthase [EC:2.5.1.-]
       K24872  yvoF; heptaprenylglycerol acetyltransferase [EC:2.3.1.-]
     00565 Ether lipid metabolism [PATH:ko00565]
     00600 Sphingolipid metabolism [PATH:ko00600]
     00590 Arachidonic acid metabolism [PATH:ko00590]
     00591 Linoleic acid metabolism [PATH:ko00591]
     00592 alpha-Linolenic acid metabolism [PATH:ko00592]
     01040 Biosynthesis of unsaturated fatty acids [PATH:ko01040]
 
   09104 Nucleotide metabolism
 
   09105 Amino acid metabolism
 
   09106 Metabolism of other amino acids
 
   09107 Glycan biosynthesis and metabolism
 
   09108 Metabolism of cofactors and vitamins
 
   09109 Metabolism of terpenoids and polyketides
 
   09110 Biosynthesis of other secondary metabolites
 
   09111 Xenobiotics biodegradation and metabolism
 
   09112 Not included in regular maps
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
 09160 Human Diseases
 
   09161 Cancer: overview
     05200 Pathways in cancer [PATH:ko05200]
     05202 Transcriptional misregulation in cancer [PATH:ko05202]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis - DNA adducts [PATH:ko05204]
     05207 Chemical carcinogenesis - receptor activation [PATH:ko05207]
     05208 Chemical carcinogenesis - reactive oxygen species [PATH:ko05208]
     05203 Viral carcinogenesis [PATH:ko05203]
     05230 Central carbon metabolism in cancer [PATH:ko05230]
     05231 Choline metabolism in cancer [PATH:ko05231]
       K04357  EGF; epidermal growth factor
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-bound protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07206  TSC1; tuberous sclerosis 1
       K07207  TSC2; tuberous sclerosis 2
       K07208  RHEB; Ras homolog enriched in brain
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
       K05747  WAS; Wiskott-Aldrich syndrome protein
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K05753  WASF1; WAS protein family, member 1
       K05748  WASF2; WAS protein family, member 2
       K06083  WASF3; WAS protein family, member 3
       K04684  SP1; transcription factor Sp1
       K01115  PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
       K14387  SLC5A7, CHT1; solute carrier family 5 (high affinity choline transporter), member 7
       K06515  SLC44A1, CD92; solute carrier family 44 (choline transporter-like protein), member 1
       K15377  SLC44A2_4_5; solute carrier family 44 (choline transporter-like protein), member 2/4/5
       K15282  SLC44A3; solute carrier family 44 (choline transporter-like protein), member 3
       K08198  SLC22A1, OCT1; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 1
       K08199  SLC22A2, OCT2; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 2
       K08200  SLC22A3, OCT3; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 3
       K08202  SLC22A4_5, OCTN; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5
       K14156  CHK; choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]
       K08268  HIF1A; hypoxia-inducible factor 1 alpha
       K04448  JUN; transcription factor AP-1
       K04379  FOS; proto-oncogene protein c-fos
       K00968  PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15]
       K00994  CHPT1, CPT1; diacylglycerol cholinephosphotransferase [EC:2.7.8.2]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K01080  PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]
       K00901  dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K06128  LYPLA1; lysophospholipase I [EC:3.1.1.5]
       K18695  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2]
     05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:ko05235]
 
   09162 Cancer: specific types
 
   09172 Infectious disease: viral
 
   09171 Infectious disease: bacterial
 
   09174 Infectious disease: parasitic
 
   09163 Immune disease
 
   09164 Neurodegenerative disease
 
   09165 Substance dependence
 
   09166 Cardiovascular disease
 
   09167 Endocrine and metabolic disease
 
   09175 Drug resistance: antimicrobial
 
   09176 Drug resistance: antineoplastic
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

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Last updated: April 19, 2024