KEGG Orthology (KO)

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 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
 09160 Human Diseases
 
   09161 Cancer: overview
     05200 Pathways in cancer [PATH:ko05200]
     05202 Transcriptional misregulation in cancer [PATH:ko05202]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis [PATH:ko05204]
     05203 Viral carcinogenesis [PATH:ko05203]
       K21854  X; HBV protein X
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K10610  DDB1; DNA damage-binding protein 1
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K06630  YWHAE; 14-3-3 protein epsilon
       K16198  YWHAG_H; 14-3-3 protein gamma/eta
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K08665  HPN; hepsin [EC:3.4.21.106]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04735  RELA; transcription factor p65
       K09254  REL; c-Rel proto-oncogene protein
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04451  TP53, P53; tumor protein p53
       K06626  CCNE; G1/S-specific cyclin-E1
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K12496  EGR2; early growth response protein 2
       K12497  EGR3; early growth response protein 3
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K22271  Core; HCV core protein
       K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
       K15413  SP100; nuclear autoantigen Sp-100
       K12886  HNRNPK; heterogeneous nuclear ribonucleoprotein K
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K11594  DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
       K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
       K22273  NS3; HCV serine protease NS3 [EC:3.4.21.98]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K11252  H2B; histone H2B
       K11254  H4; histone H4
       K22275  NS5A; HCV non-structural protein 5A
       K02159  BAX; apoptosis regulator BAX
       K04364  GRB2; growth factor receptor-binding protein 2
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02087  CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
       K03120  TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
       K19461  EBNA1, BKRF1; EBV nuclear antigen 1
       K19456  EBNALP; EBV nuclear antigen leader protein
       K19457  EBNA2; EBV nuclear antigen 2
       K21855  EBNA3, EBNA3A; EBV nuclear antigen 3
       K21856  EBNA4, EBNA3B; EBV nuclear antigen 4
       K19458  EBNA6, EBNA3C; EBV nuclear antigen 6
       K19459  LMP1; EBV latent membrane protein 1
       K19460  LMP2A; EBV latent membrane protein 2A
       K11838  USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K06053  RBPSUH, RBPJK; recombining binding protein suppressor of hairless
       K06063  SNW1, SKIIP, SKIP; SNW domain-containing protein 1
       K03141  TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
       K03142  TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
       K03143  TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
       K03144  TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
       K03136  TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha
       K03137  TFIIE2, GTF2E2, TFA2; transcription initiation factor TFIIE subunit beta
       K15979  SND1; staphylococcal nuclease domain-containing protein 1
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K03124  TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB
       K04503  CCND1; G1/S-specific cyclin-D1
       K10151  CCND2; G1/S-specific cyclin-D2
       K10152  CCND3; G1/S-specific cyclin-D3
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06627  CCNA; cyclin-A
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K16174  MRPS18B, MRPS18-2; small subunit ribosomal protein S18b, mitochondrial
       K03172  TRAF1; TNF receptor-associated factor 1
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K03174  TRAF3; TNF receptor-associated factor 3
       K09849  TRAF5; TNF receptor-associated factor 5
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K21812  E5; HPV protein E5
       K21807  E6; HPV protein E6
       K21809  E7; HPV protein E7
       K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
       K10587  UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:2.3.2.26]
       K12076  DLG1; disks large protein 1
       K16175  SCRIB; protein scribble
       K05760  PXN; paxillin
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K05411  IRF3; interferon regulatory factor 3
       K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
       K06618  RB1; retinoblastoma-associated protein
       K04681  RBL1; retinoblastoma-like protein 1
       K16332  RBL2; retinoblastoma-like protein 2
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K10691  UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]
       K04448  JUN; transcription factor AP-1
       K11643  CHD4, MI2B; chromodomain-helicase-DNA-binding protein 4 [EC:3.6.4.12]
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K11404  HDAC3; histone deacetylase 3 [EC:3.5.1.98]
       K11406  HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
       K11407  HDAC6; histone deacetylase 6 [EC:3.5.1.98]
       K11408  HDAC7; histone deacetylase 7 [EC:3.5.1.98]
       K11405  HDAC8; histone deacetylase 8 [EC:3.5.1.98]
       K11409  HDAC9; histone deacetylase 9 [EC:3.5.1.98]
       K18671  HDAC10; histone deacetylase 10 [EC:3.5.1.98]
       K11418  HDAC11; histone deacetylase 11 [EC:3.5.1.98]
       K00873  PK, pyk; pyruvate kinase [EC:2.7.1.40]
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K09504  DNAJA3; DnaJ homolog subfamily A member 3
       K21857  tax; HTLV protein Tax-1
       K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
       K03122  TFIIA1, GTF2A1, TOA1; transcription initiation factor TFIIA large subunit
       K03123  TFIIA2, GTF2A2, TOA2; transcription initiation factor TFIIA small subunit
       K04378  SRF; serum response factor
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
       K04393  CDC42; cell division control protein 42
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K04513  RHOA; Ras homolog gene family, member A
       K05768  GSN; gelsolin
       K05699  ACTN1_4; actinin alpha 1/4
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K02216  CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
       K03363  CDC20; cell division cycle 20, cofactor of APC complex
       K06679  MAD1; mitotic spindle assembly checkpoint protein MAD1
       K15305  VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
       K15306  RANBP1; Ran-binding protein 1
       K02330  POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
       K21653  vIRF1, K9; KSHV interferon regulatory factor-like protein 1
       K21654  vIRF2, K11; KSHV interferon regulatory factor-like protein 2
       K21652  vIRF3; KSHV interferon regulatory factor-like protein 3
       K21858  vIRF4, K10; KSHV interferon regulatory factor-like protein 4
       K21859  KIE2, ORF45; KSHV transcription activator ORF45
       K21650  KIE1, ORF50; KSHV transcription activator ORF50
       K21670  vIL6, K2; KSHV interleukin 6
       K21659  K6; KSHV protein K6
       K21657  K4; KSHV macrophage inflammatory protein 2
       K21658  K4.1; KSHV protein vCCL3
       K21656  K12; KSHV protein K12
       K21662  vFLIP, K13, ORF71; KSHV FLICE inhibitory protein
       K21661  vIAP, K7; KSHV inhibitor of apoptosis protein
       K21664  vLANA, ORF73; KSHV latency-associated nuclear antigen
       K21663  vCyclin, ORF72; KSHV cyclin homolog
       K21660  vBCL2, ORF16; KSHV apoptosis regulator BCL2 homolog
       K21649  ORF4; KSHV complement control protein
       K21665  MIR1, K3; KSHV E3 ubiquitin-protein ligase MIR1 [EC:2.3.2.27]
       K21666  MIR2, K5; KSHV E3 ubiquitin-protein ligase MIR2 [EC:2.3.2.27]
       K21667  vGPCR; KSHV G-protein coupled receptor
       K21669  K1; KSHV protein K1
       K21651  K15; KSHV signal transducing membrane protein
       K21860  K14; KSHV OX-2 membrane glycoprotein
       K21861  ORF35; KSHV protein ORF35
       K09447  IRF7; interferon regulatory factor 7
       K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
       K04180  CCR5, CD195; C-C chemokine receptor type 5
       K04183  CCR8, CDw198; C-C chemokine receptor type 8
       K04178  CCR3, CD193; C-C chemokine receptor type 3
       K04179  CCR4, CD194; C-C chemokine receptor type 4
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02158  BAD; Bcl-2-antagonist of cell death
       K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
       K03990  C3; complement component 3
       K06751  MHC1; MHC class I antigen
     05230 Central carbon metabolism in cancer [PATH:ko05230]
     05231 Choline metabolism in cancer [PATH:ko05231]
     05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:ko05235]
 
   09162 Cancer: specific types
 
   09163 Immune disease
 
   09164 Neurodegenerative disease
 
   09165 Substance dependence
 
   09166 Cardiovascular disease
 
   09167 Endocrine and metabolic disease
 
   09171 Infectious disease: bacterial
 
   09172 Infectious disease: viral
     05166 Human T-cell leukemia virus 1 infection [PATH:ko05166]
     05170 Human immunodeficiency virus 1 infection [PATH:ko05170]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex virus 1 infection [PATH:ko05168]
     05163 Human cytomegalovirus infection [PATH:ko05163]
     05167 Kaposi sarcoma-associated herpesvirus infection [PATH:ko05167]
       K21649  ORF4; KSHV complement control protein
       K03990  C3; complement component 3
       K05401  TLR3, CD283; toll-like receptor 3
       K05842  TRIF; toll-like receptor adapter molecule 1
       K03174  TRAF3; TNF receptor-associated factor 3
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K09447  IRF7; interferon regulatory factor 7
       K21650  KIE1, ORF50; KSHV transcription activator ORF50
       K21859  KIE2, ORF45; KSHV transcription activator ORF45
       K21652  vIRF3; KSHV interferon regulatory factor-like protein 3
       K05414  IFNA; interferon alpha
       K05411  IRF3; interferon regulatory factor 3
       K21653  vIRF1, K9; KSHV interferon regulatory factor-like protein 1
       K21654  vIRF2, K11; KSHV interferon regulatory factor-like protein 2
       K21655  K8; KSHV E3 SUMO-protein ligase K-bZIP
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K05415  IFNB; interferon beta
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
       K21656  K12; KSHV protein K12
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K15308  TTP; tristetraprolin
       K05405  IL6; interleukin 6
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K21657  K4; KSHV macrophage inflammatory protein 2
       K04178  CCR3, CD193; C-C chemokine receptor type 3
       K04180  CCR5, CD195; C-C chemokine receptor type 5
       K04176  CCR1, CD191; C-C chemokine receptor type 1
       K21658  K4.1; KSHV protein vCCL3
       K04179  CCR4, CD194; C-C chemokine receptor type 4
       K21659  K6; KSHV protein K6
       K04183  CCR8, CDw198; C-C chemokine receptor type 8
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04726  BID; BH3 interacting domain death agonist
       K21660  vBCL2, ORF16; KSHV apoptosis regulator BCL2 homolog
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K21661  vIAP, K7; KSHV inhibitor of apoptosis protein
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K21662  vFLIP, K13, ORF71; KSHV FLICE inhibitory protein
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K21651  K15; KSHV signal transducing membrane protein
       K04451  TP53, P53; tumor protein p53
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K21663  vCyclin, ORF72; KSHV cyclin homolog
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K21664  vLANA, ORF73; KSHV latency-associated nuclear antigen
       K06751  MHC1; MHC class I antigen
       K21665  MIR1, K3; KSHV E3 ubiquitin-protein ligase MIR1 [EC:2.3.2.27]
       K21666  MIR2, K5; KSHV E3 ubiquitin-protein ligase MIR2 [EC:2.3.2.27]
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K06490  ICAM1, CD54; intercellular adhesion molecule 1
       K05413  CD86; CD86 antigen
       K07985  MIC; MHC class I-related protein
       K10071  CLEC2B; C-type lectin domain family 2 member B
       K04551  UBB; ubiquitin B
       K08334  BECN, VPS30, ATG6; beclin
       K17889  ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K08343  ATG3; ubiquitin-like-conjugating enzyme ATG3
       K08341  GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
       K21667  vGPCR; KSHV G-protein coupled receptor
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K08268  HIF1A; hypoxia-inducible factor 1 alpha
       K04448  JUN; transcription factor AP-1
       K04379  FOS; proto-oncogene protein c-fos
       K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
       K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K12365  PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K21668  CD200R1; cell surface glycoprotein CD200 receptor 1
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K21669  K1; KSHV protein K1
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K08893  HCK; hemopoietic cell kinase [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02183  CALM; calmodulin
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K10030  IL8, CXCL8; interleukin 8
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
       K17901  RCAN1, MCIP1; calcipressin-1
       K18497  FGF2; fibroblast growth factor 2
       K05448  VEGFA; vascular endothelial growth factor A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K21670  vIL6, K2; KSHV interleukin 6
       K05466  ANGPT2; angiopoietin 2
       K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02105  CTNNB1; catenin beta 1
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04503  CCND1; G1/S-specific cyclin-D1
       K04377  MYC; Myc proto-oncogene protein
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05165 Human papillomavirus infection [PATH:ko05165]
 
   09174 Infectious disease: parasitic
 
   09175 Drug resistance: antimicrobial
 
   09176 Drug resistance: antineoplastic
 
 09180 Brite Hierarchies
 
   09181 Protein families: metabolism
 
   09182 Protein families: genetic information processing
 
   09183 Protein families: signaling and cellular processes
     02000 Transporters [BR:ko02000]
     02044 Secretion system [BR:ko02044]
     02042 Bacterial toxins [BR:ko02042]
     02022 Two-component system [BR:ko02022]
     02035 Bacterial motility proteins [BR:ko02035]
     04812 Cytoskeleton proteins [BR:ko04812]
     04147 Exosome [BR:ko04147]
     02048 Prokaryotic defense system [BR:ko02048]
     04030 G protein-coupled receptors [BR:ko04030]
     04050 Cytokine receptors [BR:ko04050]
     04054 Pattern recognition receptors [BR:ko04054]
     03310 Nuclear receptors [BR:ko03310]
     04040 Ion channels [BR:ko04040]
     04031 GTP-binding proteins [BR:ko04031]
     04052 Cytokines and growth factors [BR:ko04052]
     04515 Cell adhesion molecules [BR:ko04515]
     04090 CD molecules [BR:ko04090]
     00535 Proteoglycans [BR:ko00535]
     00536 Glycosaminoglycan binding proteins [BR:ko00536]
     00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
     04091 Lectins [BR:ko04091]
     01504 Antimicrobial resistance genes [BR:ko01504]
     03200 Viral proteins [BR:ko03200]
       K23128  S; HBV large envelope protein
       K23129  C; HBV capsid protein
       K21854  X; HBV protein X
       K21037  P; Hepadnavirus DNA polymerase / reverse transcriptase / RNase H [EC:2.7.7.7 2.7.7.49 3.1.26.4]
       K23017  gag; HTLV-1 gag polyprotein
       K23454  gag-pro-pol; HTLV-1 gag-pro-pol polyprotein [EC:2.7.7.7 2.7.7.49 3.1.26.4]
       K19259  env; HTLV envelope glycoprotein gp62
       K21857  tax; HTLV protein Tax-1
       K23018  rex; HTLV-1 rex polyprotein
       K23069  p12I; HTLV-1 accessory protein p12I
       K23070  p13; HTLV-1 accessory protein p13
       K23068  p30II; HTLV-1 accessory protein p30II
       K23071  HBZ; HTLV-1 basic zipper factor
       K22599  PR; HIV protease [EC:3.4.23.16 3.4.23.47]
       K22951  gag; HIV-1 gag polyprotein
       K19287  gp160; HIV-1 envelope glycoprotein gp160
       K19258  tat; HIV-1 protein Tat
       K22892  vif; HIV-1 virion infectivity factor
       K22202  vpr; HIV-1 virus protein R
       K22890  vpu; HIV-1 protein Vpu
       K22891  nef; HIV-1 protein Nef
       K23453  src; RSV tyrosine-protein kinase transforming protein Src [EC:2.7.10.2]
       K19250  S1; Mammalian orthoreovirus 3 outer capsid protein sigma-1
       K19376  L; Paramyxoviridae RNA-directed RNA polymerase L
       K19378  H; Morbillivirus hemagglutinin glycoprotein
       K19379  F; Morbillivirus fusion glycoprotein F0
       K19380  N; Morbillivirus nucleoprotein
       K19381  M; Morbillivirus matrix protein
       K19377  P, P/V/C; Morbillivirus phosphoprotein
       K19389  PB1; Influenza A virus RNA-directed RNA polymerase catalytic subunit [EC:2.7.7.48]
       K19392  NA; Influenza A virus neuraminidase [EC:3.2.1.18]
       K19390  PA; Influenza A virus polymerase acidic protein
       K19388  PB2; Influenza A virus polymerase basic protein 2
       K19391  NP; Influenza A virus nucleoprotein
       K19395  NEP, NS2; Influenza A virus nuclear export protein
       K19396  NS1; Influenza A virus non-structural protein 1
       K19393  M1; Influenza A virus matrix protein 1
       K19394  M2; Influenza A virus matrix protein 2
       K19397  PB1F2; Influenza A virus protein PB1-F2
       K19251  HA; Influenza A virus hemagglutinin
       K19253  HE, HEF; Influenza C virus hemagglutinin-esterase-fusion glycoprotein [EC:3.1.1.53]
       K22201  CM2; Influenza C virus CM2 channel family protein
       K22613  vCX3C; RSV chemokine CX3C homolog
       K19261  F; Orthopneumovirus fusion glycoprotein F0
       K21924  L; Orthobornavirus RNA-directed RNA polymerase [EC:2.7.7.48]
       K19247  HN; Respirovirus hemagglutinin-neuraminidase [EC:3.2.1.18]
       K21316  L; Rhabdoviridae RNA-directed RNA polymerase [EC:2.7.7.48 2.1.1.56 2.7.7.88]
       K22271  Core; HCV core protein
       K22272  E2; HCV envelope glycoprotein E2
       K19358  HCVgp1; HCV polyprotein
       K22497  NS2; HCV non-structural protein 2
       K22274  NS4A; HCV non-structural protein 4A
       K22498  NS4B; HCV non-structural protein 4B
       K22275  NS5A; HCV non-structural protein 5A
       K22472  NS5B; HCV RNA-dependent RNA polymerase
       K22273  NS3; HCV serine protease NS3 [EC:3.4.21.98]
       K24106  N; Coronaviridae nucleocapsid protein
       K19254  S; Coronaviridae spike glycoprotein
       K19288  p130; Alphavirus structral polyprotein
       K21077  1a-1b; Beet yellows virus replicase polyprotein 1ab [EC:2.1.1.- 2.7.7.48 3.4.22.- 3.6.4.13]
       K21535  p22; Tombusvirus movement protein
       K21670  vIL6, K2; KSHV interleukin 6
       K21667  vGPCR; KSHV G-protein coupled receptor
       K21664  vLANA, ORF73; KSHV latency-associated nuclear antigen
       K21663  vCyclin, ORF72; KSHV cyclin homolog
       K21660  vBCL2, ORF16; KSHV apoptosis regulator BCL2 homolog
       K21653  vIRF1, K9; KSHV interferon regulatory factor-like protein 1
       K21654  vIRF2, K11; KSHV interferon regulatory factor-like protein 2
       K21652  vIRF3; KSHV interferon regulatory factor-like protein 3
       K21858  vIRF4, K10; KSHV interferon regulatory factor-like protein 4
       K21661  vIAP, K7; KSHV inhibitor of apoptosis protein
       K21662  vFLIP, K13, ORF71; KSHV FLICE inhibitory protein
       K21657  K4; KSHV macrophage inflammatory protein 2
       K21649  ORF4; KSHV complement control protein
       K21651  K15; KSHV signal transducing membrane protein
       K21860  K14; KSHV OX-2 membrane glycoprotein
       K21669  K1; KSHV protein K1
       K21658  K4.1; KSHV protein vCCL3
       K21659  K6; KSHV protein K6
       K21656  K12; KSHV protein K12
       K21861  ORF35; KSHV protein ORF35
       K21650  KIE1, ORF50; KSHV transcription activator ORF50
       K21859  KIE2, ORF45; KSHV transcription activator ORF45
       K21665  MIR1, K3; KSHV E3 ubiquitin-protein ligase MIR1 [EC:2.3.2.27]
       K21666  MIR2, K5; KSHV E3 ubiquitin-protein ligase MIR2 [EC:2.3.2.27]
       K21655  K8; KSHV E3 SUMO-protein ligase K-bZIP
       K21533  vIL10; EBV viral interleukin 10
       K22974  BNLF2A; EBV protein BNLF2a
       K19461  EBNA1, BKRF1; EBV nuclear antigen 1
       K19457  EBNA2; EBV nuclear antigen 2
       K21855  EBNA3, EBNA3A; EBV nuclear antigen 3
       K21856  EBNA4, EBNA3B; EBV nuclear antigen 4
       K19458  EBNA6, EBNA3C; EBV nuclear antigen 6
       K19456  EBNALP; EBV nuclear antigen leader protein
       K19459  LMP1; EBV latent membrane protein 1
       K19460  LMP2A; EBV latent membrane protein 2A
       K23074  LMP2B; EBV latent membrane protein 2B
       K19455  BGLF4; EBV serine/threonine-protein kinase BGLF4 [EC:2.7.11.1]
       K19454  BMLF1; EBV mRNA export factor ICP27
       K19463  BHRF1; EBV apoptosis regulator BHRF1
       K19462  BZLF1; EBV trans-activator protein BZLF1
       K19453  BBRF2; EBV virion egress protein UL7
       K21532  BNRF1; EBV major tegument protein
       K22972  BPLF1; EBV large tegment protein deneddylase [EC:3.4.19.12]
       K19450  BLLF1; EBV envelope glycoprotein GP350
       K22973  BARF1; EBV secreted protein BARF1
       K22975  BILF1; EBV G-protein coupled receptor BILF1
       K19451  gH; EBV envelope glycoprotein H
       K19452  gL; EBV envelope glycoprotein L
       K19260  L1; HPV major capsid protein L1
       K21808  L2; HPV minor capsid protein L2
       K21810  E1; HPV replication protein E1 [EC:3.6.4.12]
       K21811  E2; HPV regulatory protein E2
       K21812  E5; HPV protein E5
       K21807  E6; HPV protein E6
       K21809  E7; HPV protein E7
       K19441  US1; Simplexvirus transcriptional regulator ICP22
       K19445  ICP4, RS1; Simplexvirus major viral transcription factor ICP4
       K19437  RL1; HSV1 neurovirulence factor ICP34.5
       K19443  UL54; Simplexvirus mRNA export factor
       K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit [EC:1.17.4.1]
       K19439  US3; Simplexvirus serine/threonine-protein kinase US3 [EC:2.7.11.1]
       K19440  UL13; Simplexvirus serine/threonine-protein kinase UL13 [EC:2.7.11.1]
       K19447  UL41; Simplexvirus virion host shutoff protein [EC:3.1.27.-]
       K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
       K19438  US11; HSV1 RNA-binding protein
       K19442  ICP8, DBP, UL29; Simplexvirus major DNA-binding protein
       K21501  UL9; Alphaherpesvirinae replication origin-binding protein
       K23212  UL46; HSV tegument protein VP11/12
       K19444  UL48; Simplexvirus tegument protein VP16
       K19255  gB; Herpesviridae envelope glycoprotein B
       K19256  gC; Simplexvirus envelope glycoprotein C
       K19264  gD; Simplexvirus envelope glycoprotein D
       K19434  gH, UL22; Simplexvirus envelope glycoprotein H
       K19435  gL, UL1; Simplexvirus envelope glycoprotein L
       K19446  US12; HSV1 ICP47 protein
       K21046  UL146; HCMV chemokine vCXCL1
       K22782  UL33; Cytomegalovirus G-protein coupled receptor UL33
       K21043  UL16; HCMV immunoevasion protein
       K21047  UL144; HCMV TNF alpha-like receptor UL144
       K21041  UL7_8; HCMV CEACAM1-like protein
       K21042  UL11; HCMV protein UL11
       K21044  UL40; HCMV protein UL40
       K21049  UL141; Cytomegalovirus protein UL141
       K22780  UL26; Cytomegalovirus tegument protein UL26
       K22779  UL82; Cytomegalovirus tegument protein pp71
       K21045  UL83; Cytomegalovirus tegument protein UL83
       K21078  UL80; Betaherpesvirinae capsid scaffolding protein [EC:3.4.21.97]
       K22784  UL22A; HCMV glycoprotein UL22A
       K21050  US2; HCMV unique short US2 glycoprotein
       K21051  US10; HCMV unique short US10 glycoprotein
       K22787  US3; HCMV membrane glycoprotein US3
       K22785  US6; HCMV membrane glycoprotein US6
       K22786  US11; HCMV membrane glycoprotein US11
       K21048  UL142; HCMV membrane glycoprotein UL142
       K22783  US27; HCMV envelope glycoprotein US27
       K22781  US28; HCMV envelope protein US28
       K19257  gM; Herpesviridae envelope glycoprotein M
       K22773  gB, UL55; Betaherpesvirinae envelope glycoprotein B
       K22777  gH, UL75; Cytomegalovirus envelope glycoprotein H
       K22778  gL, UL115; Cytomegalovirus envelope glycoprotein L
       K22789  UL37; UL37 HCMV immediate early glycoprotein
       K22774  UL123; HCMV immediate-early protein 1
       K22775  UL122; Cytomegalovirus viral transcription factor IE2
       K22788  UL36; Cytomegalovirus viral inhibitor of caspase-8-induced apoptosis
       K22776  UL38; Cytomegalovirus apoptosis inhibitor UL38
       K23392  vCCL4a, U83; HHV6 CCRs chemokine agonist
       K21040  vCCL4b, U83; HHV6 CCR2 chemokine agonist
       K23431  HHV6-U12; HHV6 CC-chemokine receptor U12
       K23433  HHV6-U51; HHV6 G-protein coupled receptor homolog U51
       K23432  HHV7-U12; HHV7 CC-chemokine receptor U12
       K23434  HHV7-U51; HHV7 G-protein coupled receptor homolog U51
       K18964  UL30; Herpesvirus DNA polymerase catalytic subunit [EC:2.7.7.7]
       K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase [EC:3.4.19.12 3.4.22.-]
       K23382  gG; Simplexvirus envelope glycoprotein G
       K21076  L3; Mastadenovirus pre-protein VI
       K19262  L5; Mastadenovirus fiber protein
       K21923  POL; Adenovirus DNA polymerase [EC:2.7.7.7]
       K19249  VP4; Rotavirus outer capsid protein VP4
       K19248  VP1; Polyomaviridae major capsid protein VP1
       K22612  vVEGFA; Poxvirus vascular endothelial growth factor A homolog
       K21538  vTNFR2; Poxvirus tumor necrosis factor receptor II
       K23381  vCCI; Poxvirus chemokine inhibitor
       K23427  7L; Poxvirus chemokine receptor 7L
       K23426  134R; YLDV 134R protein
       K23428  2L; TPV TNF binding protein 2L
       K21516  PAPS; Orthopoxvirus cap-specific mRNA (nucleoside-2'-O-)-methyltransferase [EC:2.1.1.57]
       K21081  RPO18; Poxviridae DNA-directed RNA polymerase [EC:2.7.7.6]
       K21315  PAPL; Poxviridae poly(A) polymerase catalytic subunit [EC:2.7.7.19]
       K21506  VPK1; Orthopoxvirus serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K21518  VPK2; Orthopoxvirus serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K21517  NPH1; Orthopoxvirus nucleoside triphosphatase I [EC:3.6.1.15]
       K21505  NPH2; Orthopoxvirus RNA helicase NPH-II [EC:3.6.4.13]
       K21519  A18R; Orthopoxvirus transcript termination protein [EC:3.6.4.-]
       K21082  A20R; Chordopoxvirinae DNA polymerase processivity factor component
       K21080  RAP94; Chordopoxvirinae RNA polymerase-associated transcription-specificity factor
       K21537  SPI-2; Orthopoxvirus serine proteinase inhibitor 2
       K21536  VGF-1; Orthopoxvirus pro-vaccinia growth factor
       K12969  E3L; Vaccinia virus protein E3
       K19263  A27L; Orthopoxvirus protein A27
       K21529  A28L; Orthopoxvirus envelope protein A28
       K12970  M45; Murid betaherpesvirus 1 ribonucleoside-diphosphate reductase [EC:1.17.4.1]
       K21504  IAP3; Baculoviridae E3 ubiquitin-protein ligase [EC:2.3.2.27]
       K18963  pol; Baculovirus DNA polymerase [EC:2.7.7.7]
       K21243  LEF-4; Alphabaculovirus DNA-dependent RNA polymerase subunit LEF-4 [EC:2.7.7.50]
       K21241  LEF-1; Alphabaculovirus DNA primase [EC:2.7.7.-]
       K20741  VCATH; Autographa californica nucleopolyhedrovirus V-cath endopeptidase [EC:3.4.22.50]
       K21242  HELI; Baculoviridae DNA replication helicase [EC:3.6.4.12]
       K21233  AN; Alphabaculovirus alkaline nuclease
       K21244  LEF-2; Alphabaculovirus primase-associated factor LEF-2
       K21236  L230; Mimivirus procollagen lysyl hydroxylase and glycosyltransferase [EC:1.14.11.4 2.4.1.-]
       K21865  kcv; Chlorovirus potassium channel protein kcv
       K22623  vIL17; Herpesvirus interleukin 17
       K22624  vCCL27; MOCV1 CC chemokine receptor antagonist
       K23391  MC053L, MC054L; MOCV1 interleukin 18 binding protein
       K22625  vIL8; Marek's disease virus interleukin 8 homolog
       K18969  CURLY_70; Bacillus virus DNA polymerase III epsilon subunit
       K21237  gp2; Phi29virus DNA polymerase [EC:2.7.7.7]
       K21038  brt; reverse transcriptase [EC:2.7.7.49]
       K21239  gp50; virion DNA-directed RNA polymerase [EC:2.7.7.6]
       K18943  gp45; DNA polymerase processivity component
       K21534  SAMase; S-adenosyl-L-methionine hydrolase (L-homoserine-forming) [EC:3.3.1.2]
       K19796  gp42; dCMP hydroxymethylase [EC:2.1.2.8]
       K21521  agt; DNA alpha-glucosyltransferase [EC:2.4.1.26]
       K19797  gp1; T-even-induced deoxynucleotide kinase [EC:2.7.4.12]
       K18942  gp43; T4virus DNA polymerase [EC:2.7.7.7]
       K20841  denA; T4 deoxyribonuclease II [EC:3.1.21.8]
       K20842  denB; T4 deoxyribonuclease IV [EC:3.1.21.9]
       K18950  rnh; ribonuclease H [EC:3.1.26.4]
       K21523  gp17; terminase, large subunit [EC:3.1.-.-]
       K21524  gp16; terminase, small subunit
       K21522  denV; endonuclease V [EC:3.2.2.17]
       K21499  dda; ATP-dependent DNA helicase [EC:3.6.4.12]
       K18959  uvsW; ATP-dependent DNA helicase UvsW [EC:3.6.4.12]
       K05345  regB; T4 restriction endoribonuclease [EC:4.6.1.25]
       K18951  gp30; DNA ligase [EC:6.5.1.1]
       K18961  rnlA; T4 RNA ligase 1 [EC:6.5.1.3]
       K18962  rnlB; T4 RNA ligase 2 [EC:6.5.1.3]
       K18948  gp61; DNA primase
       K18947  gp41; ATP-dependent helicase
       K18960  gp49; recombination endonuclease VII
       K22007  gp55; RNA polymerase sigma factor
       K18946  gp32, ssb; single-stranded DNA-binding protein
       K21074  mrh; rpoH-modulating protein
       K21079  gp23; major capsid protein
       K21531  gp18; tail sheath protein
       K21530  gp25; baseplate wedge protein
       K18949  gp59; protein Gp59
       K18944  gp44; sliding clamp loader
       K18945  gp62; sliding clamp loader
       K21500  dnk; deoxynucleoside-5'-monophosphate kinase [EC:2.7.4.13]
       K21314  pol; T5 DNA polymerase [EC:2.7.7.7]
       K21510  dmp; 5'-deoxynucleotidase [EC:3.1.3.89]
       K21313  1; T7 RNA polymerase [EC:2.7.7.6]
       K21238  Gp5; T7virus DNA-directed DNA polymerase [EC:2.7.7.7]
       K21502  Gp4; DNA primase/helicase [EC:2.7.7.- 3.6.4.12]
       K21526  Gp6; exonuclease [EC:3.1.11.3]
       K21525  Gp3; endonuclease I [EC:3.1.21.2]
       K21508  Gp16; peptidoglycan hydrolase [EC:4.2.2.-]
       K21509  gp36; peptidoglycan hydrolase [EC:3.2.1.17]
       K21503  56; dCTP pyrophosphatase [EC:3.6.1.12]
       K19252  VP1; Dependoparvovirus capsid protein VP1, adeno-associated virus type
       K21240  Rep; Dependoparvovirus virus replication protein
       K21234  BC1; Begomovirus movement protein BC1
       K21235  BR1, BV1; Begomovirus nuclear shuttle protein
       K21520  C1; Bean yellow dwarf virus replication-associated protein A [EC:3.1.21.-]
 
   09184 RNA family
 
 09190 Not Included in Pathway or Brite

[ KO | BRITE | KEGG2 | KEGG ]
Last updated: April 8, 2020