KEGG Orthology (KO)

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 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
 09160 Human Diseases
 
   09161 Cancer: overview
 
   09162 Cancer: specific types
 
   09163 Immune disease
 
   09164 Neurodegenerative disease
 
   09165 Substance dependence
 
   09166 Cardiovascular disease
 
   09167 Endocrine and metabolic disease
 
   09171 Infectious disease: bacterial
     05110 Vibrio cholerae infection [PATH:ko05110]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
       K11014  cdtB; cytolethal distending toxin subunit B
       K11023  ptxA, artA, pltA; pertussis toxin subunit 1 [EC:2.4.2.-]
       K19298  subB, artB, pltB; subtilase cytotoxin, subunit B
       K06817  PODXL; podocalyxin-like
       K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
       K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K15347  sifA; secreted effector protein SifA
       K07897  RAB7A; Ras-related protein Rab-7A
       K07898  RAB7B; Ras-related protein Rab-7B
       K23282  PLEKHM1; pleckstrin homology domain-containing family M member 1
       K20179  VPS11, PEP5; vacuolar protein sorting-associated protein 11
       K20180  VPS16; vacuolar protein sorting-associated protein 16
       K20181  VPS18, PEP3; vacuolar protein sorting-associated protein 18
       K20182  VPS33A; vacuolar protein sorting-associated protein 33A
       K20183  VPS39, VAM6; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
       K20184  VPS41; vacuolar protein sorting-associated protein 41
       K23936  sopD2; secreted effector protein SopD2
       K13883  RILP; Rab-interacting lysosomal protein
       K10413  DYNC1H; dynein heavy chain 1, cytosolic
       K10414  DYNC2H, DNCH2; dynein heavy chain 2, cytosolic
       K10415  DYNC1I, DNCI; dynein intermediate chain, cytosolic
       K10416  DYNC1LI, DNCLI; dynein light intermediate chain 1, cytosolic
       K10417  DYNC2LI; dynein light intermediate chain 2, cytosolic
       K10418  DYNLL; dynein light chain LC8-type
       K10419  DYNLRB, DNCL2; dynein light chain roadblock-type
       K10420  DYNLT; dynein light chain Tctex-type 1
       K04648  DCTN1; dynactin 1
       K10424  DCTN2; dynactin 2
       K10425  DCTN3; dynactin 3
       K10426  DCTN4; dynactin 4
       K10427  DCTN5; dynactin 5
       K10428  DCTN6; dynactin 6
       K16575  ACTR1, ARP1; centractin
       K16576  ACTR10, ARP11; actin-related protein 10
       K07374  TUBA; tubulin alpha
       K07375  TUBB; tubulin beta
       K21954  FYCO1; FYVE and coiled-coil domain-containing protein 1
       K07955  ARL8; ADP-ribosylation factor-like protein 8
       K15348  PLEKHM2, SKIP; pleckstrin homology domain-containing family M member 2
       K10396  KIF5; kinesin family member 5
       K10407  KLC; kinesin light chain
       K15352  pipB2; secreted effector protein PipB2
       K15350  sseF; secreted effector protein SseF
       K15351  sseG; secreted effector protein SseG
       K23935  ACBD3; golgi resident protein GCP60
       K04513  RHOA; Ras homolog gene family, member A
       K15349  sseJ; secreted effector protein SseJ
       K10089  M6PR; cation-dependent mannose-6-phosphate receptor
       K07899  RAB9A, RAB9; Ras-related protein Rab-9A
       K07900  RAB9B; Ras-related protein Rab-9B
       K20282  GCC2; GRIP and coiled-coil domain-containing protein 2
       K23937  STX10; syntaxin 10
       K15353  sspH2; E3 ubiquitin-protein ligase SspH2
       K15354  sseI, srfH; secreted effector protein SseI
       K05759  PFN; profilin
       K04437  FLNA; filamin
       K15366  spvB; salmonella plasmid virulence protein B
       K07195  EXOC7, EXO70; exocyst complex component 7
       K19984  EXOC5, SEC10; exocyst complex component 5
       K06111  EXOC4, SEC8; exocyst complex component 4
       K17637  EXOC2, SEC5; exocyst complex component 2
       K07834  RALA; Ras-related protein Ral-A
       K13286  sipC, ipaC, bipC; invasin C
       K13284  sipA, ipaA; invasin A
       K05692  ACTB_G1; actin beta/gamma 1
       K17274  S100A10; protein S100-A10
       K17092  ANXA2; annexin A2
       K23934  AHNAK; neuroblast differentiation-associated protein AHNAK
       K13741  sopE; guanine nucleotide exchange factor SopE
       K13740  sptP; secreted effector protein SptP
       K07864  RHOJ, TCL; Ras homolog gene family, member J
       K13744  ARHGEF26, SGEF; Rho guanine nucleotide exchange factor 26
       K07863  RHOG; Ras homolog gene family, member G
       K12366  ELMO1, CED12; engulfment and cell motility protein 1
       K18985  ELMO2, CED12A; engulfment and cell motility protein 2
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K10351  MYL2; myosin regulatory light chain 2
       K12753  MYL5; myosin regulatory light chain 5
       K12754  MYL7; myosin regulatory light chain 7
       K12755  MYL9; myosin regulatory light chain 9
       K12756  MYL10; myosin regulatory light chain 10
       K12757  MYL12; myosin regulatory light chain 12
       K12758  MYLPF; fast skeletal myosin light chain 2
       K23938  FHOD1; FH1/FH2 domain-containing protein 1
       K04393  CDC42; cell division control protein 42
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K05750  NCKAP1, NAP125; NCK-associated protein 1
       K05749  CYFIP; cytoplasmic FMR1 interacting protein
       K23649  ABI1; abl interactor 1
       K05752  C3ORF10, HSPC300; chromosome 3 open reading frame 10
       K06083  WASF3; WAS protein family, member 3
       K17260  ACTR2, ARP2; actin-related protein 2
       K18584  ACTR3, ARP3; actin-related protein 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
       K10358  MYO6; myosin VI
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
       K00923  PIK3C2; phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
       K18441  CYTH; cytohesin
       K07941  ARF6; ADP-ribosylation factor 6
       K07937  ARF1_2; ADP-ribosylation factor 1/2
       K17923  SNX9_18_33; sorting nexin-9/18/33
       K23612  WASL; neural Wiskott-Aldrich syndrome protein
       K23484  DNM2; dynamin 2 [EC:3.6.5.5]
       K10169  TLR6, CD286; toll-like receptor 6
       K10159  TLR2, CD282; toll-like receptor 2
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04391  CD14; monocyte differentiation antigen CD14
       K10160  TLR4, CD284; toll-like receptor 4
       K05400  LY96, MD-2; lymphocyte antigen 96
       K02406  fliC, hag; flagellin
       K10168  TLR5; toll-like receptor 5
       K10161  TLR9, CD289; toll-like receptor 9
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K08727  NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
       K04079  HSP90A, htpG; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K18423  CSE1, CAS, XPO2; exportin-2 (importin alpha re-exporter)
       K23940  KPNA1; importin subunit alpha-5
       K23583  KPNA3_4; importin subunit alpha-4/3
       K02985  RP-S3e, RPS3; small subunit ribosomal protein S3e
       K02833  HRAS; GTPase HRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K04519  IL1B; interleukin 1 beta
       K05405  IL6; interleukin 6
       K10030  IL8, CXCL8; interleukin 8
       K02105  CTNNB1; catenin beta 1
       K02620  TCF7, TCF-1; transcription factor 7
       K04490  TCF7L1; transcription factor 7-like 1
       K04491  TCF7L2; transcription factor 7-like 2
       K04492  LEF1; lymphoid enhancer-binding factor 1
       K04377  MYC; Myc proto-oncogene protein
       K19557  spvD; salmonella plasmid virulence protein D
       K23941  pipA, gogA, gtgA; PipA/GogA/GtgA family effector protease
       K15343  sspH1; E3 ubiquitin-protein ligase SspH1
       K06071  PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]
       K23942  gogB; Gifsy-1 prophage leucine-rich repeat protein
       K10302  FBXO22; F-box protein 22
       K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
       K08598  yopJ; YopJ protease family
       K18015  elaD, sseL; deubiquitinase [EC:3.4.22.-]
       K13450  ospF, mkaD, spvC; phosphothreonine lyase [EC:4.2.3.-]
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K00134  GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]
       K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
       K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K08738  CYC; cytochrome c
       K02161  BCL2; apoptosis regulator Bcl-2
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04397  CASP7; caspase 7 [EC:3.4.22.60]
       K07856  RHOB; Ras homolog gene family, member B
       K07873  RHOH, TTF; Ras homolog gene family, member H
       K07829  RRAS; Ras-related protein R-Ras
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K08849  MLKL; mixed lineage kinase domain-like [EC:2.7.11.1]
       K23943  sseK3; type III secretion system effector arginine glycosyltransferase
       K23944  sseK1; type III secretion system effector arginine glycosyltransferase
       K23945  sseK2; type III secretion system effector
       K23946  slrP; E3 ubiquitin-protein ligase SlrP [EC:2.3.2.27]
       K03671  trxA; thioredoxin 1
       K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
       K22487  prgJ; type III secretion system protein
       K03221  yscF, sctF, ssaG, prgI; type III secretion protein F
       K12807  NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
       K12805  NLRC4, CARD12; NLR family CARD domain-containing protein 4
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K05482  IL18, IL1F4; interleukin 18
       K04394  CASP4, CASP11; caspase 4 [EC:3.4.22.57 3.4.22.64]
       K04395  CASP5; caspase 5 [EC:3.4.22.58]
       K20917  GSDMD; gasdermin-D
       K13285  sipB, ipaB, bipB; invasin B
     05131 Shigellosis [PATH:ko05131]
     05135 Yersinia infection [PATH:ko05135]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
 
   09172 Infectious disease: viral
 
   09174 Infectious disease: parasitic
 
   09175 Drug resistance: antimicrobial
 
   09176 Drug resistance: antineoplastic
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

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Last updated: November 28, 2020