 1. Oxidoreductases
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2. Transferases
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 3. Hydrolases
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3.1 Acting on ester bonds
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3.2 Glycosylases
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3.3 Acting on ether bonds
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3.4 Acting on peptide bonds (peptidases)
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3.4.11 Aminopeptidases
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3.4.13 Dipeptidases
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3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
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3.4.15 Peptidyl-dipeptidases
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3.4.16 Serine-type carboxypeptidases
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3.4.17 Metallocarboxypeptidases
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3.4.18 Cysteine-type carboxypeptidases
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3.4.19 Omega peptidases
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3.4.21 Serine endopeptidases
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3.4.22 Cysteine endopeptidases
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3.4.22.1 cathepsin B
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3.4.22.2 papain
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 3.4.22.3 ficain
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3.4.22.6 chymopapain
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3.4.22.7 asclepain
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3.4.22.8 clostripain
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3.4.22.10 streptopain
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3.4.22.14 actinidain
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3.4.22.15 cathepsin L
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3.4.22.16 cathepsin H
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3.4.22.24 cathepsin T
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3.4.22.25 glycyl endopeptidase
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3.4.22.26 cancer procoagulant
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3.4.22.27 cathepsin S
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3.4.22.28 picornain 3C
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3.4.22.29 picornain 2A
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3.4.22.30 caricain
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3.4.22.31 ananain
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3.4.22.32 stem bromelain
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3.4.22.33 fruit bromelain
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3.4.22.34 legumain
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3.4.22.35 histolysain
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3.4.22.36 caspase-1
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3.4.22.37 gingipain R
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3.4.22.38 cathepsin K
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3.4.22.39 adenain
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3.4.22.40 bleomycin hydrolase
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3.4.22.41 cathepsin F
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3.4.22.42 cathepsin O
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3.4.22.43 cathepsin V
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3.4.22.44 nuclear-inclusion-a endopeptidase
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3.4.22.45 helper-component proteinase
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3.4.22.46 L-peptidase
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3.4.22.47 gingipain K
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3.4.22.48 staphopain
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3.4.22.49 separase
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3.4.22.50 V-cath endopeptidase
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3.4.22.51 cruzipain
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3.4.22.52 calpain-1
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3.4.22.53 calpain-2
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3.4.22.54 calpain-3
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3.4.22.55 caspase-2
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3.4.22.56 caspase-3
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3.4.22.57 caspase-4
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3.4.22.58 caspase-5
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3.4.22.59 caspase-6
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3.4.22.60 caspase-7
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3.4.22.61 caspase-8
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3.4.22.62 caspase-9
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3.4.22.63 caspase-10
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3.4.22.64 caspase-11
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3.4.22.65 peptidase 1 (mite)
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3.4.22.66 calicivirin
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3.4.22.67 zingipain
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3.4.22.68 Ulp1 peptidase
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3.4.22.69 SARS coronavirus main proteinase
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3.4.22.70 sortase A
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3.4.22.71 sortase B
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3.4.22.-
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K01376 UFSP2; Ufm1-specific protease 2 [EC:3.4.22.-]
K04401 CASP14; caspase 14 [EC:3.4.22.-]
K04489 CASP3A; caspase 3A [EC:3.4.22.-]
K04740 CAPN12; calpain-12 [EC:3.4.22.-]
K04741 CASP12; caspase 12 [EC:3.4.22.-]
K07369 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
K08569 CTSW; cathepsin W [EC:3.4.22.-]
K08572 CPC; cysteine peptidase C [EC:3.4.22.-]
K08574 CAPN5; calpain-5 [EC:3.4.22.-]
K08575 CAPN6; calpain-6 [EC:3.4.22.-]
K08576 CAPN7; calpain-7 [EC:3.4.22.-]
K08577 CAPN8; calpain-8 [EC:3.4.22.-]
K08578 CAPN9; calpain-9 [EC:3.4.22.-]
K08579 CAPN10; calpain-10 [EC:3.4.22.-]
K08580 CAPN11; calpain-11 [EC:3.4.22.-]
K08581 CAPN13; calpain-13 [EC:3.4.22.-]
K08582 CAPN15; calpain-15 [EC:3.4.22.-]
K08585 CAPNN; calpain, invertebrate [EC:3.4.22.-]
K08586 tpr; thiol protease [EC:3.4.22.-]
K08599 yopT; YopT peptidase [EC:3.4.22.-]
K08658 RCE1, FACE2; prenyl protein peptidase [EC:3.4.22.-]
K09599 CTSP; cathepsin P [EC:3.4.22.-]
K09600 CTSM; cathepsin M [EC:3.4.22.-]
K09601 CTSR; cathepsin R [EC:3.4.22.-]
K11863 ATXN3, MJD; Ataxin-3 [EC:3.4.22.-]
K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
K13439 avrRpt2; cysteine protease avirulence protein AvrRpt2 [EC:3.4.22.-]
K13440 avrPphB; cysteine protease avirulence protein AvrPphB [EC:3.4.22.-]
K13442 CAPN14; calpain-14 [EC:3.4.22.-]
K13537 CPB; cysteine peptidase B [EC:3.4.22.-]
K13538 CPA; cysteine peptidase A [EC:3.4.22.-]
K13715 sspB; staphopain B [EC:3.4.22.-]
K16290 XCP; xylem cysteine proteinase [EC:3.4.22.-]
K16292 CEP, CYSEP; KDEL-tailed cysteine endopeptidase [EC:3.4.22.-]
K18015 elaD, sseL; deubiquitinase [EC:3.4.22.-]
K20008 DCP1; death caspase-1 [EC:3.4.22.-]
K20009 DRONC; caspase Dronc [EC:3.4.22.-]
K20010 STRICA; Ser/Thr-rich caspase [EC:3.4.22.-]
K21075 UL36, UL48; Herpesviridae large tegument protein deneddylase [EC:3.4.19.12 3.4.22.-]
K21077 1a-1b; Beet yellows virus replicase polyprotein 1ab [EC:2.1.1.- 2.7.7.48 3.4.22.- 3.6.4.13]
K22684 MCA1; metacaspase-1 [EC:3.4.22.-]
K23008 USPL1; SUMO-specific isopeptidase USPL1 [EC:3.4.22.-]
K23832 ipaJ; cysteine protease IpaJ [EC:3.4.22.-]
K24378 CTSQ; cathepsin Q [EC:3.4.22.-]
K24379 CTS8; cathepsin 8 [EC:3.4.22.-]
K24447 artA; archaeosortase A [EC:3.4.22.-]
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3.4.23 Aspartic endopeptidases
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3.4.24 Metalloendopeptidases
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3.4.25 Threonine endopeptidases
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3.4.- Acting on peptide bonds (peptidases)
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3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
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3.6 Acting on acid anhydrides
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3.7 Acting on carbon-carbon bonds
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3.8 Acting on halide bonds
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3.9 Acting on phosphorus-nitrogen bonds
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3.10 Acting on sulfur-nitrogen bonds
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3.11 Acting on carbon-phosphorus bonds
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3.12 Acting on sulfur-sulfur bonds
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3.13 Acting on carbon-sulfur bonds
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3.-
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4. Lyases
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5. Isomerases
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6. Ligases
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7. Translocases
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Enzymes