 1. Oxidoreductases
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2. Transferases
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3. Hydrolases
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 4. Lyases
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4.1 Carbon-carbon lyases
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4.1.1 Carboxy-lyases
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4.1.2 Aldehyde-lyases
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 4.1.2.2 ketotetrose-phosphate aldolase
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4.1.2.4 deoxyribose-phosphate aldolase
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4.1.2.5 L-threonine aldolase
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4.1.2.8 indole-3-glycerol-phosphate lyase
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4.1.2.9 phosphoketolase
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4.1.2.10 (R)-mandelonitrile lyase
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4.1.2.11 hydroxymandelonitrile lyase
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4.1.2.12 2-dehydropantoate aldolase
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4.1.2.13 fructose-bisphosphate aldolase
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4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
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4.1.2.17 L-fuculose-phosphate aldolase
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4.1.2.18 2-dehydro-3-deoxy-L-pentonate aldolase
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4.1.2.19 rhamnulose-1-phosphate aldolase
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4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
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4.1.2.21 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
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4.1.2.22 fructose-6-phosphate phosphoketolase
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4.1.2.23 3-deoxy-D-manno-octulosonate aldolase
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4.1.2.24 dimethylaniline-N-oxide aldolase
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4.1.2.25 dihydroneopterin aldolase
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4.1.2.26 phenylserine aldolase
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4.1.2.27 sphinganine-1-phosphate aldolase
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4.1.2.28 2-dehydro-3-deoxy-D-pentonate aldolase
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4.1.2.29 5-dehydro-2-deoxyphosphogluconate aldolase
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4.1.2.32 trimethylamine-oxide aldolase
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4.1.2.33 fucosterol-epoxide lyase
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4.1.2.34 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
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4.1.2.35 propioin synthase
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4.1.2.36 lactate aldolase
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4.1.2.38 benzoin aldolase
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4.1.2.40 tagatose-bisphosphate aldolase
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4.1.2.42 D-threonine aldolase
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4.1.2.43 3-hexulose-6-phosphate synthase
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K08093 hxlA; 3-hexulose-6-phosphate synthase [EC:4.1.2.43]
K13812 fae-hps; bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]
K13831 hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
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4.1.2.44 2,3-epoxybenzoyl-CoA dihydrolase
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4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
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4.1.2.46 aliphatic (R)-hydroxynitrile lyase
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4.1.2.47 (S)-hydroxynitrile lyase
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4.1.2.48 low-specificity L-threonine aldolase
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4.1.2.49 L-allo-threonine aldolase
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4.1.2.50 6-carboxytetrahydropterin synthase
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4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
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4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
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4.1.2.53 2-keto-3-deoxy-L-rhamnonate aldolase
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4.1.2.54 L-threo-3-deoxy-hexylosonate aldolase
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4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
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4.1.2.56 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase
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4.1.2.57 sulfofructosephosphate aldolase
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4.1.2.58 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase
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4.1.2.59 dihydroneopterin phosphate aldolase
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4.1.2.60 dihydroneopterin triphosphate aldolase
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4.1.2.61 feruloyl-CoA hydratase/lyase
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4.1.2.62 5-deoxyribulose 1-phosphate aldolase
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4.1.2.63 2-hydroxyacyl-CoA lyase
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4.1.2.64 2-dehydro-3-deoxy-L-fuconate aldolase
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4.1.2.65 ferulate hydratase/lyase
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4.1.2.66 4-coumarate hydratase/lyase
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4.1.3 Oxo-acid-lyases
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4.1.99 Other carbon-carbon lyases
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4.2 Carbon-oxygen lyases
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4.3 Carbon-nitrogen lyases
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4.4 Carbon-sulfur lyases
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4.5 Carbon-halide lyases
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4.6 Phosphorus-oxygen lyases
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4.7 carbon-phosphorus lyases
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4.8 Nitrogen-oxygen lyases
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4.98 ATP-independent chelatases
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4.99 Other lyases
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5. Isomerases
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5.1 Racemases and epimerases
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5.2 cis-trans-Isomerases
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5.3 Intramolecular oxidoreductases
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5.3.1 Interconverting aldoses and ketoses, and related compounds
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5.3.1.1 triose-phosphate isomerase
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5.3.1.3 D-arabinose isomerase
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5.3.1.4 L-arabinose isomerase
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5.3.1.5 xylose isomerase
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5.3.1.6 ribose-5-phosphate isomerase
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5.3.1.7 mannose isomerase
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5.3.1.8 mannose-6-phosphate isomerase
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5.3.1.9 glucose-6-phosphate isomerase
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5.3.1.12 glucuronate isomerase
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5.3.1.13 arabinose-5-phosphate isomerase
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5.3.1.14 L-rhamnose isomerase
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5.3.1.15 D-lyxose ketol-isomerase
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5.3.1.16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
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5.3.1.17 5-dehydro-4-deoxy-D-glucuronate isomerase
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5.3.1.20 ribose isomerase
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5.3.1.21 corticosteroid side-chain-isomerase
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5.3.1.22 hydroxypyruvate isomerase
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5.3.1.23 S-methyl-5-thioribose-1-phosphate isomerase
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5.3.1.24 phosphoribosylanthranilate isomerase
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5.3.1.25 L-fucose isomerase
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5.3.1.26 galactose-6-phosphate isomerase
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5.3.1.27 6-phospho-3-hexuloisomerase
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K08094 hxlB; 6-phospho-3-hexuloisomerase [EC:5.3.1.27]
K13831 hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
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5.3.1.28 D-sedoheptulose-7-phosphate isomerase
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5.3.1.29 ribose-1,5-bisphosphate isomerase
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5.3.1.30 5-deoxy-glucuronate isomerase
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5.3.1.31 sulfoquinovose isomerase
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5.3.1.32 (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase
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5.3.1.33 L-erythrulose-1-phosphate isomerase
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5.3.1.34 D-erythrulose 4-phosphate isomerase
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5.3.1.35 2-dehydrotetronate isomerase
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5.3.1.36 D-apiose isomerase
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5.3.1.37 4-deoxy-4-sulfo-D-erythrose isomerase
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5.3.2 Interconverting keto- and enol-groups
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5.3.3 Transposing C=C bonds
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5.3.4 Transposing S-S bonds
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5.3.99 Other intramolecular oxidoreductases
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5.4 Intramolecular transferases
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5.5 Intramolecular lyases
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5.6 Isomerases altering macromolecular conformation
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5.99 Other isomerases
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6. Ligases
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7. Translocases
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Enzymes