 1. Oxidoreductases
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 2. Transferases
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2.1 Transferring one-carbon groups
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2.2 Transferring aldehyde or ketonic groups
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2.3 Acyltransferases
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2.3.1 Transferring groups other than aminoacyl groups
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2.3.2 Aminoacyltransferases
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 2.3.2.1 D-glutamyltransferase
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2.3.2.2 gamma-glutamyltransferase
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2.3.2.3 lysyltransferase
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2.3.2.5 glutaminyl-peptide cyclotransferase
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2.3.2.6 lysine/arginine leucyltransferase
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2.3.2.7 aspartyltransferase
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2.3.2.8 arginyltransferase
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2.3.2.9 agaritine gamma-glutamyltransferase
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2.3.2.10 UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase
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2.3.2.11 alanylphosphatidylglycerol synthase
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2.3.2.12 peptidyltransferase
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2.3.2.13 protein-glutamine gamma-glutamyltransferase
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2.3.2.14 D-alanine gamma-glutamyltransferase
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2.3.2.15 glutathione gamma-glutamylcysteinyltransferase
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2.3.2.16 lipid II:glycine glycyltransferase
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2.3.2.17 N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
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2.3.2.18 N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
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2.3.2.19 ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
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2.3.2.20 cyclo(L-leucyl-L-phenylalanyl) synthase
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2.3.2.21 cyclo(L-tyrosyl-L-tyrosyl) synthase
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2.3.2.22 cyclo(L-leucyl-L-leucyl) synthase
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2.3.2.23 E2 ubiquitin-conjugating enzyme
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2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme
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2.3.2.25 N-terminal E2 ubiquitin-conjugating enzyme
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2.3.2.26 HECT-type E3 ubiquitin transferase
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2.3.2.27 RING-type E3 ubiquitin transferase
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K01931 NEUR; protein neuralized [EC:2.3.2.27]
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K07963 TRIM23, ARFD1; tripartite motif-containing protein 23 [EC:2.3.2.27]
K08285 TRIM18, MID1; midline 1 [EC:2.3.2.27]
K08742 SIAH2; E3 ubiquitin-protein ligase SIAH2 [EC:2.3.2.27]
K08881 TRIM24, TIF1A; tripartite motif-containing protein 24 [EC:2.3.2.27]
K08882 TRIM28, TIF1B; tripartite motif-containing protein 28 [EC:2.3.2.27]
K08883 TRIM33, TIF1G; tripartite motif-containing protein 33 [EC:2.3.2.27]
K09561 STUB1, CHIP; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
K10143 RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K10144 RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K10596 UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]
K10597 UBE4B, UFD2; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
K10599 PRPF19, PRP19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
K10601 SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
K10602 NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27]
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K10606 FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
K10607 TRIM32, HT2A; tripartite motif-containing protein 32 [EC:2.3.2.27]
K10608 TRIM37, MUL; tripartite motif-containing protein 37 [EC:2.3.2.27]
K10624 RBBP6; E3 ubiquitin-protein ligase RBBP6 [EC:2.3.2.27]
K10625 UBR1; E3 ubiquitin-protein ligase UBR1 [EC:2.3.2.27]
K10626 UBR2; E3 ubiquitin-protein ligase UBR2 [EC:2.3.2.27]
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]
K10629 RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]
K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
K10633 PJA1; E3 ubiquitin-protein ligase Praja1 [EC:2.3.2.27]
K10634 PJA2; E3 ubiquitin-protein ligase Praja2 [EC:2.3.2.27]
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]
K10637 MYLIP, MIR; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]
K10638 UHRF1, NP95; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
K10639 CCNB1IP1, HEI10; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
K10640 RNF25, AO7; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
K10642 DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27]
K10643 CNOT4, NOT4, MOT2; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
K10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K10646 TRAF7, RFWD1; E3 ubiquitin-protein ligase TRAF7 [EC:2.3.2.27]
K10647 TRIM1, MID2; midline 2 [EC:2.3.2.27]
K10648 TRIM5; tripartite motif-containing protein 5 [EC:2.3.2.27]
K10650 TRIM11; tripartite motif-containing protein 11 [EC:2.3.2.27]
K10651 TRIM21, SSA1; tripartite motif-containing protein 21 [EC:2.3.2.27]
K10652 TRIM25, EFP; tripartite motif-containing protein 25 [EC:2.3.2.27]
K10655 TRIM63, MURF1; tripartite motif-containing protein 63 [EC:2.3.2.27]
K10656 MARCH1_8; E3 ubiquitin-protein ligase MARCH1/8 [EC:2.3.2.27]
K10657 MARCH2_3; E3 ubiquitin-protein ligase MARCH2/3 [EC:2.3.2.27]
K10659 MARCH4_9_11; E3 ubiquitin-protein ligase MARCH4/9/11 [EC:2.3.2.27]
K10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]
K10661 MARCH6, DOA10; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
K10662 MARCH7, AXOT; E3 ubiquitin-protein ligase MARCH7 [EC:2.3.2.27]
K10663 ATL4; E3 ubiquitin-protein ligase ATL4 [EC:2.3.2.27]
K10664 ATL6S; E3 ubiquitin-protein ligase ATL6/9/15/31/42/55 [EC:2.3.2.27]
K10665 MARCH10; E3 ubiquitin-protein ligase MARCH10 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]
K10691 UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]
K10692 LNX1_2; ligand of Numb protein X 1/2 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
K11964 PELI; pellino [EC:2.3.2.27]
K11978 UBR3; E3 ubiquitin-protein ligase UBR3 [EC:2.3.2.27]
K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
K11981 RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K11983 RNF182; E3 ubiquitin-protein ligase RNF182 [EC:2.3.2.27]
K11985 TRAIP, TRIP; TRAF-interacting protein [EC:2.3.2.27]
K11998 TRIM4; tripartite motif-containing protein 4 [EC:2.3.2.27]
K12001 TRIM8; tripartite motif-containing protein 8 [EC:2.3.2.27]
K12003 TRIM13; tripartite motif-containing protein 13 [EC:2.3.2.27]
K12007 TRIM17; tripartite motif-containing protein 17 [EC:2.3.2.27]
K12009 TRIM27, RFP; tripartite motif-containing protein 27 [EC:2.3.2.27]
K12011 TRIM31; tripartite motif-containing protein 31 [EC:2.3.2.27]
K12013 TRIM36; tripartite motif-containing protein 36 [EC:2.3.2.27]
K12014 TRIM38; tripartite motif-containing protein 38 [EC:2.3.2.27]
K12015 TRIM39; tripartite motif-containing protein 39 [EC:2.3.2.27]
K12017 TRIM41; tripartite motif-containing protein 41 [EC:2.3.2.27]
K12026 TRIM56; tripartite motif-containing protein 56 [EC:2.3.2.27]
K12027 TRIM58; tripartite motif-containing protein 58 [EC:2.3.2.27]
K12030 TRIM62; tripartite motif-containing protein 62 [EC:2.3.2.27]
K12033 TRIM68; tripartite motif-containing protein 68 [EC:2.3.2.27]
K12034 TRIM69; tripartite motif-containing protein 69 [EC:2.3.2.27]
K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]
K12169 KPC1, RNF123; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27]
K12171 SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K15682 PDZRN3_4, LNX3_4; ligand of Numb protein X 3/4 [EC:2.3.2.27]
K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
K15686 MEX3, RKHD; RNA-binding protein MEX3 [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]
K15689 NEURL3, LINCR; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]
K15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]
K15692 RNF13, RZF; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]
K15693 RNF26; E3 ubiquitin-protein ligase RNF26 [EC:2.3.2.27]
K15694 RNF43; E3 ubiquitin-protein ligase RNF43 [EC:2.3.2.27]
K15695 RNF103, KF1; E3 ubiquitin-protein ligase RNF103 [EC:2.3.2.27]
K15697 RNF114; E3 ubiquitin-protein ligase RNF114 [EC:2.3.2.27]
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
K15701 RNF130, GOLIATH; E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27]
K15702 RNF133; E3 ubiquitin-protein ligase RNF133 [EC:2.3.2.27]
K15703 RNF139, TRC8; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]
K15704 RNF149; E3 ubiquitin-protein ligase RNF149 [EC:2.3.2.27]
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]
K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27]
K15707 RNF170; E3 ubiquitin-protein ligase RNF170 [EC:2.3.2.27]
K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
K15709 RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27]
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
K15711 SMARCA3, HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
K15712 TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27]
K15713 UHRF2, NIRF; E3 ubiquitin-protein ligase UHRF2 [EC:2.3.2.27]
K15714 ZNF645; E3 ubiquitin-protein ligase ZNF645 [EC:2.3.2.27]
K15715 ZNRF4; E3 ubiquitin-protein ligase ZNRF4 [EC:2.3.2.27]
K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]
K16065 PIAS4; E3 SUMO-protein ligase PIAS4 [EC:2.3.2.27]
K16271 RLIM, RNF12; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27]
K16272 RNF135; E3 ubiquitin-protein ligase RNF135 [EC:2.3.2.27]
K16273 ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27]
K16274 AIP2; E3 ubiquitin-protein ligase AIP2 [EC:2.3.2.27]
K16275 BAH, NLA; E3 ubiquitin-protein ligase BAH [EC:2.3.2.27]
K16277 DRIP; E3 ubiquitin-protein ligase DRIP [EC:2.3.2.27]
K16278 HOS1; E3 ubiquitin-protein ligase HOS1 [EC:2.3.2.27]
K16279 KEG; E3 ubiquitin-protein ligase KEG [EC:2.7.11.1 2.3.2.27]
K16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]
K16282 RHA2; E3 ubiquitin-protein ligase RHA2 [EC:2.3.2.27]
K16283 SDIR1; E3 ubiquitin-protein ligase SDIR1 [EC:2.3.2.27]
K16284 SIS3; E3 ubiquitin-protein ligase SIS3 [EC:2.3.2.27]
K16285 XERICO; RING/U-box domain-containing protein [EC:2.3.2.27]
K16286 EL5; E3 ubiquitin-protein ligase EL5 [EC:2.3.2.27]
K17044 RNF166; E3 ubiquitin-protein ligase RNF166 [EC:2.3.2.27]
K17821 RNF165; E3 ubiquitin-protein ligase RNF165 [EC:2.3.2.27]
K19037 ATL23; E3 ubiquitin-protein ligase ATL23 [EC:2.3.2.27]
K19038 ATL41; E3 ubiquitin-protein ligase ATL41 [EC:2.3.2.27]
K19039 ATL7_58_59; E3 ubiquitin-protein ligase ATL7/58/59 [EC:2.3.2.27]
K19040 ATL76S; E3 ubiquitin-protein ligase ATL10/75/76/77/78 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K19042 BOI; E3 ubiquitin-protein ligase BOI and related proteins [EC:2.3.2.27]
K19043 RHF; E3 ubiquitin-protein ligase RHF [EC:2.3.2.27]
K19044 XBAT32_33; E3 ubiquitin-protein ligase XBAT32/33 [EC:2.3.2.27]
K19045 BB; E3 ubiquitin-protein ligase BIG BROTHER and related proteins [EC:2.3.2.27]
K21504 IAP3; Baculoviridae E3 ubiquitin-protein ligase [EC:2.3.2.27]
K21920 KCTD11; BTB/POZ domain-containing protein KCTD11 [EC:2.3.2.27]
K22155 JADE2; E3 ubiquitin-protein ligase Jade-2 [EC:2.3.2.27]
K22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]
K22376 KCMF1, FIGC; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]
K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
K22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]
K22379 RNFT1; E3 ubiquitin-protein ligase RNFT1 [EC:2.3.2.27]
K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]
K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
K22401 E4F1; transcription factor E4F1 / E3 ubiquitin-protein ligase [EC:2.3.2.27]
K22517 CBLB; E3 ubiquitin-protein ligase CBL-B [EC:2.3.2.27]
K22518 CBLC; E3 ubiquitin-protein ligase CBL-C [EC:2.3.2.27]
K22645 SLX5; E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 [EC:2.3.2.27]
K22646 SLX8; E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 [EC:2.3.2.27]
K22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]
K22753 RNF6; E3 ubiquitin-protein ligase RNF6 [EC:2.3.2.27]
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]
K22817 NSMCE1, NSE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]
K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
K23787 DMA1_2; E3 ubiquitin-protein ligase DMA1/2 [EC:2.3.2.27]
K23788 TUL1, FLY1_2; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
K23789 RNF145; E3 ubiquitin-protein ligase RNF145 [EC:2.3.2.27]
K23828 ipaH1.4_2.5; E3 ubiquitin-protein ligase IpaH1.4/2.5 [EC:2.3.2.27]
K23830 ipaH4.5; E3 ubiquitin-protein ligase IpaH4.5 [EC:2.3.2.27]
K23831 ipaH0722; E3 ubiquitin-protein ligase IpaH0722 [EC:2.3.2.27]
K23834 ipaH7.8; E3 ubiquitin-protein ligase IpaH7.8 [EC:2.3.2.27]
K23946 slrP; E3 ubiquitin-protein ligase SlrP [EC:2.3.2.27]
K24091 OBI1; ORC ubiquitin ligase 1 [EC:2.3.2.27]
K25173 RNF112; E3 ubiquitin-protein ligase RNF112 [EC:2.3.2.27]
K25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]
K25175 ZFP91; E3 ubiquitin-protein ligase ZFP91 [EC:2.3.2.27]
K25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]
K25214 RNF186; E3 ubiquitin-protein ligase RNF186 [EC:2.3.2.27]
K25840 AIRP2; E3 ubiquitin-protein ligase AIRP2 [EC:2.3.2.27]
K26452 IE2; Alphabaculovirus E3 ubiquitin-protein ligase IE2 [EC:2.3.2.27]
K26506 p28; Orthopoxvirus E3 ubiquitin-protein ligase p28 [EC:2.3.2.27]
K26509 ORF63; Equid alphaherpesvirus E3 ubiquitin-protein ligase ICP0 [EC:2.3.2.27]
K26516 LAP; Leporipoxvirus E3 ubiquitin-protein ligase LAP [EC:2.3.2.27]
K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
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2.3.2.28 L-allo-isoleucyltransferase
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2.3.2.29 aspartate/glutamate leucyltransferase
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2.3.2.30 L-ornithine Nalpha-acyltransferase
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2.3.2.31 RBR-type E3 ubiquitin transferase
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2.3.2.32 cullin-RING-type E3 NEDD8 transferase
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2.3.2.33 RCR-type E3 ubiquitin transferase
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2.3.2.34 E2 NEDD8-conjugating enzyme
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2.3.2.35 capsaicin synthase
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2.3.2.36 RING-type E3 ubiquitin transferase (cysteine targeting)
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2.3.2.37 ergosteryl-3beta-O-L-aspartate synthase
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2.3.3 Acyl groups converted into alkyl groups on transfer
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2.4 Glycosyltransferases
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2.5 Transferring alkyl or aryl groups, other than methyl groups
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2.6 Transferring nitrogenous groups
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2.7 Transferring phosphorus-containing groups
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2.8 Transferring sulfur-containing groups
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2.9 Transferring selenium-containing groups
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2.10 Transferring molybdenum- or tungsten-containing groups
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3. Hydrolases
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4. Lyases
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5. Isomerases
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6. Ligases
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7. Translocases
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Enzymes