 1. Oxidoreductases
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2. Transferases
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 3. Hydrolases
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3.1 Acting on ester bonds
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3.2 Glycosylases
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3.3 Acting on ether bonds
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3.4 Acting on peptide bonds (peptidases)
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3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
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3.6 Acting on acid anhydrides
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3.6.1 In phosphorus-containing anhydrides
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3.6.1.1 inorganic diphosphatase
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 3.6.1.2 trimetaphosphatase
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3.6.1.5 apyrase
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3.6.1.6 nucleoside diphosphate phosphatase
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3.6.1.7 acylphosphatase
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3.6.1.8 ATP diphosphatase
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3.6.1.9 nucleotide diphosphatase
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3.6.1.10 endopolyphosphatase
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3.6.1.11 exopolyphosphatase
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3.6.1.12 dCTP diphosphatase
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3.6.1.13 ADP-ribose diphosphatase
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K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-]
K01517 ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.13 3.6.1.16 3.6.1.53]
K04977 TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]
K13987 NUDT5; ADP-ribose diphosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase [EC:3.6.1.13 3.6.1.58 2.7.7.96]
K13988 NUDT9; ADP-ribose diphosphatase [EC:3.6.1.13]
K18453 NUDT23; ADP-ribose/FAD diphosphatase [EC:3.6.1.13 3.6.1.18]
K26448 ORF38; Alphabaculovirus/Betabaculovirus ADP-ribose diphosphatase [EC:3.6.1.13]
K26956 NUDT2_6_7_10; ADP-ribose/NAD+ diphosphatase [EC:3.6.1.13 3.6.1.22]
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3.6.1.14 adenosine-tetraphosphatase
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3.6.1.15 nucleoside-triphosphate phosphatase
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3.6.1.16 CDP-glycerol diphosphatase
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3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
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3.6.1.18 FAD diphosphatase
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K18453 NUDT23; ADP-ribose/FAD diphosphatase [EC:3.6.1.13 3.6.1.18]
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3.6.1.20 5'-acylphosphoadenosine hydrolase
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3.6.1.21 ADP-sugar diphosphatase
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3.6.1.22 NAD+ diphosphatase
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3.6.1.23 dUTP diphosphatase
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3.6.1.24 nucleoside phosphoacylhydrolase
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3.6.1.25 triphosphatase
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3.6.1.26 CDP-diacylglycerol diphosphatase
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3.6.1.27 undecaprenyl-diphosphate phosphatase
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3.6.1.28 thiamine-triphosphatase
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3.6.1.29 bis(5'-adenosyl)-triphosphatase
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3.6.1.31 phosphoribosyl-ATP diphosphatase
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3.6.1.39 thymidine-triphosphatase
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3.6.1.40 guanosine-5'-triphosphate,3'-diphosphate phosphatase
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3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
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3.6.1.42 guanosine-diphosphatase
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3.6.1.43 dolichyldiphosphatase
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3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase
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3.6.1.45 UDP-sugar diphosphatase
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3.6.1.52 diphosphoinositol-polyphosphate diphosphatase
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3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
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3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase
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3.6.1.55 8-oxo-dGTP diphosphatase
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3.6.1.56 2-hydroxy-dATP diphosphatase
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3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase
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3.6.1.58 8-oxo-dGDP phosphatase
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3.6.1.59 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase
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3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)
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3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)
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3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase
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3.6.1.63 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
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3.6.1.64 inosine diphosphate phosphatase
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3.6.1.65 (d)CTP diphosphatase
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3.6.1.66 XTP/dITP diphosphatase
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3.6.1.67 dihydroneopterin triphosphate diphosphatase
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3.6.1.68 geranyl diphosphate phosphohydrolase
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3.6.1.69 8-oxo-(d)GTP phosphatase
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3.6.1.70 guanosine-5'-diphospho-5'-[DNA] diphosphatase
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3.6.1.71 adenosine-5'-diphospho-5'-[DNA] diphosphatase
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3.6.1.72 DNA-3'-diphospho-5'-guanosine diphosphatase
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3.6.1.73 inosine/xanthosine triphosphatase
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3.6.1.74 mRNA 5'-phosphatase
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3.6.1.75 diacylglycerol diphosphate phosphatase
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3.6.1.76 prenyl-diphosphate phosphatase
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3.6.1.77 coenzyme A diphosphatase
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3.6.2 In sulfonyl-containing anhydrides
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3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
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3.6.5 Acting on GTP to facilitate cellular and subcellular movement
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3.7 Acting on carbon-carbon bonds
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3.8 Acting on halide bonds
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3.9 Acting on phosphorus-nitrogen bonds
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3.10 Acting on sulfur-nitrogen bonds
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3.11 Acting on carbon-phosphorus bonds
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3.12 Acting on sulfur-sulfur bonds
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3.13 Acting on carbon-sulfur bonds
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4. Lyases
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5. Isomerases
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6. Ligases
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7. Translocases
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Enzymes