Peptidases and Inhibitors

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1st Level  2nd Level  3rd Level 

 Aspartic peptidases
 Cysteine peptidases
   Family C1: papain family
   Family C2: calpain family
   Family C10: streptopain family
   Family C11: clostripain family
   Family C12: ubiquitin C-terminal hydrolase family
   Family C13: legumain family
   Family C14: caspase family
     K01370  CASP1; caspase 1 [EC:]
     K02186  CASP2; caspase 2 [EC:]
     K02187  CASP3; caspase 3 [EC:]
     K04394  CASP4, CASP11; caspase 4 [EC:]
     K04395  CASP5; caspase 5 [EC:]
     K04396  CASP6; caspase 6 [EC:]
     K04397  CASP7; caspase 7 [EC:]
     K04398  CASP8; caspase 8 [EC:]
     K04399  CASP9; caspase 9 [EC:]
     K04400  CASP10; caspase 10 [EC:]
     K04741  CASP12; caspase 12 [EC:3.4.22.-]
     K04401  CASP14; caspase 14 [EC:3.4.22.-]
     K13521  CASP15; caspase 15
     K20106  CED-3; cell death protein 3
     K20008  DCP1; death caspase-1 [EC:3.4.22.-]
     K20009  DRONC; caspase Dronc [EC:3.4.22.-]
     K20010  STRICA; Ser/Thr-rich caspase [EC:3.4.22.-]
     K04489  CASP3A; caspase 3A [EC:3.4.22.-]
     K07369  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
     K22684  MCA1; metacaspase-1 [EC:3.4.22.-]
     K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
   Family C15: pyroglutamyl peptidase I family
   Family C19: ubiquitin-specific protease family
   Family C25: gingipain family
   Family C26: gamma-glutamyl hydrolase family
   Family C40
   Family C44
   Family C45
   Family C46: hedgehog family
   Family C47: staphopain family
   Family C48: Ulp1 endopeptidase family
   Family C50: separase family
   Family C54: Aut2 peptidase family
   Family C55: YopJ protease family
   Family C56: PfpI endopeptidase family
   Family C58
   Family C59
   Family C60
   Family C64
   Family C65
   Family C67
   Family C69
   Family C70
   Family C75
   Family C78
   Family C79
   Family C82
   Family C85
   Family C86
   Family C88
   Family C89
   Family C97
   Family C98
   Family C110
 Glutamic peptidases
 Metallo peptidases
 Mixed peptidases
 Serine peptidases
 Threonine peptidases
 Peptidases of unknown catalytic type
 Peptidase inhibitors

Last updated: January 14, 2021
Classification taken and modified from MEROPS