Ubiquitin System

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 Ubiquitins and ubiquitin-like proteins
 
 Ubiquitin-activating enzymes (E1)
 
 Ubiquitin-conjugating enzymes (E2)
 
 Ubiquitin ligases (E3)
   HECT type E3
   U-box type E3
   Single Ring-finger type E3
     BRE1 proteins
     CBL proteins
     SINA (Seven in absentia) proteins
     Ligand of Numb proteins
     March proteins
     MDM2/MDM4 proteins
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K10127  MDM4, MDMX; protein Mdm4
     NFX1 proteins
     Pellino proteins
     Peripheral membrane proteins
     RBR proteins
     TRAF proteins
     TRIM/RBCC proteins
     UBR box proteins
     ATL proteins
     Other single Ring-finger type E3
   Atypical E3
   UBL E3 ligases
   Multi subunit Ring-finger type E3
 
 Deubiquitinating enzyme (DUB)

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Last updated: April 5, 2024