KEGG Orthology (KO) - Loxodonta africana (African savanna elephant)

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     KO
 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
   09151 Immune system
 
   09152 Endocrine system
     04911 Insulin secretion [PATH:lav04911]
     04910 Insulin signaling pathway [PATH:lav04910]
     04922 Glucagon signaling pathway [PATH:lav04922]
     04923 Regulation of lipolysis in adipocytes [PATH:lav04923]
       100660279 TSHB; thyrotropin subunit beta
       100673911 CGA; glycoprotein hormones alpha chain
       100659046 TSHR; thyrotropin receptor isoform X1
       100654973 ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor
       100664615 ADRB2; beta-2 adrenergic receptor
       100674524 ADRB3; beta-3 adrenergic receptor
       100655206 guanine nucleotide-binding protein G(s) subunit alpha isoform X1
       100669226 neuroendocrine secretory protein 55-like
       100671072 ADCY1; adenylate cyclase type 1
       100673570 ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2
       100674724 ADCY3; adenylate cyclase type 3
       100675525 ADCY4; adenylate cyclase type 4
       100670244 ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5
       100653532 ADCY6; adenylate cyclase type 6 isoform X1
       100653771 ADCY7; adenylate cyclase type 7 isoform X1
       100661616 ADCY8; adenylate cyclase type 8
       100663448 ADCY9; LOW QUALITY PROTEIN: adenylate cyclase type 9
       100656966 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1
       100674245 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha
       100660875 NPPA; natriuretic peptides A
       100671961 NPR1; atrial natriuretic peptide receptor 1
       100662471 PRKG1; cGMP-dependent protein kinase 1 isoform X1
       100657163 PRKG2; cGMP-dependent protein kinase 2
       100675020 PLIN1; LOW QUALITY PROTEIN: perilipin-1
       100670874 LIPE; hormone-sensitive lipase
       100657987 PNPLA2; patatin-like phospholipase domain-containing protein 2
       100664173 ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
       100671842 MGLL; monoglyceride lipase isoform X1
       100660274 FABP4; fatty acid-binding protein, adipocyte
       100659041 FABP9; fatty acid-binding protein 9
       100676974 AQP7; aquaporin-7
       100661112 INS; insulin
       100668116 INSR; LOW QUALITY PROTEIN: insulin receptor
       100664968 IRS1; insulin receptor substrate 1
       100676904 IRS2; insulin receptor substrate 2 isoform X3
       100660353 LOW QUALITY PROTEIN: insulin receptor substrate 1-like
       100667324 IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4
       100657948 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
       100658340 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
       100666266 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
       100653731 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
       100665045 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta
       100675496 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma
       100663184 AKT2; RAC-beta serine/threonine-protein kinase isoform X1
       100657536 AKT3; RAC-gamma serine/threonine-protein kinase isoform X2
       100660187 AKT1; RAC-alpha serine/threonine-protein kinase
       100660871 PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B
       100666679 HRAS-like suppressor 3 isoform X1
       100667251 HRAS-like suppressor 3
       100653633 PTGS1; prostaglandin G/H synthase 1 isoform X1
       100666359 PTGS2; prostaglandin G/H synthase 2
       100676506 ADORA1; adenosine receptor A1 isoform X1
       100675292 PTGER3; prostaglandin E2 receptor EP3 subtype
       100658837 NPY; pro-neuropeptide Y
       100668572 NPY1R; neuropeptide Y receptor type 1
       100666344 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1
       100670234 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2
       100667957 GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha
K05251 TSHB; thyrotropin subunit beta
K08522 CGA; glycoprotein hormones alpha chain
K04249 TSHR; thyrotropin receptor
K04141 ADRB1; adrenergic receptor beta-1
K04142 ADRB2; adrenergic receptor beta-2
K04143 ADRB3; adrenergic receptor beta-3
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K12334 NPPA; natriuretic peptide A
K12323 ANPRA; atrial natriuretic peptide receptor A [EC:4.6.1.2]
K07376 PRKG1; cGMP-dependent protein kinase 1 [EC:2.7.11.12]
K19477 PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12]
K08768 PLIN1; perilipin-1
K07188 LIPE; hormone-sensitive lipase [EC:3.1.1.79]
K16816 PNPLA2; patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]
K13699 ABHD5; abhydrolase domain-containing protein 5 [EC:2.3.1.51]
K01054 MGLL; acylglycerol lipase [EC:3.1.1.23]
K08753 FABP4; fatty acid-binding protein 4, adipocyte
K08753 FABP4; fatty acid-binding protein 4, adipocyte
K08771 AQP7; aquaporin-7
K04526 INS; insulin
K04527 INSR; insulin receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17445 IRS3; insulin receptor substrate 3
K17446 IRS4; insulin receptor substrate 4
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K13296 PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17]
K16817 PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
K16817 PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
K00509 PTGS1; prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K04265 ADORA1; adenosine receptor A1
K04260 PTGER3; prostaglandin E receptor 3
K05232 NPY; neuropeptide Y
K04204 NPY1R; neuropeptide Y receptor type 1
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
     04920 Adipocytokine signaling pathway [PATH:lav04920]
     03320 PPAR signaling pathway [PATH:lav03320]
       100666060 CD36; platelet glycoprotein 4
       100654297 SLC27A4; long-chain fatty acid transport protein 4 isoform X2
       100675017 SLC27A1; long-chain fatty acid transport protein 1
       100660142 SLC27A2; very long-chain acyl-CoA synthetase
       100676206 SLC27A5; LOW QUALITY PROTEIN: bile acyl-CoA synthetase
       100654841 SLC27A6; long-chain fatty acid transport protein 6
       100653694 FABP1; fatty acid-binding protein, liver
       100667307 FABP2; fatty acid-binding protein, intestinal
       100663150 FABP3; fatty acid-binding protein, heart
       100660274 FABP4; fatty acid-binding protein, adipocyte
       100659041 FABP9; fatty acid-binding protein 9
       100659987 FABP5; fatty acid-binding protein, epidermal
       100676285 FABP6; gastrotropin
       100662431 FABP7; fatty acid-binding protein, brain
       100657770 PPARA; peroxisome proliferator-activated receptor alpha isoform X1
       100674208 retinoic acid receptor RXR-alpha-like
       100662699 RXRB; retinoic acid receptor RXR-beta isoform X2
       100653765 RXRG; retinoic acid receptor RXR-gamma
       100666968 PPARD; peroxisome proliferator-activated receptor delta isoform X1
       100654408 PPARG; peroxisome proliferator-activated receptor gamma isoform X1
       100661527 HMGCS1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2
       100675409 APOA1; apolipoprotein A-I
       100672349 APOA2; apolipoprotein A-II
       100675130 APOC3; apolipoprotein C-III
       100674552 APOA5; apolipoprotein A-V
       100665324 PLTP; phospholipid transfer protein isoform X1
       100658351 ME1; NADP-dependent malic enzyme isoform X1
       100674466 ME3; NADP-dependent malic enzyme, mitochondrial
       100677680 fatty acid desaturase 2
       100663795 SCD; acyl-CoA desaturase
       100655279 SCD5; stearoyl-CoA desaturase 5
       100671887 cholesterol 7-alpha-monooxygenase
       100665029 LOW QUALITY PROTEIN: 5-beta-cholestane-3-alpha
       100673961 NR1H3; oxysterols receptor LXR-alpha isoform X1
       100662261 sterol 26-hydroxylase
       100661283 DBI; acyl-CoA-binding protein
       100667686 LPL; lipoprotein lipase
       100670254 ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X4
       100675620 ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X2
       100656393 ACSL5; long-chain-fatty-acid--CoA ligase 5
       100675480 ACSL1; long-chain-fatty-acid--CoA ligase 1
       100657037 ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X3
       100675671 ACSBG1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1
       100658062 ACSBG2; long-chain-fatty-acid--CoA ligase ACSBG2
       100659709 OLR1; oxidized low-density lipoprotein receptor 1
       100677184 EHHADH; peroxisomal bifunctional enzyme
       100667518 ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal
       100666078 LOW QUALITY PROTEIN: non-specific lipid-transfer protein
       100676729 ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1
       100668073 ACOX3; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3
       100655728 ACOX2; peroxisomal acyl-coenzyme A oxidase 2
       100665922 CPT1A; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, liver isoform
       100677247 CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1
       100667001 CPT1C; carnitine O-palmitoyltransferase 1, brain isoform
       100665512 CPT2; carnitine O-palmitoyltransferase 2, mitochondrial
       100657035 ACADL; long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1
       100673289 ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1
       100675527 ANGPTL4; angiopoietin-related protein 4
       100672319 SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1
       100675020 PLIN1; LOW QUALITY PROTEIN: perilipin-1
       100668338 PLIN2; perilipin-2 isoform X1
       100659870 PLIN4; perilipin-4
       100660152 PLIN5; perilipin-5
       100655838 ADIPOQ; adiponectin
       100656422 MMP1; interstitial collagenase
       100656582 UCP1; LOW QUALITY PROTEIN: mitochondrial brown fat uncoupling protein 1
       100666830 ILK; integrin-linked protein kinase isoform X1
       100660030 PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1
       100677220 PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP]
       100676836 PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial
       100657738 GK2; glycerol kinase 2
       100656821 GK; glycerol kinase isoform X6
       100676974 AQP7; aquaporin-7
K06259 CD36; CD36 antigen
K08745 SLC27A1_4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K08745 SLC27A1_4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K08746 SLC27A2; solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.- 6.2.1.3]
K08748 SLC27A5; solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7]
K08749 SLC27A6; solute carrier family 27 (fatty acid transporter), member 6
K08750 FABP1; fatty acid-binding protein 1, liver
K08751 FABP2; fatty acid-binding protein 2, intestinal
K08752 FABP3; fatty acid-binding protein 3, muscle and heart
K08753 FABP4; fatty acid-binding protein 4, adipocyte
K08753 FABP4; fatty acid-binding protein 4, adipocyte
K08754 FABP5; fatty acid-binding protein 5, epidermal
K08755 FABP6; fatty acid-binding protein 6, ileal (gastrotropin)
K08756 FABP7; fatty acid-binding protein 7, brain
K07294 NR1C1; peroxisome proliferator-activated receptor alpha
K08524 RXRA; retinoid X receptor alpha
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K04504 NR1C2; peroxisome proliferator-activated receptor delta
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K01641 E2.3.3.10; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
K08757 APOA1; apolipoprotein A-I
K08758 APOA2; apolipoprotein A-II
K08759 APOC3; apolipoprotein C-III
K09025 APOA5; apolipoprotein A-V
K08761 PLTP; phospholipid transfer protein
K00029 E1.1.1.40; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]
K00029 E1.1.1.40; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]
K10226 FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]
K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]
K00489 CYP7A1; cholesterol 7alpha-monooxygenase [EC:1.14.14.23]
K07431 CYP8B1; sterol 12-alpha-hydroxylase [EC:1.14.14.139]
K08536 NR1H3; liver X receptor alpha
K00488 CYP27A1; cholestanetriol 26-monooxygenase [EC:1.14.15.15]
K08762 DBI; diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein)
K01059 LPL; lipoprotein lipase [EC:3.1.1.34]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K08763 OLR1; oxidised low-density lipoprotein receptor 1
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07513 ACAA1; acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K08764 SCP2; sterol carrier protein 2 [EC:2.3.1.176]
K00232 E1.3.3.6; acyl-CoA oxidase [EC:1.3.3.6]
K00232 E1.3.3.6; acyl-CoA oxidase [EC:1.3.3.6]
K10214 ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]
K08765 CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
K19523 CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21]
K19524 CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
K08766 CPT2; carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]
K00255 ACADL; long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]
K08767 ANGPTL4; angiopoietin-like 4
K06086 SORBS1; sorbin and SH3 domain containing protein 1
K08768 PLIN1; perilipin-1
K17284 PLIN2; perilipin-2
K20254 PLIN4; perilipin-4
K20255 PLIN5; perilipin-5
K07296 ADIPOQ; adiponectin
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K08769 UCP1; solute carrier family 25 (mitochondrial uncoupling protein), member 7
K06272 ILK; integrin-linked kinase [EC:2.7.11.1]
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K00864 glpK; glycerol kinase [EC:2.7.1.30]
K00864 glpK; glycerol kinase [EC:2.7.1.30]
K08771 AQP7; aquaporin-7
     04929 GnRH secretion [PATH:lav04929]
     04912 GnRH signaling pathway [PATH:lav04912]
     04913 Ovarian steroidogenesis [PATH:lav04913]
     04915 Estrogen signaling pathway [PATH:lav04915]
     04914 Progesterone-mediated oocyte maturation [PATH:lav04914]
     04917 Prolactin signaling pathway [PATH:lav04917]
     04921 Oxytocin signaling pathway [PATH:lav04921]
     04926 Relaxin signaling pathway [PATH:lav04926]
     04935 Growth hormone synthesis, secretion and action [PATH:lav04935]
     04918 Thyroid hormone synthesis [PATH:lav04918]
     04919 Thyroid hormone signaling pathway [PATH:lav04919]
     04928 Parathyroid hormone synthesis, secretion and action [PATH:lav04928]
     04916 Melanogenesis [PATH:lav04916]
     04924 Renin secretion [PATH:lav04924]
     04614 Renin-angiotensin system [PATH:lav04614]
     04925 Aldosterone synthesis and secretion [PATH:lav04925]
     04927 Cortisol synthesis and secretion [PATH:lav04927]
 
   09153 Circulatory system
 
   09154 Digestive system
 
   09155 Excretory system
 
   09156 Nervous system
 
   09157 Sensory system
 
   09158 Development and regeneration
 
   09149 Aging
 
   09159 Environmental adaptation
 
 09160 Human Diseases
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

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Last updated: February 24, 2021