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KO |
 09100 Metabolism
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09120 Genetic Information Processing
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09130 Environmental Information Processing
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 09140 Cellular Processes
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09141 Transport and catabolism
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09143 Cell growth and death
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04110 Cell cycle [PATH:lav04110]
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 04111 Cell cycle - yeast
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04112 Cell cycle - Caulobacter
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04113 Meiosis - yeast
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04114 Oocyte meiosis [PATH:lav04114]
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04210 Apoptosis [PATH:lav04210]
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04214 Apoptosis - fly
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04215 Apoptosis - multiple species [PATH:lav04215]
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04216 Ferroptosis [PATH:lav04216]
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04217 Necroptosis [PATH:lav04217]
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04115 p53 signaling pathway [PATH:lav04115]
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100663914 ATM; serine-protein kinase ATM isoform X1
100666208 CHEK2; serine/threonine-protein kinase Chk2 isoform X1
100661281 ATR; serine/threonine-protein kinase ATR isoform X1
100658513 CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1
100661448 GORAB; RAB6-interacting golgin
104845647 cyclin-dependent kinase inhibitor 2A-like
100669448 MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2
100658206 MDM4; protein Mdm4 isoform X1
100663725 TP53; cellular tumor antigen p53 isoform X1
100669170 PPP1R13L; relA-associated inhibitor isoform X2
100671706 CDKN1A; cyclin-dependent kinase inhibitor 1
100669703 CCND1; G1/S-specific cyclin-D1
100668070 CCND2; G1/S-specific cyclin-D2
100668683 CCND3; G1/S-specific cyclin-D3 isoform X1
104847103 CDK4; cyclin-dependent kinase 4
100655429 CDK6; cyclin-dependent kinase 6 isoform X1
100668342 CCNE2; G1/S-specific cyclin-E2 isoform X1
100659451 CCNE1; G1/S-specific cyclin-E1 isoform X1
100668134 CDK2; cyclin-dependent kinase 2 isoform X2
100676629 SFN; 14-3-3 protein sigma
100655521 RPRM; protein reprimo
100654684 CCNB1; G2/mitotic-specific cyclin-B1
100659655 CCNB2; G2/mitotic-specific cyclin-B2
100668529 CDK1; cyclin-dependent kinase 1 isoform X1
100658253 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma
100655692 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2
100653562 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha
100655495 GTSE1; G2 and S phase-expressed protein 1
100665093 ZNF385A; zinc finger protein 385A isoform X1
100657715 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1
100657698 PIDD1; p53-induced death domain-containing protein 1 isoform X1
104846103 tumor necrosis factor receptor superfamily member 10A-like isoform X1
104846102 tumor necrosis factor receptor superfamily member 10B-like isoform X1
100663575 caspase-8
100660542 CASP8; caspase-8 isoform X1
100662196 BID; BH3-interacting domain death agonist
100673560 BAX; apoptosis regulator BAX
100677531 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
100671262 BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3
100659905 SIVA1; apoptosis regulatory protein Siva
100655646 BCL2L1; bcl-2-like protein 1 isoform X1
100675268 BCL2; apoptosis regulator Bcl-2
100667114 TP53I3; LOW QUALITY PROTEIN: quinone oxidoreductase PIG3
100667395 quinone oxidoreductase PIG3-like
100659082 EI24; etoposide-induced protein 2.4 homolog
100669432 PERP; p53 apoptosis effector related to PMP-22
100658232 ZMAT3; zinc finger matrin-type protein 3 isoform X1
100669493 SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1
100654286 cytochrome c, testis-specific
100657132 cytochrome c
100665091 APAF1; apoptotic protease-activating factor 1 isoform X2
100656597 CASP9; caspase-9 isoform X3
100672256 CASP3; caspase-3 isoform X2
100654018 AIFM2; apoptosis-inducing factor 2 isoform X1
100674990 IGFBP3; insulin-like growth factor-binding protein 3
100664710 IGF1; insulin-like growth factor I isoform X1
100660994 SERPINE1; plasminogen activator inhibitor 1
100655451 CD82; LOW QUALITY PROTEIN: CD82 antigen
100667431 THBS1; thrombospondin-1
100674695 SERPINB5; serpin B5
100665802 DDB2; DNA damage-binding protein 2 isoform X1
100664945 RRM2; ribonucleoside-diphosphate reductase subunit M2
100673076 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B
100656546 SESN1; sestrin-1 isoform X2
100676440 SESN3; sestrin-3 isoform X2
100657842 SESN2; sestrin-2
100660561 PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1
100670924 TSC2; tuberin isoform X4
100659559 STEAP3; LOW QUALITY PROTEIN: metalloreductase STEAP3
100667310 COP1; E3 ubiquitin-protein ligase RFWD2 isoform X1
100664562 RCHY1; LOW QUALITY PROTEIN: RING finger and CHY zinc finger domain-containing protein 1
100660439 CCNG1; LOW QUALITY PROTEIN: cyclin-G1
100660300 CCNG2; cyclin-G2 isoform X1
100658588 PPM1D; protein phosphatase 1D isoform X1
100670813 TP73; LOW QUALITY PROTEIN: tumor protein p73
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K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K19748 GORAB; RAB6-interacting golgin
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K10127 MDM4; protein Mdm4
K04451 TP53; tumor protein p53
K27356 PPP1R13L; RelA-associated inhibitor
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06644 SFN; stratifin
K10128 RPRM; reprimo, TP53-dependent G2 arrest mediator candidate
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K10129 GTSE1; G-2 and S-phase expressed protein 1
K26543 ZNF385A; zinc finger protein 385A
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K22744 SIVA1; apoptosis regulatory protein Siva
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K10133 TP53I3; tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10133 TP53I3; tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10134 EI24; etoposide-induced 2.4 mRNA
K10136 PERP; TP53 apoptosis effector
K10137 ZMAT3; zinc finger, matrin type 3
K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
K08738 CYC; cytochrome c
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K22745 AIFM2; apoptosis-inducing factor 2
K10138 IGFBP3; insulin-like growth factor-binding protein 3
K05459 IGF1; insulin-like growth factor 1
K03982 SERPINE1; plasminogen activator inhibitor 1
K06509 KAI1; CD82 antigen
K16857 THBS1; thrombospondin 1
K10139 SERPINB5; serpin B5
K10140 DDB2; DNA damage-binding protein 2
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K07207 TSC2; tuberous sclerosis 2
K10142 STEAP3; metalloreductase STEAP3 [EC:1.16.1.-]
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K10145 CCNG1; cyclin G1
K10146 CCNG2; cyclin G2
K10147 PPM1D; protein phosphatase 1D [EC:3.1.3.16]
K10148 TP73; tumor protein p73
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04218 Cellular senescence [PATH:lav04218]
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09144 Cellular community - eukaryotes
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09145 Cellular community - prokaryotes
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09142 Cell motility
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09150 Organismal Systems
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09160 Human Diseases
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Loxodonta africana (African savanna elephant)