Ubiquitin System - Meriones unguiculatus (Mongolian gerbil)

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 Ubiquitins and ubiquitin-like proteins

 





 Ubiquitin-activating enzymes (E1)





 







 Ubiquitin-conjugating enzymes (E2)





 







 Ubiquitin ligases (E3)





   HECT type E3





   U-box type E3





   Single Ring-finger type E3





     BRE1 proteins





     CBL proteins





     SINA (Seven in absentia) proteins





     Ligand of Numb proteins





     March proteins





     MDM2/MDM4 proteins





     NFX1 proteins





     Pellino proteins





     Peripheral membrane proteins





     RBR proteins





     TRAF proteins





     TRIM/RBCC proteins





     UBR box proteins





     ATL proteins





     Other single Ring-finger type E3





       110561149 Amfr; E3 ubiquitin-protein ligase AMFR
       110556100 Aire; autoimmune regulator isoform X1
       110556843 Bfar; bifunctional apoptosis regulator isoform X1
       110553751 Birc3; baculoviral IAP repeat-containing protein 3 isoform X1
       110553757 baculoviral IAP repeat-containing protein 2 isoform X1
       110542115 Xiap; E3 ubiquitin-protein ligase XIAP
       110554792 baculoviral IAP repeat-containing protein 7-like
       110554754 baculoviral IAP repeat-containing protein 7-like
       110546393 Brap; BRCA1-associated protein isoform X1
       110550902 Brca1; breast cancer type 1 susceptibility protein isoform X1
       110558986 Cbll1; E3 ubiquitin-protein ligase Hakai isoform X1
       110549722 Ccnb1ip1; E3 ubiquitin-protein ligase CCNB1IP1
       110541432 E3 ubiquitin-protein ligase CHFR-like isoform X1
       110558571 Cnot4; CCR4-NOT transcription complex subunit 4
       110545395 Dcst1; DC-STAMP domain-containing protein 1
       110561344 Dtx3; probable E3 ubiquitin-protein ligase DTX3 isoform X1
       110563978 Dtx4; E3 ubiquitin-protein ligase DTX4
       110555868 Dtx2; probable E3 ubiquitin-protein ligase DTX2 isoform X1
       110546403 Dtx1; E3 ubiquitin-protein ligase DTX1
       110547231 Dtx3l; E3 ubiquitin-protein ligase DTX3L
       110557696 Fancl; E3 ubiquitin-protein ligase FANCL
       110566226 Kcmf1; E3 ubiquitin-protein ligase KCMF1 isoform X1
       110554175 E3 ubiquitin-protein ligase LRSAM1
       110554176 E3 ubiquitin-protein ligase LRSAM1
       110555026 Ltn1; E3 ubiquitin-protein ligase listerin
       110546648 Map3k1; mitogen-activated protein kinase kinase kinase 1
       110552827 Mex3b; RNA-binding protein MEX3B
       110550724 Mex3c; RNA-binding E3 ubiquitin-protein ligase MEX3C
       110549005 Mex3a; RNA-binding protein MEX3A
       110551325 Mex3d; RNA-binding protein MEX3D
       110545938 Mgrn1; E3 ubiquitin-protein ligase MGRN1 isoform X1
       110560013 Mib2; E3 ubiquitin-protein ligase MIB2 isoform X1
       110551556 Mib1; E3 ubiquitin-protein ligase MIB1 isoform X1
       110550815 Mkrn2; probable E3 ubiquitin-protein ligase makorin-2 isoform X1
       110545782 Mkrn1; E3 ubiquitin-protein ligase makorin-1 isoform X1
       110547430 Mkrn3; probable E3 ubiquitin-protein ligase makorin-3
       110544994 Mul1; mitochondrial ubiquitin ligase activator of NFKB 1
       110560794 E3 ubiquitin-protein ligase MYCBP2
       110556603 Mylip; E3 ubiquitin-protein ligase MYLIP isoform X1
       110547819 Neurl1b; E3 ubiquitin-protein ligase NEURL1B
       110550373 Neurl1; E3 ubiquitin-protein ligase NEURL1
       110545431 Neurl3; E3 ubiquitin-protein ligase NEURL3 isoform X1
       110549711 Nhlrc1; E3 ubiquitin-protein ligase NHLRC1
       110554412 Rnf219; RING finger protein 219
       110559165 Pja1; E3 ubiquitin-protein ligase Praja-1 isoform X1
       110550522 Pja2; E3 ubiquitin-protein ligase Praja-2
       110548314 Rad18; E3 ubiquitin-protein ligase RAD18 isoform X1
       110557494 Rag1; V(D)J recombination-activating protein 1
       110555423 Rchy1; RING finger and CHY zinc finger domain-containing protein 1
       110560839 roquin-2 isoform X1
       110560840 roquin-2 isoform X1
       110560731 Rc3h1; roquin-1
       110539372 E3 ubiquitin-protein ligase RFWD2
       110546032 Rfwd3; E3 ubiquitin-protein ligase RFWD3 isoform X1
       110544076 Ring1; E3 ubiquitin-protein ligase RING1
       110550258 Rnf2; E3 ubiquitin-protein ligase RING2
       110552402 Rnf4; E3 ubiquitin-protein ligase RNF4
       110557654 Rnf185; E3 ubiquitin-protein ligase RNF185 isoform X1
       110565391 Rnf5; E3 ubiquitin-protein ligase RNF5
       110546568 Rnf8; E3 ubiquitin-protein ligase RNF8 isoform X1
       110563611 Rnf11; RING finger protein 11
       110542955 Rlim; E3 ubiquitin-protein ligase RLIM
       110554228 Rnf13; E3 ubiquitin-protein ligase RNF13
       110566717 Rnf25; E3 ubiquitin-protein ligase RNF25 isoform X1
       110548556 Rnf26; E3 ubiquitin-protein ligase RNF26
       110553819 Rnf38; E3 ubiquitin-protein ligase RNF38 isoform X1
       110541038 Rnf44; RING finger protein 44 isoform X1
       110559397 Rnf41; E3 ubiquitin-protein ligase NRDP1
       110566144 Rnf43; E3 ubiquitin-protein ligase RNF43
       110540734 Rnf103; E3 ubiquitin-protein ligase RNF103
       110560853 E3 ubiquitin-protein ligase Arkadia isoform X1
       110560856 E3 ubiquitin-protein ligase Arkadia isoform X1
       110548959 Rnf114; E3 ubiquitin-protein ligase RNF114
       110560314 Rnf115; E3 ubiquitin-protein ligase RNF115
       110551346 Rnf126; E3 ubiquitin-protein ligase RNF126
       110557549 Rnf121; RING finger protein 121 isoform X1
       110549817 Rnf122; RING finger protein 122 isoform X1
       110564986 Rnf123; E3 ubiquitin-protein ligase RNF123
       110541501 Rnf125; E3 ubiquitin-protein ligase RNF125
       110541484 Rnf128; E3 ubiquitin-protein ligase RNF128
       110557388 Rnf130; E3 ubiquitin-protein ligase RNF130 isoform X1
       110540351 Rnf133; E3 ubiquitin-protein ligase RNF133 isoform X1
       110545097 Rnf135; E3 ubiquitin-protein ligase RNF135 isoform X1
       110541058 Rnf138; E3 ubiquitin-protein ligase RNF138 isoform X1
       110540556 E3 ubiquitin-protein ligase RNF138-like isoform X1
       110552426 Rnf139; E3 ubiquitin-protein ligase RNF139
       110548439 Rnf145; RING finger protein 145
       110557227 Rnf146; E3 ubiquitin-protein ligase RNF146
       110559884 Rnf149; E3 ubiquitin-protein ligase RNF149
       110558851 Rnf152; E3 ubiquitin-protein ligase RNF152
       110553534 Rnf165; E3 ubiquitin-protein ligase RNF165
       110545220 Rnf166; RING finger protein 166 isoform X1
       110557346 Rnf167; E3 ubiquitin-protein ligase RNF167
       110550196 Rnf170; E3 ubiquitin-protein ligase RNF170 isoform X1
       110558866 Rnf180; E3 ubiquitin-protein ligase RNF180
       110558897 Rnf181; E3 ubiquitin-protein ligase RNF181 isoform X1
       110544233 Rnf182; E3 ubiquitin-protein ligase RNF182
       110552181 Rnf187; E3 ubiquitin-protein ligase RNF187
       110549909 Rnf213; E3 ubiquitin-protein ligase RNF213
       110553744 Rnft1; RING finger and transmembrane domain-containing protein 1
       110549346 Sart1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1
       110556386 Shprh; E3 ubiquitin-protein ligase SHPRH
       110542165 E3 ubiquitin-protein ligase SHPRH
       110556798 Sh3rf2; putative E3 ubiquitin-protein ligase SH3RF2 isoform X1
       110563358 E3 ubiquitin-protein ligase SH3RF1
       110557431 Sh3rf3; SH3 domain-containing RING finger protein 3
       110563359 E3 ubiquitin-protein ligase SH3RF1
       110549047 Hltf; helicase-like transcription factor
       110549320 Syvn1; E3 ubiquitin-protein ligase synoviolin isoform X1
       110557327 Tmem129; E3 ubiquitin-protein ligase TM129 isoform X1
       110561671 Topors; E3 ubiquitin-protein ligase Topors
       110564949 Traip; E3 ubiquitin-protein ligase TRAIP
       110566718 E3 ubiquitin-protein ligase TTC3-like
       110546278 Uhrf1; E3 ubiquitin-protein ligase UHRF1 isoform X1
       110554964 Uhrf2; E3 ubiquitin-protein ligase UHRF2
       110548722 Unkl; putative E3 ubiquitin-protein ligase UNKL isoform X1
       110553024 Znf598; E3 ubiquitin-protein ligase ZNF598 isoform X1
       110546013 Znrf1; E3 ubiquitin-protein ligase ZNRF1
       110555044 Znrf2; E3 ubiquitin-protein ligase ZNRF2
       110546125 Znrf3; E3 ubiquitin-protein ligase ZNRF3
       110546217 Znrf4; E3 ubiquitin-protein ligase ZNRF4
       110559158 Zswim2; E3 ubiquitin-protein ligase ZSWIM2



K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36] 
K10603 AIRE; autoimmune regulator 
K15684 BFAR; bifunctional apoptosis regulator 
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3 
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3 
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27] 
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8 
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8 
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27] 
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27] 
K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27] 
K10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27] 
K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27] 
K22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
K22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27] 
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27] 
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27] 
K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27] 
K04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27] 
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27] 
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27] 
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27] 
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27] 
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27] 
K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27] 
K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33] 
K10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27] 
K01931 NEUR; protein neuralized [EC:2.3.2.27] 
K01931 NEUR; protein neuralized [EC:2.3.2.27] 
K15689 NEURL3; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27] 
K10602 NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27] 
K24091 OBI1; ORC ubiquitin ligase 1 [EC:2.3.2.27] 
K10633 PJA1; E3 ubiquitin-protein ligase Praja1 [EC:2.3.2.27] 
K10634 PJA2; E3 ubiquitin-protein ligase Praja2 [EC:2.3.2.27] 
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27] 
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27] 
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27] 
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein 
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein 
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein 
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27] 
K15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27] 
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27] 
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27] 
K22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27] 
K10666 RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27] 
K10666 RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27] 
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] 
K11980 RNF11; E3 ubiquitin-protein ligase RNF11 
K16271 RLIM; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27] 
K15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27] 
K10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27] 
K15693 RNF26; RING finger protein 26 
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27] 
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27] 
K11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27] 
K15694 RNF43; RING finger protein 43 [EC:2.3.2.27] 
K15695 RNF103; E3 ubiquitin-protein ligase RNF103 [EC:2.3.2.27] 
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27] 
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27] 
K15697 RNF114; RING finger protein 114 [EC:2.3.2.27] 
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27] 
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27] 
K15698 RNF121_175; RING finger protein 121/175 
K15699 RNF122; RING finger protein 122 
K12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27] 
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27] 
K10629 RNF128; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27] 
K15701 RNF130; E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27] 
K15702 RNF133; E3 ubiquitin-protein ligase RNF133 [EC:2.3.2.27] 
K16272 RNF135; E3 ubiquitin-protein ligase RNF135 [EC:2.3.2.27] 
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27] 
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27] 
K15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27] 
K23789 RNF145; RING finger protein 145 [EC:2.3.2.27] 
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27] 
K15704 RNF149; E3 ubiquitin-protein ligase RNF149 [EC:2.3.2.27] 
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27] 
K17821 RNF165; RING finger protein 165 
K17044 RNF166; RING finger protein 166 
K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27] 
K15707 RNF170; RING finger protein 170 [EC:2.3.2.27] 
K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27] 
K22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27] 
K11983 RNF182; E3 ubiquitin-protein ligase RNF182 [EC:2.3.2.27] 
K15709 RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27] 
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27] 
K22379 RNFT1; E3 ubiquitin-protein ligase RNFT1 [EC:2.3.2.27] 
K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1 
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:3.6.4.- 2.3.2.27] 
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:3.6.4.- 2.3.2.27] 
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27] 
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27] 
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27] 
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27] 
K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:3.6.4.- 2.3.2.27] 
K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27] 
K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27] 
K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27] 
K11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27] 
K15712 TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27] 
K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27] 
K15713 UHRF2; E3 ubiquitin-protein ligase UHRF2 [EC:2.3.2.27] 
K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27] 
K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27] 
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27] 
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27] 
K16273 ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27] 
K15715 ZNRF4; Zinc/RING finger protein 4 
K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27] 





   Atypical E3





   UBL E3 ligases





   Multi subunit Ring-finger type E3





 







 Deubiquitinating enzyme (DUB)













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Last updated: February 24, 2021