| |
KO |
 09100 Metabolism
|
|
|
 09120 Genetic Information Processing
|
|
|
09121 Transcription
|
|
|
09122 Translation
|
|
|
09123 Folding, sorting and degradation
|
|
|
09124 Replication and repair
|
03030 DNA replication [PATH:pale03030]
|
03410 Base excision repair [PATH:pale03410]
|
03420 Nucleotide excision repair [PATH:pale03420]
|
03430 Mismatch repair [PATH:pale03430]
|
 102898494 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X2
102879718 PMS2; mismatch repair endonuclease PMS2 isoform X1
102898392 MLH1; DNA mismatch repair protein Mlh1 isoform X1
102892999 MSH6; DNA mismatch repair protein Msh6
102893728 MSH2; DNA mismatch repair protein Msh2 isoform X3
102878992 MSH3; DNA mismatch repair protein Msh3 isoform X1
102890288 MLH3; DNA mismatch repair protein Mlh3 isoform X1
102892618 RFC1; replication factor C subunit 1 isoform X3
102886215 RFC4; replication factor C subunit 4 isoform X2
102888919 RFC2; replication factor C subunit 2 isoform X1
102885071 RFC5; replication factor C subunit 5
102891620 RFC3; replication factor C subunit 3 isoform X1
102890018 PCNA; proliferating cell nuclear antigen
102880463 EXO1; exonuclease 1 isoform X1
102889870 RPA1; replication protein A 70 kDa DNA-binding subunit
102883783 RPA2; replication protein A 32 kDa subunit
102884493 RPA3; replication protein A 14 kDa subunit isoform X1
102878725 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit
102896397 POLD1; DNA polymerase delta catalytic subunit
102884073 POLD2; DNA polymerase delta subunit 2
102895310 POLD3; DNA polymerase delta subunit 3
102893003 POLD4; DNA polymerase delta subunit 4
102888944 LIG1; LOW QUALITY PROTEIN: DNA ligase 1
|
K03111 ssb; single-strand DNA-binding protein
K10858 PMS2; DNA mismatch repair protein PMS2
K08734 MLH1; DNA mismatch repair protein MLH1
K08737 MSH6; DNA mismatch repair protein MSH6
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08739 MLH3; DNA mismatch repair protein MLH3
K10754 RFC1; replication factor C subunit 1
K10755 RFC2_4; replication factor C subunit 2/4
K10755 RFC2_4; replication factor C subunit 2/4
K10756 RFC3_5; replication factor C subunit 3/5
K10756 RFC3_5; replication factor C subunit 3/5
K04802 PCNA; proliferating cell nuclear antigen
K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
K07466 RFA1; replication factor A1
K10739 RFA2; replication factor A2
K10740 RPA3; replication factor A3
K10741 RPA4; replication factor A4
K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328 POLD2; DNA polymerase delta subunit 2
K03504 POLD3; DNA polymerase delta subunit 3
K03505 POLD4; DNA polymerase delta subunit 4
K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
|
03440 Homologous recombination [PATH:pale03440]
|
03450 Non-homologous end-joining [PATH:pale03450]
|
03460 Fanconi anemia pathway [PATH:pale03460]
|
|
|
09130 Environmental Information Processing
|
|
|
09140 Cellular Processes
|
|
|
09150 Organismal Systems
|
|
|
09160 Human Diseases
|
|
|
09161 Cancer: overview
|
05200 Pathways in cancer [PATH:pale05200]
|
102886027 DCC; netrin receptor DCC
102897289 CASP3; caspase-3
102878565 CASP9; caspase-9
102887604 APPL1; DCC-interacting protein 13-alpha
102886394 CDH1; cadherin-1 isoform X1
102880017 CTNNB1; LOW QUALITY PROTEIN: catenin beta-1
102893948 CTNNA2; catenin alpha-2 isoform X3
102881133 CTNNA3; catenin alpha-3
102891804 CTNNA1; catenin alpha-1
102878657 AXIN1; axin-1 isoform X1
102885831 AXIN2; axin-2
102880260 APC; adenomatous polyposis coli protein isoform X3
102891886 APC2; adenomatous polyposis coli protein 2
102882441 GSK3B; glycogen synthase kinase-3 beta isoform X4
102885788 TCF7; transcription factor 7 isoform X4
102886093 TCF7L1; transcription factor 7-like 1
102880370 TCF7L2; transcription factor 7-like 2 isoform X2
102886933 LEF1; lymphoid enhancer-binding factor 1 isoform X1
102888083 BIRC5; baculoviral IAP repeat-containing protein 5
102895524 MYC; myc proto-oncogene protein
102885330 CCND1; G1/S-specific cyclin-D1
102888016 WNT1; proto-oncogene Wnt-1
102880959 WNT2B; protein Wnt-2b isoform X1
102885080 WNT2; protein Wnt-2
102895795 WNT3A; protein Wnt-3a
102877979 WNT3; proto-oncogene Wnt-3
102888866 WNT4; protein Wnt-4
102890342 WNT5A; protein Wnt-5a isoform X5
102881682 WNT5B; protein Wnt-5b isoform X2
102882368 WNT6; protein Wnt-6 isoform X1
102888597 WNT7A; protein Wnt-7a
102898026 WNT7B; protein Wnt-7b isoform X1
102896480 WNT8A; protein Wnt-8a
102878209 WNT8B; protein Wnt-8b
102885223 protein Wnt-9b
102884543 WNT9A; protein Wnt-9a
102882121 WNT10A; protein Wnt-10a
102888263 WNT10B; protein Wnt-10b
102877879 WNT11; protein Wnt-11
102882050 WNT16; LOW QUALITY PROTEIN: protein Wnt-16
102880538 FZD7; frizzled-7
102895634 FZD1; frizzled-1
102884150 FZD2; frizzled-2
102890038 FZD3; frizzled-3 isoform X1
102892989 FZD4; LOW QUALITY PROTEIN: frizzled-4
102877864 FZD8; LOW QUALITY PROTEIN: frizzled-8
102883426 FZD5; LOW QUALITY PROTEIN: frizzled-5
102890002 FZD6; frizzled-6
102894135 FZD10; frizzled-10
102878169 FZD9; frizzled-9
102894479 LRP5; low-density lipoprotein receptor-related protein 5
102878233 LRP6; low-density lipoprotein receptor-related protein 6
102895469 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1
102880039 DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1
102881158 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1
102896339 LOW QUALITY PROTEIN: proto-oncogene FRAT1
102877724 F2; prothrombin isoform X2
102892951 AGT; angiotensinogen
102886001 F2R; proteinase-activated receptor 1
102891888 F2RL3; proteinase-activated receptor 4
102891503 LPAR1; lysophosphatidic acid receptor 1 isoform X1
102891807 LPAR2; lysophosphatidic acid receptor 2
102880785 LPAR3; lysophosphatidic acid receptor 3
102881134 LPAR4; lysophosphatidic acid receptor 4
102892521 LPAR5; lysophosphatidic acid receptor 5
102892775 LPAR6; lysophosphatidic acid receptor 6
102895602 AGTR1; type-1 angiotensin II receptor
102891706 GNA12; guanine nucleotide-binding protein subunit alpha-12
102891607 GNA13; guanine nucleotide-binding protein subunit alpha-13
102879072 ARHGEF12; rho guanine nucleotide exchange factor 12
102892639 ARHGEF11; rho guanine nucleotide exchange factor 11
102894194 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1
102892928 PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1
102891515 RHOA; transforming protein RhoA
102879861 ROCK1; rho-associated protein kinase 1 isoform X1
102897424 ROCK2; rho-associated protein kinase 2
102881363 CXCL12; stromal cell-derived factor 1 isoform X1
102888277 CXCR4; C-X-C chemokine receptor type 4
102892785 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha
102885642 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1
102898665 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2
102894012 PTGER1; prostaglandin E2 receptor EP1 subtype
102884861 PTGER2; prostaglandin E2 receptor EP2 subtype
102890353 PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1
102886026 PTGER4; prostaglandin E2 receptor EP4 subtype
102889764 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
102884106 neuroendocrine secretory protein 55-like
102887497 ADCY1; adenylate cyclase type 1
102893265 ADCY2; adenylate cyclase type 2
102886232 ADCY3; adenylate cyclase type 3
102890575 ADCY4; adenylate cyclase type 4
102897495 ADCY5; adenylate cyclase type 5
102890588 ADCY6; adenylate cyclase type 6 isoform X2
102881535 ADCY7; adenylate cyclase type 7
102896789 ADCY8; adenylate cyclase type 8 isoform X1
102885676 ADCY9; adenylate cyclase type 9
102886679 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha
102877853 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1
102883771 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
102882744 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
102893506 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
102890410 GNB4; guanine nucleotide-binding protein subunit beta-4
102881664 GNB5; guanine nucleotide-binding protein subunit beta-5
102886028 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
102888735 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
102889599 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
102879439 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
102886041 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
112479655 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1
107196679 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
102898925 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
102886682 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
102877921 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14
102892764 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X6
102898674 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
102881686 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
102879139 COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain
102879385 COL4A4; collagen alpha-4(IV) chain
102898331 COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain
102891781 COL4A5; collagen alpha-5(IV) chain isoform X1
102895248 COL4A6; collagen alpha-6(IV) chain
102898083 COL4A2; collagen alpha-2(IV) chain
102894718 LAMA2; laminin subunit alpha-2 isoform X1
102884860 LAMA1; laminin subunit alpha-1 isoform X1
102897225 LAMA3; laminin subunit alpha-3 isoform X6
102892706 LAMA5; laminin subunit alpha-5
102877962 LAMA4; laminin subunit alpha-4
102881611 LAMB1; laminin subunit beta-1 isoform X1
102889392 LAMB2; laminin subunit beta-2 isoform X1
102896504 LAMB3; laminin subunit beta-3
102896150 LAMB4; laminin subunit beta-4
102885413 LAMC1; laminin subunit gamma-1
102892078 LAMC2; laminin subunit gamma-2
102881476 LAMC3; laminin subunit gamma-3
102891509 FN1; fibronectin isoform X1
102897185 ITGA2; integrin alpha-2 isoform X1
102883900 ITGA2B; integrin alpha-IIb
102884713 ITGA3; integrin alpha-3 isoform X1
102883425 ITGA6; integrin alpha-6 isoform X1
102895440 ITGAV; integrin alpha-V
102886785 ITGB1; integrin beta-1
102898998 PTK2; focal adhesion kinase 1
102889227 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
102880320 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
102889576 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
102879163 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
102891637 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3
102879453 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta
102881949 PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1
102880253 NKX3-1; homeobox protein Nkx-3.1
102885144 AKT1; RAC-alpha serine/threonine-protein kinase isoform X1
102879337 AKT3; RAC-gamma serine/threonine-protein kinase isoform X1
102898305 AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase
102879469 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
102893261 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
102880203 IKBKG; NF-kappa-B essential modulator isoform X1
102891056 NFKBIA; NF-kappa-B inhibitor alpha
102880692 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1
102894780 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1
102878395 RELA; transcription factor p65
102886561 PTGS2; prostaglandin G/H synthase 2
102878456 NOS2; nitric oxide synthase, inducible
102896443 BCL2; apoptosis regulator Bcl-2
102884388 baculoviral IAP repeat-containing protein 3
102884651 BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1
102885349 XIAP; E3 ubiquitin-protein ligase XIAP
102889019 BIRC7; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 7
102887704 BCL2L1; bcl-2-like protein 1
102894412 TRAF1; TNF receptor-associated factor 1
102889343 TRAF2; TNF receptor-associated factor 2 isoform X1
102881091 TRAF3; TNF receptor-associated factor 3
102896659 TRAF4; TNF receptor-associated factor 4 isoform X1
102879730 TRAF5; TNF receptor-associated factor 5 isoform X1
102886476 TRAF6; TNF receptor-associated factor 6 isoform X1
102885092 MTOR; serine/threonine-protein kinase mTOR
102891214 RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1
102889369 RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1
102877892 BAD; bcl2-associated agonist of cell death isoform X1
102892244 FOXO1; forkhead box protein O1
102884281 MDM2; E3 ubiquitin-protein ligase Mdm2
102889604 TP53; cellular tumor antigen p53
102880085 CDKN1B; cyclin-dependent kinase inhibitor 1B
102894049 CDKN1A; cyclin-dependent kinase inhibitor 1
102897172 BCR; breakpoint cluster region protein
102895947 ABL1; tyrosine-protein kinase ABL1
102898080 CRKL; crk-like protein
102885553 CRK; adapter molecule crk isoform X1
102895335 CBL; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL
102884638 signal transducer and activator of transcription 5A
102884882 signal transducer and activator of transcription 5B isoform X1
102891826 PIM1; serine/threonine-protein kinase pim-1
102886532 PIM2; serine/threonine-protein kinase pim-2
102885643 KNG1; kininogen-1 isoform X1
102895320 EDN1; endothelin-1
102895893 B2 bradykinin receptor isoform X1
102898148 EDNRA; endothelin-1 receptor
102880014 EDNRB; endothelin receptor type B
102877919 guanine nucleotide-binding protein G(q) subunit alpha
102888619 GNA11; guanine nucleotide-binding protein subunit alpha-11
102879238 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
102885207 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
102885781 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
102885953 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
102887078 PRKCA; protein kinase C alpha type
102880663 PRKCB; protein kinase C beta type
102888961 PRKCG; protein kinase C gamma type
102895516 IL2; interleukin-2
102896574 interleukin-3
102890025 IL4; interleukin-4
102890771 IL5; interleukin-5
102895746 IL6; interleukin-6
112472586 IL7; interleukin-7
102887571 IL12A; interleukin-12 subunit alpha
102884214 IL12B; interleukin-12 subunit beta
102890275 IL13; interleukin-13
102887558 IL15; interleukin-15 isoform X2
102879394 IL23A; interleukin-23 subunit alpha
102883166 EPO; erythropoietin
102893886 interferon alpha-1
102890009 interferon alpha-4
102882436 IFNG; interferon gamma precursor
102891511 IL2RA; interleukin-2 receptor subunit alpha
102883396 IL2RB; interleukin-2 receptor subunit beta
102888070 IL2RG; cytokine receptor common subunit gamma
102878242 IL3RA; interleukin-3 receptor subunit alpha
102882815 IL4R; interleukin-4 receptor subunit alpha isoform X1
102897194 CSF2RB; cytokine receptor common subunit beta
102896000 IL5RA; interleukin-5 receptor subunit alpha
102878027 IL6R; interleukin-6 receptor subunit alpha
102880415 IL6ST; interleukin-6 receptor subunit beta isoform X1
102889092 IL7R; interleukin-7 receptor subunit alpha
102878946 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1
102885605 IL12RB2; interleukin-12 receptor subunit beta-2
102897874 IL13RA1; interleukin-13 receptor subunit alpha-1
102892156 IL15RA; interleukin-15 receptor subunit alpha
102885363 IL23R; interleukin-23 receptor
102886625 EPOR; erythropoietin receptor
102892040 IFNAR1; interferon alpha/beta receptor 1
102891485 IFNAR2; interferon alpha/beta receptor 2 isoform X1
102888010 IFNGR1; interferon gamma receptor 1
102877930 IFNGR2; interferon gamma receptor 2
102879824 EML4; echinoderm microtubule-associated protein-like 4 isoform X1
102884662 ALK; ALK tyrosine kinase receptor
102877927 RASGRP1; RAS guanyl-releasing protein 1 isoform X1
102896690 RASGRP2; RAS guanyl-releasing protein 2
102888491 RASGRP3; ras guanyl-releasing protein 3
102885173 RASGRP4; RAS guanyl-releasing protein 4 isoform X1
102880365 JAK1; tyrosine-protein kinase JAK1 isoform X1
102882079 JAK2; tyrosine-protein kinase JAK2
102898620 JAK3; tyrosine-protein kinase JAK3
102884374 STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3
102886603 STAT1; signal transducer and activator of transcription 1-alpha/beta
102879640 STAT2; signal transducer and activator of transcription 2
102886854 STAT4; signal transducer and activator of transcription 4
102885160 STAT6; signal transducer and activator of transcription 6 isoform X1
102890394 VEGFA; vascular endothelial growth factor A isoform X2
102883443 vascular endothelial growth factor B
102882963 VEGFB; vascular endothelial growth factor B
102889783 PGF; placenta growth factor isoform X1
102889143 VEGFD; vascular endothelial growth factor D
102884251 VEGFC; vascular endothelial growth factor C
102887662 TGFA; protransforming growth factor alpha isoform X1
102891552 EGF; pro-epidermal growth factor isoform X1
102893495 EGFR; epidermal growth factor receptor
102885300 ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2
102893670 PDGFA; platelet-derived growth factor subunit A
102897699 PDGFB; platelet-derived growth factor subunit B isoform X1
102895362 PDGFRA; platelet-derived growth factor receptor alpha isoform X1
102887643 PDGFRB; platelet-derived growth factor receptor beta isoform X1
102890331 IGF1; insulin-like growth factor I isoform X3
102880410 IGF2; insulin-like growth factor II
102885962 IGF1R; insulin-like growth factor 1 receptor
102884034 KITLG; kit ligand isoform X1
102895969 KIT; mast/stem cell growth factor receptor Kit
102881080 FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1
102891572 FLT3; receptor-type tyrosine-protein kinase FLT3
102884470 HGF; hepatocyte growth factor isoform X1
102885990 MET; hepatocyte growth factor receptor isoform X1
102894192 FGF1; fibroblast growth factor 1 isoform X1
107196088 FGF2; fibroblast growth factor 2
102895922 FGF10; fibroblast growth factor 10
102887777 FGF7; fibroblast growth factor 7
102892141 FGF6; fibroblast growth factor 6
102895642 FGF5; fibroblast growth factor 5
102890153 FGF16; fibroblast growth factor 16
102893226 FGF8; fibroblast growth factor 8 isoform X4
102894115 FGF18; fibroblast growth factor 18
102888098 FGF20; fibroblast growth factor 20
102893244 FGF4; fibroblast growth factor 4
102894279 FGF17; fibroblast growth factor 17 isoform X1
102887882 FGF9; fibroblast growth factor 9
102896895 FGF22; fibroblast growth factor 22
102885081 FGF19; fibroblast growth factor 19
102886540 FGF21; fibroblast growth factor 21
102883346 FGF23; fibroblast growth factor 23
102898943 FGFR1; fibroblast growth factor receptor 1 isoform X9
102882899 FGFR2; fibroblast growth factor receptor 2 isoform X8
102878342 FGFR3; fibroblast growth factor receptor 3
102879288 FGFR4; fibroblast growth factor receptor 4 isoform X3
102878822 GRB2; growth factor receptor-bound protein 2 isoform X1
102882462 SOS1; son of sevenless homolog 1 isoform X1
102889597 SOS2; son of sevenless homolog 2
102896270 HRAS; GTPase HRas isoform X3
102895590 KRAS; GTPase KRas isoform X1
102885950 NRAS; GTPase NRas isoform X2
102877877 ARAF; serine/threonine-protein kinase A-Raf isoform X2
102878393 BRAF; serine/threonine-protein kinase B-raf isoform X2
102893439 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1
102897122 MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1
102879034 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2
102895390 MAPK1; mitogen-activated protein kinase 1
102885749 MAPK3; mitogen-activated protein kinase 3
102896121 JUN; transcription factor AP-1
102891428 FOS; proto-oncogene c-Fos
102893422 ETS1; protein C-ets-1
102893881 MMP1; interstitial collagenase
102883808 MMP2; 72 kDa type IV collagenase
102889517 MMP9; matrix metalloproteinase-9
102892534 CXCL8; interleukin-8
102894222 CDK4; cyclin-dependent kinase 4
102897813 RPS6KA5; ribosomal protein S6 kinase alpha-5
102878133 RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X4
102879174 CCDC6; coiled-coil domain-containing protein 6
102896808 NCOA4; nuclear receptor coactivator 4 isoform X3
112472150 NTRK1; high affinity nerve growth factor receptor
102898874 TPM3; tropomyosin alpha-3 chain isoform X1
102887317 TPR; LOW QUALITY PROTEIN: nucleoprotein TPR
102892687 TFG; protein TFG isoform X1
102879898 RASSF1; ras association domain-containing protein 1 isoform X1
102888616 RASSF5; ras association domain-containing protein 5 isoform X2
102881410 STK4; serine/threonine-protein kinase 4 isoform X1
102892714 DAPK3; death-associated protein kinase 3
102885201 DAPK2; death-associated protein kinase 2 isoform X2
102891860 DAPK1; death-associated protein kinase 1
102896228 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
102883128 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
102878877 ELK1; ETS domain-containing protein Elk-1 isoform X1
102894226 CALM2; calmodulin-2 isoform X1
102897273 CALM3; calmodulin-3
102886058 CALM1; calmodulin-1
102884196 CALML6; calmodulin-like protein 6
102891673 calmodulin-like
102893109 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4
102881744 calmodulin-like
102888982 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta
102888385 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1
102880869 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta
102896030 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma
102880177 RALGDS; ral guanine nucleotide dissociation stimulator isoform X2
102898811 RALA; ras-related protein Ral-A
102899030 RALB; ras-related protein Ral-B
102890515 RALBP1; ralA-binding protein 1 isoform X1
102889114 CDC42; cell division control protein 42 homolog
102897644 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1
102885507 RAC2; ras-related C3 botulinum toxin substrate 2
102887421 RAC3; ras-related C3 botulinum toxin substrate 3
102884736 PLD1; phospholipase D1 isoform X1
102894598 PLD2; phospholipase D2 isoform X1
102885064 MAPK10; mitogen-activated protein kinase 10 isoform X5
102890689 MAPK9; mitogen-activated protein kinase 9 isoform X1
102892777 MAPK8; mitogen-activated protein kinase 8 isoform X1
102894983 PAX8; paired box protein Pax-8 isoform X1
102892450 PPARG; peroxisome proliferator-activated receptor gamma isoform X1
102881572 RXRA; retinoic acid receptor RXR-alpha
102888877 RXRB; retinoic acid receptor RXR-beta isoform X1
102897820 RXRG; retinoic acid receptor RXR-gamma
102886545 RARB; retinoic acid receptor beta
102877910 ESR1; estrogen receptor isoform X1
102878324 ESR2; estrogen receptor beta isoform X2
102885576 NCOA1; nuclear receptor coactivator 1 isoform X1
102892705 NCOA3; nuclear receptor coactivator 3 isoform X1
102894100 SP1; transcription factor Sp1 isoform X1
102898485 PPARD; peroxisome proliferator-activated receptor delta isoform X2
102890702 JUP; junction plakoglobin isoform X2
102881382 ZBTB16; zinc finger and BTB domain-containing protein 16 isoform X1
102880130 RARA; retinoic acid receptor alpha isoform X1
102890664 CCNA1; cyclin-A1
102894080 CCNA2; cyclin-A2
102895190 PML; protein PML isoform X3
102879444 RUNX1; runt-related transcription factor 1
102888477 RUNX1T1; protein CBFA2T1 isoform X1
102880490 SPI1; transcription factor PU.1
102893139 CEBPA; CCAAT/enhancer-binding protein alpha
102878494 granulocyte-macrophage colony-stimulating factor receptor subunit alpha
102897878 CSF3R; granulocyte colony-stimulating factor receptor isoform X1
102886964 CSF1R; macrophage colony-stimulating factor 1 receptor
102896422 LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 2A
102895276 E2F1; transcription factor E2F1
102884459 E2F2; transcription factor E2F2 isoform X1
102887239 E2F3; transcription factor E2F3 isoform X1
102881979 MAX; protein max isoform X2
102877831 ZBTB17; zinc finger and BTB domain-containing protein 17
102893142 CDKN2B; cyclin-dependent kinase 4 inhibitor B
102896272 CDK6; cyclin-dependent kinase 6
102892640 CCND2; G1/S-specific cyclin-D2
102881884 CCND3; G1/S-specific cyclin-D3
102894196 CKS1B; cyclin-dependent kinases regulatory subunit 1
102879697 CKS2; cyclin-dependent kinases regulatory subunit 2
102885538 SKP1; S-phase kinase-associated protein 1
102887109 CUL1; cullin-1
102893437 RBX1; E3 ubiquitin-protein ligase RBX1
102880695 SKP2; S-phase kinase-associated protein 2
102893397 CDK2; cyclin-dependent kinase 2 isoform X1
102882411 CCNE2; G1/S-specific cyclin-E2 isoform X1
102882260 CCNE1; LOW QUALITY PROTEIN: G1/S-specific cyclin-E1
102893019 RB1; retinoblastoma-associated protein
102886440 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha
102878191 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma
102885790 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta
102885135 BAX; apoptosis regulator BAX isoform X1
102883540 BAK1; bcl-2 homologous antagonist/killer
102879479 DDB2; DNA damage-binding protein 2 isoform X1
102890888 POLK; DNA polymerase kappa isoform X1
102895256 TERT; telomerase reverse transcriptase
102899015 MITF; microphthalmia-associated transcription factor isoform X1
102884154 TGFB1; transforming growth factor beta-1
102881295 TGFB2; transforming growth factor beta-2 isoform X2
102893304 TGFB3; transforming growth factor beta-3
102880759 TGFBR1; TGF-beta receptor type-1 isoform X2
102889618 TGFBR2; TGF-beta receptor type-2 isoform X1
102893928 SMAD2; mothers against decapentaplegic homolog 2
102895268 SMAD3; mothers against decapentaplegic homolog 3
102886521 SMAD4; mothers against decapentaplegic homolog 4
102878481 MECOM; MDS1 and EVI1 complex locus protein isoform X1
102899024 CTBP1; C-terminal-binding protein 1 isoform X1
102879836 CTBP2; C-terminal-binding protein 2 isoform X3
102890938 HDAC1; histone deacetylase 1
102878536 HDAC2; histone deacetylase 2
102898392 MLH1; DNA mismatch repair protein Mlh1 isoform X1
102893728 MSH2; DNA mismatch repair protein Msh2 isoform X3
102878992 MSH3; DNA mismatch repair protein Msh3 isoform X1
102892999 MSH6; DNA mismatch repair protein Msh6
102896802 BRCA2; breast cancer type 2 susceptibility protein
102894016 RAD51; DNA repair protein RAD51 homolog 1
102883204 FASLG; tumor necrosis factor ligand superfamily member 6
102879561 FAS; tumor necrosis factor receptor superfamily member 6 isoform X5
102892511 FADD; FAS-associated death domain protein
102878181 CASP8; caspase-8
102887379 BID; BH3-interacting domain death agonist isoform X3
102894490 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
102892591 BBC3; bcl-2-binding component 3
102890309 BCL2L11; bcl-2-like protein 11 isoform X1
102879159 cytochrome c
102893036 cytochrome c
102897687 APAF1; apoptotic protease-activating factor 1
102879606 CASP7; caspase-7
102894870 KEAP1; kelch-like ECH-associated protein 1
102892042 NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1
102880347 HMOX1; LOW QUALITY PROTEIN: heme oxygenase 1
102889138 NQO1; NAD(P)H dehydrogenase [quinone] 1
102885225 MGST2; microsomal glutathione S-transferase 2
102886852 GSTO2; glutathione S-transferase omega-2
102887110 GSTO1; glutathione S-transferase omega-1
102887332 MGST1; microsomal glutathione S-transferase 1
102891202 MGST3; microsomal glutathione S-transferase 3
102891351 GSTA4; glutathione S-transferase A4
102897012 glutathione S-transferase A3-like
102883042 glutathione S-transferase theta-1
102883292 glutathione S-transferase theta-3
102893685 GSTM4; glutathione S-transferase Mu 4 isoform X3
102894088 glutathione S-transferase Mu 5
102891589 glutathione S-transferase A4
107195441 glutathione S-transferase theta-1
102882795 glutathione S-transferase theta-4
102889068 glutathione S-transferase P isoform X2
102896271 glutathione S-transferase P
102887506 TXNRD1; thioredoxin reductase 1, cytoplasmic
102894141 TXNRD3; thioredoxin reductase 3
102890334 TXNRD2; thioredoxin reductase 2, mitochondrial isoform X2
102884716 von Hippel-Lindau disease tumor suppressor-like
102895455 ELOC; elongin-C
102895498 ELOB; elongin-B
102895656 CUL2; cullin-2 isoform X2
102894690 EGLN1; egl nine homolog 1
102886969 EGLN3; egl nine homolog 3
102881942 EGLN2; egl nine homolog 2 isoform X2
102881861 FH; fumarate hydratase, mitochondrial isoform X1
102897284 HIF1A; hypoxia-inducible factor 1-alpha
102894133 EPAS1; endothelial PAS domain-containing protein 1 isoform X1
102885691 ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1
102895548 ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X8
102886172 CREBBP; LOW QUALITY PROTEIN: CREB-binding protein
102881042 EP300; histone acetyltransferase p300
102885620 SLC2A1; solute carrier family 2, facilitated glucose transporter member 1
102883084 JAG1; protein jagged-1
102891267 JAG2; protein jagged-2
102891557 DLL4; delta-like protein 4 isoform X2
102882856 DLL3; delta-like protein 3
102892930 DLL1; delta-like protein 1
102889752 NOTCH1; neurogenic locus notch homolog protein 1
102887446 NOTCH2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2
102898799 NOTCH3; neurogenic locus notch homolog protein 3
102895453 NOTCH4; neurogenic locus notch homolog protein 4
102890128 HES1; transcription factor HES-1
102893116 HES5; transcription factor HES-5
102893208 hairy/enhancer-of-split related with YRPW motif protein 1
102891586 HEY2; hairy/enhancer-of-split related with YRPW motif protein 2
102895448 HEYL; hairy/enhancer-of-split related with YRPW motif-like protein
102889771 FLT4; vascular endothelial growth factor receptor 3
102882514 SHH; sonic hedgehog protein
102884350 PTCH1; LOW QUALITY PROTEIN: protein patched homolog 1
102892668 SMO; smoothened homolog
102882111 KIF7; kinesin-like protein KIF7
102892289 SUFU; suppressor of fused homolog isoform X1
102889893 GLI1; zinc finger protein GLI1 isoform X1
102880962 GLI2; zinc finger protein GLI2 isoform X1
102894872 GLI3; transcriptional activator GLI3 isoform X1
102886941 BMP2; bone morphogenetic protein 2
102881920 BMP4; bone morphogenetic protein 4 isoform X1
102880475 HHIP; hedgehog-interacting protein
102887248 PTCH2; protein patched homolog 2
102893723 LOW QUALITY PROTEIN: androgen receptor-like
102894221 AR; androgen receptor
102879632 HSP90AA1; heat shock protein HSP 90-alpha
102887985 HSP90AB1; heat shock protein HSP 90-beta
102889156 HSP90B1; endoplasmin
|
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08733 APPL1; DCC-interacting protein 13 alpha
K05689 CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02085 APC; adenomatosis polyposis coli protein
K02085 APC; adenomatosis polyposis coli protein
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; G1/S-specific cyclin-D1
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7; frizzled 1/7
K02432 FZD1_7; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4; frizzled 4
K02375 FZD5_8; frizzled 5/8
K02375 FZD5_8; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02842 FZD9_10; frizzled 9/10
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K03069 FRAT1; frequently rearranged in advanced T-cell lymphomas 1
K01313 F2; coagulation factor II (thrombin) [EC:3.4.21.5]
K09821 AGT; angiotensinogen
K03914 F2R; coagulation factor II (thrombin) receptor
K04236 F2RL3; coagulation factor II (thrombin) receptor-like 3
K04289 LPAR1; lysophosphatidic acid receptor 1
K04291 LPAR2; lysophosphatidic acid receptor 2
K04294 LPAR3; lysophosphatidic acid receptor 3
K04275 LPAR4; lysophosphatidic acid receptor 4
K08390 LPAR5; lysophosphatidic acid receptor 5
K04273 LPAR6; lysophosphatidic acid receptor 6
K04166 AGTR1; angiotensin II receptor type 1
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
K07532 ARHGEF12; Rho guanine nucleotide exchange factor 12
K12331 ARHGEF11; Rho guanine nucleotide exchange factor 11
K12330 ARHGEF1; Rho guanine nucleotide exchange factor 1
K19464 PLEKHG5; pleckstrin homology domain-containing family G member 5
K04513 RHOA; Ras homolog gene family, member A
K04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
K10031 CXCL12; C-X-C motif chemokine 12
K04189 CXCR4; C-X-C chemokine receptor type 4
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04258 PTGER1; prostaglandin E receptor 1
K04259 PTGER2; prostaglandin E receptor 2
K04260 PTGER3; prostaglandin E receptor 3
K04261 PTGER4; prostaglandin E receptor 4
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04536 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538 GNB4; guanine nucleotide-binding protein subunit beta-4
K04539 GNB5; guanine nucleotide-binding protein subunit beta-5
K07826 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K05637 LAMA1_2; laminin, alpha 1/2
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09348 NKX3-1; homeobox protein Nkx-3.1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161 BCL2; apoptosis regulator Bcl-2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K07201 FOXO1; forkhead box protein O1
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451 TP53; tumor protein p53
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K08878 BCR1; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK; C-crk adapter molecule crk
K04438 CRK; C-crk adapter molecule crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K04702 PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
K08806 PIM2; proto-oncogene serine/threonine-protein kinase Pim-2 [EC:2.7.11.1]
K03898 KNG; kininogen
K16366 EDN1; endothelin-1
K03916 BDKRB2; bradykinin receptor B2
K04197 EDNRA; endothelin receptor type A
K04198 EDNRB; endothelin receptor type B
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04635 GNA11; guanine nucleotide-binding protein subunit alpha-11
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K05429 IL2; interleukin 2
K04736 IL3; interleukin 3
K05430 IL4; interleukin 4
K05428 IL5; interleukin 5
K05405 IL6; interleukin 6
K05431 IL7; interleukin 7
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K05435 IL13; interleukin 13
K05433 IL15; interleukin 15
K05426 IL23A; interleukin 23 subunit alpha
K05437 EPO; erythropoietin
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K04687 IFNG; interferon gamma
K05068 IL2RA; interleukin 2 receptor alpha
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K04737 IL3RA; interleukin 3 receptor alpha
K05071 IL4R; interleukin 4 receptor
K04738 CSF2RB; cytokine receptor common subunit beta
K05067 IL5RA. CD125; interleukin 5 receptor alpha
K05055 IL6R; interleukin 6 receptor
K05060 IL6ST; interleukin 6 signal transducer
K05072 IL7R; interleukin 7 receptor
K05063 IL12RB1; interleukin 12 receptor beta-1
K05064 IL12RB2; interleukin 12 receptor beta-2
K05076 IL13RA1; interleukin 13 receptor alpha-1
K05074 IL15RA; interleukin 15 receptor alpha
K05065 IL23R; interleukin 23 receptor
K05079 EPOR; erythropoietin receptor
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05132 IFNGR1; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K15420 EML4; echinoderm microtubule-associated protein-like 4
K05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K11222 STAT4; signal transducer and activator of transcription 4
K11225 STAT6; signal transducer and activator of transcription 6
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K05449 VEGFC_D; vascular endothelial growth factor C/D
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359 PDGFA; platelet-derived growth factor subunit A
K17386 PDGFB; platelet-derived growth factor subunit B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K13769 IGF2; insulin-like growth factor 2
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461 KITLG; KIT ligand
K05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K18496 FGF1; fibroblast growth factor 1
K18497 FGF2; fibroblast growth factor 2
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K22603 FGF19; fibroblast growth factor 19
K22429 FGF21; fibroblast growth factor 21
K22428 FGF23; fibroblast growth factor 23
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K02678 ETS1; C-ets-1
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030 IL8; interleukin 8
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6; coiled-coil domain-containing protein 6
K09289 NCOA4; nuclear receptor coactivator 4
K03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5; Ras association domain-containing protein 5
K04411 STK4; serine/threonine kinase 4
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04375 ELK1; ETS domain-containing protein Elk-1
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K08524 RXRA; retinoid X receptor alpha
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K08528 RARB; retinoic acid receptor beta
K08550 ESR1; estrogen receptor alpha
K08551 ESR2; estrogen receptor beta
K09101 NCOA1; nuclear receptor coactivator 1 [EC:2.3.1.48]
K11256 NCOA3; nuclear receptor coactivator 3 [EC:2.3.1.48]
K04684 SP1; transcription factor Sp1
K04504 NR1C2; peroxisome proliferator-activated receptor delta
K10056 JUP; junction plakoglobin
K10055 ZBTB16; zinc finger and BTB domain-containing protein 16
K08527 RARA; retinoic acid receptor alpha
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K10054 PML; probable transcription factor PML
K08367 RUNX1; runt-related transcription factor 1
K10053 RUNX1T1; CBFA2/RNUX1 translocation partner 1
K09438 SPI1; transcription factor PU.1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K05066 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor alpha
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K04453 MAX; Max protein
K10500 ZBTB17; zinc finger and BTB domain-containing protein 17
K04685 CDKN2B; cyclin-dependent kinase inhibitor 2B
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03094 SKP1; S-phase kinase-associated protein 1
K03347 CUL1; cullin 1
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K06618 RB1; retinoblastoma-associated protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
K09455 MITF; microphthalmia-associated transcription factor
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 MECOM; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
K04496 CTBP; C-terminal binding protein
K04496 CTBP; C-terminal binding protein
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K08775 BRCA2; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K16341 BCL2L11; Bcl-2-like protein 11
K08738 CYC; cytochrome c
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K10456 KLHL19; kelch-like protein 19
K05638 NFE2L2; nuclear factor erythroid 2-related factor 2
K00510 HMOX1; heme oxygenase 1 [EC:1.14.14.18]
K00355 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 ELOC; elongin-C
K03873 ELOB; elongin-B
K03870 CUL2; cullin 2
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A; hypoxia-inducible factor 2 alpha
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K06052 JAG1; jagged-1
K21635 JAG2; jagged-2
K06051 DLL; delta
K06051 DLL; delta
K06051 DLL; delta
K02599 NOTCH1; Notch 1
K20994 NOTCH2; Notch 2
K20995 NOTCH3; Notch 3
K20996 NOTCH4; Notch 4
K06054 HES1; hairy and enhancer of split 1
K06055 HES5; hairy and enhancer of split 5
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K11988 SHH; sonic hedgehog
K06225 PTCH1; patched 1
K06226 SMO; smoothened
K18806 KIF7; kinesin family member 7
K06229 SUFU; suppressor of fused
K16797 GLI1; zinc finger protein GLI1
K16798 GLI2; zinc finger protein GLI2
K06230 GLI3; zinc finger protein GLI3
K21283 BMP2; bone morphogenetic protein 2
K04662 BMP4; bone morphogenetic protein 4
K06231 HHIP; hedgehog interacting protein
K11101 PTCH2; patched 2
K08557 AR; androgen receptor
K08557 AR; androgen receptor
K04079 HSP90A; molecular chaperone HtpG
K04079 HSP90A; molecular chaperone HtpG
K09487 HSP90B; heat shock protein 90kDa beta
|
05202 Transcriptional misregulation in cancer [PATH:pale05202]
|
05206 MicroRNAs in cancer [PATH:pale05206]
|
05205 Proteoglycans in cancer [PATH:pale05205]
|
05204 Chemical carcinogenesis [PATH:pale05204]
|
05203 Viral carcinogenesis [PATH:pale05203]
|
05230 Central carbon metabolism in cancer [PATH:pale05230]
|
05231 Choline metabolism in cancer [PATH:pale05231]
|
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:pale05235]
|
|
|
09162 Cancer: specific types
|
05210 Colorectal cancer [PATH:pale05210]
|
102882441 GSK3B; glycogen synthase kinase-3 beta isoform X4
102878657 AXIN1; axin-1 isoform X1
102885831 AXIN2; axin-2
102880017 CTNNB1; LOW QUALITY PROTEIN: catenin beta-1
102880260 APC; adenomatous polyposis coli protein isoform X3
102891886 APC2; adenomatous polyposis coli protein 2
102885788 TCF7; transcription factor 7 isoform X4
102886093 TCF7L1; transcription factor 7-like 1
102880370 TCF7L2; transcription factor 7-like 2 isoform X2
102886933 LEF1; lymphoid enhancer-binding factor 1 isoform X1
102888083 BIRC5; baculoviral IAP repeat-containing protein 5
102895524 MYC; myc proto-oncogene protein
102885330 CCND1; G1/S-specific cyclin-D1
102895590 KRAS; GTPase KRas isoform X1
102889227 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
102880320 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
102889576 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
102879163 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
102891637 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3
102879453 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta
102885144 AKT1; RAC-alpha serine/threonine-protein kinase isoform X1
102879337 AKT3; RAC-gamma serine/threonine-protein kinase isoform X1
102898305 AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase
102877892 BAD; bcl2-associated agonist of cell death isoform X1
102878565 CASP9; caspase-9
102877877 ARAF; serine/threonine-protein kinase A-Raf isoform X2
102878393 BRAF; serine/threonine-protein kinase B-raf isoform X2
102893439 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1
102897122 MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1
102879034 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2
102895390 MAPK1; mitogen-activated protein kinase 1
102885749 MAPK3; mitogen-activated protein kinase 3
102896121 JUN; transcription factor AP-1
102891428 FOS; proto-oncogene c-Fos
102880177 RALGDS; ral guanine nucleotide dissociation stimulator isoform X2
102898811 RALA; ras-related protein Ral-A
102899030 RALB; ras-related protein Ral-B
102897644 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1
102885507 RAC2; ras-related C3 botulinum toxin substrate 2
102887421 RAC3; ras-related C3 botulinum toxin substrate 3
102891515 RHOA; transforming protein RhoA
102885064 MAPK10; mitogen-activated protein kinase 10 isoform X5
102890689 MAPK9; mitogen-activated protein kinase 9 isoform X1
102892777 MAPK8; mitogen-activated protein kinase 8 isoform X1
102886027 DCC; netrin receptor DCC
102897289 CASP3; caspase-3
102887604 APPL1; DCC-interacting protein 13-alpha
102884154 TGFB1; transforming growth factor beta-1
102881295 TGFB2; transforming growth factor beta-2 isoform X2
102893304 TGFB3; transforming growth factor beta-3
102880759 TGFBR1; TGF-beta receptor type-1 isoform X2
102889618 TGFBR2; TGF-beta receptor type-2 isoform X1
102893928 SMAD2; mothers against decapentaplegic homolog 2
102895268 SMAD3; mothers against decapentaplegic homolog 3
102886521 SMAD4; mothers against decapentaplegic homolog 4
102898392 MLH1; DNA mismatch repair protein Mlh1 isoform X1
102893728 MSH2; DNA mismatch repair protein Msh2 isoform X3
102878992 MSH3; DNA mismatch repair protein Msh3 isoform X1
102892999 MSH6; DNA mismatch repair protein Msh6
102885135 BAX; apoptosis regulator BAX isoform X1
102894490 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
102890309 BCL2L11; bcl-2-like protein 11 isoform X1
102892591 BBC3; bcl-2-binding component 3
102896443 BCL2; apoptosis regulator Bcl-2
102879159 cytochrome c
102893036 cytochrome c
102889604 TP53; cellular tumor antigen p53
102894049 CDKN1A; cyclin-dependent kinase inhibitor 1
102886440 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha
102878191 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma
102885790 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta
102883540 BAK1; bcl-2 homologous antagonist/killer
102879479 DDB2; DNA damage-binding protein 2 isoform X1
102890888 POLK; DNA polymerase kappa isoform X1
102891552 EGF; pro-epidermal growth factor isoform X1
102887662 TGFA; protransforming growth factor alpha isoform X1
102884726 EREG; proepiregulin
102884477 AREG; amphiregulin
102893495 EGFR; epidermal growth factor receptor
102878822 GRB2; growth factor receptor-bound protein 2 isoform X1
102882462 SOS1; son of sevenless homolog 1 isoform X1
102889597 SOS2; son of sevenless homolog 2
102896270 HRAS; GTPase HRas isoform X3
102885950 NRAS; GTPase NRas isoform X2
102885092 MTOR; serine/threonine-protein kinase mTOR
102891214 RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1
102889369 RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1
|
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02105 CTNNB1; catenin beta 1
K02085 APC; adenomatosis polyposis coli protein
K02085 APC; adenomatosis polyposis coli protein
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; G1/S-specific cyclin-D1
K07827 KRAS; GTPase KRas
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04513 RHOA; Ras homolog gene family, member A
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K08733 APPL1; DCC-interacting protein 13 alpha
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K02159 BAX; apoptosis regulator BAX
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K16341 BCL2L11; Bcl-2-like protein 11
K10132 BBC3; Bcl-2-binding component 3
K02161 BCL2; apoptosis regulator Bcl-2
K08738 CYC; cytochrome c
K08738 CYC; cytochrome c
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K04357 EGF; epidermal growth factor
K08774 TGFA; transforming growth factor, alpha
K09784 EREG; epiregulin
K09782 AREG; amphiregulin
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07828 NRAS; GTPase NRas
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
|
05212 Pancreatic cancer [PATH:pale05212]
|
05225 Hepatocellular carcinoma [PATH:pale05225]
|
05226 Gastric cancer [PATH:pale05226]
|
05214 Glioma [PATH:pale05214]
|
05216 Thyroid cancer [PATH:pale05216]
|
05221 Acute myeloid leukemia [PATH:pale05221]
|
05220 Chronic myeloid leukemia [PATH:pale05220]
|
05217 Basal cell carcinoma [PATH:pale05217]
|
05218 Melanoma [PATH:pale05218]
|
05211 Renal cell carcinoma [PATH:pale05211]
|
05219 Bladder cancer [PATH:pale05219]
|
05215 Prostate cancer [PATH:pale05215]
|
05213 Endometrial cancer [PATH:pale05213]
|
05224 Breast cancer [PATH:pale05224]
|
05222 Small cell lung cancer [PATH:pale05222]
|
05223 Non-small cell lung cancer [PATH:pale05223]
|
|
|
09172 Infectious disease: viral
|
|
|
09171 Infectious disease: bacterial
|
|
|
09174 Infectious disease: parasitic
|
|
|
09163 Immune disease
|
|
|
09164 Neurodegenerative disease
|
|
|
09165 Substance dependence
|
|
|
09166 Cardiovascular disease
|
|
|
09167 Endocrine and metabolic disease
|
|
|
09175 Drug resistance: antimicrobial
|
|
|
09176 Drug resistance: antineoplastic
|
01521 EGFR tyrosine kinase inhibitor resistance [PATH:pale01521]
|
01524 Platinum drug resistance [PATH:pale01524]
|
102883932 SLC31A1; high affinity copper uptake protein 1
102887660 ATP7B; copper-transporting ATPase 2 isoform X1
102888320 ATP7A; copper-transporting ATPase 1 isoform X1
102885225 MGST2; microsomal glutathione S-transferase 2
102886852 GSTO2; glutathione S-transferase omega-2
102887110 GSTO1; glutathione S-transferase omega-1
102887332 MGST1; microsomal glutathione S-transferase 1
102891202 MGST3; microsomal glutathione S-transferase 3
102891351 GSTA4; glutathione S-transferase A4
102897012 glutathione S-transferase A3-like
102883042 glutathione S-transferase theta-1
102883292 glutathione S-transferase theta-3
102893685 GSTM4; glutathione S-transferase Mu 4 isoform X3
102894088 glutathione S-transferase Mu 5
102891589 glutathione S-transferase A4
107195441 glutathione S-transferase theta-1
102882795 glutathione S-transferase theta-4
102889068 glutathione S-transferase P isoform X2
102896271 glutathione S-transferase P
102894298 ABCC2; canalicular multispecific organic anion transporter 1
102891912 POLH; DNA polymerase eta isoform X1
102896156 REV3L; DNA polymerase zeta catalytic subunit isoform X2
102893728 MSH2; DNA mismatch repair protein Msh2 isoform X3
102878992 MSH3; DNA mismatch repair protein Msh3 isoform X1
102892999 MSH6; DNA mismatch repair protein Msh6
102898392 MLH1; DNA mismatch repair protein Mlh1 isoform X1
102883387 XPA; DNA repair protein complementing XP-A cells isoform X1
102891932 ERCC1; DNA excision repair protein ERCC-1 isoform X2
102879885 TOP2A; DNA topoisomerase 2-alpha
102879554 TOP2B; DNA topoisomerase 2-beta
102895982 BRCA1; breast cancer type 1 susceptibility protein isoform X1
102898588 ATM; serine-protein kinase ATM isoform X1
102889604 TP53; cellular tumor antigen p53
102896422 LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 2A
102884281 MDM2; E3 ubiquitin-protein ligase Mdm2
102879561 FAS; tumor necrosis factor receptor superfamily member 6 isoform X5
102885135 BAX; apoptosis regulator BAX isoform X1
102883540 BAK1; bcl-2 homologous antagonist/killer
102894490 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
102892591 BBC3; bcl-2-binding component 3
102883204 FASLG; tumor necrosis factor ligand superfamily member 6
102892511 FADD; FAS-associated death domain protein
102878181 CASP8; caspase-8
102897289 CASP3; caspase-3
102887379 BID; BH3-interacting domain death agonist isoform X3
102884388 baculoviral IAP repeat-containing protein 3
102884651 BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1
102885349 XIAP; E3 ubiquitin-protein ligase XIAP
102888083 BIRC5; baculoviral IAP repeat-containing protein 5
102885300 ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2
102889227 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
102880320 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
102889576 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
102879163 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
102891637 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3
102879453 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta
102896950 PDPK1; 3-phosphoinositide-dependent protein kinase 1
102885144 AKT1; RAC-alpha serine/threonine-protein kinase isoform X1
102879337 AKT3; RAC-gamma serine/threonine-protein kinase isoform X1
102898305 AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase
102894049 CDKN1A; cyclin-dependent kinase inhibitor 1
102888994 MAP3K5; mitogen-activated protein kinase kinase kinase 5
102895390 MAPK1; mitogen-activated protein kinase 1
102885749 MAPK3; mitogen-activated protein kinase 3
102877892 BAD; bcl2-associated agonist of cell death isoform X1
102887704 BCL2L1; bcl-2-like protein 1
102896443 BCL2; apoptosis regulator Bcl-2
102879159 cytochrome c
102893036 cytochrome c
102897687 APAF1; apoptotic protease-activating factor 1
102878565 CASP9; caspase-9
|
K14686 SLC31A1; solute carrier family 31 (copper transporter), member 1
K17686 copA; P-type Cu+ transporter [EC:7.2.2.8]
K17686 copA; P-type Cu+ transporter [EC:7.2.2.8]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K05666 ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2
K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K08734 MLH1; DNA mismatch repair protein MLH1
K10847 XPA; DNA-repair protein complementing XP-A cells
K10849 ERCC1; DNA excision repair protein ERCC-1
K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K04451 TP53; tumor protein p53
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04726 BID; BH3 interacting domain death agonist
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K02158 BAD; Bcl-2-antagonist of cell death
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K08738 CYC; cytochrome c
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
|
01523 Antifolate resistance [PATH:pale01523]
|
01522 Endocrine resistance [PATH:pale01522]
|
|
|
09180 Brite Hierarchies
|
|
|
09181 Protein families: metabolism
|
|
|
09182 Protein families: genetic information processing
|
03000 Transcription factors [BR:pale03000]
|
03021 Transcription machinery [BR:pale03021]
|
03019 Messenger RNA biogenesis [BR:pale03019]
|
03041 Spliceosome [BR:pale03041]
|
03011 Ribosome [BR:pale03011]
|
03009 Ribosome biogenesis [BR:pale03009]
|
03016 Transfer RNA biogenesis [BR:pale03016]
|
03012 Translation factors [BR:pale03012]
|
03110 Chaperones and folding catalysts [BR:pale03110]
|
04131 Membrane trafficking [BR:pale04131]
|
04121 Ubiquitin system [BR:pale04121]
|
03051 Proteasome [BR:pale03051]
|
03032 DNA replication proteins [BR:pale03032]
|
03036 Chromosome and associated proteins [BR:pale03036]
|
03400 DNA repair and recombination proteins [BR:pale03400]
|
102888658 MGMT; methylated-DNA--protein-cysteine methyltransferase
102887953 ALKBH2; DNA oxidative demethylase ALKBH2
102889640 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X2
102883572 CRY1; cryptochrome-1
102887705 UNG; uracil-DNA glycosylase
102885996 CCNO; cyclin-O
102888665 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X2
102881650 MPG; DNA-3-methyladenine glycosylase isoform X2
102889610 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1
102888194 MUTYH; adenine DNA glycosylase isoform X2
102894925 MBD4; methyl-CpG-binding domain protein 4 isoform X2
102884174 OGG1; N-glycosylase/DNA lyase isoform X2
102887454 NEIL1; endonuclease 8-like 1 isoform X1
102882777 NEIL2; endonuclease 8-like 2
102894583 NEIL3; endonuclease 8-like 3 isoform X1
102880592 NTHL1; endonuclease III-like protein 1 isoform X2
102897846 APEX1; DNA-(apurinic or apyrimidinic site) lyase isoform X1
102898078 APEX2; DNA-(apurinic or apyrimidinic site) lyase 2
102896397 POLD1; DNA polymerase delta catalytic subunit
102884073 POLD2; DNA polymerase delta subunit 2
102895310 POLD3; DNA polymerase delta subunit 3
102893003 POLD4; DNA polymerase delta subunit 4
102892506 POLE; DNA polymerase epsilon catalytic subunit A isoform X1
102883769 POLE2; DNA polymerase epsilon subunit 2
102880775 POLE3; DNA polymerase epsilon subunit 3
102896323 POLE4; DNA polymerase epsilon subunit 4 isoform X1
102890018 PCNA; proliferating cell nuclear antigen
102894568 FEN1; flap endonuclease 1
102888944 LIG1; LOW QUALITY PROTEIN: DNA ligase 1
102893018 POLB; DNA polymerase beta
102885428 XRCC1; DNA repair protein XRCC1
102896329 LIG3; DNA ligase 3
102885143 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X2
102880269 APTX; aprataxin isoform X1
102893075 APLF; aprataxin and PNK-like factor
102898132 PNKP; bifunctional polynucleotide phosphatase/kinase
102882684 HMGB1; high mobility group protein B1
102894809 POLL; DNA polymerase lambda isoform X1
102882722 PARP1; poly [ADP-ribose] polymerase 1
102895597 PARP4; poly [ADP-ribose] polymerase 4
102896370 PARP2; poly [ADP-ribose] polymerase 2
102884230 PARP3; poly [ADP-ribose] polymerase 3
102895308 XPC; DNA repair protein complementing XP-C cells isoform X1
102888054 RAD23B; UV excision repair protein RAD23 homolog B isoform X1
102882080 RAD23A; UV excision repair protein RAD23 homolog A
102879702 CETN2; centrin-2
102893437 RBX1; E3 ubiquitin-protein ligase RBX1
102892859 CUL4B; cullin-4B isoform X1
102883045 CUL4A; cullin-4A
102897514 DDB1; DNA damage-binding protein 1
102879479 DDB2; DNA damage-binding protein 2 isoform X1
102885614 POLR2A; DNA-directed RNA polymerase II subunit RPB1 isoform X1
102879872 POLR2B; DNA-directed RNA polymerase II subunit RPB2
102890873 POLR2C; DNA-directed RNA polymerase II subunit RPB3
102882561 POLR2D; DNA-directed RNA polymerase II subunit RPB4
102877935 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1
102881812 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1
102887999 POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X2
102878376 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3
102892810 POLR2I; DNA-directed RNA polymerase II subunit RPB9
102878984 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5
102897120 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a
102894671 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4
102878531 ERCC8; DNA excision repair protein ERCC-8 isoform X1
102895255 ERCC6; DNA excision repair protein ERCC-6 isoform X1
102878840 UVSSA; UV-stimulated scaffold protein A
102881014 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB
102891047 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD
102887484 GTF2H1; general transcription factor IIH subunit 1 isoform X2
102883057 GTF2H2; general transcription factor IIH subunit 2
102896263 GTF2H3; general transcription factor IIH subunit 3 isoform X2
102883568 GTF2H4; general transcription factor IIH subunit 4
102896540 GTF2H5; general transcription factor IIH subunit 5 isoform X1
102880932 CDK7; cyclin-dependent kinase 7 isoform X1
102883058 CCNH; cyclin-H isoform X2
102896029 MNAT1; CDK-activating kinase assembly factor MAT1
102889870 RPA1; replication protein A 70 kDa DNA-binding subunit
102883783 RPA2; replication protein A 32 kDa subunit
102884493 RPA3; replication protein A 14 kDa subunit isoform X1
102878725 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit
102883387 XPA; DNA repair protein complementing XP-A cells isoform X1
102891932 ERCC1; DNA excision repair protein ERCC-1 isoform X2
102881542 ERCC4; LOW QUALITY PROTEIN: DNA repair endonuclease XPF
102890150 DNA repair protein complementing XP-G cells isoform X4
102886470 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1
102879889 CUL3; cullin-3
102897835 CUL5; cullin-5 isoform X1
102895455 ELOC; elongin-C
102895498 ELOB; elongin-B
102886128 ELOA; elongin-A
102893728 MSH2; DNA mismatch repair protein Msh2 isoform X3
102878992 MSH3; DNA mismatch repair protein Msh3 isoform X1
102892999 MSH6; DNA mismatch repair protein Msh6
102893605 MSH4; mutS protein homolog 4
102881600 MSH5; mutS protein homolog 5 isoform X1
102884442 PMS1; PMS1 protein homolog 1 isoform X1
102898392 MLH1; DNA mismatch repair protein Mlh1 isoform X1
102879718 PMS2; mismatch repair endonuclease PMS2 isoform X1
102890288 MLH3; DNA mismatch repair protein Mlh3 isoform X1
102892618 RFC1; replication factor C subunit 1 isoform X3
102886215 RFC4; replication factor C subunit 4 isoform X2
102888919 RFC2; replication factor C subunit 2 isoform X1
102885071 RFC5; replication factor C subunit 5
102891620 RFC3; replication factor C subunit 3 isoform X1
102880463 EXO1; exonuclease 1 isoform X1
102881924 WDR76; WD repeat-containing protein 76 isoform X1
102878053 MRE11; double-strand break repair protein MRE11 isoform X1
102890531 RAD50; DNA repair protein RAD50 isoform X1
102881755 NBN; nibrin isoform X1
102895982 BRCA1; breast cancer type 1 susceptibility protein isoform X1
102893717 BARD1; LOW QUALITY PROTEIN: BRCA1-associated RING domain protein 1
102888310 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X3
102878605 UIMC1; BRCA1-A complex subunit RAP80 isoform X2
102894026 BABAM1; BRISC and BRCA1-A complex member 1 isoform X1
102880922 BABAM2; BRISC and BRCA1-A complex member 2
102897805 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X2
102890464 BRIP1; Fanconi anemia group J protein
102887896 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1
102898606 RBBP8; DNA endonuclease RBBP8 isoform X1
102896802 BRCA2; breast cancer type 2 susceptibility protein
102895844 PALB2; partner and localizer of BRCA2 isoform X1
102894016 RAD51; DNA repair protein RAD51 homolog 1
102895090 RAD51B; DNA repair protein RAD51 homolog 2 isoform X6
102885802 RAD51C; DNA repair protein RAD51 homolog 3 isoform X3
102882022 RAD51D; DNA repair protein RAD51 homolog 4 isoform X3
102888362 XRCC2; DNA repair protein XRCC2
102887560 XRCC3; LOW QUALITY PROTEIN: DNA repair protein XRCC3
102878828 DMC1; meiotic recombination protein DMC1/LIM15 homolog
102880900 RAD52; DNA repair protein RAD52 homolog isoform X1
102898831 RDM1; RAD52 motif-containing protein 1 isoform X1
102892784 RAD54L; DNA repair and recombination protein RAD54-like isoform X2
102883044 RAD54L2; helicase ARIP4 isoform X1
102891752 RAD54B; DNA repair and recombination protein RAD54B isoform X2
102890323 RECQL; ATP-dependent DNA helicase Q1 isoform X2
102886512 WRN; Werner syndrome ATP-dependent helicase
102888215 BLM; Bloom syndrome protein isoform X1
102887502 RECQL4; ATP-dependent DNA helicase Q4
102898994 RECQL5; ATP-dependent DNA helicase Q5
102880328 TOP3B; DNA topoisomerase 3-beta-1 isoform X2
102878631 TOP3A; DNA topoisomerase 3-alpha isoform X1
102883483 RMI1; recQ-mediated genome instability protein 1
102891141 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit isoform X1
102890758 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1
102882836 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 1-like
102897115 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1
102886393 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1
102886799 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1
102895206 serine/threonine-protein phosphatase 4 regulatory subunit 3B
102893476 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1
102886819 AP5B1; AP-5 complex subunit beta-1
102896468 AP5M1; AP-5 complex subunit mu-1
102892877 AP5S1; AP-5 complex subunit sigma-1
102878794 AP5Z1; AP-5 complex subunit zeta-1
102888758 SMC5; structural maintenance of chromosomes protein 5 isoform X2
102878639 SMC6; structural maintenance of chromosomes protein 6
102898420 FAM84A; protein FAM84A
102893085 NSMCE1; non-structural maintenance of chromosomes element 1 homolog isoform X1
102894409 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1
102891587 NSMCE3; non-structural maintenance of chromosomes element 3 homolog
102884411 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A
102887259 EID3; EP300-interacting inhibitor of differentiation 3
102890767 SYCP2; synaptonemal complex protein 2
102893012 SYCP3; synaptonemal complex protein 3
102887468 EME1; crossover junction endonuclease EME1 isoform X1
102878659 EME2; probable crossover junction endonuclease EME2 isoform X1
102888910 EXD2; exonuclease 3'-5' domain-containing protein 2
102888358 HFM1; probable ATP-dependent DNA helicase HFM1
102885920 MUS81; crossover junction endonuclease MUS81 isoform X7
102881642 SEM1; 26S proteasome complex subunit SEM1
102881411 SPO11; meiotic recombination protein SPO11 isoform X1
102889663 SLX1A; structure-specific endonuclease subunit SLX1 isoform X1
102887590 SLX4; LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4
102878891 GEN1; flap endonuclease GEN homolog 1 isoform X1
102897612 SPG11; spatacsin isoform X2
102886831 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1
102891656 RAD51AP1; RAD51-associated protein 1 isoform X1
102889615 MORF4L1; mortality factor 4-like protein 1
102883990 MEIOB; meiosis-specific with OB domain-containing protein isoform X2
102897310 SPATA22; spermatogenesis-associated protein 22 isoform X1
102889853 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1
102898253 FIGNL1; fidgetin-like protein 1 isoform X2
102896063 SPIDR; LOW QUALITY PROTEIN: DNA repair-scaffolding protein
102893433 FAM84B; protein FAM84B
102888913 BRAT1; BRCA1-associated ATM activator 1 isoform X1
102895189 CUNH21orf2; protein C21orf2 isoform X2
102890254 XRCC6; X-ray repair cross-complementing protein 6
102890386 XRCC5; X-ray repair cross-complementing protein 5
102895801 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1
102888401 LIG4; DNA ligase 4 isoform X1
102881460 XRCC4; DNA repair protein XRCC4 isoform X1
102882950 NHEJ1; non-homologous end-joining factor 1
102883214 POLM; DNA-directed DNA/RNA polymerase mu isoform X3
102888799 DNTT; DNA nucleotidylexotransferase isoform X1
102898649 DCLRE1C; protein artemis isoform X1
102896374 TDP2; tyrosyl-DNA phosphodiesterase 2 isoform X1
102883943 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
102878523 PWWP domain-containing protein MUM1L1
102878943 PWWP domain-containing protein MUM1 isoform X1
102894855 MUM1L1; PWWP domain-containing protein MUM1L1
102884278 FANCA; Fanconi anemia group A protein isoform X2
102891129 FANCB; Fanconi anemia group B protein
102881661 FANCC; Fanconi anemia group C protein isoform X5
102898238 FANCE; Fanconi anemia group E protein isoform X1
102892576 FANCF; Fanconi anemia group F protein
102890585 FANCG; Fanconi anemia group G protein
102884487 FANCL; E3 ubiquitin-protein ligase FANCL
102886782 FANCM; Fanconi anemia group M protein
102891915 FAAP24; Fanconi anemia core complex-associated protein 24
102890885 FAAP100; Fanconi anemia core complex-associated protein 100
102890128 HES1; transcription factor HES-1
102886828 CENPS; centromere protein S
107195713 CENPX; centromere protein X
102879480 UBE2T; ubiquitin-conjugating enzyme E2 T isoform X2
102887690 FANCD2; Fanconi anemia group D2 protein isoform X1
102882939 FANCI; Fanconi anemia group I protein isoform X2
102890629 FAN1; fanconi-associated nuclease 1
112475776 fanconi-associated nuclease 1-like isoform X1
102879418 TELO2; telomere length regulation protein TEL2 homolog isoform X1
102898461 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1
102895486 WDR48; WD repeat-containing protein 48
102894507 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit
102888588 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1
102881569 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1
102886572 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1
102894460 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3
102890109 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1
102898741 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
102891032 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X5
102885224 RNF168; E3 ubiquitin-protein ligase RNF168
102882290 RNF169; E3 ubiquitin-protein ligase RNF169
102887399 E3 ubiquitin-protein ligase HERC2
102889856 WRAP53; telomerase Cajal body protein 1 isoform X1
102895425 TPRN; taperin
102888190 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X2
102882919 WDR70; WD repeat-containing protein 70
102891912 POLH; DNA polymerase eta isoform X1
102894090 POLI; DNA polymerase iota
102890888 POLK; DNA polymerase kappa isoform X1
102890504 REV1; DNA repair protein REV1 isoform X5
102896156 REV3L; DNA polymerase zeta catalytic subunit isoform X2
102898460 POLN; DNA polymerase nu
102895543 UBE2A; ubiquitin-conjugating enzyme E2 A
102884788 UBE2B; ubiquitin-conjugating enzyme E2 B
102879933 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X1
102896367 HLTF; helicase-like transcription factor isoform X1
102896128 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 isoform X1
102894535 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1
102888783 UBE2N; ubiquitin-conjugating enzyme E2 N
102878327 ARMT1; protein-glutamate O-methyltransferase isoform X4
102886851 SPRTN; sprT-like domain-containing protein Spartan isoform X1
102892509 RAD9A; cell cycle checkpoint control protein RAD9A isoform X1
102879901 RAD9B; cell cycle checkpoint control protein RAD9B
102887750 HUS1; checkpoint protein HUS1 isoform X3
102898708 HUS1B; LOW QUALITY PROTEIN: checkpoint protein HUS1B
102888105 RAD1; cell cycle checkpoint protein RAD1
102881970 RAD17; cell cycle checkpoint protein RAD17 isoform X2
102879896 TIMELESS; protein timeless homolog isoform X1
102897374 TIPIN; TIMELESS-interacting protein
102892465 TTI1; TELO2-interacting protein 1 homolog
102884339 TTI2; TELO2-interacting protein 2
102885881 BAG6; large proline-rich protein BAG6
102895670 UBL4A; ubiquitin-like protein 4A
102895100 UBL4B; ubiquitin-like protein 4B
102889829 GET4; Golgi to ER traffic protein 4 homolog
102889339 ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR
102888318 ATRIP; ATR-interacting protein
102898588 ATM; serine-protein kinase ATM isoform X1
102889604 TP53; cellular tumor antigen p53
102882405 CHEK1; serine/threonine-protein kinase Chk1
102882358 CHEK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk2
102897196 CDC25A; M-phase inducer phosphatase 1 isoform X1
102893112 CDC25B; M-phase inducer phosphatase 2 isoform X1
102894193 CDC25C; M-phase inducer phosphatase 3 isoform X3
102880620 YWHAB; 14-3-3 protein beta/alpha
102894826 YWHAQ; 14-3-3 protein theta
102893263 YWHAZ; 14-3-3 protein zeta/delta
102895426 YWHAG; 14-3-3 protein gamma
102878861 YWHAH; 14-3-3 protein eta
102885303 YWHAE; 14-3-3 protein epsilon isoform X1
102890794 NAV2; neuron navigator 2 isoform X2
102880081 WEE2; wee1-like protein kinase 2
102878200 WEE1; wee1-like protein kinase
102893856 PER1; period circadian protein homolog 1 isoform X4
102896517 PER2; LOW QUALITY PROTEIN: period circadian protein homolog 2
102885184 PER3; period circadian protein homolog 3
102881647 MDC1; mediator of DNA damage checkpoint protein 1 isoform X2
102889055 PLS3; plastin-3
102881341 AEN; apoptosis-enhancing nuclease isoform X2
102886992 PLK3; serine/threonine-protein kinase PLK3
102894766 NEK4; serine/threonine-protein kinase Nek4 isoform X2
102888550 NEK1; serine/threonine-protein kinase Nek1 isoform X2
102893235 serine/threonine-protein kinase Nek5 isoform X1
102879805 NEK10; serine/threonine-protein kinase Nek10 isoform X1
102891911 NEK11; serine/threonine-protein kinase Nek11 isoform X4
102878436 DONSON; protein downstream neighbor of Son
102886342 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1
102888297 KANK2; KN motif and ankyrin repeat domain-containing protein 2
102889748 KANK3; KN motif and ankyrin repeat domain-containing protein 3
102898211 KANK4; KN motif and ankyrin repeat domain-containing protein 4
102880732 KLLN; LOW QUALITY PROTEIN: killin
102880906 SLFN11; schlafen family member 11 isoform X1
102885054 POLQ; DNA polymerase theta isoform X1
102882590 MYBBP1A; myb-binding protein 1A
102897941 PRIMPOL; DNA-directed primase/polymerase protein isoform X1
102883126 TREX1; three-prime repair exonuclease 1
102882649 TREX2; three prime repair exonuclease 2
102878934 DCLRE1A; DNA cross-link repair 1A protein
102883941 DCLRE1B; LOW QUALITY PROTEIN: 5' exonuclease Apollo
102878511 EXO5; exonuclease V
102892843 ENDOV; LOW QUALITY PROTEIN: endonuclease V
102882181 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
102888560 HELQ; helicase POLQ-like isoform X4
102881400 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1
102878394 PRPF19; pre-mRNA-processing factor 19
102886976 CDC5L; cell division cycle 5-like protein
102884857 BCAS2; pre-mRNA-splicing factor SPF27
102887184 PLRG1; pleiotropic regulator 1
102892026 NUDT15; nucleotide triphosphate diphosphatase NUDT15
102895707 NUDT18; 8-oxo-dGDP phosphatase NUDT18
102890105 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1
102879969 RRM1; ribonucleoside-diphosphate reductase large subunit
102895346 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B
102895581 uncharacterized protein LOC102895581
112469018 RRM2; ribonucleoside-diphosphate reductase subunit M2
102898494 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X2
|
K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
K02295 CRY; cryptochrome
K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
K10569 NEIL3; endonuclease VIII-like 3
K10773 NTH; endonuclease III [EC:4.2.99.18]
K10771 APEX1; AP endonuclease 1 [EC:4.2.99.18]
K10772 APEX2; AP endonuclease 2 [EC:4.2.99.18]
K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328 POLD2; DNA polymerase delta subunit 2
K03504 POLD3; DNA polymerase delta subunit 3
K03505 POLD4; DNA polymerase delta subunit 4
K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
K04802 PCNA; proliferating cell nuclear antigen
K04799 FEN1; flap endonuclease-1 [EC:3.-.-.-]
K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
K10803 XRCC1; DNA-repair protein XRCC1
K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
K13295 APLF; aprataxin and PNK-like factor [EC:4.2.99.18]
K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
K10802 HMGB1; high mobility group protein B1
K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10838 XPC; xeroderma pigmentosum group C-complementing protein
K10839 RAD23; UV excision repair protein RAD23
K10839 RAD23; UV excision repair protein RAD23
K10840 CETN2; centrin-2
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K10609 CUL4; cullin 4
K10609 CUL4; cullin 4
K10610 DDB1; DNA damage-binding protein 1
K10140 DDB2; DNA damage-binding protein 2
K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
K03013 RPB5; DNA-directed RNA polymerases I, II, and III subunit RPABC1
K03014 RPB6; DNA-directed RNA polymerases I, II, and III subunit RPABC2
K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
K03016 RPB8; DNA-directed RNA polymerases I, II, and III subunit RPABC3
K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
K03007 RPB10; DNA-directed RNA polymerases I, II, and III subunit RPABC5
K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
K03009 RPB12; DNA-directed RNA polymerases I, II, and III subunit RPABC4
K10570 ERCC8; DNA excision repair protein ERCC-8
K10841 ERCC6; DNA excision repair protein ERCC-6
K23720 UVSSA; UV-stimulated scaffold protein A
K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:3.6.4.12]
K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:3.6.4.12]
K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
K06634 CCNH; cyclin H
K10842 MNAT1; CDK-activating kinase assembly factor MAT1
K07466 RFA1; replication factor A1
K10739 RFA2; replication factor A2
K10740 RPA3; replication factor A3
K10741 RPA4; replication factor A4
K10847 XPA; DNA-repair protein complementing XP-A cells
K10849 ERCC1; DNA excision repair protein ERCC-1
K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
K10846 ERCC5; DNA excision repair protein ERCC-5
K15075 MET18; DNA repair/transcription protein MET18/MMS19
K03869 CUL3; cullin 3
K10612 CUL5; cullin 5
K03872 ELOC; elongin-C
K03873 ELOB; elongin-B
K15076 ELOA; elongin-A
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K08740 MSH4; DNA mismatch repair protein MSH4
K08741 MSH5; DNA mismatch repair protein MSH5
K10864 PMS1; DNA mismatch repair protein PMS1
K08734 MLH1; DNA mismatch repair protein MLH1
K10858 PMS2; DNA mismatch repair protein PMS2
K08739 MLH3; DNA mismatch repair protein MLH3
K10754 RFC1; replication factor C subunit 1
K10755 RFC2_4; replication factor C subunit 2/4
K10755 RFC2_4; replication factor C subunit 2/4
K10756 RFC3_5; replication factor C subunit 3/5
K10756 RFC3_5; replication factor C subunit 3/5
K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
K24755 WDR76; WD repeat-containing protein 76
K10865 MRE11; double-strand break repair protein MRE11
K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
K10867 NBN; nibrin
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K10683 BARD1; BRCA1-associated RING domain protein 1
K20774 FAM175A; BRCA1-A complex subunit Abraxas
K20775 UIMC1; BRCA1-A complex subunit RAP80
K20776 BABAM; BRISC and BRCA1-A complex member 1
K12173 BRE; BRCA1-A complex subunit BRE
K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
K15362 BRIP1; fanconi anemia group J protein [EC:3.6.4.12]
K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
K08775 BRCA2; breast cancer 2 susceptibility protein
K10897 PALB2; partner and localizer of BRCA2
K04482 RAD51; DNA repair protein RAD51
K10869 RAD51L1; RAD51-like protein 1
K10870 RAD51L2; RAD51-like protein 2
K10871 RAD51L3; RAD51-like protein 3
K10879 XRCC2; DNA-repair protein XRCC2
K10880 XRCC3; DNA-repair protein XRCC3
K10872 DMC1; meiotic recombination protein DMC1
K10873 RAD52; DNA repair and recombination protein RAD52
K10874 RDM1; RAD52 motif-containing protein 1
K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-]
K10876 RAD54L2; RAD54-like protein 2 [EC:3.6.4.12]
K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:3.6.4.-]
K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:3.6.4.12]
K10900 WRN; werner syndrome ATP-dependent helicase [EC:3.6.4.12]
K10901 BLM; bloom syndrome protein [EC:3.6.4.12]
K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:3.6.4.12]
K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:3.6.4.12]
K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
K10990 RMI1; RecQ-mediated genome instability protein 1
K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
K17491 SMEK; protein phosphatase 4 regulatory subunit 3
K17491 SMEK; protein phosphatase 4 regulatory subunit 3
K17491 SMEK; protein phosphatase 4 regulatory subunit 3
K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
K19022 AP5B1; AP-5 complex subunit beta-1
K19023 AP5M1; AP-5 complex subunit mu-1
K19024 AP5S1; AP-5 complex subunit sigma-1
K19025 AP5Z1; AP-5 complex subunit zeta-1
K22803 SMC5; structural maintenance of chromosomes protein 5
K22804 SMC6; structural maintenance of chromosomes protein 6
K22805 FAM84A; protein FAM84A
K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
K22823 NSMCE3; non-structural maintenance of chromosomes element 3
K22825 NSMCE4; non-structural maintenance of chromosomes element 4
K22826 EID3; EP300-interacting inhibitor of differentiation 3
K19529 SYCP2; synaptonemal complex protein 2
K19528 SYCP3; synaptonemal complex protein 3
K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
K10883 EME2; crossover junction endonuclease EME2
K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
K15271 HFM1; ATP-dependent DNA helicase HFM1/MER3 [EC:3.6.4.12]
K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
K10881 SHFM1; 26 proteasome complex subunit DSS1
K10878 SPO11; meiotic recombination protein SPO11
K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
K15338 GEN1; flap endonuclease GEN [EC:3.1.-.-]
K19026 SPG11; spatacsin
K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
K20778 RAD51AP1; RAD51-associated protein 1
K11339 MORF4L1; mortality factor 4-like protein 1
K22420 MEIOB; meiosis-specific with OB domain-containing protein [EC:3.1.-.-]
K22421 SPATA22; spermatogenesis-associated protein 22
K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
K22766 FIGNL1; fidgetin-like protein 1 [EC:3.6.4.-]
K22806 SPIDR; DNA repair-scaffolding protein
K22810 FAM84B; protein FAM84B
K23112 BRAT1; BRCA1-associated ATM activator 1
K23456 CFAP410; cilla- and flagella-associated protein
K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
K10886 XRCC4; DNA-repair protein XRCC4
K10980 NHEJ1; non-homologous end-joining factor 1
K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
K23386 PWWP3; PWWP domain-containing DNA repair factor 3
K23386 PWWP3; PWWP domain-containing DNA repair factor 3
K23386 PWWP3; PWWP domain-containing DNA repair factor 3
K10888 FANCA; fanconi anemia group A protein
K10889 FANCB; fanconi anemia group B protein
K10890 FANCC; fanconi anemia group C protein
K10892 FANCE; fanconi anemia group E protein
K10893 FANCF; fanconi anemia group F protein
K10894 FANCG; fanconi anemia group G protein
K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
K10896 FANCM; fanconi anemia group M protein
K10898 FAAP24; fanconi anemia-associated protein
K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
K06054 HES1; hairy and enhancer of split 1
K11511 APITD1; centromere protein S
K15360 STRA13; centromere protein X
K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
K10891 FANCD2; fanconi anemia group D2 protein
K10895 FANCI; fanconi anemia group I protein
K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
K11137 TELO2; telomere length regulation protein
K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
K15361 WDR48; WD repeat-containing protein 48
K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
K23314 WRAP53; telomerase Cajal body protein 1
K24164 TPRN; taperin
K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
K24752 WDR70; WD repeat-containing protein 70
K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:3.6.4.- 2.3.2.27]
K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
K23114 ARMT1; protein-glutamate O-methyltransferase [EC:2.1.1.-]
K24051 SPRTN; SprT-like domain-contaning protein Spartan
K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
K10995 RAD9B; cell cycle checkpoint control protein RAD9B
K10903 HUS1; HUS1 checkpoint protein
K10996 HUS1B; checkpoint protein HUS1B
K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
K06662 HRAD17; cell cycle checkpoint protein
K03155 TIMELESS; timeless
K10904 TIPIN; TIMELESS-interacting protein
K20403 TTI1; TELO2-interacting protein 1
K23115 TTI2; TELO2-interacting protein 2
K23390 BAG6; large proline-rich protein BAG6
K23388 UBL4; ubiquitin-like protein 4
K23388 UBL4; ubiquitin-like protein 4
K23387 GET4; golgi to ER traffic protein 4
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K10905 ATRIP; ATR interacting protein
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K04451 TP53; tumor protein p53
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K06630 YWHAE; 14-3-3 protein epsilon
K19483 NAV2; neuron navigator 2 [EC:3.6.4.12]
K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
K21944 PER1; period circadian protein 1
K02633 PER2; period circadian protein 2
K21945 PER3; period circadian protein 3
K20780 MDC1; mediator of DNA damage checkpoint protein 1
K17336 PLS3; plastin-3
K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
K08857 NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]
K08857 NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]
K08857 NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]
K20879 NEK10; NIMA (never in mitosis gene a)-related kinase 10 [EC:2.7.11.1]
K20880 NEK11; NIMA (never in mitosis gene a)-related kinase 11 [EC:2.7.11.1]
K22422 DONSON; protein downstream neighbor of Son
K22808 KANK; KN motif and ankyrin repeat domain-containing protein
K22808 KANK; KN motif and ankyrin repeat domain-containing protein
K22808 KANK; KN motif and ankyrin repeat domain-containing protein
K22808 KANK; KN motif and ankyrin repeat domain-containing protein
K23389 KLLN; killin
K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
K15340 DCLRE1A; DNA cross-link repair 1A protein
K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
K17815 EXO5; exonuclease V [EC:3.1.-.-]
K21813 ENDOV; endonuclease V [EC:3.1.26.-]
K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
K19178 HELQ; POLQ-like helicase [EC:3.6.4.12]
K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:3.6.4.-]
K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
K12861 BCAS2; pre-mRNA-splicing factor SPF27
K12862 PLRG1; pleiotropic regulator 1
K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
K01520 dut; dUTP pyrophosphatase [EC:3.6.1.23]
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K03111 ssb; single-strand DNA-binding protein
|
03029 Mitochondrial biogenesis [BR:pale03029]
|
|
|
09183 Protein families: signaling and cellular processes
|
|
|
09184 RNA family
|
|
|
09190 Not Included in Pathway or Brite
|
KEGG Orthology (KO) - Pteropus alecto (black flying fox)