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KO |
 Ubiquitins and ubiquitin-like proteins
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Ubiquitin-activating enzymes (E1)
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Ubiquitin-conjugating enzymes (E2)
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 Ubiquitin ligases (E3)
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HECT type E3
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U-box type E3
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Single Ring-finger type E3
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BRE1 proteins
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CBL proteins
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SINA (Seven in absentia) proteins
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Ligand of Numb proteins
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March proteins
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MDM2/MDM4 proteins
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NFX1 proteins
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Pellino proteins
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Peripheral membrane proteins
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RBR proteins
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TRAF proteins
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TRIM/RBCC proteins
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UBR box proteins
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 ATL proteins
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Other single Ring-finger type E3
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100461567 AMFR; E3 ubiquitin-protein ligase AMFR isoform X1
100439085 AIRE; autoimmune regulator
100456085 BFAR; bifunctional apoptosis regulator
100457858 BIRC2; baculoviral IAP repeat-containing protein 2
100457249 BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1
100449741 XIAP; E3 ubiquitin-protein ligase XIAP isoform X1
100937717 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP
100432733 BIRC7; baculoviral IAP repeat-containing protein 7 isoform X2
100435798 BRAP; BRCA1-associated protein
100439533 BRCA1; breast cancer type 1 susceptibility protein isoform X5
100461624 CBLL1; E3 ubiquitin-protein ligase Hakai isoform X3
100451268 CCNB1IP1; E3 ubiquitin-protein ligase CCNB1IP1
100171543 CHFR; E3 ubiquitin-protein ligase CHFR
100171979 CNOT4; CCR4-NOT transcription complex subunit 4
100451900 DCST1; E3 ubiquitin-protein ligase DCST1 isoform X1
100171717 DTX3; probable E3 ubiquitin-protein ligase DTX3
100436680 DTX4; E3 ubiquitin-protein ligase DTX4 isoform X1
100447071 DTX2; probable E3 ubiquitin-protein ligase DTX2 isoform X1
100445005 DTX1; E3 ubiquitin-protein ligase DTX1
100460956 DTX3L; E3 ubiquitin-protein ligase DTX3L
100450062 DZIP3; E3 ubiquitin-protein ligase DZIP3 isoform X1
100440776 FANCL; E3 ubiquitin-protein ligase FANCL isoform X2
100437707 KCMF1; E3 ubiquitin-protein ligase KCMF1 isoform X1
100435055 LRSAM1; E3 ubiquitin-protein ligase LRSAM1
100443975 LTN1; E3 ubiquitin-protein ligase listerin
100453309 MAP3K1; mitogen-activated protein kinase kinase kinase 1
100438445 MEX3D; RNA-binding protein MEX3D
100438912 MEX3A; LOW QUALITY PROTEIN: RNA-binding protein MEX3A
100440173 MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C
100440510 MEX3B; RNA-binding protein MEX3B
100454855 MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X5
100441208 MIB1; E3 ubiquitin-protein ligase MIB1
100450421 MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1
100433865 MKRN2; probable E3 ubiquitin-protein ligase makorin-2 isoform X2
100434216 MKRN3; probable E3 ubiquitin-protein ligase makorin-3 isoform X1
100440464 MKRN1; E3 ubiquitin-protein ligase makorin-1 isoform X1
100444825 putative E3 ubiquitin-protein ligase makorin-4
100444535 MUL1; mitochondrial ubiquitin ligase activator of NFKB 1
100451266 MYCBP2; E3 ubiquitin-protein ligase MYCBP2 isoform X1
100436766 MYLIP; E3 ubiquitin-protein ligase MYLIP
100434514 NEURL1B; E3 ubiquitin-protein ligase NEURL1B isoform X1
100445738 NEURL1; E3 ubiquitin-protein ligase NEURL1
100446405 NEURL3; E3 ubiquitin-protein ligase NEURL3 isoform X1
100443623 NHLRC1; E3 ubiquitin-protein ligase NHLRC1
100171997 RNF219; RING finger protein 219
100189838 PJA1; E3 ubiquitin-protein ligase Praja-1
100169739 PJA2; E3 ubiquitin-protein ligase Praja-2
100172537 RAD18; E3 ubiquitin-protein ligase RAD18
100447109 RAG1; V(D)J recombination-activating protein 1
100446564 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1
100447341 RC3H2; roquin-2 isoform X1
100459202 RC3H1; roquin-1 isoform X1
100447738 COP1; E3 ubiquitin-protein ligase RFWD2 isoform X1
100461058 RFWD3; E3 ubiquitin-protein ligase RFWD3
100461906 RING1; E3 ubiquitin-protein ligase RING1
100174504 RNF2; E3 ubiquitin-protein ligase RING2
100438954 RNF4; E3 ubiquitin-protein ligase RNF4 isoform X1
100436126 RNF5; E3 ubiquitin-protein ligase RNF5
100171457 RNF185; E3 ubiquitin-protein ligase RNF185
100174577 RNF6; E3 ubiquitin-protein ligase RNF6
100173982 RNF8; E3 ubiquitin-protein ligase RNF8
100452385 RNF10; RING finger protein 10 isoform X1
100457761 RNF11; RING finger protein 11
100445446 RLIM; E3 ubiquitin-protein ligase RLIM
100172087 RNF13; E3 ubiquitin-protein ligase RNF13 precursor
100439168 RNF25; E3 ubiquitin-protein ligase RNF25
100172449 RNF26; RING finger protein 26
100452090 RNF44; RING finger protein 44 isoform X1
100460162 RNF38; E3 ubiquitin-protein ligase RNF38
100173246 RNF41; E3 ubiquitin-protein ligase NRDP1
100436481 RNF43; E3 ubiquitin-protein ligase RNF43 isoform X1
100169738 RNF111; E3 ubiquitin-protein ligase Arkadia
100452794 RNF112; RING finger protein 112
100450155 RNF113B; RING finger protein 113B
100449829 RNF126; E3 ubiquitin-protein ligase RNF126 isoform X1
100431951 RNF115; E3 ubiquitin-protein ligase RNF115 isoform X1
100437678 RNF121; RING finger protein 121 isoform X1
100456814 RNF175; RING finger protein 175 isoform X1
100445581 RNF122; RING finger protein 122
100434857 RNF123; E3 ubiquitin-protein ligase RNF123 isoform X1
100460705 RNF125; E3 ubiquitin-protein ligase RNF125
100171545 RNF128; E3 ubiquitin-protein ligase RNF128 precursor
100457688 RNF130; E3 ubiquitin-protein ligase RNF130
100455536 RNF133; E3 ubiquitin-protein ligase RNF133
100439670 RNF135; E3 ubiquitin-protein ligase RNF135 isoform X1
100461071 RNF138; E3 ubiquitin-protein ligase RNF138 isoform X1
100447707 RNF139; E3 ubiquitin-protein ligase RNF139
100434387 RNF145; RING finger protein 145
100174320 RNF146; E3 ubiquitin-protein ligase RNF146
100435720 RNF149; E3 ubiquitin-protein ligase RNF149
100432474 RNF152; E3 ubiquitin-protein ligase RNF152
100462066 RNF157; E3 ubiquitin ligase RNF157 isoform X1
100452536 RNF165; E3 ubiquitin-protein ligase RNF165 isoform X1
100454130 RNF166; RING finger protein 166 isoform X2
100459963 RNF167; E3 ubiquitin-protein ligase RNF167 isoform X1
100448077 RNF170; E3 ubiquitin-protein ligase RNF170
100172634 RNF180; E3 ubiquitin-protein ligase RNF180
100461310 RNF181; E3 ubiquitin-protein ligase RNF181 isoform X2
100431999 RNF182; E3 ubiquitin-protein ligase RNF182
100449568 RNF186; RING finger protein 186
100450283 RNF187; E3 ubiquitin-protein ligase RNF187
100461806 RNF213; E3 ubiquitin-protein ligase RNF213 isoform X1
100172238 RNF220; E3 ubiquitin-protein ligase RNF220
100461640 RNFT1; E3 ubiquitin-protein ligase RNFT1 isoform X1
100449660 SART1; U4/U6.U5 tri-snRNP-associated protein 1
100450709 SHPRH; E3 ubiquitin-protein ligase SHPRH
100172363 SH3RF1; E3 ubiquitin-protein ligase SH3RF1
100442891 SH3RF2; putative E3 ubiquitin-protein ligase SH3RF2 isoform X1
100435082 SH3RF3; SH3 domain-containing RING finger protein 3
100431605 HLTF; helicase-like transcription factor isoform X3
100436053 SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X1
100432363 TMEM129; E3 ubiquitin-protein ligase TM129 isoform X1
100443889 TOPORS; E3 ubiquitin-protein ligase Topors isoform X1
100433719 TRAIP; E3 ubiquitin-protein ligase TRAIP isoform X1
100457794 TTC3; E3 ubiquitin-protein ligase TTC3 isoform X3
100457177 UHRF1; E3 ubiquitin-protein ligase UHRF1 isoform X1
100436036 UHRF2; E3 ubiquitin-protein ligase UHRF2
100460202 UNKL; putative E3 ubiquitin-protein ligase UNKL isoform X1
100440399 ZNF598; E3 ubiquitin-protein ligase ZNF598 isoform X1
100455995 CBLL2; E3 ubiquitin-protein ligase ZNF645
100445487 ZFP91; E3 ubiquitin-protein ligase ZFP91 isoform X1
100432339 ZNRF1; E3 ubiquitin-protein ligase ZNRF1
100938632 ZNRF2; E3 ubiquitin-protein ligase ZNRF2
100434118 ZNRF3; E3 ubiquitin-protein ligase ZNRF3 isoform X1
100459352 ZNRF4; E3 ubiquitin-protein ligase ZNRF4
100435512 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2
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K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
K10603 AIRE; autoimmune regulator
K15684 BFAR; bifunctional apoptosis regulator
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
K10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27]
K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
K22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K10642 DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27]
K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
K22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
K04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]
K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]
K10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]
K01931 NEUR; protein neuralized [EC:2.3.2.27]
K01931 NEUR; protein neuralized [EC:2.3.2.27]
K15689 NEURL3; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]
K10602 NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27]
K24091 OBI1; ORC ubiquitin ligase 1 [EC:2.3.2.27]
K10633 PJA1; E3 ubiquitin-protein ligase Praja1 [EC:2.3.2.27]
K10634 PJA2; E3 ubiquitin-protein ligase Praja2 [EC:2.3.2.27]
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K22753 RNF6; E3 ubiquitin-protein ligase RNF6 [EC:2.3.2.27]
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
K11980 RNF11; E3 ubiquitin-protein ligase RNF11
K16271 RLIM; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27]
K15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]
K10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]
K15693 RNF26; E3 ubiquitin-protein ligase RNF26 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
K15694 RNF43; E3 ubiquitin-protein ligase RNF43 [EC:2.3.2.27]
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]
K25173 RNF112; E3 ubiquitin-protein ligase RNF112 [EC:2.3.2.27]
K15696 RNF113B; RING finger protein 113B
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K15698 RNF121_175; RING finger protein 121/175
K15698 RNF121_175; RING finger protein 121/175
K15699 RNF122; RING finger protein 122
K12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27]
K10629 RNF128; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]
K15701 RNF130; E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27]
K15702 RNF133; E3 ubiquitin-protein ligase RNF133 [EC:2.3.2.27]
K16272 RNF135; E3 ubiquitin-protein ligase RNF135 [EC:2.3.2.27]
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]
K15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]
K23789 RNF145; E3 ubiquitin-protein ligase RNF145 [EC:2.3.2.27]
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
K15704 RNF149; E3 ubiquitin-protein ligase RNF149 [EC:2.3.2.27]
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]
K25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]
K17821 RNF165; E3 ubiquitin-protein ligase RNF165 [EC:2.3.2.27]
K17044 RNF166; E3 ubiquitin-protein ligase RNF166 [EC:2.3.2.27]
K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27]
K15707 RNF170; E3 ubiquitin-protein ligase RNF170 [EC:2.3.2.27]
K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
K22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]
K11983 RNF182; E3 ubiquitin-protein ligase RNF182 [EC:2.3.2.27]
K25214 RNF186; E3 ubiquitin-protein ligase RNF186 [EC:2.3.2.27]
K15709 RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27]
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]
K25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]
K22379 RNFT1; E3 ubiquitin-protein ligase RNFT1 [EC:2.3.2.27]
K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]
K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
K11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]
K15712 TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27]
K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
K15713 UHRF2; E3 ubiquitin-protein ligase UHRF2 [EC:2.3.2.27]
K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]
K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
K15714 ZNF645; E3 ubiquitin-protein ligase ZNF645 [EC:2.3.2.27]
K25175 ZFP91; E3 ubiquitin-protein ligase ZFP91 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K16273 ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27]
K15715 ZNRF4; E3 ubiquitin-protein ligase ZNRF4 [EC:2.3.2.27]
K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]
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Atypical E3
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UBL E3 ligases
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Multi subunit Ring-finger type E3
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Deubiquitinating enzyme (DUB)
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Ubiquitin System - Pongo abelii (Sumatran orangutan)