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KO |
09100 Metabolism
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09120 Genetic Information Processing
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09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
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02020 Two-component system
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04010 MAPK signaling pathway [PATH:ptg04010]
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04013 MAPK signaling pathway - fly
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04016 MAPK signaling pathway - plant
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04011 MAPK signaling pathway - yeast
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04012 ErbB signaling pathway [PATH:ptg04012]
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04014 Ras signaling pathway [PATH:ptg04014]
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102959656 EGF; epidermal growth factor
102956554 TGFA; transforming growth factor alpha
102967663 FGF1; fibroblast growth factor 1
102969772 FGF2; fibroblast growth factor 2
102970275 FGF9; fibroblast growth factor 9
102949835 FGF5; fibroblast growth factor 5
102971941 FGF22; fibroblast growth factor 22
102964398 FGF18; fibroblast growth factor 18
102959014 FGF8; fibroblast growth factor 8
102956185 FGF7; fibroblast growth factor 7
102970087 FGF17; fibroblast growth factor 17
102957299 FGF20; fibroblast growth factor 20
102970576 FGF10; fibroblast growth factor 10
102969970 FGF6; fibroblast growth factor 6
102966317 FGF19; fibroblast growth factor 19
102963142 FGF21; fibroblast growth factor 21
102958480 FGF23; fibroblast growth factor 23
102961057 NGF; nerve growth factor
102958723 BDNF; brain derived neurotrophic factor
102966385 NTF3; neurotrophin 3
102951714 NTF4; neurotrophin 4
102962543 IGF1; insulin like growth factor 1
102971867 PDGFB; platelet derived growth factor subunit B
102970530 PDGFC; platelet derived growth factor C
102949957 PDGFD; platelet derived growth factor D
102972710 CSF1; colony stimulating factor 1
102951678 KITLG; KIT ligand
102967169 FLT3LG; fms related tyrosine kinase 3 ligand
102954556 VEGFA; vascular endothelial growth factor A
102961989 VEGFB; vascular endothelial growth factor B
102960599 PGF; placental growth factor
102952237 VEGFC; vascular endothelial growth factor C
102965995 VEGFD; vascular endothelial growth factor D
102952318 HGF; hepatocyte growth factor
102958985 ANGPT1; angiopoietin 1
102954855 ANGPT2; angiopoietin 2
102955835 ANGPT4; angiopoietin 4
102956614 EFNA5; ephrin A5
102971902 EFNA1; ephrin A1
102967370 EGFR; epidermal growth factor receptor
102972346 FGFR1; fibroblast growth factor receptor 1
102964142 FGFR2; fibroblast growth factor receptor 2
102965504 FGFR4; fibroblast growth factor receptor 4
102953999 NGFR; nerve growth factor receptor
102950315 NTRK2; neurotrophic receptor tyrosine kinase 2
102967156 INSR; insulin receptor
102949680 IGF1R; insulin like growth factor 1 receptor
102955481 PDGFRA; platelet derived growth factor receptor alpha
102954207 PDGFRB; platelet derived growth factor receptor beta
102953056 CSF1R; colony stimulating factor 1 receptor
102960767 KIT; KIT proto-oncogene receptor tyrosine kinase
102955843 FLT3; fms related tyrosine kinase 3
102955273 FLT1; fms related tyrosine kinase 1
102960922 FLT4; fms related tyrosine kinase 4
102955197 KDR; kinase insert domain receptor
102953616 MET; MET proto-oncogene, receptor tyrosine kinase
102954161 TEK; TEK receptor tyrosine kinase
102962818 EPHA2; EPH receptor A2
102970459 GRB2; growth factor receptor bound protein 2
102959239 GAB1; GRB2 associated binding protein 1
102967483 GAB2; GRB2 associated binding protein 2
102949026 SHC1; SHC adaptor protein 1
102954336 SHC2; SHC adaptor protein 2
102965813 SHC3; SHC adaptor protein 3
102955115 SHC4; SHC adaptor protein 4
102951653 PTPN11; protein tyrosine phosphatase, non-receptor type 11
102954137 tyrosine-protein phosphatase non-receptor type 11-like
102949403 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
102950748 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
102952137 PLCG1; phospholipase C gamma 1
102963653 PLCG2; phospholipase C gamma 2
102957207 RASGRP1; RAS guanyl releasing protein 1
102958860 RASGRP2; RAS guanyl releasing protein 2
102954264 RASGRP3; RAS guanyl releasing protein 3
102971379 RASGRP4; RAS guanyl releasing protein 4
102969244 ZAP70; tyrosine-protein kinase ZAP-70
102972473 LAT; linker for activation of T-cells
102953970 HTR7; 5-hydroxytryptamine receptor 7
102950533 GNB1; G protein subunit beta 1
102955271 GNB2; G protein subunit beta 2
102953535 GNB3; G protein subunit beta 3
102963895 GNB4; G protein subunit beta 4
102954935 GNB5; G protein subunit beta 5
102962902 GNG2; G protein subunit gamma 2
102968307 GNG3; G protein subunit gamma 3
102953604 GNG4; G protein subunit gamma 4
102963799 GNG7; G protein subunit gamma 7
102956095 GNG10; G protein subunit gamma 10
102972135 GNG11; G protein subunit gamma 11
102951416 GNG12; G protein subunit gamma 12
102949358 GNG13; G protein subunit gamma 13
102972425 GNGT1; G protein subunit gamma transducin 1
102967045 GNGT2; G protein subunit gamma transducin 2
102948983 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
102972158 PRKACB; protein kinase cAMP-activated catalytic subunit beta
102950866 RASGRF1; Ras protein specific guanine nucleotide releasing factor 1
102970038 ras-specific guanine nucleotide-releasing factor 1-like
102960805 RASGRF2; Ras protein specific guanine nucleotide releasing factor 2
102949242 GRIN1; glutamate ionotropic receptor NMDA type subunit 1
102969126 GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A
102962401 GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B
102953457 CALM3; calmodulin 3
102963939 calmodulin-like
102964234 CALML3; calmodulin-like protein 3
102954552 CALM2; calmodulin 2
102960923 calmodulin-like
102950842 CALML6; calmodulin like 6
102951822 CALM1; calmodulin 1
102971520 calmodulin-alpha-like
102950182 CALML4; calmodulin like 4
102952119 HRAS; HRas proto-oncogene, GTPase
102957350 KRAS; KRAS proto-oncogene, GTPase
102952980 NRAS; neuroblastoma RAS viral oncogene homolog
102970438 MRAS; muscle RAS oncogene homolog
102968314 RRAS; related RAS viral (r-ras) oncogene homolog
102967033 RRAS2; related RAS viral (r-ras) oncogene homolog 2
102971943 NF1; neurofibromin 1
102959932 RASA1; RAS p21 protein activator 1
102972756 RASA2; RAS p21 protein activator 2
102969989 RASA3; RAS p21 protein activator 3
102972886 RASA4B; RAS p21 protein activator 4B
102967929 SYNGAP1; synaptic Ras GTPase activating protein 1
102952794 RASAL1; RAS protein activator like 1
102955291 RASAL2; RAS protein activator like 2
102955438 RASAL3; RAS protein activator like 3
102966666 RASSF1; Ras association domain family member 1
102963911 RASSF5; Ras association domain family member 5
102954711 STK4; serine/threonine kinase 4
102955456 TIAM1; T-cell lymphoma invasion and metastasis 1
102968561 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
102961922 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
102955504 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
102963927 PAK1; p21 (RAC1) activated kinase 1
102968498 PAK2; p21 (RAC1) activated kinase 2
102960506 PAK3; p21 (RAC1) activated kinase 3
102950254 PAK4; p21 (RAC1) activated kinase 4
102959873 PAK5; p21 (RAC1) activated kinase 5
102972937 PAK6; p21 (RAC1) activated kinase 6
102952555 RHOA; ras homolog family member A
102953082 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
102965070 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
102972487 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
102949853 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
102952993 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
102967709 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
102952603 AKT3; AKT serine/threonine kinase 3
102954757 AKT2; AKT serine/threonine kinase 2
102949289 CHUK; conserved helix-loop-helix ubiquitous kinase
102963734 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
102964232 NFKB1; nuclear factor kappa B subunit 1
102951132 RELA; RELA proto-oncogene, NF-kB subunit
102956027 BAD; BCL2 associated agonist of cell death
102950221 BCL2L1; BCL2 like 1
102970063 FOXO4; forkhead box O4
102953222 FASLG; Fas ligand
102955359 RALGAPA1; Ral GTPase activating protein catalytic alpha subunit 1
102950146 RALGAPA2; Ral GTPase activating protein catalytic alpha subunit 2
102949267 RALGAPB; Ral GTPase activating protein non-catalytic beta subunit
102965767 RALGDS; ral guanine nucleotide dissociation stimulator
102968930 RGL1; ral guanine nucleotide dissociation stimulator like 1
102949949 RGL2; ral guanine nucleotide dissociation stimulator like 2
102961464 RALA; RAS like proto-oncogene A
102968600 RALB; RAS like proto-oncogene B
102962016 PLD1; phospholipase D1
102971823 PLD2; phospholipase D2
102968999 EXOC2; exocyst complex component 2
102960158 TBK1; TANK binding kinase 1
102956997 REL; REL proto-oncogene, NF-kB subunit
102959159 MAPK10; mitogen-activated protein kinase 10
102950880 MAPK8; mitogen-activated protein kinase 8
102963096 MAPK9; mitogen-activated protein kinase 9
102971211 RALBP1; ralA binding protein 1
102973021 CDC42; cell division cycle 42
102949607 AFDN; afadin, adherens junction formation factor
102967704 SHOC2; SHOC2, leucine rich repeat scaffold protein
102955852 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
102969757 MAP2K1; mitogen-activated protein kinase kinase 1
102956808 MAP2K2; mitogen-activated protein kinase kinase 2
102964841 MAPK1; mitogen-activated protein kinase 1
102960964 MAPK3; mitogen-activated protein kinase 3
102963545 protein ADP-ribosylarginine hydrolase
102951081 PLA2G3; phospholipase A2 group III
102955993 PLA2G2C; phospholipase A2 group IIC
102956556 PLA2G2D; phospholipase A2 group IID
102956283 PLA2G2F; phospholipase A2 group IIF
102957111 PLA2G5; phospholipase A2 group V
102957589 PLA2G2E; group IIE secretory phospholipase A2
102958779 PLA2G1B; phospholipase A2 group IB
102969127 PLA2G12B; phospholipase A2 group XIIB
102970253 group 10 secretory phospholipase A2-like
102964036 PLA2G4D; phospholipase A2 group IVD
102959937 PLA2G4F; phospholipase A2 group IVF
102959018 PLA2G4B; phospholipase A2 group IVB
102959667 PLA2G4E; phospholipase A2 group IVE
102948969 PLA2G4A; phospholipase A2 group IVA
102968751 PLA2G6; phospholipase A2 group VI
102962180 PLA2G16; HRAS-like suppressor 3
102966062 ELK1; ELK1, ETS transcription factor
102967030 ETS1; ETS proto-oncogene 1, transcription factor
102968205 ETS2; ETS proto-oncogene 2, transcription factor
102949574 BRAP; BRCA1 associated protein
102972531 KSR1; kinase suppressor of ras 1
102957378 KSR2; kinase suppressor of ras 2
102960844 RAPGEF5; Rap guanine nucleotide exchange factor 5
102963243 RAP1A; RAP1A, member of RAS oncogene family
102965011 RAP1B; RAP1B, member of RAS oncogene family
102949488 PLCE1; phospholipase C epsilon 1
102968590 PRKCA; protein kinase C alpha
102952814 PRKCB; protein kinase C beta
102956490 PRKCG; protein kinase C gamma
102949050 RIN1; Ras and Rab interactor 1
102949569 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
102951925 ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase
102956448 RAB5A; RAB5A, member RAS oncogene family
102960245 RAB5B; RAB5B, member RAS oncogene family
102956967 RAB5C; RAB5C, member RAS oncogene family
102959274 ARF6; ADP ribosylation factor 6
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K04357 EGF; epidermal growth factor
K08774 TGFA; transforming growth factor, alpha
K18496 FGF1; fibroblast growth factor 1
K18497 FGF2; fibroblast growth factor 2
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K22603 FGF19; fibroblast growth factor 19
K22429 FGF21; fibroblast growth factor 21
K22428 FGF23; fibroblast growth factor 23
K02582 NGFB; nerve growth factor, beta
K04355 BDNF; brain-derived neurotrophic factor
K04356 NTF3; neurotrophin 3
K12457 NTF4; neurotrophin 4
K05459 IGF1; insulin-like growth factor 1
K17386 PDGFB; platelet-derived growth factor subunit B
K05450 PDGFC_D; platelet derived growth factor C/D
K05450 PDGFC_D; platelet derived growth factor C/D
K05453 CSF1; macrophage colony-stimulating factor 1
K05461 KITLG; KIT ligand
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K05449 VEGFC_D; vascular endothelial growth factor C/D
K05460 HGF; hepatocyte growth factor
K05465 ANGPT1; angiopoietin 1
K05466 ANGPT2; angiopoietin 2
K05467 ANGPT4; angiopoietin 4
K05462 EFNA; ephrin-A
K05462 EFNA; ephrin-A
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K02583 NGFR; tumor necrosis factor receptor superfamily member 16
K04360 NTRK2; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
K04527 INSR; insulin receptor [EC:2.7.10.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K05098 KDR; kinase insert domain protein receptor [EC:2.7.10.1]
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K05121 TEK; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
K05103 EPHA2; Eph receptor A2 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K09593 GAB1; GRB2-associated-binding protein 1
K08091 GAB2; GRB2-associated-binding protein 2
K06279 SHC1; SHC-transforming protein 1
K17447 SHC2; SHC-transforming protein 2
K17448 SHC3; SHC-transforming protein 3
K17449 SHC4; SHC-transforming protein 4
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K07360 ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
K07362 LAT; linker for activation of T cells family member 1
K04163 HTR7; 5-hydroxytryptamine receptor 7
K04536 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538 GNB4; guanine nucleotide-binding protein subunit beta-4
K04539 GNB5; guanine nucleotide-binding protein subunit beta-5
K07826 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04543 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04545 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04349 RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
K04349 RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
K12326 RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
K05208 GRIN1; glutamate receptor ionotropic, NMDA 1
K05209 GRIN2A; glutamate receptor ionotropic, NMDA 2A
K05210 GRIN2B; glutamate receptor ionotropic, NMDA 2B
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K07831 MRAS; Ras-related protein M-Ras
K07829 RRAS; Ras-related protein R-Ras
K07830 RRAS2; Ras-related protein R-Ras2
K08052 NF1; neurofibromin 1
K04352 RASA1; Ras GTPase-activating protein 1
K08053 RASA2; Ras GTPase-activating protein 2
K12380 RASA3; Ras GTPase-activating protein 3
K17630 RASA4; Ras GTPase-activating protein 4
K17631 SYNGAP; Ras/Rap GTPase-activating protein SynGAP
K17632 RASAL1; RAS protein activator-like 1
K17633 RASAL2; RAS protein activator-like 2
K17634 RASAL3; RAS protein activator-like 3
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5; Ras association domain-containing protein 5
K04411 STK4; serine/threonine kinase 4
K05731 TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]
K05733 PAK3; p21-activated kinase 3 [EC:2.7.11.1]
K05734 PAK4; p21-activated kinase 4 [EC:2.7.11.1]
K05736 PAK5; p21-activated kinase 5 [EC:2.7.11.1]
K05735 PAK6; p21-activated kinase 6 [EC:2.7.11.1]
K04513 RHOA; Ras homolog gene family, member A
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K02158 BAD; Bcl-2-antagonist of cell death
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K12358 FOXO4; forkhead box protein O4
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K25768 RALGAPA; Ral GTPase-activating protein subunit alpha
K25768 RALGAPA; Ral GTPase-activating protein subunit alpha
K25769 RALGAPB; Ral GTPase-activating protein subunit beta
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K17635 RGL1; ral guanine nucleotide dissociation stimulator-like 1
K17636 RGL2; ral guanine nucleotide dissociation stimulator-like 2
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K17637 EXOC2; exocyst complex component 2
K05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K09254 REL; c-Rel proto-oncogene protein
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K05702 AF6; afadin
K19613 SHOC2; leucine-rich repeat protein SHOC2
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K13618 PLA1A; phosphatidylserine sn-1 acylhydrolase [EC:3.1.1.111]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K01047 PLA2G; secretory phospholipase A2 [EC:3.1.1.4]
K16342 PLA2G4; cytosolic phospholipase A2 [EC:3.1.1.4]
K16342 PLA2G4; cytosolic phospholipase A2 [EC:3.1.1.4]
K16342 PLA2G4; cytosolic phospholipase A2 [EC:3.1.1.4]
K16342 PLA2G4; cytosolic phospholipase A2 [EC:3.1.1.4]
K16342 PLA2G4; cytosolic phospholipase A2 [EC:3.1.1.4]
K16343 PLA2G6; calcium-independent phospholipase A2 [EC:3.1.1.4]
K16817 PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
K04375 ELK1; ETS domain-containing protein Elk-1
K02678 ETS1; C-ets-1
K21932 ETS2; C-ets-2
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
K14958 KSR1; kinase suppressor of Ras 1
K18529 KSR2; kinase suppressor of Ras 2 [EC:2.7.11.1]
K08019 RAPGEF5; Rap guanine nucleotide exchange factor 5
K04353 RAP1A; Ras-related protein Rap-1A
K07836 RAP1B; Ras-related protein Rap-1B
K05860 PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K17638 RIN1; Ras and Rab interactor 1
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K08887 ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
K07887 RAB5A; Ras-related protein Rab-5A
K07888 RAB5B; Ras-related protein Rab-5B
K07889 RAB5C; Ras-related protein Rab-5C
K07941 ARF6; ADP-ribosylation factor 6
|
04015 Rap1 signaling pathway [PATH:ptg04015]
|
04310 Wnt signaling pathway [PATH:ptg04310]
|
04330 Notch signaling pathway [PATH:ptg04330]
|
04340 Hedgehog signaling pathway [PATH:ptg04340]
|
04341 Hedgehog signaling pathway - fly
|
04350 TGF-beta signaling pathway [PATH:ptg04350]
|
04390 Hippo signaling pathway [PATH:ptg04390]
|
102948781 CRB2; crumbs 2, cell polarity complex component
102960499 CRB1; crumbs 1, cell polarity complex component
102949054 PARD3; par-3 family cell polarity regulator
102950652 PARD6B; par-6 family cell polarity regulator beta
102966585 PARD6A; par-6 family cell polarity regulator alpha
102960973 protein kinase C zeta type
102960685 protein kinase C zeta type-like
102958797 PRKCI; protein kinase C iota
102967151 PATJ; PATJ, crumbs cell polarity complex component
102962597 MPP5; membrane palmitoylated protein 5
102964220 AMOT; angiomotin
102952013 YAP1; Yes associated protein 1
102965028 WWTR1; WW domain containing transcription regulator 1
102971532 cadherin-1-like
102949516 CDH1; cadherin 1
102949270 WTIP; Wilms tumor 1 interacting protein
102966144 AJUBA; ajuba LIM protein
102971134 LIMD1; LIM domains containing 1
102963652 NF2; neurofibromin 2
102955495 WWC1; WW and C2 domain containing 1
102952227 FRMD6; FERM domain containing 6
102962029 SAV1; salvador family WW domain containing protein 1
102972219 STK3; serine/threonine kinase 3
102966660 RASSF6; Ras association domain family member 6
102966666 RASSF1; Ras association domain family member 1
102956715 PPP2CB; protein phosphatase 2 catalytic subunit beta
102954008 PPP2CA; protein phosphatase 2 catalytic subunit alpha
102951141 PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha
102961543 PPP2R1B; protein phosphatase 2 scaffold subunit Abeta
102970289 PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma
102949872 PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta
102951261 PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta
102952971 PPP2R2A; protein phosphatase 2 regulatory subunit Balpha
102961246 LATS2; serine/threonine-protein kinase LATS2
102960543 LATS1; large tumor suppressor kinase 1
102960817 MOB1A; MOB kinase activator 1A
102965212 MOB1B; MOB kinase activator 1B
102948702 PPP1CC; protein phosphatase 1 catalytic subunit gamma
107180886 PPP1CA; protein phosphatase 1 catalytic subunit alpha
102970154 PPP1CB; protein phosphatase 1 catalytic subunit beta
102972442 TP53BP2; tumor protein p53 binding protein 2
102966253 LLGL1; LLGL1, scribble cell polarity complex component
102971041 LLGL2; LLGL2, scribble cell polarity complex component
102957139 SCRIB; scribbled planar cell polarity protein
102971040 DLG1; discs large MAGUK scaffold protein 1
102972156 DLG2; discs large MAGUK scaffold protein 2
102967577 DLG3; discs large MAGUK scaffold protein 3
102968603 DLG4; discs large MAGUK scaffold protein 4
102972810 DLG5; discs large MAGUK scaffold protein 5
102949868 CSNK1D; casein kinase 1 delta
102969346 CSNK1E; casein kinase 1 epsilon
102962015 FBXW11; F-box and WD repeat domain containing 11
102953972 BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase
102955464 BBC3; BCL2 binding component 3
102966306 TEAD2; TEA domain transcription factor 2
102965305 TEAD1; TEA domain transcription factor 1
102949137 TEAD4; TEA domain transcription factor 4
102970247 TEAD3; TEA domain transcription factor 3
102948975 CTGF; connective tissue growth factor
102950503 GLI2; GLI family zinc finger 2
102954670 AREG; amphiregulin
102950505 BIRC5; baculoviral IAP repeat containing 5
102952736 AFP; alpha fetoprotein
102966372 alpha-fetoprotein-like
102962262 ITGB2; integrin subunit beta 2
102967663 FGF1; fibroblast growth factor 1
102951285 TGFB1; transforming growth factor beta 1
102951894 TGFB2; transforming growth factor beta 2
102949760 TGFB3; transforming growth factor beta 3
102950020 TGFBR1; transforming growth factor beta receptor 1
102958413 TGFBR2; transforming growth factor beta receptor 2
102970121 SMAD7; SMAD family member 7
102971687 SMAD2; SMAD family member 2
102971888 SMAD3; SMAD family member 3
102961093 SMAD4; SMAD family member 4
102972312 SERPINE1; serpin family E member 1
102961685 BMP2; bone morphogenetic protein 2
102950088 BMP4; bone morphogenetic protein 4
102965938 BMP5; bone morphogenetic protein 5
102949636 BMP6; bone morphogenetic protein 6
102966172 BMP7; bone morphogenetic protein 7
102957846 bone morphogenetic protein 8A-like
102966107 GDF5; growth differentiation factor 5
102972795 BMPR1A; bone morphogenetic protein receptor type 1A
102968798 BMPR1B; bone morphogenetic protein receptor type 1B
102972964 BMPR2; bone morphogenetic protein receptor type 2
102956798 SMAD1; SMAD family member 1
102959242 ID1; inhibitor of DNA binding 1, HLH protein
102972352 ID2; inhibitor of DNA binding 2, HLH protein
102962277 WNT1; Wnt family member 1
102963336 WNT2B; Wnt family member 2B
102954954 WNT2; Wnt family member 2
102950040 WNT3A; Wnt family member 3A
102962551 WNT3; Wnt family member 3
102965201 WNT5A; Wnt family member 5A
102958778 WNT5B; Wnt family member 5B
102972888 WNT7A; Wnt family member 7A
102966525 WNT8A; Wnt family member 8A
102956179 WNT8B; Wnt family member 8B
102950323 WNT9A; Wnt family member 9A
102962257 WNT9B; Wnt family member 9B
102961987 WNT10B; Wnt family member 10B
102956294 WNT10A; Wnt family member 10A
102971675 WNT11; Wnt family member 11
102959880 WNT16; Wnt family member 16
102968815 FZD1; frizzled class receptor 1
102948653 FZD7; frizzled class receptor 7
102962395 FZD2; frizzled class receptor 2
102961371 FZD3; frizzled class receptor 3
102952336 FZD4; frizzled class receptor 4
102953646 FZD6; frizzled class receptor 6
102970273 FZD9; frizzled class receptor 9
102953438 FZD10; frizzled class receptor 10
102954084 DVL3; dishevelled segment polarity protein 3
102967723 DVL2; dishevelled segment polarity protein 2
102957003 DVL1; dishevelled segment polarity protein 1
102962314 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
102966103 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
102960626 14-3-3 protein zeta/delta-like
102948901 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
102960323 14-3-3 protein epsilon
102970295 YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
102965301 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
102972607 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
102961382 GSK3B; glycogen synthase kinase 3 beta
102959570 CTNNB1; catenin beta 1
102948725 APC; APC, WNT signaling pathway regulator
102951323 AXIN1; axin 1
102967280 AXIN2; axin 2
102972345 NKD1; naked cuticle homolog 1
102964681 NKD2; naked cuticle homolog 2
102957988 TCF7; transcription factor 7 (T-cell specific, HMG-box)
102958078 TCF7L1; transcription factor 7 like 1
102961321 TCF7L2; transcription factor 7 like 2
102970026 LEF1; lymphoid enhancer binding factor 1
102954147 MYC; v-myc avian myelocytomatosis viral oncogene homolog
102959906 CCND1; cyclin D1
102970259 CCND2; cyclin D2
102970915 CCND3; cyclin D3
102957900 SNAI2; snail family transcriptional repressor 2
102972419 BIRC2; baculoviral IAP repeat containing 2
102951731 BIRC3; baculoviral IAP repeat-containing protein 3
102971629 ACTG1; actin gamma 1
102971401 ACTB; actin beta
102970304 CTNNA1; catenin alpha 1
107179737 catenin alpha-2-like
102949889 CTNNA2; catenin alpha 2
|
K16681 CRB; protein crumbs
K16681 CRB; protein crumbs
K04237 PARD3; partitioning defective protein 3
K06093 PARD6; partitioning defective protein 6
K06093 PARD6; partitioning defective protein 6
K18952 PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
K18952 PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
K06069 PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]
K06092 INADL; InaD-like protein
K06091 MPP5; MAGUK p55 subfamily member 5
K16819 AMOT; angiomotin
K16687 YAP1; transcriptional coactivator YAP1
K16820 WWTR1; WW domain-containing transcription regulator protein 1
K05689 CDH1; cadherin 1, type 1, E-cadherin
K05689 CDH1; cadherin 1, type 1, E-cadherin
K16682 AJUBA; LIM domain-containing protein
K16682 AJUBA; LIM domain-containing protein
K16682 AJUBA; LIM domain-containing protein
K16684 NF2; merlin
K16685 WWC1; protein KIBRA
K16822 FRMD6; FERM domain-containing protein 6
K16686 SAV1; scaffold protein salvador
K04412 STK3; serine/threonine kinase 3
K09854 RASSF6; Ras association domain-containing protein 6
K09850 RASSF1; Ras association domain-containing protein 1
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K08791 LATS1_2; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]
K08791 LATS1_2; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]
K06685 MOB1; MOB kinase activator 1
K06685 MOB1; MOB kinase activator 1
K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K16823 TP53BP2; apoptosis-stimulating of p53 protein 2
K06094 LLGL; lethal(2) giant larvae protein
K06094 LLGL; lethal(2) giant larvae protein
K16175 SCRIB; protein scribble
K12076 DLG1; disks large protein 1
K12075 DLG2; discs large protein 2
K21098 DLG3; discs large protein 3
K11828 DLG4; discs large protein 4
K24050 DLG5; discs large protein 5
K08959 CSNK1D; casein kinase 1, delta [EC:2.7.11.1]
K08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
K10132 BBC3; Bcl-2-binding component 3
K09448 TEAD; transcriptional enhancer factor
K09448 TEAD; transcriptional enhancer factor
K09448 TEAD; transcriptional enhancer factor
K09448 TEAD; transcriptional enhancer factor
K06827 CTGF; connective tissue growth factor (insulin-like growth factor-binding protein 8)
K16798 GLI2; zinc finger protein GLI2
K09782 AREG; amphiregulin
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K16144 AFP; alpha-fetoprotein
K16144 AFP; alpha-fetoprotein
K06464 ITGB2; integrin beta 2
K18496 FGF1; fibroblast growth factor 1
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K19631 SMAD7; mothers against decapentaplegic homolog 7
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K03982 SERPINE1; plasminogen activator inhibitor 1
K21283 BMP2; bone morphogenetic protein 2
K04662 BMP4; bone morphogenetic protein 4
K04663 BMP5; bone morphogenetic protein 5
K16620 BMP6; bone morphogenetic protein 6
K16621 BMP7; bone morphogenetic protein 7
K16622 BMP8; bone morphogenetic protein 8
K04664 GDF5; growth differentiation factor 5
K04673 BMPR1A; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K13578 BMPR1B; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K04676 SMAD1; mothers against decapentaplegic homolog 1
K04680 ID1; DNA-binding protein inhibitor ID1
K17693 ID2; DNA-binding protein inhibitor ID2
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7; frizzled 1/7
K02432 FZD1_7; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4; frizzled 4
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02842 FZD9_10; frizzled 9/10
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K06630 YWHAE; 14-3-3 protein epsilon
K06630 YWHAE; 14-3-3 protein epsilon
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02105 CTNNB1; catenin beta 1
K02085 APC; adenomatosis polyposis coli protein
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K03213 NKD; naked cuticle
K03213 NKD; naked cuticle
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K05706 SNAI2; snail 2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K05692 ACTB_G1; actin beta/gamma 1
K05692 ACTB_G1; actin beta/gamma 1
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
|
04391 Hippo signaling pathway - fly
|
04392 Hippo signaling pathway - multiple species [PATH:ptg04392]
|
102963100 DCHS2; dachsous cadherin-related 2
102955902 DCHS1; dachsous cadherin-related 1
102953324 FAT4; FAT atypical cadherin 4
102969346 CSNK1E; casein kinase 1 epsilon
102963652 NF2; neurofibromin 2
102955495 WWC1; WW and C2 domain containing 1
102952227 FRMD6; FERM domain containing 6
102966666 RASSF1; Ras association domain family member 1
102966660 RASSF6; Ras association domain family member 6
102972219 STK3; serine/threonine kinase 3
102962029 SAV1; salvador family WW domain containing protein 1
102961246 LATS2; serine/threonine-protein kinase LATS2
102960543 LATS1; large tumor suppressor kinase 1
102960817 MOB1A; MOB kinase activator 1A
102965212 MOB1B; MOB kinase activator 1B
102949270 WTIP; Wilms tumor 1 interacting protein
102966144 AJUBA; ajuba LIM protein
102971134 LIMD1; LIM domains containing 1
102952013 YAP1; Yes associated protein 1
102965028 WWTR1; WW domain containing transcription regulator 1
102966306 TEAD2; TEA domain transcription factor 2
102965305 TEAD1; TEA domain transcription factor 1
102949137 TEAD4; TEA domain transcription factor 4
102970247 TEAD3; TEA domain transcription factor 3
102965139 RASSF2; Ras association domain family member 2
102961663 RASSF4; Ras association domain family member 4
102963927 PAK1; p21 (RAC1) activated kinase 1
|
K16507 DCHS1_2; protocadherin-16/23
K16507 DCHS1_2; protocadherin-16/23
K16669 FAT4; protocadherin Fat 4
K08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
K16684 NF2; merlin
K16685 WWC1; protein KIBRA
K16822 FRMD6; FERM domain-containing protein 6
K09850 RASSF1; Ras association domain-containing protein 1
K09854 RASSF6; Ras association domain-containing protein 6
K04412 STK3; serine/threonine kinase 3
K16686 SAV1; scaffold protein salvador
K08791 LATS1_2; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]
K08791 LATS1_2; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]
K06685 MOB1; MOB kinase activator 1
K06685 MOB1; MOB kinase activator 1
K16682 AJUBA; LIM domain-containing protein
K16682 AJUBA; LIM domain-containing protein
K16682 AJUBA; LIM domain-containing protein
K16687 YAP1; transcriptional coactivator YAP1
K16820 WWTR1; WW domain-containing transcription regulator protein 1
K09448 TEAD; transcriptional enhancer factor
K09448 TEAD; transcriptional enhancer factor
K09448 TEAD; transcriptional enhancer factor
K09448 TEAD; transcriptional enhancer factor
K09851 RASSF2_4; Ras association domain-containing protein 2/4
K09851 RASSF2_4; Ras association domain-containing protein 2/4
K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
|
04370 VEGF signaling pathway [PATH:ptg04370]
|
04371 Apelin signaling pathway [PATH:ptg04371]
|
04630 JAK-STAT signaling pathway [PATH:ptg04630]
|
04064 NF-kappa B signaling pathway [PATH:ptg04064]
|
04668 TNF signaling pathway [PATH:ptg04668]
|
04066 HIF-1 signaling pathway [PATH:ptg04066]
|
04068 FoxO signaling pathway [PATH:ptg04068]
|
04020 Calcium signaling pathway [PATH:ptg04020]
|
04070 Phosphatidylinositol signaling system [PATH:ptg04070]
|
04072 Phospholipase D signaling pathway [PATH:ptg04072]
|
04071 Sphingolipid signaling pathway [PATH:ptg04071]
|
04024 cAMP signaling pathway [PATH:ptg04024]
|
04022 cGMP-PKG signaling pathway [PATH:ptg04022]
|
04151 PI3K-Akt signaling pathway [PATH:ptg04151]
|
04152 AMPK signaling pathway [PATH:ptg04152]
|
04150 mTOR signaling pathway [PATH:ptg04150]
|
04075 Plant hormone signal transduction
|
|
|
09133 Signaling molecules and interaction
|
|
|
09140 Cellular Processes
|
|
|
09150 Organismal Systems
|
|
|
09160 Human Diseases
|
|
|
09161 Cancer: overview
|
05200 Pathways in cancer [PATH:ptg05200]
|
102963748 DCC; DCC netrin 1 receptor
102954729 CASP3; caspase 3
102967404 CASP9; caspase 9
102956094 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
102971532 cadherin-1-like
102949516 CDH1; cadherin 1
102959570 CTNNB1; catenin beta 1
102970304 CTNNA1; catenin alpha 1
107179737 catenin alpha-2-like
102949889 CTNNA2; catenin alpha 2
102951323 AXIN1; axin 1
102967280 AXIN2; axin 2
102948725 APC; APC, WNT signaling pathway regulator
102961382 GSK3B; glycogen synthase kinase 3 beta
102957988 TCF7; transcription factor 7 (T-cell specific, HMG-box)
102958078 TCF7L1; transcription factor 7 like 1
102961321 TCF7L2; transcription factor 7 like 2
102970026 LEF1; lymphoid enhancer binding factor 1
102950505 BIRC5; baculoviral IAP repeat containing 5
102954147 MYC; v-myc avian myelocytomatosis viral oncogene homolog
102959906 CCND1; cyclin D1
102962277 WNT1; Wnt family member 1
102963336 WNT2B; Wnt family member 2B
102954954 WNT2; Wnt family member 2
102950040 WNT3A; Wnt family member 3A
102962551 WNT3; Wnt family member 3
102965201 WNT5A; Wnt family member 5A
102958778 WNT5B; Wnt family member 5B
102972888 WNT7A; Wnt family member 7A
102966525 WNT8A; Wnt family member 8A
102956179 WNT8B; Wnt family member 8B
102950323 WNT9A; Wnt family member 9A
102962257 WNT9B; Wnt family member 9B
102961987 WNT10B; Wnt family member 10B
102956294 WNT10A; Wnt family member 10A
102971675 WNT11; Wnt family member 11
102959880 WNT16; Wnt family member 16
102968815 FZD1; frizzled class receptor 1
102948653 FZD7; frizzled class receptor 7
102962395 FZD2; frizzled class receptor 2
102961371 FZD3; frizzled class receptor 3
102952336 FZD4; frizzled class receptor 4
102953646 FZD6; frizzled class receptor 6
102970273 FZD9; frizzled class receptor 9
102953438 FZD10; frizzled class receptor 10
102968327 LRP5; LDL receptor related protein 5
102968142 LRP6; LDL receptor related protein 6
102954084 DVL3; dishevelled segment polarity protein 3
102967723 DVL2; dishevelled segment polarity protein 2
102957003 DVL1; dishevelled segment polarity protein 1
102950768 F2; coagulation factor II, thrombin
102964727 AGT; angiotensinogen
102964799 F2R; coagulation factor II thrombin receptor
102968521 LPAR1; lysophosphatidic acid receptor 1
102966758 LPAR2; lysophosphatidic acid receptor 2
102968459 LPAR3; lysophosphatidic acid receptor 3
102962731 LPAR4; lysophosphatidic acid receptor 4
102965799 LPAR6; lysophosphatidic acid receptor 6
102968872 AGTR1; angiotensin II receptor type 1
102961052 GNA12; G protein subunit alpha 12
102964498 GNA13; G protein subunit alpha 13
102949630 ARHGEF12; Rho guanine nucleotide exchange factor 12
102962367 ARHGEF11; Rho guanine nucleotide exchange factor 11
102956204 ARHGEF1; Rho guanine nucleotide exchange factor 1
102948691 PLEKHG5; pleckstrin homology and RhoGEF domain containing G5
102952555 RHOA; ras homolog family member A
102963520 ROCK1; Rho associated coiled-coil containing protein kinase 1
102949986 ROCK2; Rho associated coiled-coil containing protein kinase 2
102962805 CXCL12; C-X-C motif chemokine ligand 12
102955333 CXCR4; C-X-C motif chemokine receptor 4
102954501 GNAI1; G protein subunit alpha i1
102951159 GNAI3; G protein subunit alpha i3
102962946 GNAI2; G protein subunit alpha i2
102953086 PTGER2; prostaglandin E receptor 2
102951795 PTGER3; prostaglandin E receptor 3
102957452 PTGER4; prostaglandin E receptor 4
102964541 GNAS; GNAS complex locus
102961712 ADCY1; adenylate cyclase 1
102949732 ADCY2; adenylate cyclase 2
102965866 ADCY4; adenylate cyclase 4
102969833 ADCY5; adenylate cyclase 5
102949044 ADCY6; adenylate cyclase 6
102972917 ADCY7; adenylate cyclase 7
102948581 ADCY8; adenylate cyclase 8
102969003 ADCY9; adenylate cyclase 9
102948983 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
102972158 PRKACB; protein kinase cAMP-activated catalytic subunit beta
102950533 GNB1; G protein subunit beta 1
102955271 GNB2; G protein subunit beta 2
102953535 GNB3; G protein subunit beta 3
102963895 GNB4; G protein subunit beta 4
102954935 GNB5; G protein subunit beta 5
102962902 GNG2; G protein subunit gamma 2
102968307 GNG3; G protein subunit gamma 3
102953604 GNG4; G protein subunit gamma 4
102963799 GNG7; G protein subunit gamma 7
102956095 GNG10; G protein subunit gamma 10
102972135 GNG11; G protein subunit gamma 11
102951416 GNG12; G protein subunit gamma 12
102949358 GNG13; G protein subunit gamma 13
102972425 GNGT1; G protein subunit gamma transducin 1
102967045 GNGT2; G protein subunit gamma transducin 2
102965922 COL4A2; collagen type IV alpha 2 chain
102966202 COL4A1; collagen type IV alpha 1 chain
102965883 COL4A3; collagen type IV alpha 3 chain
102962233 COL4A4; collagen type IV alpha 4 chain
102951304 COL4A6; collagen type IV alpha 6 chain
102951890 COL4A5; collagen type IV alpha 5 chain
102950444 LAMA2; laminin subunit alpha 2
102969465 LAMA1; laminin subunit alpha 1
102956725 LAMA3; laminin subunit alpha 3
102953957 LAMA4; laminin subunit alpha 4
102962439 LAMB1; laminin subunit beta 1
102950017 LAMB2; laminin subunit beta 2
102966519 LAMB3; laminin subunit beta 3
102953694 LAMB4; laminin subunit beta 4
102970302 LAMC1; laminin subunit gamma 1
102966330 LAMC2; laminin subunit gamma 2
102961184 LAMC3; laminin subunit gamma 3
102970250 FN1; fibronectin 1
102958888 ITGA2; integrin subunit alpha 2
102951724 ITGA2B; integrin subunit alpha 2b
102966946 ITGA3; integrin subunit alpha 3
102963994 ITGA6; integrin subunit alpha 6
102972745 ITGAV; integrin subunit alpha V
102967350 ITGB1; integrin subunit beta 1
102953254 PTK2; protein tyrosine kinase 2
102953082 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
102965070 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
102972487 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
102949853 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
102952993 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
102967709 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
102972446 PTEN; phosphatase and tensin homolog
102950628 NKX3-1; NK3 homeobox 1
102952603 AKT3; AKT serine/threonine kinase 3
102954757 AKT2; AKT serine/threonine kinase 2
102949289 CHUK; conserved helix-loop-helix ubiquitous kinase
102963734 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
102956127 NFKBIA; NFKB inhibitor alpha
102964232 NFKB1; nuclear factor kappa B subunit 1
102960153 NFKB2; nuclear factor kappa B subunit 2
102951132 RELA; RELA proto-oncogene, NF-kB subunit
102948685 PTGS2; prostaglandin-endoperoxide synthase 2
102950049 NOS2; nitric oxide synthase 2
102953487 BCL2; BCL2, apoptosis regulator
102972419 BIRC2; baculoviral IAP repeat containing 2
102951731 BIRC3; baculoviral IAP repeat-containing protein 3
102957920 XIAP; X-linked inhibitor of apoptosis
102957324 BIRC7; baculoviral IAP repeat containing 7
102950221 BCL2L1; BCL2 like 1
102961906 TRAF1; TNF receptor associated factor 1
102966802 TRAF2; TNF receptor associated factor 2
102952767 TRAF3; TNF receptor associated factor 3
102951157 TRAF4; TNF receptor associated factor 4
102972430 TRAF5; TNF receptor associated factor 5
102960157 TRAF6; TNF receptor associated factor 6
102967196 MTOR; mechanistic target of rapamycin
102950850 RPS6KB2; ribosomal protein S6 kinase B2
102960736 RPS6KB1; ribosomal protein S6 kinase B1
102956027 BAD; BCL2 associated agonist of cell death
102969147 FOXO1; forkhead box O1
102965880 MDM2; MDM2 proto-oncogene
102962571 TP53; tumor protein p53
102965656 CDKN1B; cyclin dependent kinase inhibitor 1B
102964051 CDKN1A; cyclin dependent kinase inhibitor 1A
102969308 BCR; BCR, RhoGEF and GTPase activating protein
102949569 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
102957241 CRKL; CRK like proto-oncogene, adaptor protein
102956621 CRK; CRK proto-oncogene, adaptor protein
102960753 CBL; Cbl proto-oncogene
102972762 STAT5A; signal transducer and activator of transcription 5A
102972489 STAT5B; signal transducer and activator of transcription 5B
102961019 PIM1; Pim-1 proto-oncogene, serine/threonine kinase
102949413 PIM2; Pim-2 proto-oncogene, serine/threonine kinase
102960528 KNG1; kininogen 1
102969504 EDN1; endothelin 1
107180825 BDKRB1; bradykinin receptor B1
102961054 BDKRB2; bradykinin receptor B2
102952387 EDNRA; endothelin receptor type A
102948490 EDNRB; endothelin receptor type B
102954227 GNAQ; G protein subunit alpha q
107181018 GNA11; G protein subunit alpha 11
102959485 PLCB2; phospholipase C beta 2
102961437 PLCB3; phospholipase C beta 3
102960646 PLCB4; phospholipase C beta 4
102961121 PLCB1; phospholipase C beta 1
102968590 PRKCA; protein kinase C alpha
102952814 PRKCB; protein kinase C beta
102956490 PRKCG; protein kinase C gamma
102957506 IL2; interleukin 2
102963113 IL4; interleukin 4
102964358 IL5; interleukin 5
102968780 IL6; interleukin 6
102960296 IL7; interleukin 7
102971802 IL12A; interleukin 12A
102959546 IL12B; interleukin 12B
102963390 IL13; interleukin 13
102960289 IL15; interleukin 15
102967682 IL23A; interleukin 23 subunit alpha
102949527 EPO; erythropoietin
102956750 interferon alpha-2-like
102963756 IFNG; interferon gamma
102965369 IL2RB; interleukin 2 receptor subunit beta
102966580 IL2RG; interleukin 2 receptor subunit gamma
102949893 IL4R; interleukin 4 receptor
102966236 CSF2RB; colony stimulating factor 2 receptor beta common subunit
102972625 IL5RA; interleukin 5 receptor subunit alpha
102951407 IL6R; interleukin 6 receptor
102968948 IL6ST; interleukin 6 signal transducer
102953956 IL7R; interleukin 7 receptor
102959877 IL12RB1; interleukin 12 receptor subunit beta 1
102953239 IL12RB2; interleukin 12 receptor subunit beta 2
102949045 IL13RA1; interleukin 13 receptor subunit alpha 1
102970696 IL15RA; interleukin 15 receptor subunit alpha
102953911 IL23R; interleukin 23 receptor
102948529 EPOR; erythropoietin receptor
102955444 IFNAR1; interferon alpha and beta receptor subunit 1
102954859 IFNAR2; interferon alpha and beta receptor subunit 2
102952498 IFNGR1; interferon gamma receptor 1
102955729 IFNGR2; interferon gamma receptor 2
102967307 EML4; echinoderm microtubule associated protein like 4
102970257 ALK; anaplastic lymphoma receptor tyrosine kinase
102957207 RASGRP1; RAS guanyl releasing protein 1
102958860 RASGRP2; RAS guanyl releasing protein 2
102954264 RASGRP3; RAS guanyl releasing protein 3
102971379 RASGRP4; RAS guanyl releasing protein 4
102960189 JAK1; Janus kinase 1
102950330 JAK2; Janus kinase 2
102966280 JAK3; Janus kinase 3
102957987 STAT3; signal transducer and activator of transcription 3
102953174 STAT1; signal transducer and activator of transcription 1
102967399 STAT2; signal transducer and activator of transcription 2
102953648 STAT4; signal transducer and activator of transcription 4
102949991 STAT6; signal transducer and activator of transcription 6
102954556 VEGFA; vascular endothelial growth factor A
102961989 VEGFB; vascular endothelial growth factor B
102960599 PGF; placental growth factor
102952237 VEGFC; vascular endothelial growth factor C
102965995 VEGFD; vascular endothelial growth factor D
102956554 TGFA; transforming growth factor alpha
102959656 EGF; epidermal growth factor
102967370 EGFR; epidermal growth factor receptor
102961961 ERBB2; erb-b2 receptor tyrosine kinase 2
102971867 PDGFB; platelet derived growth factor subunit B
102955481 PDGFRA; platelet derived growth factor receptor alpha
102954207 PDGFRB; platelet derived growth factor receptor beta
102962543 IGF1; insulin like growth factor 1
102949680 IGF1R; insulin like growth factor 1 receptor
102951678 KITLG; KIT ligand
102960767 KIT; KIT proto-oncogene receptor tyrosine kinase
102967169 FLT3LG; fms related tyrosine kinase 3 ligand
102955843 FLT3; fms related tyrosine kinase 3
102952318 HGF; hepatocyte growth factor
102953616 MET; MET proto-oncogene, receptor tyrosine kinase
102967663 FGF1; fibroblast growth factor 1
102969772 FGF2; fibroblast growth factor 2
102970275 FGF9; fibroblast growth factor 9
102949835 FGF5; fibroblast growth factor 5
102971941 FGF22; fibroblast growth factor 22
102964398 FGF18; fibroblast growth factor 18
102959014 FGF8; fibroblast growth factor 8
102956185 FGF7; fibroblast growth factor 7
102970087 FGF17; fibroblast growth factor 17
102957299 FGF20; fibroblast growth factor 20
102970576 FGF10; fibroblast growth factor 10
102969970 FGF6; fibroblast growth factor 6
102966317 FGF19; fibroblast growth factor 19
102963142 FGF21; fibroblast growth factor 21
102958480 FGF23; fibroblast growth factor 23
102972346 FGFR1; fibroblast growth factor receptor 1
102964142 FGFR2; fibroblast growth factor receptor 2
102965504 FGFR4; fibroblast growth factor receptor 4
102970459 GRB2; growth factor receptor bound protein 2
102949403 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
102950748 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
102952119 HRAS; HRas proto-oncogene, GTPase
102957350 KRAS; KRAS proto-oncogene, GTPase
102952980 NRAS; neuroblastoma RAS viral oncogene homolog
102956086 ARAF; A-Raf proto-oncogene, serine/threonine kinase
102951082 BRAF; B-Raf proto-oncogene, serine/threonine kinase
102955852 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
102969757 MAP2K1; mitogen-activated protein kinase kinase 1
102956808 MAP2K2; mitogen-activated protein kinase kinase 2
102964841 MAPK1; mitogen-activated protein kinase 1
102960964 MAPK3; mitogen-activated protein kinase 3
102958666 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
102952769 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
102967030 ETS1; ETS proto-oncogene 1, transcription factor
102951453 interstitial collagenase-like
102970572 MMP1; matrix metallopeptidase 1
102956398 MMP2; matrix metallopeptidase 2
102959269 MMP9; matrix metallopeptidase 9
102953898 interleukin-8-like
102953024 IL8; interleukin-8
102970281 CDK4; cyclin dependent kinase 4
102952316 RPS6KA5; ribosomal protein S6 kinase A5
102951366 RET; ret proto-oncogene
102960889 CCDC6; coiled-coil domain containing 6
102957031 NCOA4; nuclear receptor coactivator 4
102952176 TPM3; tropomyosin 3
102950759 tropomyosin alpha-3 chain-like
102972338 TPR; translocated promoter region, nuclear basket protein
102957752 TFG; TRK-fused gene
102966666 RASSF1; Ras association domain family member 1
102963911 RASSF5; Ras association domain family member 5
102954711 STK4; serine/threonine kinase 4
102961109 DAPK2; death associated protein kinase 2
102951891 DAPK1; death associated protein kinase 1
102952137 PLCG1; phospholipase C gamma 1
102963653 PLCG2; phospholipase C gamma 2
102966062 ELK1; ELK1, ETS transcription factor
102953457 CALM3; calmodulin 3
102963939 calmodulin-like
102964234 CALML3; calmodulin-like protein 3
102954552 CALM2; calmodulin 2
102960923 calmodulin-like
102950842 CALML6; calmodulin like 6
102951822 CALM1; calmodulin 1
102971520 calmodulin-alpha-like
102950182 CALML4; calmodulin like 4
102964851 CAMK2B; calcium/calmodulin dependent protein kinase II beta
102966494 CAMK2A; calcium/calmodulin dependent protein kinase II alpha
102957556 CAMK2G; calcium/calmodulin dependent protein kinase II gamma
102950197 CAMK2D; calcium/calmodulin dependent protein kinase II delta
102965767 RALGDS; ral guanine nucleotide dissociation stimulator
102961464 RALA; RAS like proto-oncogene A
102968600 RALB; RAS like proto-oncogene B
102971211 RALBP1; ralA binding protein 1
102973021 CDC42; cell division cycle 42
102968561 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
102961922 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
102955504 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
102962016 PLD1; phospholipase D1
102971823 PLD2; phospholipase D2
102959159 MAPK10; mitogen-activated protein kinase 10
102950880 MAPK8; mitogen-activated protein kinase 8
102963096 MAPK9; mitogen-activated protein kinase 9
102965881 PAX8; paired box 8
102957164 PPARG; peroxisome proliferator activated receptor gamma
102952674 RXRB; retinoid X receptor beta
102969338 RXRG; retinoid X receptor gamma
102951058 RARB; retinoic acid receptor beta
102969728 ESR1; estrogen receptor 1
102972623 ESR2; estrogen receptor 2
102950417 NCOA1; nuclear receptor coactivator 1
102961259 NCOA3; nuclear receptor coactivator 3
102955984 SP1; Sp1 transcription factor
102971511 PPARD; peroxisome proliferator activated receptor delta
102953425 JUP; junction plakoglobin
102952489 ZBTB16; zinc finger and BTB domain containing 16
102969575 RARA; retinoic acid receptor alpha
102970677 CCNA1; cyclin A1
102970341 CCNA2; cyclin A2
102963011 PML; promyelocytic leukemia
102970421 RUNX1T1; RUNX1 translocation partner 1
102951664 SPI1; Spi-1 proto-oncogene
102966764 CSF2RA; colony stimulating factor 2 receptor alpha subunit
102961715 CSF3R; colony stimulating factor 3 receptor
102953056 CSF1R; colony stimulating factor 1 receptor
102963506 E2F1; E2F transcription factor 1
102952251 E2F2; E2F transcription factor 2
102948948 E2F3; E2F transcription factor 3
102965935 MAX; MYC associated factor X
102967948 CDK6; cyclin dependent kinase 6
102970259 CCND2; cyclin D2
102970915 CCND3; cyclin D3
102949508 CKS1B; CDC28 protein kinase regulatory subunit 1B
102957702 SKP1; S-phase kinase associated protein 1
102957061 CUL1; cullin 1
102955881 RBX1; ring-box 1
102964396 SKP2; S-phase kinase associated protein 2
102959572 CDK2; cyclin dependent kinase 2
102955833 CCNE2; cyclin E2
102966425 CCNE1; cyclin E1
102952365 RB1; RB transcriptional corepressor 1
102964763 GADD45B; growth arrest and DNA damage inducible beta
102951885 GADD45A; growth arrest and DNA damage inducible alpha
102949153 BAX; BCL2 associated X, apoptosis regulator
102970767 BAK1; BCL2 antagonist/killer 1
102961097 DDB2; damage specific DNA binding protein 2
102962803 POLK; DNA polymerase kappa
102971944 TERT; telomerase reverse transcriptase
102971074 MITF; melanogenesis associated transcription factor
102951285 TGFB1; transforming growth factor beta 1
102951894 TGFB2; transforming growth factor beta 2
102949760 TGFB3; transforming growth factor beta 3
102950020 TGFBR1; transforming growth factor beta receptor 1
102958413 TGFBR2; transforming growth factor beta receptor 2
102971687 SMAD2; SMAD family member 2
102971888 SMAD3; SMAD family member 3
102961093 SMAD4; SMAD family member 4
102955865 MECOM; MDS1 and EVI1 complex locus
102971287 CTBP2; C-terminal binding protein 2
102952507 HDAC2; histone deacetylase 2
102968123 HDAC1; histone deacetylase 1
102968664 MLH1; mutL homolog 1
102954275 MSH2; mutS homolog 2
102950877 MSH3; mutS homolog 3
102953993 MSH6; mutS homolog 6
102965865 BRCA2; BRCA2, DNA repair associated
102951494 RAD51; RAD51 recombinase
102953222 FASLG; Fas ligand
102958442 FAS; Fas cell surface death receptor
102962460 CASP8; caspase 8
102951809 BID; BH3 interacting domain death agonist
102958923 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
102955464 BBC3; BCL2 binding component 3
102956471 BCL2L11; BCL2 like 11
102966744 cytochrome c 2-like
102952864 cytochrome c-like
102960081 cytochrome c
102964536 APAF1; apoptotic peptidase activating factor 1
102951959 CASP7; caspase 7
102969048 KEAP1; kelch like ECH associated protein 1
102949833 NFE2L2; nuclear factor, erythroid 2 like 2
102948800 HMOX1; heme oxygenase 1
102951595 NQO1; NAD(P)H quinone dehydrogenase 1
102971089 MGST3; microsomal glutathione S-transferase 3
102966922 GSTO1; glutathione S-transferase omega 1
102967394 GSTO2; glutathione S-transferase omega 2
102955989 MGST1; microsomal glutathione S-transferase 1
102962954 MGST2; microsomal glutathione S-transferase 2
102970472 glutathione S-transferase theta-2B-like
102960578 glutathione S-transferase theta-1-like
102959987 glutathione S-transferase theta-1-like
102960295 glutathione S-transferase theta-1
102958890 glutathione S-transferase A4
102958324 GSTA2; glutathione S-transferase A2
102949073 glutathione S-transferase-like
102958599 glutathione S-transferase A4-like
102949368 glutathione S-transferase alpha M14-like
102949663 GSTM3; glutathione S-transferase Mu 3
102949366 GSTM4; glutathione S-transferase Mu 4
102960863 glutathione S-transferase theta-4-like
102964863 GSTP1; glutathione S-transferase pi 1
102969342 TXNRD3; thioredoxin reductase 3
102957366 TXNRD1; thioredoxin reductase 1
102959709 TXNRD2; thioredoxin reductase 2
102955568 VHL; von Hippel-Lindau tumor suppressor
102959091 ELOC; elongin C
102959496 transcription elongation factor B polypeptide 1-like
102962424 ELOB; elongin B
102968019 CUL2; cullin 2
102958475 EGLN2; egl-9 family hypoxia inducible factor 2
102951182 EGLN3; egl-9 family hypoxia inducible factor 3
102957902 EGLN1; egl-9 family hypoxia inducible factor 1
102956633 FH; fumarate hydratase
102951241 HIF1A; hypoxia inducible factor 1 alpha subunit
102956746 EPAS1; endothelial PAS domain protein 1
102969285 ARNT; aryl hydrocarbon receptor nuclear translocator
102952035 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
102968704 CREBBP; CREB binding protein
102953207 EP300; E1A binding protein p300
102957363 SLC2A1; solute carrier family 2 member 1
102963021 JAG1; jagged 1
102961766 DLL4; delta like canonical Notch ligand 4
102952034 DLL3; delta like canonical Notch ligand 3
102951103 DLL1; delta like canonical Notch ligand 1
102961729 NOTCH2; notch 2
102953716 NOTCH3; notch 3
102970846 NOTCH4; notch 4
102955935 HES1; hes family bHLH transcription factor 1
102959515 HEY1; hes related family bHLH transcription factor with YRPW motif 1
102965569 HEYL; hes related family bHLH transcription factor with YRPW motif-like
102962900 HEY2; hes related family bHLH transcription factor with YRPW motif 2
102960922 FLT4; fms related tyrosine kinase 4
102972008 PTCH1; patched 1
102967957 SMO; smoothened, frizzled class receptor
102963170 KIF7; kinesin family member 7
102960717 SUFU; SUFU negative regulator of hedgehog signaling
102965253 GLI1; GLI family zinc finger 1
102950503 GLI2; GLI family zinc finger 2
102961685 BMP2; bone morphogenetic protein 2
102950088 BMP4; bone morphogenetic protein 4
102958115 HHIP; hedgehog interacting protein
102958893 PTCH2; patched 2
102968735 AR; androgen receptor
102954497 HSP90AA1; heat shock protein 90 alpha family class A member 1
102950898 HSP90AB1; heat shock protein 90 alpha family class B member 1
102959647 HSP90B1; heat shock protein 90 beta family member 1
|
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08733 APPL1; DCC-interacting protein 13 alpha
K05689 CDH1; cadherin 1, type 1, E-cadherin
K05689 CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02085 APC; adenomatosis polyposis coli protein
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; G1/S-specific cyclin-D1
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7; frizzled 1/7
K02432 FZD1_7; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4; frizzled 4
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02842 FZD9_10; frizzled 9/10
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K01313 F2; coagulation factor II (thrombin) [EC:3.4.21.5]
K09821 AGT; angiotensinogen
K03914 F2R; coagulation factor II (thrombin) receptor
K04289 LPAR1; lysophosphatidic acid receptor 1
K04291 LPAR2; lysophosphatidic acid receptor 2
K04294 LPAR3; lysophosphatidic acid receptor 3
K04275 LPAR4; lysophosphatidic acid receptor 4
K04273 LPAR6; lysophosphatidic acid receptor 6
K04166 AGTR1; angiotensin II receptor type 1
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
K07532 ARHGEF12; Rho guanine nucleotide exchange factor 12
K12331 ARHGEF11; Rho guanine nucleotide exchange factor 11
K12330 ARHGEF1; Rho guanine nucleotide exchange factor 1
K19464 PLEKHG5; pleckstrin homology domain-containing family G member 5
K04513 RHOA; Ras homolog gene family, member A
K04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
K10031 CXCL12; C-X-C motif chemokine 12
K04189 CXCR4; C-X-C chemokine receptor type 4
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04259 PTGER2; prostaglandin E receptor 2
K04260 PTGER3; prostaglandin E receptor 3
K04261 PTGER4; prostaglandin E receptor 4
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04536 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538 GNB4; guanine nucleotide-binding protein subunit beta-4
K04539 GNB5; guanine nucleotide-binding protein subunit beta-5
K07826 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04543 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04545 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K05637 LAMA1_2; laminin, alpha 1/2
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09348 NKX3-1; homeobox protein Nkx-3.1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161 BCL2; apoptosis regulator Bcl-2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K07201 FOXO1; forkhead box protein O1
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451 TP53; tumor protein p53
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K08878 BCR1; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK; C-crk adapter molecule crk
K04438 CRK; C-crk adapter molecule crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K04702 PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
K08806 PIM2; proto-oncogene serine/threonine-protein kinase Pim-2 [EC:2.7.11.1]
K03898 KNG; kininogen
K16366 EDN1; endothelin-1
K03915 BDKRB1; bradykinin receptor B1
K03916 BDKRB2; bradykinin receptor B2
K04197 EDNRA; endothelin receptor type A
K04198 EDNRB; endothelin receptor type B
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04635 GNA11; guanine nucleotide-binding protein subunit alpha-11
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K05429 IL2; interleukin 2
K05430 IL4; interleukin 4
K05428 IL5; interleukin 5
K05405 IL6; interleukin 6
K05431 IL7; interleukin 7
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K05435 IL13; interleukin 13
K05433 IL15; interleukin 15
K05426 IL23A; interleukin 23 subunit alpha
K05437 EPO; erythropoietin
K05414 IFNA; interferon alpha
K04687 IFNG; interferon gamma
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K05071 IL4R; interleukin 4 receptor
K04738 CSF2RB; cytokine receptor common subunit beta
K05067 IL5RA; interleukin 5 receptor alpha
K05055 IL6R; interleukin 6 receptor
K05060 IL6ST; interleukin 6 signal transducer
K05072 IL7R; interleukin 7 receptor
K05063 IL12RB1; interleukin 12 receptor beta-1
K05064 IL12RB2; interleukin 12 receptor beta-2
K05076 IL13RA1; interleukin 13 receptor alpha-1
K05074 IL15RA; interleukin 15 receptor alpha
K05065 IL23R; interleukin 23 receptor
K05079 EPOR; erythropoietin receptor
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05132 IFNGR1; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K15420 EML4; echinoderm microtubule-associated protein-like 4
K05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K11222 STAT4; signal transducer and activator of transcription 4
K11225 STAT6; signal transducer and activator of transcription 6
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K05449 VEGFC_D; vascular endothelial growth factor C/D
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K17386 PDGFB; platelet-derived growth factor subunit B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461 KITLG; KIT ligand
K05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K18496 FGF1; fibroblast growth factor 1
K18497 FGF2; fibroblast growth factor 2
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K22603 FGF19; fibroblast growth factor 19
K22429 FGF21; fibroblast growth factor 21
K22428 FGF23; fibroblast growth factor 23
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K02678 ETS1; C-ets-1
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030 IL8; interleukin 8
K10030 IL8; interleukin 8
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6; coiled-coil domain-containing protein 6
K09289 NCOA4; nuclear receptor coactivator 4
K09290 TPM3; tropomyosin 3
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5; Ras association domain-containing protein 5
K04411 STK4; serine/threonine kinase 4
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04375 ELK1; ETS domain-containing protein Elk-1
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K08528 RARB; retinoic acid receptor beta
K08550 ESR1; estrogen receptor alpha
K08551 ESR2; estrogen receptor beta
K09101 NCOA1; nuclear receptor coactivator 1 [EC:2.3.1.48]
K11256 NCOA3; nuclear receptor coactivator 3 [EC:2.3.1.48]
K04684 SP1; transcription factor Sp1
K04504 NR1C2; peroxisome proliferator-activated receptor delta
K10056 JUP; junction plakoglobin
K10055 ZBTB16; zinc finger and BTB domain-containing protein 16
K08527 RARA; retinoic acid receptor alpha
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K10054 PML; E3 SUMO-protein ligase PML [EC:2.3.2.-]
K10053 RUNX1T1; CBFA2/RNUX1 translocation partner 1
K09438 SPI1; transcription factor PU.1
K05066 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor alpha
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K04453 MAX; Max protein
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03094 SKP1; S-phase kinase-associated protein 1
K03347 CUL1; cullin 1
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K06618 RB1; retinoblastoma-associated protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
K09455 MITF; microphthalmia-associated transcription factor
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 MECOM; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
K04496 CTBP; C-terminal binding protein [EC:1.1.1.428]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K08775 BRCA2; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K16341 BCL2L11; Bcl-2-like protein 11
K08738 CYC; cytochrome c
K08738 CYC; cytochrome c
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K10456 KLHL19; kelch-like protein 19
K05638 NFE2L2; nuclear factor erythroid 2-related factor 2
K00510 HMOX1; heme oxygenase 1 [EC:1.14.14.18]
K00355 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 ELOC; elongin-C
K03872 ELOC; elongin-C
K03873 ELOB; elongin-B
K03870 CUL2; cullin 2
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A; hypoxia-inducible factor 2 alpha
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K06052 JAG1; jagged-1
K06051 DLL; delta
K06051 DLL; delta
K06051 DLL; delta
K20994 NOTCH2; Notch 2
K20995 NOTCH3; Notch 3
K20996 NOTCH4; Notch 4
K06054 HES1; hairy and enhancer of split 1
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K06225 PTCH1; patched 1
K06226 SMO; smoothened
K18806 KIF7; kinesin family member 7
K06229 SUFU; suppressor of fused
K16797 GLI1; zinc finger protein GLI1
K16798 GLI2; zinc finger protein GLI2
K21283 BMP2; bone morphogenetic protein 2
K04662 BMP4; bone morphogenetic protein 4
K06231 HHIP; hedgehog interacting protein
K11101 PTCH2; patched 2
K08557 AR; androgen receptor
K04079 HSP90A; molecular chaperone HtpG
K04079 HSP90A; molecular chaperone HtpG
K09487 HSP90B; heat shock protein 90kDa beta
|
05202 Transcriptional misregulation in cancer [PATH:ptg05202]
|
05206 MicroRNAs in cancer [PATH:ptg05206]
|
102972446 PTEN; phosphatase and tensin homolog
102965656 CDKN1B; cyclin dependent kinase inhibitor 1B
102950252 TIMP3; TIMP metallopeptidase inhibitor 3
102957350 KRAS; KRAS proto-oncogene, GTPase
102967948 CDK6; cyclin dependent kinase 6
102957057 CDC25A; cell division cycle 25A
102962278 CDC25B; cell division cycle 25B
102968740 CDC25C; cell division cycle 25C
102959906 CCND1; cyclin D1
102970259 CCND2; cyclin D2
102955833 CCNE2; cyclin E2
102966425 CCNE1; cyclin E1
102957241 CRKL; CRK like proto-oncogene, adaptor protein
102956621 CRK; CRK proto-oncogene, adaptor protein
102960966 HDAC5; histone deacetylase 5
102963015 HDAC4; histone deacetylase 4
102970383 FOXP1; forkhead box P1
102961019 PIM1; Pim-1 proto-oncogene, serine/threonine kinase
102953616 MET; MET proto-oncogene, receptor tyrosine kinase
102951977 DNMT3A; DNA methyltransferase 3 alpha
102956318 DNMT3B; DNA methyltransferase 3 beta
102965985 MCL1; BCL2 family apoptosis regulator
102971389 BCL2L2; BCL2 like 2
102967370 EGFR; epidermal growth factor receptor
102954556 VEGFA; vascular endothelial growth factor A
102972226 ZEB1; zinc finger E-box binding homeobox 1
102951894 TGFB2; transforming growth factor beta 2
102949476 EZR; ezrin
102966757 PDCD4; programmed cell death 4
102968704 CREBBP; CREB binding protein
102953207 EP300; E1A binding protein p300
102950451 SPRY2; sprouty RTK signaling antagonist 2
102953487 BCL2; BCL2, apoptosis regulator
102951552 SERPINB5; serpin family B member 5
102953519 ST14; suppression of tumorigenicity 14
102950579 cytochrome P450 1B1
102967196 MTOR; mechanistic target of rapamycin
102958566 RPTOR; regulatory associated protein of MTOR complex 1
102967619 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
102961961 ERBB2; erb-b2 receptor tyrosine kinase 2
102948909 ERBB3; erb-b2 receptor tyrosine kinase 3
102949569 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
102950776 TP63; tumor protein p63
102956778 ZEB2; zinc finger E-box binding homeobox 2
102970695 FSCN1; fascin actin-bundling protein 1
102966666 RASSF1; Ras association domain family member 1
102952585 HOXD10; homeobox D10
102952604 DDIT4; DNA damage inducible transcript 4
102971785 BMF; Bcl2 modifying factor
102950254 PAK4; p21 (RAC1) activated kinase 4
102959269 MMP9; matrix metallopeptidase 9
102963231 SLC7A1; solute carrier family 7 member 1
102968536 CCNG1; cyclin G1
102948800 HMOX1; heme oxygenase 1
102955417 STMN1; stathmin 1
102957987 STAT3; signal transducer and activator of transcription 3
102954147 MYC; v-myc avian myelocytomatosis viral oncogene homolog
102954729 CASP3; caspase 3
102952119 HRAS; HRas proto-oncogene, GTPase
102952980 NRAS; neuroblastoma RAS viral oncogene homolog
102961483 DNMT1; DNA methyltransferase 1
102948725 APC; APC, WNT signaling pathway regulator
102965599 IRS1; insulin receptor substrate 1
102949853 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
102952993 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
102967709 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
102964803 MAPK7; mitogen-activated protein kinase 7
102953082 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
102965070 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
102972487 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
102950296 HNRNPK; heterogeneous nuclear ribonucleoprotein K
102956728 RECK; reversion inducing cysteine rich protein with kazal motifs
102948948 E2F3; E2F transcription factor 3
102961729 NOTCH2; notch 2
102953716 NOTCH3; notch 3
102970846 NOTCH4; notch 4
102973015 BMI1; BMI1 proto-oncogene, polycomb ring finger
102972474 MMP16; matrix metallopeptidase 16
102958898 ATM; ATM serine/threonine kinase
102957786 CD44; CD44 molecule (Indian blood group)
102963060 DICER1; dicer 1, ribonuclease III
102961371 FZD3; frizzled class receptor 3
102959936 ITGA5; integrin subunit alpha 5
102956919 RDX; radixin
102952555 RHOA; ras homolog family member A
102957275 PLAU; plasminogen activator, urokinase
102970767 BAK1; BCL2 antagonist/killer 1
102967368 ZFPM2; zinc finger protein, FOG family member 2
102963673 ITGB3; integrin subunit beta 3
102965290 UBE2I; ubiquitin conjugating enzyme E2 I
102957683 TNN; tenascin N
102970818 TNR; tenascin R
102961256 TNC; tenascin C
102971740 tenascin-X-like
102971562 ABCB1; ATP binding cassette subfamily B member 1
102968778 ABCC1; ATP binding cassette subfamily C member 1
102966376 BRCA1; BRCA1, DNA repair associated
102964051 CDKN1A; cyclin dependent kinase inhibitor 1A
102956614 EFNA5; ephrin A5
102971902 EFNA1; ephrin A1
102969748 THBS1; thrombospondin 1
102967697 IGF2BP1; insulin like growth factor 2 mRNA binding protein 1
102972561 TRIM71; tripartite motif containing 71
102964232 NFKB1; nuclear factor kappa B subunit 1
102963734 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
102948685 PTGS2; prostaglandin-endoperoxide synthase 2
102964841 MAPK1; mitogen-activated protein kinase 1
102960964 MAPK3; mitogen-activated protein kinase 3
102968590 PRKCA; protein kinase C alpha
102952814 PRKCB; protein kinase C beta
102956490 PRKCG; protein kinase C gamma
102970459 GRB2; growth factor receptor bound protein 2
102952316 RPS6KA5; ribosomal protein S6 kinase A5
102962571 TP53; tumor protein p53
102965880 MDM2; MDM2 proto-oncogene
102966847 MDM4; MDM4, p53 regulator
102955481 PDGFRA; platelet derived growth factor receptor alpha
102952137 PLCG1; phospholipase C gamma 1
102963653 PLCG2; phospholipase C gamma 2
102955852 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
102969757 MAP2K1; mitogen-activated protein kinase kinase 1
102956808 MAP2K2; mitogen-activated protein kinase kinase 2
102949403 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
102950748 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
102949026 SHC1; SHC adaptor protein 1
102955115 SHC4; SHC adaptor protein 4
102971867 PDGFB; platelet derived growth factor subunit B
102954207 PDGFRB; platelet derived growth factor receptor beta
102963506 E2F1; E2F transcription factor 1
102952251 E2F2; E2F transcription factor 2
102956471 BCL2L11; BCL2 like 11
102972964 BMPR2; bone morphogenetic protein receptor type 2
102952507 HDAC2; histone deacetylase 2
102968123 HDAC1; histone deacetylase 1
102956220 EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit
102968848 GLS2; glutaminase 2
102967942 GLS; glutaminase
102963908 SIRT1; sirtuin 1
102950040 WNT3A; Wnt family member 3A
102962551 WNT3; Wnt family member 3
102948933 sororin-like
102955738 CDCA5; cell division cycle associated 5
102953110 KIF23; kinesin family member 23
102963520 ROCK1; Rho associated coiled-coil containing protein kinase 1
102956451 PRKCE; protein kinase C epsilon
102972002 SLC45A3; solute carrier family 45 member 3
102964431 VIM; vimentin
|
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K16866 TIMP3; metalloproteinase inhibitor 3
K07827 KRAS; GTPase KRas
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K04438 CRK; C-crk adapter molecule crk
K04438 CRK; C-crk adapter molecule crk
K11406 HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
K11406 HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
K23582 FOXP1; forkhead box protein P1
K04702 PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
K02539 MCL1; myeloid leukemia cell differntiation protein MCL-1
K02163 BCLW; apoptosis regulator BCL-W
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05448 VEGFA; vascular endothelial growth factor A
K09299 ZEB1; zinc finger homeobox protein 1
K13376 TGFB2; transforming growth factor beta-2
K08007 EZR; ezrin
K16865 PDCD4; programmed cell death protein 4
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K17383 SPRY2; protein sprouty homolog 2
K02161 BCL2; apoptosis regulator Bcl-2
K10139 SERPINB5; serpin B5
K08670 ST14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]
K07410 CYP1B1; cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07204 RAPTOR; regulatory associated protein of mTOR
K07436 CYP24A1; vitamin D3 24-hydroxylase [EC:1.14.15.16]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K05084 ERBB3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K10149 TP63; tumor protein p63
K23560 ZEB2; zinc finger homeobox protein 2
K23551 FSCN1; fascin 1
K09850 RASSF1; Ras association domain-containing protein 1
K09295 HOXD10; homrobox protein Hox-D10
K08270 DDIT4; DNA-damage-inducible transcript 4
K17460 BMF; Bcl-2-modifying factor
K05734 PAK4; p21-activated kinase 4 [EC:2.7.11.1]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K13863 SLC7A1; solute carrier family 7 (cationic amino acid transporter), member 1
K10145 CCNG1; cyclin G1
K00510 HMOX1; heme oxygenase 1 [EC:1.14.14.18]
K04381 STMN1; stathmin 1
K04692 STAT3; signal transducer and activator of transcription 3
K04377 MYC; Myc proto-oncogene protein
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K02833 HRAS; GTPase HRas
K07828 NRAS; GTPase NRas
K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
K02085 APC; adenomatosis polyposis coli protein
K16172 IRS1; insulin receptor substrate 1
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04464 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K12886 HNRNPK; heterogeneous nuclear ribonucleoprotein K
K17461 RECK; reversion-inducing-cysteine-rich protein with kazal motifs
K06620 E2F3; transcription factor E2F3
K20994 NOTCH2; Notch 2
K20995 NOTCH3; Notch 3
K20996 NOTCH4; Notch 4
K11459 PCGF4; polycomb group RING finger protein 4
K07996 MMP16; matrix metalloproteinase-16 (membrane-inserted) [EC:3.4.24.-]
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K06256 CD44; CD44 antigen
K11592 DICER1; endoribonuclease Dicer [EC:3.1.26.-]
K02329 FZD3; frizzled 3
K06484 ITGA5; integrin alpha 5
K05762 RDX; radixin
K04513 RHOA; Ras homolog gene family, member A
K01348 PLAU; urokinase plasminogen activator [EC:3.4.21.73]
K14021 BAK; Bcl-2 homologous antagonist/killer
K17442 ZFPM2; zinc finger protein ZFPM2
K06493 ITGB3; integrin beta 3
K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
K06252 TN; tenascin
K06252 TN; tenascin
K06252 TN; tenascin
K06252 TN; tenascin
K05658 ABCB1; ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2]
K05665 ABCC1; ATP-binding cassette, subfamily C (CFTR/MRP), member 1 [EC:7.6.2.3]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K05462 EFNA; ephrin-A
K05462 EFNA; ephrin-A
K16857 THBS1; thrombospondin 1
K17391 IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1
K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K04364 GRB2; growth factor receptor-bound protein 2
K04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K04451 TP53; tumor protein p53
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K10127 MDM4; protein Mdm4
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K06279 SHC1; SHC-transforming protein 1
K17449 SHC4; SHC-transforming protein 4
K17386 PDGFB; platelet-derived growth factor subunit B
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K16341 BCL2L11; Bcl-2-like protein 11
K04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11430 EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
K01425 glsA; glutaminase [EC:3.5.1.2]
K01425 glsA; glutaminase [EC:3.5.1.2]
K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K17390 CDCA5; sororin
K17390 CDCA5; sororin
K17387 KIF23; kinesin family member 23
K04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
K18050 PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
K15379 SLC45A3; solute carrier family 45, member 3
K07606 VIM; vimentin
|
05205 Proteoglycans in cancer [PATH:ptg05205]
|
05204 Chemical carcinogenesis - DNA adducts [PATH:ptg05204]
|
05207 Chemical carcinogenesis - receptor activation [PATH:ptg05207]
|
05208 Chemical carcinogenesis - reactive oxygen species [PATH:ptg05208]
|
05203 Viral carcinogenesis [PATH:ptg05203]
|
05230 Central carbon metabolism in cancer [PATH:ptg05230]
|
05231 Choline metabolism in cancer [PATH:ptg05231]
|
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:ptg05235]
|
|
|
09162 Cancer: specific types
|
05210 Colorectal cancer [PATH:ptg05210]
|
05212 Pancreatic cancer [PATH:ptg05212]
|
05225 Hepatocellular carcinoma [PATH:ptg05225]
|
05226 Gastric cancer [PATH:ptg05226]
|
05214 Glioma [PATH:ptg05214]
|
05216 Thyroid cancer [PATH:ptg05216]
|
05221 Acute myeloid leukemia [PATH:ptg05221]
|
05220 Chronic myeloid leukemia [PATH:ptg05220]
|
05217 Basal cell carcinoma [PATH:ptg05217]
|
05218 Melanoma [PATH:ptg05218]
|
05211 Renal cell carcinoma [PATH:ptg05211]
|
05219 Bladder cancer [PATH:ptg05219]
|
102952119 HRAS; HRas proto-oncogene, GTPase
102957350 KRAS; KRAS proto-oncogene, GTPase
102952980 NRAS; neuroblastoma RAS viral oncogene homolog
102956086 ARAF; A-Raf proto-oncogene, serine/threonine kinase
102951082 BRAF; B-Raf proto-oncogene, serine/threonine kinase
102955852 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
102969757 MAP2K1; mitogen-activated protein kinase kinase 1
102956808 MAP2K2; mitogen-activated protein kinase kinase 2
102964841 MAPK1; mitogen-activated protein kinase 1
102960964 MAPK3; mitogen-activated protein kinase 3
102952316 RPS6KA5; ribosomal protein S6 kinase A5
102954147 MYC; v-myc avian myelocytomatosis viral oncogene homolog
102966666 RASSF1; Ras association domain family member 1
102961109 DAPK2; death associated protein kinase 2
102951891 DAPK1; death associated protein kinase 1
102965880 MDM2; MDM2 proto-oncogene
102962571 TP53; tumor protein p53
102964051 CDKN1A; cyclin dependent kinase inhibitor 1A
102959906 CCND1; cyclin D1
102970281 CDK4; cyclin dependent kinase 4
102952365 RB1; RB transcriptional corepressor 1
102963506 E2F1; E2F transcription factor 1
102952251 E2F2; E2F transcription factor 2
102948948 E2F3; E2F transcription factor 3
102969748 THBS1; thrombospondin 1
102950862 HBEGF; heparin binding EGF like growth factor
102956398 MMP2; matrix metallopeptidase 2
102959269 MMP9; matrix metallopeptidase 9
102958581 UPK3A; uroplakin 3A
102968822 SRC; SRC proto-oncogene, non-receptor tyrosine kinase
102959656 EGF; epidermal growth factor
102961961 ERBB2; erb-b2 receptor tyrosine kinase 2
102967370 EGFR; epidermal growth factor receptor
102954556 VEGFA; vascular endothelial growth factor A
102951453 interstitial collagenase-like
102970572 MMP1; matrix metallopeptidase 1
102953898 interleukin-8-like
102953024 IL8; interleukin-8
102971532 cadherin-1-like
102949516 CDH1; cadherin 1
|
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K04377 MYC; Myc proto-oncogene protein
K09850 RASSF1; Ras association domain-containing protein 1
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04503 CCND1; G1/S-specific cyclin-D1
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K06618 RB1; retinoblastoma-associated protein
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K16857 THBS1; thrombospondin 1
K08523 HBEGF; heparin-binding EGF-like growth factor
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K19520 UPK3A; uroplakin-3a
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K04357 EGF; epidermal growth factor
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05448 VEGFA; vascular endothelial growth factor A
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K10030 IL8; interleukin 8
K10030 IL8; interleukin 8
K05689 CDH1; cadherin 1, type 1, E-cadherin
K05689 CDH1; cadherin 1, type 1, E-cadherin
|
05215 Prostate cancer [PATH:ptg05215]
|
05213 Endometrial cancer [PATH:ptg05213]
|
05224 Breast cancer [PATH:ptg05224]
|
05222 Small cell lung cancer [PATH:ptg05222]
|
05223 Non-small cell lung cancer [PATH:ptg05223]
|
102968381 FHIT; fragile histidine triad
102951058 RARB; retinoic acid receptor beta
102952674 RXRB; retinoid X receptor beta
102969338 RXRG; retinoid X receptor gamma
102970281 CDK4; cyclin dependent kinase 4
102967948 CDK6; cyclin dependent kinase 6
102959906 CCND1; cyclin D1
102952365 RB1; RB transcriptional corepressor 1
102963506 E2F1; E2F transcription factor 1
102952251 E2F2; E2F transcription factor 2
102948948 E2F3; E2F transcription factor 3
102957350 KRAS; KRAS proto-oncogene, GTPase
102966666 RASSF1; Ras association domain family member 1
102963911 RASSF5; Ras association domain family member 5
102954711 STK4; serine/threonine kinase 4
102953082 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
102965070 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
102972487 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
102949853 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
102952993 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
102967709 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
102960424 PDPK1; 3-phosphoinositide dependent protein kinase 1
102952603 AKT3; AKT serine/threonine kinase 3
102954757 AKT2; AKT serine/threonine kinase 2
102956027 BAD; BCL2 associated agonist of cell death
102967404 CASP9; caspase 9
102961930 FOXO3; forkhead box O3
102959656 EGF; epidermal growth factor
102956554 TGFA; transforming growth factor alpha
102967370 EGFR; epidermal growth factor receptor
102961961 ERBB2; erb-b2 receptor tyrosine kinase 2
102952318 HGF; hepatocyte growth factor
102953616 MET; MET proto-oncogene, receptor tyrosine kinase
102970459 GRB2; growth factor receptor bound protein 2
102949403 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
102950748 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
102952119 HRAS; HRas proto-oncogene, GTPase
102952980 NRAS; neuroblastoma RAS viral oncogene homolog
102956086 ARAF; A-Raf proto-oncogene, serine/threonine kinase
102951082 BRAF; B-Raf proto-oncogene, serine/threonine kinase
102955852 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
102969757 MAP2K1; mitogen-activated protein kinase kinase 1
102956808 MAP2K2; mitogen-activated protein kinase kinase 2
102964841 MAPK1; mitogen-activated protein kinase 1
102960964 MAPK3; mitogen-activated protein kinase 3
102952137 PLCG1; phospholipase C gamma 1
102963653 PLCG2; phospholipase C gamma 2
102968590 PRKCA; protein kinase C alpha
102952814 PRKCB; protein kinase C beta
102956490 PRKCG; protein kinase C gamma
102962571 TP53; tumor protein p53
102964051 CDKN1A; cyclin dependent kinase inhibitor 1A
102964763 GADD45B; growth arrest and DNA damage inducible beta
102951885 GADD45A; growth arrest and DNA damage inducible alpha
102949153 BAX; BCL2 associated X, apoptosis regulator
102970767 BAK1; BCL2 antagonist/killer 1
102961097 DDB2; damage specific DNA binding protein 2
102962803 POLK; DNA polymerase kappa
102967932 KIF5A; kinesin family member 5A
102971278 KIF5C; kinesin family member 5C
102965837 KIF5B; kinesin family member 5B
102951366 RET; ret proto-oncogene
102967307 EML4; echinoderm microtubule associated protein like 4
102970257 ALK; anaplastic lymphoma receptor tyrosine kinase
102966280 JAK3; Janus kinase 3
102957987 STAT3; signal transducer and activator of transcription 3
102972762 STAT5A; signal transducer and activator of transcription 5A
102972489 STAT5B; signal transducer and activator of transcription 5B
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K01522 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
K08528 RARB; retinoic acid receptor beta
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K04503 CCND1; G1/S-specific cyclin-D1
K06618 RB1; retinoblastoma-associated protein
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K07827 KRAS; GTPase KRas
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5; Ras association domain-containing protein 5
K04411 STK4; serine/threonine kinase 4
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K09408 FOXO3; forkhead box protein O3
K04357 EGF; epidermal growth factor
K08774 TGFA; transforming growth factor, alpha
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K10396 KIF5; kinesin family member 5
K10396 KIF5; kinesin family member 5
K10396 KIF5; kinesin family member 5
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K15420 EML4; echinoderm microtubule-associated protein-like 4
K05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
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09172 Infectious disease: viral
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09171 Infectious disease: bacterial
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09174 Infectious disease: parasitic
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09163 Immune disease
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09164 Neurodegenerative disease
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09165 Substance dependence
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09166 Cardiovascular disease
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09167 Endocrine and metabolic disease
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09175 Drug resistance: antimicrobial
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09176 Drug resistance: antineoplastic
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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