Search BRITE hierarchies

KEGG Orthology (KO) [BR:hsa00001]
  09130 Environmental Information Processing
    09132 Signal transduction
      04014 Ras signaling pathway [PATH:hsa04014]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04015 Rap1 signaling pathway [PATH:hsa04015]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04010 MAPK signaling pathway [PATH:hsa04010]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04012 ErbB signaling pathway [PATH:hsa04012]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04370 VEGF signaling pathway [PATH:hsa04370]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04371 Apelin signaling pathway [PATH:hsa04371]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04630 Jak-STAT signaling pathway [PATH:hsa04630]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04668 TNF signaling pathway [PATH:hsa04668]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04066 HIF-1 signaling pathway [PATH:hsa04066]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04068 FoxO signaling pathway [PATH:hsa04068]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04072 Phospholipase D signaling pathway [PATH:hsa04072]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04071 Sphingolipid signaling pathway [PATH:hsa04071]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04024 cAMP signaling pathway [PATH:hsa04024]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04022 cGMP-PKG signaling pathway [PATH:hsa04022]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04151 PI3K-Akt signaling pathway [PATH:hsa04151]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04152 AMPK signaling pathway [PATH:hsa04152]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04150 mTOR signaling pathway [PATH:hsa04150]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
  09140 Cellular Processes
    09141 Transport and catabolism
      04140 Autophagy - animal [PATH:hsa04140]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09143 Cell growth and death
      04210 Apoptosis [PATH:hsa04210]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04218 Cellular senescence [PATH:hsa04218]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09144 Cellular community - eukaryotes
      04510 Focal adhesion [PATH:hsa04510]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
  09150 Organismal Systems
    09151 Immune system
      04611 Platelet activation [PATH:hsa04611]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04620 Toll-like receptor signaling pathway [PATH:hsa04620]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04625 C-type lectin receptor signaling pathway [PATH:hsa04625]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04660 T cell receptor signaling pathway [PATH:hsa04660]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04662 B cell receptor signaling pathway [PATH:hsa04662]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04664 Fc epsilon RI signaling pathway [PATH:hsa04664]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04666 Fc gamma R-mediated phagocytosis [PATH:hsa04666]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04062 Chemokine signaling pathway [PATH:hsa04062]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09152 Endocrine system
      04910 Insulin signaling pathway [PATH:hsa04910]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04922 Glucagon signaling pathway [PATH:hsa04922]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04923 Regulation of lipolysis in adipocytes [PATH:hsa04923]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04920 Adipocytokine signaling pathway [PATH:hsa04920]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04915 Estrogen signaling pathway [PATH:hsa04915]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04917 Prolactin signaling pathway [PATH:hsa04917]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04926 Relaxin signaling pathway [PATH:hsa04926]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04919 Thyroid hormone signaling pathway [PATH:hsa04919]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09153 Circulatory system
      04261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09154 Digestive system
      04973 Carbohydrate digestion and absorption [PATH:hsa04973]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09156 Nervous system
      04725 Cholinergic synapse [PATH:hsa04725]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04728 Dopaminergic synapse [PATH:hsa04728]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04722 Neurotrophin signaling pathway [PATH:hsa04722]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09158 Development and regeneration
      04380 Osteoclast differentiation [PATH:hsa04380]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09149 Aging
      04211 Longevity regulating pathway [PATH:hsa04211]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04213 Longevity regulating pathway - multiple species [PATH:hsa04213]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
  09160 Human Diseases
    09161 Cancer: overview
      05200 Pathways in cancer [PATH:hsa05200]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05205 Proteoglycans in cancer [PATH:hsa05205]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05230 Central carbon metabolism in cancer [PATH:hsa05230]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05231 Choline metabolism in cancer [PATH:hsa05231]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:hsa05235]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09162 Cancer: specific types
      05210 Colorectal cancer [PATH:hsa05210]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05212 Pancreatic cancer [PATH:hsa05212]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05225 Hepatocellular carcinoma [PATH:hsa05225]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05226 Gastric cancer [PATH:hsa05226]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05214 Glioma [PATH:hsa05214]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05221 Acute myeloid leukemia [PATH:hsa05221]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05220 Chronic myeloid leukemia [PATH:hsa05220]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05218 Melanoma [PATH:hsa05218]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05211 Renal cell carcinoma [PATH:hsa05211]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05215 Prostate cancer [PATH:hsa05215]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05213 Endometrial cancer [PATH:hsa05213]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05224 Breast cancer [PATH:hsa05224]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05222 Small cell lung cancer [PATH:hsa05222]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05223 Non-small cell lung cancer [PATH:hsa05223]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09166 Cardiovascular disease
      05418 Fluid shear stress and atherosclerosis [PATH:hsa05418]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09167 Endocrine and metabolic disease
      04932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04931 Insulin resistance [PATH:hsa04931]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      04933 AGE-RAGE signaling pathway in diabetic complications [PATH:hsa04933]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09171 Infectious disease: bacterial
      05135 Yersinia infection [PATH:hsa05135]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05152 Tuberculosis [PATH:hsa05152]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09172 Infectious disease: viral
      05166 Human T-cell leukemia virus 1 infection [PATH:hsa05166]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05170 Human immunodeficiency virus 1 infection [PATH:hsa05170]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05162 Measles [PATH:hsa05162]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05164 Influenza A [PATH:hsa05164]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05161 Hepatitis B [PATH:hsa05161]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05160 Hepatitis C [PATH:hsa05160]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05168 Herpes simplex virus 1 infection [PATH:hsa05168]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05163 Human cytomegalovirus infection [PATH:hsa05163]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05167 Kaposi sarcoma-associated herpesvirus infection [PATH:hsa05167]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05169 Epstein-Barr virus infection [PATH:hsa05169]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05165 Human papillomavirus infection [PATH:hsa05165]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09174 Infectious disease: parasitic
      05145 Toxoplasmosis [PATH:hsa05145]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      05142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
    09176 Drug resistance: antineoplastic
      01521 EGFR tyrosine kinase inhibitor resistance [PATH:hsa01521]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      01524 Platinum drug resistance [PATH:hsa01524]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
      01522 Endocrine resistance [PATH:hsa01522]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
  09180 Brite Hierarchies
    09181 Protein families: metabolism
      01001 Protein kinases [BR:hsa01001]
        207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]

Enzymes [BR:hsa01000]
  2. Transferases
    2.7  Transferring phosphorus-containing groups
      2.7.11  Protein-serine/threonine kinases
        2.7.11.1  non-specific serine/threonine protein kinase
          207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1] 

Protein kinases [BR:hsa01001]
  Serine/threonine kinases: AGC group
    AKT/PKB family
      207 AKT1; AKT serine/threonine kinase 1	K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1] 

[ BRITE | KEGG2 | KEGG ]