Search BRITE hierarchies

KEGG Orthology (KO) [BR:hsa00001]
  09130 Environmental Information Processing
    09132 Signal transduction
      04014 Ras signaling pathway [PATH:hsa04014]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04015 Rap1 signaling pathway [PATH:hsa04015]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04010 MAPK signaling pathway [PATH:hsa04010]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04012 ErbB signaling pathway [PATH:hsa04012]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04370 VEGF signaling pathway [PATH:hsa04370]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04371 Apelin signaling pathway [PATH:hsa04371]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04066 HIF-1 signaling pathway [PATH:hsa04066]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04068 FoxO signaling pathway [PATH:hsa04068]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04072 Phospholipase D signaling pathway [PATH:hsa04072]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04071 Sphingolipid signaling pathway [PATH:hsa04071]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04024 cAMP signaling pathway [PATH:hsa04024]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04022 cGMP-PKG signaling pathway [PATH:hsa04022]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04151 PI3K-Akt signaling pathway [PATH:hsa04151]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04150 mTOR signaling pathway [PATH:hsa04150]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
  09140 Cellular Processes
    09141 Transport and catabolism
      04140 Autophagy - animal [PATH:hsa04140]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09143 Cell growth and death
      04210 Apoptosis [PATH:hsa04210]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04218 Cellular senescence [PATH:hsa04218]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09144 Cellular community - eukaryotes
      04540 Gap junction [PATH:hsa04540]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09142 Cell motility
      04810 Regulation of actin cytoskeleton [PATH:hsa04810]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
  09150 Organismal Systems
    09151 Immune system
      04620 Toll-like receptor signaling pathway [PATH:hsa04620]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04660 T cell receptor signaling pathway [PATH:hsa04660]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04662 B cell receptor signaling pathway [PATH:hsa04662]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04664 Fc epsilon RI signaling pathway [PATH:hsa04664]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09152 Endocrine system
      04910 Insulin signaling pathway [PATH:hsa04910]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04912 GnRH signaling pathway [PATH:hsa04912]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04915 Estrogen signaling pathway [PATH:hsa04915]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04917 Prolactin signaling pathway [PATH:hsa04917]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04921 Oxytocin signaling pathway [PATH:hsa04921]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04926 Relaxin signaling pathway [PATH:hsa04926]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04919 Thyroid hormone signaling pathway [PATH:hsa04919]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04916 Melanogenesis [PATH:hsa04916]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09153 Circulatory system
      04270 Vascular smooth muscle contraction [PATH:hsa04270]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09156 Nervous system
      04720 Long-term potentiation [PATH:hsa04720]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04730 Long-term depression [PATH:hsa04730]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      04722 Neurotrophin signaling pathway [PATH:hsa04722]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
  09160 Human Diseases
    09161 Cancer: overview
      05200 Pathways in cancer [PATH:hsa05200]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05206 MicroRNAs in cancer [PATH:hsa05206]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05205 Proteoglycans in cancer [PATH:hsa05205]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05230 Central carbon metabolism in cancer [PATH:hsa05230]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05231 Choline metabolism in cancer [PATH:hsa05231]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:hsa05235]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09162 Cancer: specific types
      05210 Colorectal cancer [PATH:hsa05210]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05225 Hepatocellular carcinoma [PATH:hsa05225]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05226 Gastric cancer [PATH:hsa05226]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05214 Glioma [PATH:hsa05214]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05216 Thyroid cancer [PATH:hsa05216]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05221 Acute myeloid leukemia [PATH:hsa05221]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05220 Chronic myeloid leukemia [PATH:hsa05220]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05218 Melanoma [PATH:hsa05218]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05211 Renal cell carcinoma [PATH:hsa05211]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05219 Bladder cancer [PATH:hsa05219]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05215 Prostate cancer [PATH:hsa05215]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05213 Endometrial cancer [PATH:hsa05213]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05224 Breast cancer [PATH:hsa05224]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05223 Non-small cell lung cancer [PATH:hsa05223]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09164 Neurodegenerative disease
      05020 Prion diseases [PATH:hsa05020]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09167 Endocrine and metabolic disease
      04934 Cushing syndrome [PATH:hsa04934]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09171 Infectious disease: bacterial
      05135 Yersinia infection [PATH:hsa05135]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09172 Infectious disease: viral
      05166 Human T-cell leukemia virus 1 infection [PATH:hsa05166]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05170 Human immunodeficiency virus 1 infection [PATH:hsa05170]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05164 Influenza A [PATH:hsa05164]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05161 Hepatitis B [PATH:hsa05161]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05160 Hepatitis C [PATH:hsa05160]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05163 Human cytomegalovirus infection [PATH:hsa05163]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05167 Kaposi sarcoma-associated herpesvirus infection [PATH:hsa05167]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      05165 Human papillomavirus infection [PATH:hsa05165]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
    09176 Drug resistance: antineoplastic
      01521 EGFR tyrosine kinase inhibitor resistance [PATH:hsa01521]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
      01522 Endocrine resistance [PATH:hsa01522]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
  09180 Brite Hierarchies
    09181 Protein families: metabolism
      01001 Protein kinases [BR:hsa01001]
        5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]

Enzymes [BR:hsa01000]
  2. Transferases
    2.7  Transferring phosphorus-containing groups
      2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
        2.7.12.2  mitogen-activated protein kinase kinase
          5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] 

Protein kinases [BR:hsa01001]
  Serine/threonine kinases: STE group
    STE7 family
      5605 MAP2K2; mitogen-activated protein kinase kinase 2	K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] 

[ BRITE | KEGG2 | KEGG ]