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Entry Thumbnail Image Name Description Object Legend
hsa05130 Pathogenic Escherichia coli infection Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... ...0 (ACTR3B), 653857 (ACTR3C), 81873 (ARPC5L) 60 (ACTB), 71 (ACTG1) 55971 (BAIAP2L1) 10458 (BAIAP2) 14... Golgi Regulation of actin cytoskeleton Flagellar assembly Tight junction Toll-like receptor signalin...
hsa04530 Tight junction Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion th... ...2C), 55844 (PPP2R2D) 81 (ACTN4), 87 (ACTN1) 60 (ACTB), 71 (ACTG1) 11346 (SYNPO) 79778 (MICALL2) 5872... PAR6 PATJ Cdc42 TIGHT JUNCTION Inside Paracellular space LKB1 Cingulin Tiam1 Decreased paracellul...
hsa04670 Leukocyte transendothelial migration Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. ... ... 5296 (PIK3R2), 8503 (PIK3R3) 1499 (CTNNB1) 60 (ACTB), 71 (ACTG1) 103910 (MYL12B), 10398 (MYL9), 106... CAMs MMPs CAMs SHP-2 CDH5 CD99 PECAM1 ITGB2 p120ctn p130 AF-6 SPA-1 PECAM1 JAM1 ITGAL CDH5 SHP-2 CD9...
hsa04810 Regulation of actin cytoskeleton ...(FGF16), 9965 (FGF19) 3630 (INS) 2149 (F2R) 60 (ACTB), 71 (ACTG1) 60 (ACTB), 71 (ACTG1) 4627 (MYH9),... PIP PIP PIP Acetylcholine TMSB4 Arp2/3 PFN WAVE2 WAVE1 HSPC300 APC NWASP Asef Abi2 Nap125 PIR121 IRS...
hsa05131 Shigellosis Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... ...CK1), 9475 (ROCK2) 1729 (DIAPH1) 387 (RHOA) 60 (ACTB), 71 (ACTG1) 27128 (CYTH4), 9265 (CYTH3), 9266 ... SHIGELLOSIS Shigella dysenteria Shigella flexneri Shigella boydii Shigella sonnei TNF-R1 TNFα IκB...
hsa05132 Salmonella infection Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid ... ...71 (NCKAP1L) 23191 (CYFIP1), 26999 (CYFIP2) 60 (ACTB), 71 (ACTG1) 10092 (ARPC5), 10093 (ARPC4), 1009... SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 ...
hsa05135 Yersinia infection Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a typ... ...6 (PIP5K1C), 8394 (PIP5K1A), 8395 (PIP5K1B) 60 (ACTB), 71 (ACTG1) 2185 (PTK2B), 5747 (PTK2) 147179 (... ITGB1 Src N-WASP Arp2/3 Fibronectin p130Cas Crk DOCK180 PIP(5)KIα Actin PI(4,5)P PIP -binding prote...
hsa04520 Adherens junction Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important f... ...RAC1), 5880 (RAC2), 5881 (RAC3) 998 (CDC42) 60 (ACTB), 71 (ACTG1) 60 (ACTB), 71 (ACTG1) 1495 (CTNNA1... Smad4 Cadherin α-Catenin p120ctn p120ctn Cadherin Cadherin Cadherin TCF/LEF NLK TAK1 CBP Smad3 Yes ...
hsa05014 Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... ...3), 375189 (PFN4), 5216 (PFN1), 5217 (PFN2) 60 (ACTB), 71 (ACTG1) 60 (ACTB), 71 (ACTG1) 80208 (SPG11... SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell...
hsa05100 Bacterial invasion of epithelial cells Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellu... ...0 (ACTR3B), 653857 (ACTR3C), 81873 (ARPC5L) 60 (ACTB), 71 (ACTG1) 1793 (DOCK1) 5829 (PXN) 5747 (PTK2... BACTERIAL INVASION OF EPITHELIAL CELLS ECM-receptor interaction Regulation of actin cytoskel...
hsa05205 Proteoglycans in cancer Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that... ...PAK1) 2316 (FLNA), 2317 (FLNB), 2318 (FLNC) 60 (ACTB), 71 (ACTG1) 8826 (IQGAP1) 5594 (MAPK1), 5595 (... CD44v3 Tiam1 HER2 RhoA ROCK Ankyrin Cytoskeleton activation PI3K AKT CD44 Lipid Raft IP3R CAMKII Fil...
hsa05225 Hepatocellular carcinoma Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neo... ...71 (E2F3) 595 (CCND1) 572 (BAD) 2549 (GAB1) 60 (ACTB), 71 (ACTG1) 55274 (PHF10), 8110 (DPF3), 8193 (... HEPATOCELLULAR CARCINOMA EGFR Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K IGF-II IGF1R PI3K-Akt signal...
hsa05410 Hypertrophic cardiomyopathy Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant patter... ...3 (TGFB3) 7124 (TNF) 3569 (IL6) 4634 (MYL3) 60 (ACTB), 71 (ACTG1) 60 (ACTB), 71 (ACTG1) 1674 (DES) 4... SGCD HYPERTROPHIC CARDIOMYOPATHY DHPR RyR SERCA2a NCX Sarcoplasmic reticulum (SR) T-tubule Cardiac ...
hsa05412 Arrhythmogenic right ventricular cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may... ...), 3694 (ITGB6), 3695 (ITGB7), 3696 (ITGB8) 60 (ACTB), 71 (ACTG1) 1674 (DES) 1000 (CDH2) 1000 (CDH2)... SGCD ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY DHPR RyR2 SERCA2a NCX Sarcoplasmic reticulum...
hsa05414 Dilated cardiomyopathy Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contra... ...KACB), 5568 (PRKACG) 5350 (PLN) 4633 (MYL2) 60 (ACTB), 71 (ACTG1) 60 (ACTB), 71 (ACTG1) 1674 (DES) 4... SGCD DILATED CARDIOMYOPATHY DHPR RyR SERCA2a NCX Sarcoplasmic reticulum (SR) T-tubule Cardiac muscl...
hsa04015 Rap1 signaling pathway Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... ...3), 375189 (PFN4), 5216 (PFN1), 5217 (PFN2) 60 (ACTB), 71 (ACTG1) 999 (CDH1) 5906 (RAP1A), 5908 (RAP... MAPK signaling pathway RAP1 SIGNALING PATHWAY ERK MEK Raf-1 Rap1 RIAM RTK RalGDS Rac RapL MEK3,6 p...
hsa04145 Phagosome Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mech... ...2), 3688 (ITGB1) 3678 (ITGA5), 3688 (ITGB1) 60 (ACTB), 71 (ACTG1) 5289 (PIK3C3) 8411 (EEA1) 5868 (RA... PHAGOSOME Fc gamma R-mediated phagocytosis Endocytosis Phagocytic cup pathogen Conventional p...
hsa04210 Apoptosis Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... ...IDD1) 55367 (PIDD1) 3002 (GZMB) 5551 (PRF1) 60 (ACTB), 71 (ACTG1) 10376 (TUBA1B), 112714 (TUBA3E), 1... Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X...
hsa04390 Hippo signaling pathway Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies... ... 126374 (WTIP), 84962 (AJUBA), 8994 (LIMD1) 60 (ACTB), 71 (ACTG1) 10413 (YAP1), 25937 (WWTR1) 23418 ... HIPPO SIGNALING PATHWAY KIBRA Mer FRMD SAV1 Mst1/2 YAP/TAZ Lats1/2 Crb α-Catenin RASSF1A CTGF Bi...
hsa04510 Focal adhesion Cell-matrix adhesions play essential roles in important biological processes including cell motility... ...V1), 7410 (VAV2) 1499 (CTNNB1) 2932 (GSK3B) 60 (ACTB), 71 (ACTG1) hsa04512: ECM-receptor interaction... ECM-receptor interaction Cytokine-cytokine receptor interaction MAPK signaling pathway ITGB ITGA Fil...

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