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Name |
Description |
Object |
Legend |
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hsa04141
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Protein processing in endoplasmic reticulum |
...ewly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded pro... |
...06742 (CASP12) 823 (CAPN1), 824 (CAPN2) 10952 (SEC61B), 23480 (SEC61G), 29927 (SEC61A1), 55176 (SEC6... |
...ion (ERAD) ERP57 CASP12 Calpain Sec61 p97 Sec61 OSTs EDEM Accumulation of misfolded p... |
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hsa03060
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Protein export |
... trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (... |
...9) 6734 (SRPRA) 6726 (SRP9) 6729 (SRP54) 7095 (SEC62) 11231 (SEC63) 28972 (SPCS1) 9789 (SPCS2) 29927... |
...-arginine translocation) system RN7SL Ffh FtsY SEC62 SEC63 SPCS1 SPCS2 SEC61α Trasnlocation channel... |
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hsa05110
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Vibrio cholerae infection |
... the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol... |
... (PRKACA), 5567 (PRKACB), 5568 (PRKACG) 10952 (SEC61B), 23480 (SEC61G), 29927 (SEC61A1), 55176 (SEC6... |
...rylation GNAS KCNQ1 PKCα SLC12A2 PLC PKA RtxA Sec61 G-Actin PDI Zot receptor ERD2 VIBRIO CHOLERAE... |
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hsa04022
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cGMP-PKG signaling pathway |
... potential receptor canonical channel family, TRPC6, suppressing this nonselective ion channel's Ca2... |
... 9475 (ROCK2) 2767 (GNA11), 2776 (GNAQ) 7225 (TRPC6) 5530 (PPP3CA), 5532 (PPP3CB), 5533 (PPP3CC), 55... |
...type Cav RhoA ROCK Hyperpolarization IP3 q/11 TRPC6 NFAT MEF2 GATA-4 SRF Vascular smooth muscle cont... |
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hsa04721
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Synaptic vesicle cycle |
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles ... |
... (SLC1A3), 6511 (SLC1A6), 6512 (SLC1A7), 6529 (SLC6A1), 6530 (SLC6A2), 6531 (SLC6A3), 6532 (SLC6A4),... |
SYNAPTIC VESICLE CYCLE Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VGCC Glutamatergic... |
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hsa04740
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Olfactory transduction |
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity tr... |
...16), 219429 (OR4C11), 219431 (OR4S2), 219432 (OR4C6), 219436 (OR5D14), 219437 (OR5L1), 219438 (OR5D1... |
OLFACTORY TRANSDUCTION cAMP Golf ACⅢ CNG CaCC Olfactory receptor neuron (ORN) Depolarization ODO... |
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hsa05034
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Alcoholism |
Alcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is pro... |
...70 (SLC18A1), 6571 (SLC18A2) 1812 (DRD1) 6531 (SLC6A3) 116443 (GRIN3A), 116444 (GRIN3B), 2902 (GRIN1... |
ALCOHOLISM Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopaminergic synaps... |
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hsa00601
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Glycosphingolipid biosynthesis - lacto and neolacto series |
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...078 (iso-nLc8Cer) G00057 G00090 (V3Fuc,III3Fuc-nLc6Cer) G00091 G00089 (V3Fuc-nLc6Cer) G00088 (VI3Neu... |
2.4.1.152 2.4.1.152 2.4.1.152 2.4.1.152 2.4.1.- 2.4.1.65 2.4.1.65 2.4.1.65 2.4.1.65 2.4.1.65 B4GALT4... |
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hsa01100
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Metabolic pathways |
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...060 (III3Fuc-nLc4Cer) G00066 (nLc5Cer) G00067 (nLc6Cer) G00077 G00052 (Type II B antigen) G00059 (Ty... |
Metabolism of Terpenoids and Polyketides Lipid Metabolism Glycan Biosynthesis and Metabolism Carbohy... |
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hsa04613
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Neutrophil extracellular trap formation |
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action... |
...I4) 2243 (FGA), 2244 (FGB), 2266 (FGG) 10013 (HDAC6), 10014 (HDAC5), 3065 (HDAC1), 3066 (HDAC2), 515... |
Neutrophil FcγRIIA FcγRI Src Syk IgG PI3K PIP PLC DAG PKC Raf1 MEK ERK1/2 Akt NOD-like receptor si... |
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hsa04727
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GABAergic synapse |
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian cen... |
...(Succinate) 2550 (GABBR1), 9568 (GABBR2) 6538 (SLC6A11), 6540 (SLC6A13) 140679 (SLC32A1) 107 (ADCY1)... |
GABAERGIC SYNAPSE Glial cell Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) GABA GAT2/3 V... |
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hsa05322
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Systemic lupus erythematosus |
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the productio... |
...12 (C1QA), 713 (C1QB), 714 (C1QC) 715 (C1R) 729 (C6) 730 (C7) 731 (C8A), 732 (C8B), 733 (C8G) 727 (C... |
BCR FcγR FcγR IgG IgG IgG IgG Elastase Cathepsin C1s C1q C1r MAC TNF-α IFN-γ IL-10 C1q C1q CD80/... |
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hsa05031
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Amphetamine addiction |
Amphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs... |
..., 2892 (GRIA3), 2893 (GRIA4) 1812 (DRD1) 6531 (SLC6A3) 775 (CACNA1C), 776 (CACNA1D) 116443 (GRIN3A),... |
AMPHETAMINE ADDICTION Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopamin... |
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hsa04145
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Phagosome |
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mech... |
...TPA2), 78989 (COLEC11), 81035 (COLEC12) 10952 (SEC61B), 23480 (SEC61G), 29927 (SEC61A1), 55176 (SEC6... |
...athway Antigen processing and presentation Sec61 CALR calnexin MHCII MHCII DCSIGN Dectin1 TAP ca... |
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hsa00604
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Glycosphingolipid biosynthesis - ganglio series |
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...) 2583 (B4GALNT1) 29906 (ST8SIA5) 30815 (ST6GALNAC6) 30815 (ST6GALNAC6) 29906 (ST8SIA5) 256435 (ST6G... |
2.4.99.4 3.2.1.23 3.2.1.52 Siat8a GQ1bα GT1aα GD1α GD1β GM1α GM2α O-Acetylated GT3 GP1c GQ1c G... |
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hsa00592
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alpha-Linolenic acid metabolism |
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...noyl-OPC4-CoA) C16335 (OPC4-CoA) C16334 (3-Oxo-OPC6-CoA) C16332 (trans-2-Enoyl-OPC6-CoA) C16331 (OPC... |
...OPC4-CoA trans-2-Enoyl-OPC4-CoA OPC4-CoA 3-Oxo-OPC6-CoA trans-2-Enoyl-OPC6-CoA OPC6-CoA 3-Oxo-OPC8-C... |
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hsa04110
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Cell cycle |
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replic... |
..., 4174 (MCM5), 4175 (MCM6), 4176 (MCM7) 23594 (ORC6), 23595 (ORC3), 4998 (ORC1), 4999 (ORC2), 5000 (... |
ARF Cdh1 MCM ORC APC/C APC/C SCF SCF Orc6 Orc3 Orc5 Orc4 Orc2 Orc1 Mcm7 Mcm6 Mcm5 Mcm4 Mcm3 Mcm2 CDK... |
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hsa05012
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Parkinson disease |
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... |
..., 7326 (UBE2G1), 7327 (UBE2G2) 7054 (TH) 6531 (SLC6A3) 842 (CASP9) 836 (CASP3) 317 (APAF1) 6570 (SLC... |
...ion Endoplasmic-reticulum- associated E2 Ubc6/7 Tyrosine metabolism PARKINSON DISEASE Dopamin... |
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hsa04360
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Axon guidance |
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a var... |
...22 (TRPC3), 7223 (TRPC4), 7224 (TRPC5), 7225 (TRPC6) 7474 (WNT5A), 81029 (WNT5B) 5290 (PIK3CA), 5291... |
Par6 Par3 CXCR4 ERK Rac Rac Rac DCC NFAT CaN Netrin-G1 Netrin-4 Slit3 Slit2 Slit1 FAK Cdc42 ROCK PAK... |
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hsa05030
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Cocaine addiction |
Drug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking beh... |
...M2), 2913 (GRM3) 1813 (DRD2) 1812 (DRD1) 6531 (SLC6A3) 2912 (GRM2), 2913 (GRM3) 1813 (DRD2) 1812 (DR... |
COCAINE ADDICTION Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopaminergi... |