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Entry Thumbnail Image Name Description Object Legend
hsa05031 Amphetamine addiction Amphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs... ...91860 (CALML4) 814 (CAMK4), 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 84152 (PPP1R1B) 5... AMPHETAMINE ADDICTION Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopamin...
hsa04713 Circadian entrainment Circadian entrainment is a fundamental property by which the period of the internal biological clock... ...10 (CALML3), 91860 (CALML4) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 4842 (NOS1) 2977 ... CIRCADIAN ENTRAINMENT NMDAR CaM CaMKII nNOS cGMP PKG PLC DAG PKC Melatonin T-VDCC RyR Postsynaptic ...
hsa04911 Insulin secretion Pancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood su... ...993 (CREB3L1), 9586 (CREB5) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 2864 (FFAR1) 5479... INSULIN SECRETION GLUT1/2 Kir6.2 VDCC M3R GLP-1R PLC Glucose Citrate cycle (TCA cycle) PKA Gq/G11 G...
hsa05152 Tuberculosis Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the... ...10 (CALML3), 91860 (CALML4) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 5868 (RAB5A), 586... SapM TUBERCULOSIS DC-SIGN Raf1 IL-10 Pro-inflammatory cytokines Phagosome maturation arrest Rab5 VPS...
hsa05214 Glioma Gliomas are the most common of the primary brain tumors and account for more than 40% of all central... ...7172 (CAMK1G), 814 (CAMK4), 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G), 8536 (CAMK1) 557... EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR CAM CAMK PKC Shc Grb2 Sos ...
hsa04012 ErbB signaling pathway The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor l... ... 5579 (PRKCB), 5582 (PRKCG) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 5335 (PLCG1), 533... Non-small cell lung cancer Grb2 Elk ErbB-4 ErbB-4 ErbB-3 ErbB-3 STAT5 ErbB-2 ErbB-2 ErbB-2 ErbB-2...
hsa04020 Calcium signaling pathway Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is dr... ...7172 (CAMK1G), 814 (CAMK4), 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G), 8536 (CAMK1) 553... Long term depression Long term potentiation Phosphatidylinositol signaling pathway Apoptosis ...
hsa04024 cAMP signaling pathway cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... ...659 (PPP1R12A) 814 (CAMK4), 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 117 (ADCYAP1R1), ... cAMP SIGNALING PATHWAY Sarcoplasmic Reticulum (SR) VDCC RyR2 SERCA2a TnI Calcium signaling pathway...
hsa04066 HIF-1 signaling pathway Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of... ...2), 5162 (PDHB) 5163 (PDK1) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 3098 (HK1), 3099 ... CUL2 Rbx1 ElonginB ElonginC VEGF PHD VHL HIF-1β p300/CBP HIF-1α Glut1 HIF-1 SIGNALING PATHWAY mT...
hsa04114 Oocyte meiosis During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregatio... ...23291 (FBXW11), 8945 (BTRC) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 5347 (PLK1) 6790 ... Mos Cdc2 Mad1/2 CycB2/B5 Myt1 Rsk1/2 p42MAPK MEK1 Progesterone OOCYTE MEIOSIS Early translation of ...
hsa04217 Necroptosis Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumo... ...2G4C), 8681 (JMJD7-PLA2G4B) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 1536 (CYBB) 10052... NECROPTOSIS TNF TNFR1 TRADD TRAF2/5 MLKL TLR4 IFNR LPS IFN JAKs TRAILR TRAIL Fas FasL IAPs Casp8 cFL...
hsa04261 Adrenergic signaling in cardiomyocytes Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subty... ...10 (CALML3), 91860 (CALML4) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 185 (AGTR1), 186 ... ADRENERGIC SIGNALING IN CARDIOMYOCYTES T-tubule Sarcoplasmic Reticulum (SR) DHPR RyR2 NCX NCX SER...
hsa04310 Wnt signaling pathway Wnt proteins are secreted morphogens that are required for basic developmental processes, such as ce... ...534 (PPP3R1), 5535 (PPP3R2) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 23236 (PLCB1), 53... p53 signaling pathway Adherens junction SMAD3 TGF-β signaling pathway Cell cycle WNT SIGNALING PA...
hsa04360 Axon guidance Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a var... ...7) 3984 (LIMK1) 7976 (FZD3) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 54361 (WNT4) 6259... Par6 Par3 CXCR4 ERK Rac Rac Rac DCC NFAT CaN Netrin-G1 Netrin-4 Slit3 Slit2 Slit1 FAK Cdc42 ROCK PAK...
hsa04720 Long-term potentiation Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molec... ...1387 (CREBBP), 2033 (EP300) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 5530 (PPP3CA), 55... PKC CaMKIV CBP DAG cAMP CaMKII Glutamate CaN CaM Rsk CREB NMDAR PKA VDCC PP1 AC1/8 AMPAR EPAC1 ERK1/...
hsa04722 Neurotrophin signaling pathway Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cel... ...9252 (RPS6KA5) 814 (CAMK4), 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 468 (ATF4) 4145 (... Plasticity Cell survival TrkA TrkB TrkC Apoptosis BDNF NT4 NT3 Cellular differentiation PI3K PLCγ ...
hsa04725 Cholinergic synapse Acetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, au... ..., 9586 (CREB5) 814 (CAMK4), 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 10681 (GNB5), 277... CHOLINERGIC SYNAPSE Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) nAChR AChE vAChT AcCoA...
hsa04728 Dopaminergic synapse Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where i... ...532 (PPP3CB), 5533 (PPP3CC) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 408 (ARRB1), 409 ... DOPAMINERGIC SYNAPSE Glial cell Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) DAT VMAT ...
hsa04740 Olfactory transduction Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity tr... ... 5592 (PRKG1), 5593 (PRKG2) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 2774 (GNAL), 2782... OLFACTORY TRANSDUCTION cAMP Golf ACⅢ CNG CaCC Olfactory receptor neuron (ORN) Depolarization ODO...
hsa04750 Inflammatory mediator regulation of TRP channels The TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs.... ...567 (PRKACB), 5568 (PRKACG) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818 (CAMK2G) 1432 (MAPK14), 55... Mast cell INFLAMMATORY MEDIATOR REGULATION OF TRP CHANNELS P2YR B1/B2 5HTR TRPV1 ASIC IL1R TrkA I...

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