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Description |
Object |
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hsa05203
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Viral carcinogenesis |
There is a strong association between viruses and the development of human malignancies. We now know... |
...960 (GTF2E1), 2961 (GTF2E2) 27044 (SND1) 1387 (CREBBP), 2033 (EP300) 2959 (GTF2B) 7157 (TP53) 245972... |
VIRAL CARCINOGENESIS Hepatitis C virus (HCV) Hepatocellular carcinoma Human papillomavirus (HPV) p... |
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hsa05161
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Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
...C) 356 (FASLG) 4088 (SMAD3) 4088 (SMAD3) 1387 (CREBBP), 2033 (EP300) 1959 (EGR2), 1960 (EGR3) 3339 (... |
Mitochondria VDAC3 CytC CASP9 Apaf-1 CASP12 CASP3 Apoptosis Bax Survivin Ca release PKC Raf MEK E... |
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hsa05206
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MicroRNAs in cancer |
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... |
...R194-1), 406970 (MIR194-2) 27250 (PDCD4) 1387 (CREBBP), 2033 (EP300) 406997 (MIR215) 407020 (MIR28) ... |
MicroRNAs IN CANCER Lung cancer Lung epithelial cell Tumorigenesis Survival Invasion / metastasi... |
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hsa05211
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Renal cell carcinoma |
Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be risin... |
...) 6513 (SLC2A1) 405 (ARNT), 9915 (ARNT2) 1387 (CREBBP), 2033 (EP300) 8453 (CUL2) 9978 (RBX1) 6923 (E... |
SHP2 TGF-β VEGF Glut1 HIF-β p300/CBP CUL2 Rbx1 ElonginB ElonginC VHL HPH HIF-α Malate Fumarate CUL2 ... |
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hsa03083
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Polycomb repressive complex |
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...0238 (DCAF7) 84333 (PCGF5) 54881 (TEX10) 1387 (CREBBP), 2033 (EP300) 84108 (PCGF6) 1876 (E2F6) 7027 ... |
POLYCOMB REPRESSIVE COMPLEX Crosstalk between cPRC1 and PRC2 PRC2 Crosstalk between ncPRC1 and PRC2... |
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hsa03250
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Viral life cycle - HIV-1 |
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...L4C), 728945 (PPIAL4F), 730262 (PPIAL4E) 1387 (CREBBP), 2033 (EP300) 5901 (RAN) 100913187 (APOBEC3A_... |
Binding Preintegration complex (PIC) reverse transcriptase matrix integrase Fusion Reverse trans... |
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hsa04024
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cAMP signaling pathway |
cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... |
..., 5970 (RELA) 5465 (PPARA) 4772 (NFATC1) 1387 (CREBBP), 2033 (EP300) 6662 (SOX9) 10257 (ABCC4) 55811... |
cAMP SIGNALING PATHWAY Sarcoplasmic Reticulum (SR) VDCC RyR2 SERCA2a TnI Calcium signaling pathway... |
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hsa04066
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HIF-1 signaling pathway |
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of... |
...N3), 54583 (EGLN1) 7428 (VHL) 405 (ARNT) 1387 (CREBBP), 2033 (EP300) 3091 (HIF1A) 6513 (SLC2A1) 1950... |
CUL2 Rbx1 ElonginB ElonginC VEGF PHD VHL HIF-1β p300/CBP HIF-1α Glut1 HIF-1 SIGNALING PATHWAY mTOR... |
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hsa04068
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FoxO signaling pathway |
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellu... |
...EGF) 5728 (PTEN) 6502 (SKP2) 4193 (MDM2) 1387 (CREBBP), 2033 (EP300) 23411 (SIRT1) 3479 (IGF1) 3480 ... |
IKKα/β JNK ERK1/2 AMPK INS Glucose FOXO SOS Ras MEK1/2 INSR Raf PEPCK G6PC Akt P13K PDK1/2 IRS PIP F... |
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hsa04110
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Cell cycle |
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replic... |
...) 1026 (CDKN1A) 5591 (PRKDC) 4193 (MDM2) 1387 (CREBBP), 2033 (EP300) 6502 (SKP2) 9088 (PKMYT1) 49455... |
ARF Cdh1 MCM ORC APC/C APC/C SCF SCF CDK1 BubR1 PCNA Plk1 ATM/ATR Dbf4 Mad2 Bub1 Bub3 Cdc14b 14-3-3 ... |
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hsa04310
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Wnt signaling pathway |
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as ce... |
...32 (TCF7), 6934 (TCF7L2), 83439 (TCF7L1) 1387 (CREBBP), 2033 (EP300) 8607 (RUVBL1) 57680 (CHD8) 5699... |
p53 signaling pathway Adherens junction SMAD3 TGF-β signaling pathway Cell cycle WNT SIGNALING PAT... |
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hsa04330
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Notch signaling pathway |
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essent... |
... 11317 (RBPJL), 3516 (RBPJ) 22938 (SNW1) 1387 (CREBBP), 2033 (EP300), 2648 (KAT2A), 8850 (KAT2B) 555... |
NCSTN APH-1 PSEN MAPK signaling pathway HDAC CIR Gro/TLE CtBP Hairless SMRT PreTα Hes1/5 CSL SKIP HA... |
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hsa04350
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TGF-beta signaling pathway |
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and... |
...2), 4088 (SMAD3) 5308 (PITX2) 6667 (SP1) 1387 (CREBBP), 2033 (EP300) 1030 (CDKN2B) 4609 (MYC) 7027 (... |
LTBP1 THBS1 Cul1 Rbx1 TGF-BETA SIGNALING PATHWAY Apoptosis Cell Cycle Ubiquitin mediated proteolys... |
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hsa04520
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Adherens junction |
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important f... |
...83439 (TCF7L1) 51701 (NLK) 6885 (MAP3K7) 1387 (CREBBP), 2033 (EP300) 4088 (SMAD3) 7525 (YES1) 2534 (... |
Smad4 E-Cadherin α-Catenin p120ctn p120ctn E-Cadherin E-Cadherin E-Cadherin TCF/LEF NLK TAK1 CBP Sma... |
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hsa04630
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JAK-STAT signaling pathway |
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a h... |
...N1A) 598 (BCL2L1) 316 (AOX1) 2670 (GFAP) 1387 (CREBBP), 2033 (EP300) 10401 (PIAS3), 51588 (PIAS4), 8... |
JAK-STAT SIGNALING PATHWAY STAT JAK1/3 Receptor STAT IL2 family STAT JAK2 Receptor STAT Hormone ST... |
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hsa04720
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Long-term potentiation |
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molec... |
..., 5579 (PRKCB), 5582 (PRKCG) 814 (CAMK4) 1387 (CREBBP), 2033 (EP300) 815 (CAMK2A), 816 (CAMK2B), 817... |
PKC CaMKIV CBP DAG cAMP CaMKII Glutamate CaN CaM Rsk CREB NMDAR PKA VDCC PP1 AC1/8 AMPAR EPAC1 ERK1/... |
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hsa04916
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Melanogenesis |
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and pr... |
...), 5331 (PLCB3), 5332 (PLCB4) 434 (ASIP) 1387 (CREBBP), 2033 (EP300) 5566 (PRKACA), 5567 (PRKACB), 5... |
Dvl DCT TYRP1 TYR MITF DCT TYRP1 TYR PKA CAMK CAM Gi/o ETB-R c-Kit MITF Melanin Tyrosine SCF Frizzle... |
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hsa04919
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Thyroid hormone signaling pathway |
The thyroid hormones (THs) are important regulators of growth, development and metabolism. The actio... |
...0499 (NCOA2), 8202 (NCOA3), 8648 (NCOA1) 1387 (CREBBP), 2033 (EP300) 10025 (MED16), 116931 (MED12L),... |
MAPK signaling pathway ITGB ITGA PIP Akt/PKB PDK1 PI3K PKC THYROID HORMONE SIGNALING PATHWAY Regu... |
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hsa04922
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Glucagon signaling pathway |
Glucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical ... |
...3 (CREB3L1), 9586 (CREB5) 200186 (CRTC2) 1387 (CREBBP), 2033 (EP300) 10891 (PPARGC1A) 5105 (PCK1), 5... |
GLUCAGON SIGNALING PATHWAY GLUT1/2 Glucose G6P Pyruvate Glucose Citrate cycle (TCA cycle) Citrate ... |
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hsa04935
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Growth hormone synthesis, secretion and action |
Growth hormone (GH) is a peptide hormone secreted from the anterior pituitary and plays a critical r... |
...599 (MAPK8), 5601 (MAPK9), 5602 (MAPK10) 1387 (CREBBP), 2033 (EP300) 3483 (IGFALS) 3486 (IGFBP3) 112... |
GROWTH HORMONE SYNTHESIS, SECRETION AND ACTION PLCγ IP3 Calcium signaling pathway Somatotroph (... |