Entry |
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Name |
Description |
Object |
Legend |
hsa04012
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ErbB signaling pathway |
... exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the... |
... 5599 (MAPK8), 5601 (MAPK9), 5602 (MAPK10) 1398 (CRK), 1399 (CRKL) 5747 (PTK2) 6654 (SOS1), 6655 (SO... |
...B1 TGFα JNKK Cbl ErbB-4 ErbB-3 NRG3 NRG2 Elk JNK Crk FAK Sos Grb2 Shc PKC CAMK PLCγ HB-EGF NRG1 EPR ... |
hsa04062
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Chemokine signaling pathway |
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon... |
...NG8) 2885 (GRB2) 9564 (BCAR1) 9844 (ELMO1) 1398 (CRK), 1399 (CRKL) 131890 (GRK7), 156 (GRK2), 157 (G... |
...phocyte Macrophage Eosinophil GRB2 p130Cas ELMO1 Crk GRK β-arrestin Receptor internalization ROCK Ja... |
hsa05100
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Bacterial invasion of epithelial cells |
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellu... |
...ACTG1) 1793 (DOCK1) 5829 (PXN) 5747 (PTK2) 1398 (CRK), 1399 (CRKL) 23607 (CD2AP) 110117499 (P3R3URF-... |
...in Arp2/3 actin Rho GTPases Dock180 Paxillin FAK Crk CD2AP PI3K Cbl Met dynamin Cas Clathrin WAVE N-... |
hsa05200
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Pathways in cancer |
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... (FZD9) 26060 (APPL1) 25 (ABL1), 613 (BCR) 1398 (CRK), 1399 (CRKL) 867 (CBL) 1398 (CRK), 1399 (CRKL)... |
...ITGB Dvl ECM ITGA FAK PTEN Frizzled APPL BCR-ABL CRKL CBL CRK PI3K STAT5 Jak EGFR ERBB2 PDGFR IGFR c... |
hsa05220
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Chronic myeloid leukemia |
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. T... |
...C4), 53358 (SHC3), 6464 (SHC1) 9846 (GAB2) 1398 (CRK), 1399 (CRKL) 867 (CBL) 1398 (CRK), 1399 (CRKL)... |
...27 MDM2 IKK Bcl-xl Bad p14 p21 Sos Grb2 Shc Gab2 CRK CBL CRKL PIP MDM2 p53 E2F Smad3 CDK4/6 CyclinD1... |
hsa04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
... 5601 (MAPK9), 5602 (MAPK10) 6416 (MAP2K4) 1398 (CRK), 1399 (CRKL) 408 (ARRB1), 409 (ARRB2) 2122 (ME... |
...c42/Rac PAK1/2 MEKK2/3 JIP1/2 MLK3 MKK7 JNK MKK4 CrkII ARRB Evi1 HSP72 JunD AP1 NFAT-4 NFAT-2 PPP3C ... |
hsa04015
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Rap1 signaling pathway |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... |
..., 5330 (PLCB2), 5331 (PLCB3), 5332 (PLCB4) 1398 (CRK), 1399 (CRKL) 999 (CDH1) 2889 (RAPGEF1) 1499 (C... |
...ion of actin cytoskeleton (GAPs) (GEFs) GPCR PLC Crk E-cad C3G cAMP DAG β-cat MAGI PDZ-GEF Vav2 Tiam... |
hsa04148
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Efferocytosis |
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...(ITGB5) 4240 (MFGE8) 558 (AXL) 5747 (PTK2) 1398 (CRK), 1399 (CRKL) 9564 (BCAR1) 948 (CD36) 2621 (GAS... |
...rization ITGA STAB ITGB MFGE8 Efferocyte AXL FAK CRK Apoptotic cell p130CAS CD36 GAS6 CD47 LRP1 CALR... |
hsa04510
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Focal adhesion |
Cell-matrix adhesions play essential roles in important biological processes including cell motility... |
...4), 53358 (SHC3), 6464 (SHC1) 9564 (BCAR1) 1398 (CRK), 1399 (CRKL) 2889 (RAPGEF1) 5906 (RAP1A), 5908... |
...MEK1 B-Raf Raf-1 Ha-Ras Sos Grb2 RTK Shc p130Cas Crk GRF2 Rap1 DOCK1 JNK c-Jun PAK Rac Vav β-Catenin... |
hsa04666
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Fc gamma R-mediated phagocytosis |
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction o... |
...RPC5L) 998 (CDC42) 7454 (WAS) 1793 (DOCK1) 1398 (CRK), 1399 (CRKL) 5337 (PLD1), 5338 (PLD2) 5058 (PA... |
...70S6K Vav Rac WAVE Arp2/3 Cdc42 WASP PIP DOCK180 CrkII PLD PAK1 VASP LIMK Cofilin PAG3 Pseudopod ext... |
hsa04722
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Neurotrophin signaling pathway |
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cel... |
... (RPS6KA1), 6196 (RPS6KA2), 6197 (RPS6KA3) 1398 (CRK), 1399 (CRKL) 2889 (RAPGEF1) 5906 (RAP1A), 5908... |
... Synapse formation Axonal guidance Erk1/2 p90RSK Crk C3G Rap1 SH-PTP2 B-Raf Gab1 Bad GSK3β FKHRL1 Iκ... |
hsa04810
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Regulation of actin cytoskeleton |
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...1) 2245 (FGD1), 89846 (FGD3) 55970 (GNG12) 1398 (CRK), 1399 (CRKL) 9564 (BCAR1) 5747 (PTK2) 1128 (CH... |
...iam1 ERK MEK Raf PI3K Rac1GEF Dock180 FGD1/3 Gβγ CrkII Cas FAK GPCR c-Src ITG FN1 Ras Gα12,13 Sos RT... |
hsa04910
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Insulin signaling pathway |
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrat... |
...K1), 3099 (HK2), 3101 (HK3), 80201 (HKDC1) 1398 (CRK), 1399 (CRKL) 5584 (PRKCI), 5590 (PRKCZ) 10603 ... |
...C-1α CAP Rheb Akt P13K TC10 GSK-3β SREBP-1c GRF2 CrkII aPKC APS GLUT4 PDK1/2 Cbl IRS PIP Flotillin I... |
hsa04935
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Growth hormone synthesis, secretion and action |
Growth hormone (GH) is a peptide hormone secreted from the anterior pituitary and plays a critical r... |
...(FOS) 3726 (JUNB) 5747 (PTK2) 9564 (BCAR1) 1398 (CRK), 1399 (CRKL) 4214 (MAP3K1) 1432 (MAPK14), 5600... |
...TOR GSK3 Igf1 Socs1-3 c-Fos JunB DNA FAK p130Cas CrkII MEKK p38 STAT Cytoskeleton re-organization GH... |
hsa05131
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Shigellosis |
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... |
...), 54874 (FNBP1L) 5879 (RAC1) 1793 (DOCK1) 1398 (CRK), 1399 (CRKL) 2017 (CTTN), 3059 (HCLS1) 6714 (S... |
... in proinflammatory gene transcript Rac1 Dock180 Crk Cortactin Src ELMO Cdc42 WAVE Arp2/3 ROCK mDia1... |
hsa05135
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Yersinia infection |
Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a typ... |
...C), 81873 (ARPC5L) 2335 (FN1) 9564 (BCAR1) 1398 (CRK), 1399 (CRKL) 1793 (DOCK1) 23396 (PIP5K1C), 839... |
ITGB1 Src N-WASP Arp2/3 Fibronectin p130Cas Crk DOCK180 PIP(5)KIα Actin PI(4,5)P PIP -binding protei... |
hsa05163
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Human cytomegalovirus infection |
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-her... |
...R5) 6387 (CXCL12) 7852 (CXCR4) 5747 (PTK2) 1398 (CRK), 1399 (CRKL) 9564 (BCAR1) 5829 (PXN) 5578 (PRK... |
...kocyte chemotaxis CXCL12 CXCR4 US27 cmvIL-10 FAK Crk p130CAS Paxillin PKC PYK2 DAG PLCβ Migration IL... |
hsa05170
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Human immunodeficiency virus 1 infection |
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency... |
...GNAO1) 7124 (TNF) 7852 (CXCR4) 5747 (PTK2) 1398 (CRK), 1399 (CRKL) 5829 (PXN) 5578 (PRKCA), 5579 (PR... |
... of actin cytoskeleton Proteasome TNFα CXCR4 FAK Crk Paxillin PKC PYK2 DAG Chemotaxis Uninfected CD4... |
hsa05206
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MicroRNAs in cancer |
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... |
...I) 3845 (KRAS) 1021 (CDK6) 406913 (MIR126) 1398 (CRK), 1399 (CRKL) 406948 (MIR15A), 406949 (MIR15B),... |
...dc25 BCL2L2 VEGF-A Cdk6 Let-7 K-Ras Cdk6 miR-126 CRK miR-15/16 miR-107 miR-17-92 miR-29 DNMT3 miR-1 ... |
hsa05211
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Renal cell carcinoma |
Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be risin... |
... (FLCN) 2271 (FH) 7422 (VEGFA) 5879 (RAC1) 1398 (CRK), 1399 (CRKL) 2889 (RAPGEF1) 6654 (SOS1), 6655 ... |
...onginB ElonginC TGF-β TGF-α PDGF-β BHD VEGF Rac1 Crk C3G SOS Grb2 HPH VHL HIF-β p300/CBP HIF-α MET G... |