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Entry Thumbnail Image Name Description Object Legend
hsa04215 Apoptosis - multiple species Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally ... ...BIRC7) 840 (CASP7) 317 (APAF1) 666 (BOK) 54205 (CYCS) 842 (CASP9) 840 (CASP7) 836 (CASP3) 329 (BIRC2... APOPTOSIS - MULTIPLE SPECIES Mitochondrion DIAP1 DRONC DRICE GRIM RPR HID dArk Dcp-1 DEBCL RHG fa...
hsa05169 Epstein-Barr virus infection Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly... ...5 (FAS) 596 (BCL2) 578 (BAK1), 581 (BAX) 54205 (CYCS) 317 (APAF1) 842 (CASP9) 637 (BID) 915 (CD3D), ... ...asp3 Casp8 Bim Fas BGLF4 Apoptosis Bcl2 Bax/Bak CYCS APAF1 Casp9 EBNA3C Bid BHRF1 Δψm TCR BILF1 TA...
hsa01524 Platinum drug resistance Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid ... ...C3), 331 (XIAP), 332 (BIRC5) 317 (APAF1) 54205 (CYCS) 637 (BID) 841 (CASP8) 8772 (FADD) 355 (FAS) 35... Mitochondrion p53 signaling pathway ATM p53 Bcl-2 CASP9 CASP3 Bad IAP/XIAP Apaf-1 CytC Bid CASP8 FAD...
hsa04115 p53 signaling pathway p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... ...F10A) 841 (CASP8) 983 (CDK1) 317 (APAF1) 54205 (CYCS) 842 (CASP9) 4193 (MDM2) 7157 (TP53) 4193 (MDM2... Siah-1 IGF-BP3 Gadd45 MDM-X CHK1 ATR CHK2 ATM Reprimo 14-3-3-σ CDK2 Cyclin E Cell cycle Apoptosis T...
hsa04210 Apoptosis Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... ...5) 839 (CASP6) 4792 (NFKBIA) 317 (APAF1) 54205 (CYCS) 637 (BID) 841 (CASP8) 843 (CASP10) 823 (CAPN1)... Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X...
hsa04932 Non-alcoholic fatty liver disease Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... ...), 79602 (ADIPOR2) 841 (CASP8) 637 (BID) 54205 (CYCS) 836 (CASP3) 840 (CASP7) 581 (BAX) 355 (FAS) 94... NON-ALCOHOLIC FATTY LIVER DISEASE Simple steatosis (without inflammation and fibrosis) (Cirrhos...
hsa05010 Alzheimer disease Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... ...2 (CASP9) 100506742 (CASP12) 836 (CASP3) 54205 (CYCS) 317 (APAF1) 100532726 (NDUFC2-KCTD14), 126328 ... PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 s...
hsa05012 Parkinson disease Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... ...) 65018 (PINK1) 6622 (SNCA) 7345 (UCHL1) 54205 (CYCS) 100532726 (NDUFC2-KCTD14), 126328 (NDUFA11), 3... LRRK2 Ubiquitin mediated proteolysis Proteasome Apoptosis UBA1 UbcH7/8 Parkin CDCrel1 synphilin1 Pae...
hsa05014 Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... ...52 (TOMM40), 84134 (TOMM40L) 6647 (SOD1) 54205 (CYCS) 7124 (TNF) 834 (CASP1) 836 (CASP3) 581 (BAX) 5... SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell...
hsa05016 Huntington disease Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects m... ... (VDAC2), 7419 (VDAC3), 83447 (SLC25A31) 54205 (CYCS) 6874 (TAF4), 6875 (TAF4B) 7019 (TFAM) 4899 (NR... HUNTINGTON DISEASE Cx I Cx II Cx III Cx IV Cx V Htt Htt Htt Htt Htt REST REST coREST Sin3A HDACs DN...
hsa05017 Spinocerebellar ataxia The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... ...5719 (PSMD13), 7979 (SEM1), 9861 (PSMD6) 54205 (CYCS) 90550 (MCU) 10105 (PPIF), 291 (SLC25A4), 292 (... Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk...
hsa05020 Prion disease Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal n... ...C9) 3309 (HSPA5) 842 (CASP9) 836 (CASP3) 54205 (CYCS) 317 (APAF1) 100532726 (NDUFC2-KCTD14), 126328 ... PrP PRION DISEASE DNA Endoplasmic reticulum (ER) Neuron Endocytosis Proteasome Golgi Early endosome...
hsa05022 Pathways of neurodegeneration - multiple diseases Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... ...7) 841 (CASP8) 3064 (HTT) 120892 (LRRK2) 54205 (CYCS) 27429 (HTRA2) 10105 (PPIF), 291 (SLC25A4), 292... PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP...
hsa05130 Pathogenic Escherichia coli infection Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... ... 7009 (TMBIM6) 837 (CASP4) 10061 (ABCF2) 54205 (CYCS) 7124 (TNF) 3569 (IL6) 3576 (CXCL8) 55845 (BRK1... Golgi Regulation of actin cytoskeleton Flagellar assembly Tight junction Toll-like receptor signalin...
hsa05131 Shigellosis Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... ..., 3101 (HK3), 80201 (HKDC1) 7416 (VDAC1) 54205 (CYCS) 596 (BCL2) 664 (BNIP3) 5481 (PPID) 581 (BAX) 6... SHIGELLOSIS Shigella dysenteria Shigella flexneri Shigella boydii Shigella sonnei TNF-R1 TNFα IκB...
hsa05132 Salmonella infection Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid ... ...3) 197259 (MLKL) 7189 (TRAF6) 596 (BCL2) 54205 (CYCS) 25828 (TXN2), 7295 (TXN) 2597 (GAPDH) 5420 (PO... SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 ...
hsa05134 Legionellosis Legionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophi... ... 51128 (SAR1B), 56681 (SAR1A) 7415 (VCP) 54205 (CYCS) 842 (CASP9) 836 (CASP3) 841 (CASP8) 317 (APAF1... LEGIONELLOSIS FlaA IPAF ASC CASP1 IL-1β IL-18 Naip5 CASP7 Host cell death NF-κB DNA Anti-apoptotic...
hsa05145 Toxoplasmosis Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite ... ...3127 (HLA-DRB5) 240 (ALOX5) 8651 (SOCS1) 54205 (CYCS) 6774 (STAT3) 842 (CASP9) 836 (CASP3) 841 (CASP... MyD88 IRAK TRAF6 TAK TAB1/2 IKK IκB NFκB ERK JNK p38 MKK3/6 GRA3/5 Toxoplasma gondii tachyzoite Pa...
hsa05152 Tuberculosis Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the... ...AKT2) 843 (CASP10) 841 (CASP8) 637 (BID) 54205 (CYCS) 317 (APAF1) 572 (BAD) 842 (CASP9) 596 (BCL2) 5... SapM TUBERCULOSIS DC-SIGN Raf1 IL-10 Pro-inflammatory cytokines Phagosome maturation arrest Rab5 VPS...
hsa05160 Hepatitis C Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies... ... (CASP8) 836 (CASP3) 637 (BID) 581 (BAX) 54205 (CYCS) 842 (CASP9) 578 (BAK1) 317 (APAF1) 8837 (CFLAR... HEPATITIS C Hepatitis C virus Hepatocyte RIG-I IPS-1 TRAF3 TBK1 IKKε IRF3/7 NFκB TLR3 TRIF IκB I...

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