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Name |
Description |
Object |
Legend |
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hsa04137
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Mitophagy - animal |
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to gro... |
...45778 (MTX3), 4580 (MTX1) 9451 (EIF2AK3) 1965 (EIF2S1) 468 (ATF4) 5599 (MAPK8), 5601 (MAPK9), 5602 (... |
MITOPHAGY - ANIMAL PINK1 Parkin OPTN TBK1 P62 NDP52 NBR1 TAX1BP1 ARIH1 SIAH1 HUWE1 GP78 MUL1 SMURF... |
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hsa04140
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Autophagy - animal |
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, orga... |
...612 (DAPK1), 1613 (DAPK3), 23604 (DAPK2) 1965 (EIF2S1) 9140 (ATG12) 9474 (ATG5) 83452 (RAB33B) 9140 ... |
PI3P AUTOPHAGY - ANIMAL Nutrient starvation (Amino acids, glucose) mTORC1 complex ER stress ROS Lo... |
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hsa04141
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Protein processing in endoplasmic reticulum |
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of... |
...7186 (TRAF2) 4217 (MAP3K5) 5609 (MAP2K7) 1965 (EIF2S1) 821 (CANX) 811 (CALR) 23645 (PPP1R15A) 2923 (... |
PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM Protein export Apoptosis Proteasome ATF4 CHOP JNK TR... |
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hsa04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
... 8722 (CTSF) 1649 (DDIT3) 9451 (EIF2AK3) 1965 (EIF2S1) 468 (ATF4) 3708 (ITPR1), 3709 (ITPR2), 3710 (... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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hsa04932
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Non-alcoholic fatty liver disease |
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... |
...ASP7) 581 (BAX) 355 (FAS) 9451 (EIF2AK3) 1965 (EIF2S1) 10018 (BCL2L11) 468 (ATF4) 1649 (DDIT3) 1571 ... |
NON-ALCOHOLIC FATTY LIVER DISEASE Simple steatosis (without inflammation and fibrosis) (Cirrhos... |
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hsa05010
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Alzheimer disease |
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... |
...289 (PIK3C3) 22863 (ATG14) 5609 (MAP2K7) 1965 (EIF2S1) 468 (ATF4) 5530 (PPP3CA), 5532 (PPP3CB), 5533... |
PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 sAPP... |
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hsa05012
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Parkinson disease |
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... |
... 9451 (EIF2AK3) 2081 (ERN1) 22926 (ATF6) 1965 (EIF2S1) 468 (ATF4) 7494 (XBP1) 1649 (DDIT3) 1649 (DDI... |
LRRK2 Ubiquitin mediated proteolysis Proteasome Apoptosis UBA1 UbcH7/8 Parkin CDCrel1 synphilin1 Pae... |
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hsa05014
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Amyotrophic lateral sclerosis |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... |
... 9451 (EIF2AK3) 2081 (ERN1) 22926 (ATF6) 1965 (EIF2S1) 468 (ATF4) 7494 (XBP1) 1649 (DDIT3) 1649 (DDI... |
SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell... |
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hsa05020
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Prion disease |
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal n... |
..., 2906 (GRIN2D) 9451 (EIF2AK3) 572 (BAD) 1965 (EIF2S1) 468 (ATF4) 90550 (MCU) 10105 (PPIF), 291 (SLC... |
PrP PRION DISEASE DNA Endoplasmic reticulum (ER) Neuron Endocytosis Proteasome Golgi Early endosome... |
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hsa05022
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Pathways of neurodegeneration - multiple diseases |
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... |
... 9451 (EIF2AK3) 2081 (ERN1) 22926 (ATF6) 1965 (EIF2S1) 468 (ATF4) 7494 (XBP1) 1649 (DDIT3) 1649 (DDI... |
PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP... |
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hsa05160
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Hepatitis C |
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies... |
...4940 (OAS3) 6041 (RNASEL) 5610 (EIF2AK2) 1965 (EIF2S1) 5594 (MAPK1), 5595 (MAPK3) 3434 (IFIT1), 4399... |
HEPATITIS C Hepatitis C virus Hepatocyte RIG-I IPS-1 TRAF3 TBK1 IKKε IRF3/7 NFκB TLR3 TRIF IκB IKK ... |
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hsa05162
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Measles |
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the uniq... |
... 10399 (RACK1) 868 (CBLB) 5610 (EIF2AK2) 1965 (EIF2S1) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 355 (... |
MEASLES MV proteins TLR7/9 MyD88 IRAK IRF7 IFNα DNA TLR2/4 RIG-I MyD88 IRAK IκB NFκB LPS MDA5 IPS1 I... |
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hsa05164
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Influenza A |
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus... |
...10 (EIF2AK2) 5611 (DNAJC3) 3337 (DNAJB1) 1965 (EIF2S1) 4938 (OAS1), 4939 (OAS2), 4940 (OAS3) 6041 (R... |
INFLUENZA A Alveolar and bronchial epithelial cells Alveolar macrophages Type II pneumocytes Endoso... |
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hsa05168
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Herpes simplex virus 1 infection |
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal ... |
...) 1616 (DAXX) 7157 (TP53) 5610 (EIF2AK2) 1965 (EIF2S1) 5499 (PPP1CA), 5500 (PPP1CB), 5501 (PPP1CC) 4... |
HERPES SIMPLEX VIRUS 1 INFECTION Herpes simplex virus-1 LTα LIGHT HVEM Nectin PILRα Heparan sulf... |
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hsa05417
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Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
... 9451 (EIF2AK3) 2081 (ERN1) 22926 (ATF6) 1965 (EIF2S1) 468 (ATF4) 1649 (DDIT3) 3309 (HSPA5) 7186 (TR... |
PIP AKT PDK1 PI3K p53 signaling pathway LIPID AND ATHEROSCLEROSIS GSK3β p53 Apoptosis Apoptosis Fa... |