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Entry Thumbnail Image Name Description Object Legend
hsa01524 Platinum drug resistance Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid ... ...T2B), 9446 (GSTO1) 4292 (MLH1) 7507 (XPA) 2067 (ERCC1) 7153 (TOP2A), 7155 (TOP2B) 672 (BRCA1) 4436 (... ... DNA-Adducts Cisplatin-Thiol Conjugate MLH1 XPA ERCC1 Topo-II BRCA1 Replicative bypass Nucleotide ex...
hsa03420 Nucleotide excision repair Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by c... ...), 6118 (RPA2), 6119 (RPA3) 2968 (GTF2H4) 2067 (ERCC1) 7507 (XPA) 2967 (GTF2H3) 2966 (GTF2H2), 72834... ...g1 RFC PCNA UVRD PolĪµ XPF XPG PolĪ“ RPA TFIIH4 ERCC1 XPA TFIIH3 TFIIH2 TTDA UVRB DDB2 DDB1 Cul4 RBX...
hsa03460 Fanconi anemia pathway The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstra... ...146956 (EME1), 197342 (EME2) 2072 (ERCC4) 2067 (ERCC1) 548593 (SLX1A), 79008 (SLX1B) 84464 (SLX4) 58... ...ir DSB formation ICL unhooking Mus81 EME1/2 XPF ERCC1 Translesion synthesis (TLS) SLX1...

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