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Name |
Description |
Object |
Legend |
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hsa05216
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Thyroid cancer |
... undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found... |
3265 (HRAS), 3845 (KRAS), 4893 (NRAS) 5468 (PPARG) 673 (BRAF) 673 (BRAF) 5594 (MAPK1), 5595 (MAPK3) ... |
Ras PPARγ BRAF BRAF ERK MEK PPFP RXR β-catenin c-Myc ECAD THYROID CANCER ERK CyclinD1 MEK BRAF Ra... |
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hsa04650
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Natural killer cell mediated cytotoxicity |
...ey are equipped with various receptors whose engagement allows them to discriminate between target a... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00165 (Diacylglycerol) C00076 (Calcium cation) C0... |
IgG NFAT CaN PI(3,4,5)P Fyn TRAIL IFNγR PLCγ LAT Perforin HLA-E IFN-γ GM-CSF TNF-α PKC 3BP2 PLCÎ... |
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hsa04660
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T cell receptor signaling pathway |
...ell as costimulatory molecules such as CD28. Engagement of these receptors through the interaction w... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00165 (Diacylglycerol) C00076 (Calcium cation) C0... |
PIP DAG CDK4 TNFα GM-CSF IFN-γ IL-10 IL-5 IL-4 IL-2 IκB NFκB IKKβ IKKγ IKKα NIK COT AKT MALT1... |
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hsa04666
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Fc gamma R-mediated phagocytosis |
...which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00165... |
Macrophage Monocyte Neutrophil FcγRIIIA FcγRIIB FcγRIIA FcγRI Src Syk CD45 IgG PI3K SHIP LAT PIP... |
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hsa04722
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Neurotrophin signaling pathway |
... Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neur... |
C00165 (Diacylglycerol) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00076 (Calcium cation) C00195 (... |
Plasticity Cell survival TrkA TrkB TrkC Apoptosis BDNF NT4 NT3 Cellular differentiation PI3K PLCγ ... |
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hsa05132
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Salmonella infection |
...a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membr... |
C00338 (Lipopolysaccharide) C00338 (Lipopolysaccharide) C05981 (Phosphatidylinositol-3,4,5-trisphosp... |
SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 ... |
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hsa05220
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Chronic myeloid leukemia |
...h chromosome is the result of a molecular rearrangement between the c-ABL proto-oncogene on chromoso... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) 2122 (MECOM), 861 (RUNX1) 598 (BCL2L1) 5781 (PTPN1... |
p53 signaling pathway AML-EVI1 Bcl-xl Shp2 BCR-ABL p53 TGF-β signaling pathway Hematopoietic cell l... |
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hsa03013
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RNA transport |
RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RN... |
...), 4686 (NCBP1) 51808 (PHAX) 1207 (CLNS1A) 8487 (GEMIN2) 6606 (SMN1), 6607 (SMN2) 11218 (DDX20) 2592... |
...va mortor neuron (SMN) complex Gemin2 SMN Gemin3 Gemin5 Gemin4 Gemin7 Gemin8 Urn T... |
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hsa05146
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Amoebiasis |
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the inte... |
C00076 (Calcium cation) C00027 (Hydrogen peroxide) C00219 (Arachidonate) C00584 (Prostaglandin E2) C... |
...d ulcer formation Regulation of actin rearrangement Actin rearrangement Vinculin Actinin COL FAK... |
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hsa04024
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cAMP signaling pathway |
cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... |
C00076 (Calcium cation) C00076 (Calcium cation) C00238 (Potassium cation) C01330 (Sodium cation) C00... |
... (vascular endothelial cell) Cytoskeletal rearrangement (vascular endothelial cell) Hedgehog signali... |
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hsa04380
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Osteoclast differentiation |
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage... |
C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00076 (Calcium cation) C00027 (Hydrogen peroxide) 1436 ... |
... proliferation Cell survival Cytoskeletal rearrangement IL1 IL1R IFNγ IFNGR STAT1 AP1 FcRγ DAP12 B... |
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hsa04640
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Hematopoietic cell lineage |
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either sel... |
102723407 (IGH) 3655 (ITGA6), 3672 (ITGA1), 3673 (ITGA2), 3675 (ITGA3), 3676 (ITGA4), 3678 (ITGA5) 2... |
...le-positive CD3 CD5 Hematopoietic CD34 CD135 CFU-GEMM CD34 CD114 CD123 EPOR stem cell cell (DP) 0464... |
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hsa04973
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Carbohydrate digestion and absorption |
Dietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we... |
C00092 (D-Glucose 6-phosphate) C00092 (D-Glucose 6-phosphate) C00031 (D-Glucose) C00031 (D-Glucose) ... |
... by colonic epithelial cells Cytoskeletal rearrangement Pectins gums (Proximal colon) (Small intesti... |
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hsa05133
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Pertussis |
Pertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bact... |
C00076 (Calcium cation) C00002 (ATP) C00575 (3',5'-Cyclic AMP) C00338 (Lipopolysaccharide) C19596 (L... |
...d-phase uptake Massive actin cytoskeletal rearrangements CR3-mediated vesicular transport CASP3 CASP... |
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hsa05204
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Chemical carcinogenesis |
It has been estimated that exposure to environmental chemical carcinogens may contribute significant... |
C14869 (Trichloroethanol glucuronide) C06899 (Chloral hydrate) C07490 (Trichloroethanol) C11150 (Tri... |
...lutathione Ethylene Glutathione episulfonium ion gem-Chlorohydrin 2-Chloro-acetaldehyde Cellular mol... |
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hsa05205
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Proteoglycans in cancer |
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that... |
G10505 (Hyaluronic acid) C00925 (Heparan sulfate) C00925 (Heparan sulfate) G13064 (Binding domain fo... |
...n TGF-beta signaling pathway Cytoskeleton rearrangement Cell adhension Cell growth and survival ... |
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hsa05418
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Fluid shear stress and atherosclerosis |
Shear stress represents the frictional force that the flow of blood exerts at the endothelial surfac... |
C16845 (Peroxynitrite) C00533 (Nitric oxide) C00076 (Calcium cation) C00704 (Superoxide) C00533 (Nit... |
...ctin TNF-α IL-1 IFN-γ PDGFs ET-1 VEGF Matrix degemeration Inflammation Angiogenesis Integrin c-Src... |