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Entry Thumbnail Image Name Description Object Legend
hsa05216 Thyroid cancer ... undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found... 3265 (HRAS), 3845 (KRAS), 4893 (NRAS) 5468 (PPARG) 673 (BRAF) 673 (BRAF) 5594 (MAPK1), 5595 (MAPK3) ... Ras PPARγ BRAF BRAF ERK MEK PPFP RXR β-catenin c-Myc ECAD THYROID CANCER ERK CyclinD1 MEK BRAF Ra...
hsa04650 Natural killer cell mediated cytotoxicity ...ey are equipped with various receptors whose engagement allows them to discriminate between target a... C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00165 (Diacylglycerol) C00076 (Calcium cation) C0... IgG NFAT CaN PI(3,4,5)P Fyn TRAIL IFNγR PLCγ LAT Perforin HLA-E IFN-γ GM-CSF TNF-α PKC 3BP2 PLC...
hsa04660 T cell receptor signaling pathway ...ell as costimulatory molecules such as CD28. Engagement of these receptors through the interaction w... C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00165 (Diacylglycerol) C00076 (Calcium cation) C0... PIP DAG CDK4 TNFα GM-CSF IFN-γ IL-10 IL-5 IL-4 IL-2 IκB NFκB IKKβ IKKγ IKKα NIK COT AKT MALT1...
hsa04666 Fc gamma R-mediated phagocytosis ...which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of... C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00165... Macrophage Monocyte Neutrophil FcγRIIIA FcγRIIB FcγRIIA FcγRI Src Syk CD45 IgG PI3K SHIP LAT PIP...
hsa04722 Neurotrophin signaling pathway ... Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neur... C00165 (Diacylglycerol) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00076 (Calcium cation) C00195 (... Plasticity Cell survival TrkA TrkB TrkC Apoptosis BDNF NT4 NT3 Cellular differentiation PI3K PLCγ ...
hsa05132 Salmonella infection ...a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membr... C00338 (Lipopolysaccharide) C00338 (Lipopolysaccharide) C05981 (Phosphatidylinositol-3,4,5-trisphosp... SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 ...
hsa05220 Chronic myeloid leukemia ...h chromosome is the result of a molecular rearrangement between the c-ABL proto-oncogene on chromoso... C05981 (Phosphatidylinositol-3,4,5-trisphosphate) 2122 (MECOM), 861 (RUNX1) 598 (BCL2L1) 5781 (PTPN1... p53 signaling pathway AML-EVI1 Bcl-xl Shp2 BCR-ABL p53 TGF-β signaling pathway Hematopoietic cell l...
hsa03013 RNA transport RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RN... ...), 4686 (NCBP1) 51808 (PHAX) 1207 (CLNS1A) 8487 (GEMIN2) 6606 (SMN1), 6607 (SMN2) 11218 (DDX20) 2592... ...va mortor neuron (SMN) complex Gemin2 SMN Gemin3 Gemin5 Gemin4 Gemin7 Gemin8 Urn T...
hsa05146 Amoebiasis Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the inte... C00076 (Calcium cation) C00027 (Hydrogen peroxide) C00219 (Arachidonate) C00584 (Prostaglandin E2) C... ...d ulcer formation Regulation of actin rearrangement Actin rearrangement Vinculin Actinin COL FAK...
hsa04024 cAMP signaling pathway cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... C00076 (Calcium cation) C00076 (Calcium cation) C00238 (Potassium cation) C01330 (Sodium cation) C00... ... (vascular endothelial cell) Cytoskeletal rearrangement (vascular endothelial cell) Hedgehog signali...
hsa04380 Osteoclast differentiation The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage... C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00076 (Calcium cation) C00027 (Hydrogen peroxide) 1436 ... ... proliferation Cell survival Cytoskeletal rearrangement IL1 IL1R IFNγ IFNGR STAT1 AP1 FcRγ DAP12 B...
hsa04640 Hematopoietic cell lineage Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either sel... 102723407 (IGH) 3655 (ITGA6), 3672 (ITGA1), 3673 (ITGA2), 3675 (ITGA3), 3676 (ITGA4), 3678 (ITGA5) 2... ...le-positive CD3 CD5 Hematopoietic CD34 CD135 CFU-GEMM CD34 CD114 CD123 EPOR stem cell cell (DP) 0464...
hsa04973 Carbohydrate digestion and absorption Dietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we... C00092 (D-Glucose 6-phosphate) C00092 (D-Glucose 6-phosphate) C00031 (D-Glucose) C00031 (D-Glucose) ... ... by colonic epithelial cells Cytoskeletal rearrangement Pectins gums (Proximal colon) (Small intesti...
hsa05133 Pertussis Pertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bact... C00076 (Calcium cation) C00002 (ATP) C00575 (3',5'-Cyclic AMP) C00338 (Lipopolysaccharide) C19596 (L... ...d-phase uptake Massive actin cytoskeletal rearrangements CR3-mediated vesicular transport CASP3 CASP...
hsa05204 Chemical carcinogenesis It has been estimated that exposure to environmental chemical carcinogens may contribute significant... C14869 (Trichloroethanol glucuronide) C06899 (Chloral hydrate) C07490 (Trichloroethanol) C11150 (Tri... ...lutathione Ethylene Glutathione episulfonium ion gem-Chlorohydrin 2-Chloro-acetaldehyde Cellular mol...
hsa05205 Proteoglycans in cancer Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that... G10505 (Hyaluronic acid) C00925 (Heparan sulfate) C00925 (Heparan sulfate) G13064 (Binding domain fo... ...n TGF-beta signaling pathway Cytoskeleton rearrangement Cell adhension Cell growth and survival ...
hsa05418 Fluid shear stress and atherosclerosis Shear stress represents the frictional force that the flow of blood exerts at the endothelial surfac... C16845 (Peroxynitrite) C00533 (Nitric oxide) C00076 (Calcium cation) C00704 (Superoxide) C00533 (Nit... ...ctin TNF-α IL-1 IFN-γ PDGFs ET-1 VEGF Matrix degemeration Inflammation Angiogenesis Integrin c-Src...

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