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Name |
Description |
Object |
Legend |
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hsa04625
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C-type lectin receptor signaling pathway |
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of ... |
...) 5781 (PTPN11) 8517 (IKBKG) 1147 (CHUK), 3551 (IKBKB) 4790 (NFKB1) 5970 (RELA) 3592 (IL12A), 3593 (... |
C-TYPE LECTIN RECEPTOR SIGNALING PATHWAY Dectin-1 Dectin-2 Mincle MCL FcRγ DC-SIGN LSP-1 KSR1 CN... |
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hsa04931
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Insulin resistance |
Insulin resistance is a condition where cells become resistant to the effects of insulin. It is ofte... |
...C27A2), 28965 (SLC27A6), 376497 (SLC27A1) 3551 (IKBKB) 2475 (MTOR) 6198 (RPS6KB1), 6199 (RPS6KB2) 36... |
JNK1 TNFα FFA ER stress TNFR1 FATPs FFA IKKβ mTOR S6K INSR IRS-1 PI3K AKT2 GSK-3 +py LCFA-CoA DAG PK... |
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hsa04936
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Alcoholic liver disease |
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol ov... |
... 6416 (MAP2K4) 4792 (NFKBIA) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 50507 (NOX4) 6885 (MAP3K7) 2573... |
MyD88 TRAF3 IFN-β IFN-α TAK1 IRAK1 IL-8 TIRAP IL-1β TBK1 TRAF6 IKKε IL-6 TAB1 TAB2 IκBα TNFα IRF3 MD... |
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hsa05163
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Human cytomegalovirus infection |
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-her... |
...3R3) 1956 (EGFR) 356 (FASLG) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 4790 (NFKB1), 5970 (RELA) 2885 ... |
PIP 4EBPs S6K1/2 mTOR Rheb TSC2 TSC1 AKT PI3K HUMAN CYTOMEGALOVIRUS INFECTION EGFR FasL IKK NF κB ... |
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hsa04621
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NOD-like receptor signaling pathway |
Specific families of pattern recognition receptors are responsible for detecting various pathogens a... |
...1) 64127 (NOD2) 8767 (RIPK2) 1147 (CHUK), 3551 (IKBKB) 6885 (MAP3K7) 10454 (TAB1), 23118 (TAB2), 257... |
ASC pro-CASP1 ASC pro-CASP1 ASC pro-CASP1 ASC pro-CASP1 NOD1 NOD2 iE-DAP RIP2 IKKα/β TAK1 TAB NLRP1 ... |
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hsa04668
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TNF signaling pathway |
Tumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal... |
... 5601 (MAPK9), 5602 (MAPK10) 8517 (IKBKG) 3551 (IKBKB) 4792 (NFKBIA) 4790 (NFKB1), 5970 (RELA) 4790 ... |
TNF SIGNALING PATHWAY TNF TNFR1 TRADD TRAF2/5 RIP1 cIAP1/2 TAK1 MKK4/7 MKK3/6 p38 JNK1/2 IKKγ IKK... |
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hsa05160
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Hepatitis C |
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies... |
...48022 (TICAM1) 4792 (NFKBIA) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 7189 (TRAF6) 8737 (RIPK1) 3439 ... |
HEPATITIS C Hepatitis C virus Hepatocyte RIG-I IPS-1 TRAF3 TBK1 IKKε IRF3/7 NFκB TLR3 TRIF IκB IKK ... |
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hsa05161
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Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
...(AKT1), 208 (AKT2) 572 (BAD) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 4792 (NFKBIA) 4790 (NFKB1) 4790... |
Mitochondria VDAC3 CytC CASP9 Apaf-1 CASP12 CASP3 Apoptosis Bax Survivin Ca release PKC Raf MEK E... |
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hsa05162
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Measles |
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the uniq... |
...5610 (EIF2AK2) 1965 (EIF2S1) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 355 (FAS) 356 (FASLG) 7189 (TRA... |
MEASLES MV proteins TLR7/9 MyD88 IRAK IRF7 IFNα DNA TLR2/4 RIG-I MyD88 IRAK IκB NFκB LPS MDA5 IPS1 I... |
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hsa05164
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Influenza A |
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus... |
... 7098 (TLR3) 148022 (TICAM1) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 4790 (NFKB1), 5970 (RELA) 4792 ... |
INFLUENZA A Alveolar and bronchial epithelial cells Alveolar macrophages Type II pneumocytes Endoso... |
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hsa05167
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Kaposi sarcoma-associated herpesvirus infection |
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most... |
...3451 (IFNA17), 3452 (IFNA21) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 5599 (MAPK8), 5601 (MAPK9), 560... |
IFN-α/β TRAF3 IRF7 IFN-β IFN-α IKK JNK TBK1 IKKε AKT STAT1 IκBα IRF3 TLR3 TRIF KAPOSI SARCOMA-ASSO... |
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hsa05168
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Herpes simplex virus 1 infection |
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal ... |
...FADD) 841 (CASP8) 7124 (TNF) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 329 (BIRC2), 330 (BIRC3) 329 (B... |
HERPES SIMPLEX VIRUS 1 INFECTION Herpes simplex virus-1 LTα LIGHT HVEM Nectin PILRα Heparan sulf... |
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hsa05169
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Epstein-Barr virus infection |
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly... |
... 3654 (IRAK1), 51135 (IRAK4) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 8772 (FADD) 836 (CASP3) 841 (CA... |
gp350 gH/gL gp42 CD21 MHC-II EBNA2 EPSTEIN-BARR VIRUS INFECTION B cell RBP-Jκ SKIP SMRT EBNA3C Vir... |
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hsa05170
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Human immunodeficiency virus 1 infection |
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency... |
...), 3135 (HLA-G) 8717 (TRADD) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 581 (BAX) 578 (BAK1) 54205 (CYC... |
PIP S6K1/2 mTOR AKT PI3K HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION NF κB NFκB signaling pathway R... |
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hsa05235
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PD-L1 expression and PD-1 checkpoint pathway in cancer |
Programmed cell death 1 (PD1) and its ligand (PDL1) are key regulatory physiological immune checkpoi... |
...E) 4790 (NFKB1), 5970 (RELA) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 10000 (AKT3), 207 (AKT1), 208 (... |
PIP IκB NFκB IKK AKT PI3K RasGRP1 Ras AP1 NFAT CaN PLC-γ1 ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ CD3ζ CD3γ C... |
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hsa05417
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Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
...M1) 6347 (CCL2) 4615 (MYD88) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 6885 (MAP3K7) 1432 (MAPK14), 56... |
PIP AKT PDK1 PI3K p53 signaling pathway LIPID AND ATHEROSCLEROSIS GSK3β p53 Apoptosis Apoptosis Fa... |
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hsa01523
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Antifolate resistance |
Since the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, p... |
...429 (ABCG2) 113235 (SLC46A1) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 4790 (NFKB1), 5970 (RELA) 3569 ... |
ANTIFOLATE RESISTANCE RFC ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 GARTF Antifolate Methotrexate (MTX) Pemetre... |
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hsa04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...2), 5970 (RELA), 5971 (RELB) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 9020 (MAP3K14) 5594 (MAPK1), 55... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |
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hsa04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
...RIN1) 572 (BAD) 598 (BCL2L1) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 4790 (NFKB1), 5970 (RELA) 4303 ... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
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hsa04062
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Chemokine signaling pathway |
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon... |
...Z) 4790 (NFKB1), 5970 (RELA) 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG) 4792 (NFKBIA), 4793 (NFKBIB) 57... |
Migration Apoptosis Degranulation Cellular shape changes Cell survival chemokineR chemokine JAK2/3 ... |