Pathway Text Search

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Entry Thumbnail Image Name Description Object Legend
hsa04930 Type II diabetes mellitus ...induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, in... ...296 (PIK3R2), 8503 (PIK3R3) 6517 (SLC2A4) 3667 (IRS1) 3643 (INSR) 3630 (INS) 122809 (SOCS4), 8651 (S... PYK P13K GLUT4 IRS1 INSR INS ATP Pyruvate Glucose SOCS ERK FFA Glucose ADIPO IKK PKCε/δ PDX-1 IRS ...
hsa04920 Adipocytokine signaling pathway ... Several data have shown that TNFalpha inhibits IRS1 tyrosine phosphorylation by promoting its serin... ...KT1), 208 (AKT2) 2475 (MTOR) 7186 (TRAF2) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 7132 (TNFRSF1A) 948 ... Ceramide Long-chain fatty acid Retinoic acid NF-κB IκB SHP-2 SOCS3 CPT-1 G6PC PEPCK FACS Diglyceri...
hsa04213 Longevity regulating pathway - multiple species Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss... ...), 8503 (PIK3R3) 3479 (IGF1) 3480 (IGF1R) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 3265 (HRAS), 3845 (K... ... PATHWAY - MULTIPLE SPECIES DNA IGF-I IGF-IR IRS1-4 Ras Mammals Flies Worms Yeast dFOXO S6K mTOR ...
hsa04931 Insulin resistance Insulin resistance is a condition where cells become resistant to the effects of insulin. It is ofte... ...198 (RPS6KB1), 6199 (RPS6KB2) 3643 (INSR) 3667 (IRS1) 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5... JNK1 TNFα FFA ER stress TNFR1 FATPs FFA IKKβ mTOR S6K INSR IRS-1 PI3K AKT2 GSK-3 +py LCFA-CoA DAG ...
hsa04150 mTOR signaling pathway The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protei... ...62 (L-Arginine) 3480 (IGF1R), 3643 (INSR) 3667 (IRS1) 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5... mTOR SIGNALING PATHWAY IRS1 PI3K Raf MAPK signaling pathway ERK1/2 Ras MEK PTEN PDK1 Akt TSC1/2 Rh...
hsa04151 PI3K-Akt signaling pathway The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellul... ... 5296 (PIK3R2), 8503 (PIK3R3) 5728 (PTEN) 3667 (IRS1) 1436 (CSF1R), 1956 (EGFR), 1969 (EPHA2), 2064 ... ...-AKT SIGNALING PATHWAY Protein synthesis PTEN IRS1 RTK GPCR GSK3 Myc p27Kip1 RBL2 FasL Bim FOXO BA...
hsa04211 Longevity regulating pathway Regulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that... ...), 8503 (PIK3R3) 3479 (IGF1) 3480 (IGF1R) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 3265 (HRAS), 3845 (K... ...LONGEVITY REGULATING PATHWAY DNA IGF-I IGF-IR IRS1-4 Ras cAMP PKA AMPK INS INSR Insulin signaling ...
hsa04722 Neurotrophin signaling pathway Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cel... ...3) 4214 (MAP3K1) 3725 (JUN) 4217 (MAP3K5) 3667 (IRS1) 9261 (MAPKAPK2) 1432 (MAPK14), 5600 (MAPK11), ... ... Axon patterning Cell survival Axonal outgrowth IRS1 MK-2 p38 MEK5 Erk5 MEKK3 RhoGDI rAPS SH2B homo/...
hsa04960 Aldosterone-regulated sodium reabsorption Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of th... ... 53828 (FXYD4) 3291 (HSD11B2) 3643 (INSR) 3667 (IRS1) 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5... ...lism Collecting duct principal cell Degradation IRS1 PI3K PDK Insulin PIP Tight junction IGF ROMK 14...
hsa04022 cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO... ...808 (CALM3), 810 (CALML3), 91860 (CALML4) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 3643 (INSR) 153 (ADR... cGMP-PKG SIGNALING PATHWAY MLCP MLC NPR-A cGMP PKG s-GC Sarcoplasmic reticulum (SR) Kca NPR-B Myosi...
hsa04068 FoxO signaling pathway The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellu... ...5296 (PIK3R2), 8503 (PIK3R3) 5170 (PDPK1) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 1956 (EGFR) 2885 (GR... IKKα/β JNK ERK1/2 AMPK INS Glucose FOXO SOS Ras MEK1/2 INSR Raf PEPCK G6PC Akt P13K PDK1/2 IRS PIP...
hsa04140 Autophagy - animal Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, orga... ...GTP) C00035 (GDP) 3480 (IGF1R) 3630 (INS) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 5290 (PIK3CA), 5291 ... PI3P AUTOPHAGY - ANIMAL Nutrient starvation (Amino acids, glucose) mTORC1 complex ER stress Fusion...
hsa04152 AMPK signaling pathway AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through ev... ...5296 (PIK3R2), 8503 (PIK3R3) 5170 (PDPK1) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 3479 (IGF1) 3480 (IG... AMPK INS Glucose INSR Akt P13K PDK1/2 IRS PIP AMPK SIGNALING PATHWAY Glycolysis / Gluconeogenesis ...
hsa04910 Insulin signaling pathway Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrat... ...LC2A4) 5170 (PDPK1) 867 (CBL), 868 (CBLB) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 10211 (FLOT1), 2319 ... TSC1 SKIP SHIP2 IKK JNK LAR PTP1B SOCS Elk1 MNK ERK1/2 FAS AMPK Glycogen cAMP INS Glucose HSL PP1 PY...
hsa04923 Regulation of lipolysis in adipocytes Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and gl... ...95 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 11145 (PLAAT3) 5742 ... REGULATION OF LIPOLYSIS IN ADIPOCYTES PKA cAMP β-AR Epinephrine HSL Lypolysis Norepinephrine NP...
hsa04932 Non-alcoholic fatty liver disease Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... ...D-Glucose) C00162 (Fatty acid) 3630 (INS) 3667 (IRS1), 8660 (IRS2) 10000 (AKT3), 207 (AKT1), 208 (AK... NON-ALCOHOLIC FATTY LIVER DISEASE Simple steatosis (without inflammation and fibrosis) (Cirrhos...
hsa04935 Growth hormone synthesis, secretion and action Growth hormone (GH) is a peptide hormone secreted from the anterior pituitary and plays a critical r... ...AS), 3845 (KRAS), 4893 (NRAS) 3717 (JAK2) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 5290 (PIK3CA), 5291 ... GROWTH HORMONE SYNTHESIS, SECRETION AND ACTION PLCγ IP3 Calcium signaling pathway Somatotroph ...
hsa05010 Alzheimer disease Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... ...95 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 3667 (IRS1), 8471 (IRS4), 8660 (IRS2) 5610 (EIF2AK2) 5599 ... PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 s...
hsa05206 MicroRNAs in cancer MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... ...200C) 10297 (APC2), 324 (APC) 1956 (EGFR) 3667 (IRS1) 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 38... MicroRNAs IN CANCER Lung cancer Lung epithelial cell Tumorigenesis Survival Invasion / metastasi...
hsa05415 Diabetic cardiomyopathy Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients ... ...C1D4) 3630 (INS) 2997 (GYS1), 2998 (GYS2) 3667 (IRS1) 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5... FFA FFA LCFA-CoA DAG PKCα/δ FAT/CD36 Cer PP2A DIABETIC CARDIOMYOPATHY PKCβ Glucose Glucose UDP-Gl...

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