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Name |
Description |
Object |
Legend |
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hsa04613
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Neutrophil extracellular trap formation |
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action... |
...LPLG) 6403 (SELP) 3146 (HMGB1) 177 (AGER) 3684 (ITGAM) 7097 (TLR2) 51284 (TLR7), 51311 (TLR8) 4353 (... |
Neutrophil FcγRIIA FcγRI Src Syk IgG PI3K PIP PLC DAG PKC Raf1 MEK ERK1/2 Akt NOD-like receptor sign... |
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hsa04514
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Cell adhesion molecules |
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical... |
...2) 83700 (JAM3) 83700 (JAM3) 3689 (ITGB2) 3684 (ITGAM) 3689 (ITGB2) 3683 (ITGAL) 50848 (F11R) 50848 ... |
...CD58 CD2 ICAM3 ICAM1 ICAM2 JAM2 JAM3 JAM3 ITGB2 ITGAM ITGB2 ITGAL JAM1 JAM1 PECAM1 CD40L JAM1 JAM1 I... |
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hsa04670
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Leukocyte transendothelial migration |
Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. ... |
...1) 3676 (ITGA4) 58494 (JAM2) 3689 (ITGB2) 3684 (ITGAM) 110117499 (P3R3URF-PIK3R3), 5290 (PIK3CA), 52... |
...M1 ITGAL CDH5 SHP-2 CD99 ITGB1 ITGA4 JAM2 ITGB2 ITGAM PI3K β-Catenin Actin Cell adhesion molecules R... |
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hsa04145
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Phagosome |
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mech... |
...), 2215 (FCGR3B), 9103 (FCGR2C) 715 (C1R) 3684 (ITGAM), 3689 (ITGB2) 3685 (ITGAV), 3690 (ITGB3) 3688... |
PHAGOSOME Fc gamma R-mediated phagocytosis Endocytosis Phagocytic cup pathogen Conventional p... |
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hsa04640
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Hematopoietic cell lineage |
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either sel... |
...1R1), 7850 (IL1R2) 3581 (IL9R) 929 (CD14) 3684 (ITGAM) 3684 (ITGAM) 290 (ANPEP) 290 (ANPEP) 3570 (IL... |
IgM CD49 CD42 CD41 CD14 CD9 CD61 IL-11R CD59 CD55 CD35 CD44 CD235a CD36 CD36 CD117 EPOR CD125 CD114 ... |
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hsa04015
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Rap1 signaling pathway |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... |
...ALB) 4301 (AFDN) 673 (BRAF) 3683 (ITGAL), 3684 (ITGAM), 3688 (ITGB1), 3689 (ITGB2) 135 (ADORA2A), 13... |
MAPK signaling pathway RAP1 SIGNALING PATHWAY ERK MEK Raf-1 Rap1 RIAM RTK RalGDS Rac RapL MEK3,6 p... |
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hsa04610
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Complement and coagulation cascades |
The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a ... |
...6 (CD59) 1191 (CLU) 7448 (VTN) 1380 (CR2) 3684 (ITGAM), 3689 (ITGB2) 3687 (ITGAX), 3689 (ITGB2) 1132... |
COMPLEMENT AND COAGULATION CASCADES Plasmin Coagulation cascade Extrinsic pathway Tissue damage F... |
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hsa04810
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Regulation of actin cytoskeleton |
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...3681 (ITGAD), 3682 (ITGAE), 3683 (ITGAL), 3684 (ITGAM), 3685 (ITGAV), 3687 (ITGAX), 3688 (ITGB1), 36... |
PIP PIP PIP Acetylcholine TMSB4 Arp2/3 PFN WAVE2 WAVE1 HSPC300 APC NWASP Asef Abi2 Nap125 PIR121 IRS... |
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hsa05133
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Pertussis |
Pertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bact... |
...38 (Potassium cation) C05005 (Glycolipid) 3684 (ITGAM) 3688 (ITGB1) 3689 (ITGB2) 163688 (CALML6), 51... |
PERTUSSIS FhaC FHA SphB1 CD11b Sulfated carbohydrates CD29 FimD Fim2/3 Fimbrial proteins Adhesion Pr... |
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hsa05134
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Legionellosis |
Legionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophi... |
...ASP9) 836 (CASP3) 841 (CASP8) 317 (APAF1) 3684 (ITGAM) 3689 (ITGB2) 1378 (CR1), 1379 (CR1L) 718 (C3)... |
LEGIONELLOSIS FlaA IPAF ASC CASP1 IL-1β IL-18 Naip5 CASP7 Host cell death NF-κB DNA Anti-apoptotic p... |
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hsa05140
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Leishmaniasis |
Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and ... |
...1 (NCF1) 718 (C3) 1378 (CR1), 1379 (CR1L) 3684 (ITGAM), 3689 (ITGB2) 3458 (IFNG) 3716 (JAK1), 3717 (... |
Macrophage FNR FcγR C3b PKC p47phox Complement cascade Leishmania promastigote LPG Calcium signa... |
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hsa05146
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Amoebiasis |
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the inte... |
...R3) 4790 (NFKB1), 5970 (RELA) 3458 (IFNG) 3684 (ITGAM), 3689 (ITGB2) 383 (ARG1), 384 (ARG2) 5052 (PR... |
Extracellular matrix Intestinal epithelial cell Entamoeba histolytica trophozoite IL1β MUC2 Laminin... |
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hsa05150
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Staphylococcus aureus infection |
Staphylococcus aureus can cause multiple forms of infections ranging from superficial skin infection... |
...) 6403 (SELP) 6404 (SELPLG) 3683 (ITGAL), 3684 (ITGAM) 5724 (PTAFR) 3586 (IL10) 2358 (FPR2), 2359 (F... |
C1S C1R C1Q MBL MASP1/2 STAPHYLOCOCCUS AUREUS INFECTION Alternative pathway Lectin pathway Classic... |
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hsa05152
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Tuberculosis |
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the... |
...5534 (PPP3R1), 5535 (PPP3R2) 3689 (ITGB2) 3684 (ITGAM) 1387 (CREBBP), 2033 (EP300) 6772 (STAT1) 3716... |
SapM TUBERCULOSIS DC-SIGN Raf1 IL-10 Pro-inflammatory cytokines Phagosome maturation arrest Rab5 VPS... |
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hsa05202
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Transcriptional misregulation in cancer |
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged ... |
...CEBPA) 8864 (PER2) 6688 (SPI1) 929 (CD14) 3684 (ITGAM) 2209 (FCGR1A) 5966 (REL) 597 (BCL2A1) 329 (BI... |
TRANSCRIPTIONAL MISREGULATION IN CANCER Ewing's sarcoma Clear-cell sarcoma Desmoplastic small ro... |
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hsa05221
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Acute myeloid leukemia |
Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clo... |
...EBPE) 597 (BCL2A1) 8864 (PER2) 929 (CD14) 3684 (ITGAM) 2209 (FCGR1A) 1848 (DUSP6) 1436 (CSF1R) 4353 ... |
PLZF-RARα K-Ras N-Ras FLT3 PU.1 C/EBPα AML1-ETO Jak-STAT signaling pathway mTOR signaling pathway He... |