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Entry Thumbnail Image Name Description Object Legend
hsa04380 Osteoclast differentiation ...on patterns through transcription factors like NFATc1 and characterizes the active osteoclast. ...0 (MAPK11), 5603 (MAPK13), 6300 (MAPK12) 4772 (NFATC1) 3456 (IFNB1) 3456 (IFNB1) 3454 (IFNAR1), 3455... ...IKKβ IκB NFκB TAK1 TAB1/2 MKK6 MEK1 JNK p38 NFATc1 IFNβ DNA IFNβ IFNAR Jak1/Tyk2 STAT1/2 IRF9 S...
hsa04625 C-type lectin receptor signaling pathway C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of ... ... 5336 (PLCG2) 5594 (MAPK1), 5595 (MAPK3) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) ... C-TYPE LECTIN RECEPTOR SIGNALING PATHWAY Dectin-1 Dectin-2 Mincle MCL FcRγ DC-SIGN LSP-1 KSR1 C...
hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer Programmed cell death 1 (PD1) and its ligand (PDL1) are key regulatory physiological immune checkpoi... ...RAS), 4893 (NRAS) 2353 (FOS), 3725 (JUN) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3) 5530 (PPP3CA), ... PIP IκB NFκB IKK AKT PI3K RasGRP1 Ras AP1 NFAT CaN PLC-γ1 ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ CD3...
hsa04933 AGE-RAGE signaling pathway in diabetic complications Advanced glycation end products (AGEs) are a complex group of compounds produced through the non-enz... ...1), 998 (CDC42) 6774 (STAT3) 5292 (PIM1) 4772 (NFATC1) 2277 (VEGFD), 7422 (VEGFA), 7423 (VEGFB), 742... ... JNK PI3K Cer NOS FOXO1 Cdc42/Rac1 STAT3 Pim-1 NFATc1 Vascular remodeling VEGF MCP-1 PAI-1 Thromboge...
hsa05321 Inflammatory bowel disease Inflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is ... ...4R) 6778 (STAT6) 2625 (GATA3) 3565 (IL4) 4772 (NFATC1) 4094 (MAF) 7124 (TNF) 3569 (IL6) 3552 (IL1A),... ... Th1 lymphocyte IL-4 IL-4Rα STAT6 GATA-3 IL-4 NFATc1 c-maf Th2 lymphocyte Macrophage TNF-α IL-6 IL...
hsa04010 MAPK signaling pathway The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... ...ND) 2353 (FOS), 3725 (JUN) 4775 (NFATC3) 4772 (NFATC1) 5530 (PPP3CA), 5532 (PPP3CB), 5533 (PPP3CC), ... LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB...
hsa04022 cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO... ...3 (PPP3CC), 5534 (PPP3R1), 5535 (PPP3R2) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) ... cGMP-PKG SIGNALING PATHWAY MLCP MLC NPR-A cGMP PKG s-GC Sarcoplasmic reticulum (SR) Kca NPR-B Myosi...
hsa04024 cAMP signaling pathway cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... ...) 4790 (NFKB1), 5970 (RELA) 5465 (PPARA) 4772 (NFATC1) 1387 (CREBBP), 2033 (EP300) 6662 (SOX9) 10257... cAMP SIGNALING PATHWAY Sarcoplasmic Reticulum (SR) VDCC RyR2 SERCA2a TnI Calcium signaling pathway...
hsa04218 Cellular senescence Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... ...3 (PPP3CC), 5534 (PPP3R1), 5535 (PPP3R2) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) ... CELLULAR SENESCENCE NORE1A PP1A C-Myc HIPK2 ARF MDM2 p53 P53 signaling pathway PI3K AKT TSC1/2 RHEB...
hsa04310 Wnt signaling pathway Wnt proteins are secreted morphogens that are required for basic developmental processes, such as ce... C00076 (Calcium cation) 4088 (SMAD3) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) 5578... p53 signaling pathway Adherens junction SMAD3 TGF-β signaling pathway Cell cycle WNT SIGNALING PA...
hsa04650 Natural killer cell mediated cytotoxicity Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early def... ...tol 1,4,5-trisphosphate) 102723407 (IGH) 4772 (NFATC1), 4773 (NFATC2) 5530 (PPP3CA), 5532 (PPP3CB), ... IgG NFAT CaN PI(3,4,5)P Fyn TRAIL IFNγR PLCγ LAT Perforin HLA-E IFN-γ GM-CSF TNF-α PKC 3BP2 PLC...
hsa04658 Th1 and Th2 cell differentiation Immunity to different classes of microorganisms is orchestrated by separate lineages of effector T h... ... 3551 (IKBKB), 8517 (IKBKG) 5588 (PRKCQ) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3) 5530 (PPP3CA), ... DAG IFN-γ IL-5 IκB NFκB IKK PKCθ NFAT CaN ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ CD3ζ CD3γ CD3ε ...
hsa04659 Th17 cell differentiation Interleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in ep... ... 3551 (IKBKB), 8517 (IKBKG) 5588 (PRKCQ) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3) 5530 (PPP3CA), ... DAG IκB NFκB IKK PKCθ NFAT CaN ZAP70 TCRβ TCRα Cell adhesion molecules Th17 CELL DIFFERENT...
hsa04660 T cell receptor signaling pathway Activation of T lymphocytes is a key event for an efficient response of the immune system. It requir... ...RAS), 4893 (NRAS) 2353 (FOS), 3725 (JUN) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3) 5530 (PPP3CA), ... PIP DAG CDK4 TNFα GM-CSF IFN-γ IL-10 IL-5 IL-4 IL-2 IκB NFκB IKKβ IKKγ IKKα NIK COT AKT MALT1...
hsa04662 B cell receptor signaling pathway B cells are an important component of adaptive immunity. They produce and secrete millions of differ... ...3845 (KRAS), 4893 (NRAS) 25780 (RASGRP3) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3) 5530 (PPP3CA), ... PIP DAG IκB NFκB IKKβ IKKγ IKKα GSK3β MALT1 BCL-10 CARMA1 AKT PKCβ VAV PI3K CD21 CD19 CD81 LE...
hsa04921 Oxytocin signaling pathway Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (... ...3 (PPP3CC), 5534 (PPP3R1), 5535 (PPP3R2) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) ... MAPK signalng pathway DAG cAMP MLCK IP3R CALM ADCY PKA OXYTOCIN SIGNALING PATHWAY ER/SR OTR OXT PL...
hsa05135 Yersinia infection Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a typ... ...70) 3937 (LCP2) 27040 (LAT) 5335 (PLCG1) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3) 3558 (IL2) 3586... ITGB1 Src N-WASP Arp2/3 Fibronectin p130Cas Crk DOCK180 PIP(5)KIα Actin PI(4,5)P PIP -binding prote...
hsa05161 Hepatitis B Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... ...A) 3725 (JUN) 4089 (SMAD4) 537 (ATP6AP1) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) ... Mitochondria VDAC3 CytC CASP9 Apaf-1 CASP12 CASP3 Apoptosis Bax Survivin Ca release PKC Raf MEK E...
hsa05163 Human cytomegalovirus infection Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-her... ...ID) 3569 (IL6) 3576 (CXCL8) 7422 (VEGFA) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) ... PIP 4EBPs S6K1/2 mTOR Rheb TSC2 TSC1 AKT PI3K HUMAN CYTOMEGALOVIRUS INFECTION EGFR FasL IKK NF κB...
hsa05166 Human T-cell leukemia virus 1 infection Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult... ... 3683 (ITGAL), 3689 (ITGB2) 3383 (ICAM1) 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) ... HUMAN T-CELL LEUKEMIA VIRUS 1 INFECTION Human T-lymphotropic virus-I gp21 gp46 NRP1 CD4+ T cell...

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