Pathway Text Search

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Entry Thumbnail Image Name Description Object Legend
hsa04070 Phosphatidylinositol signaling system ...PPIP5K1) 23262 (PPIP5K2), 9677 (PPIP5K1) 5289 (PIK3C3), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) ... ...151 1PP-IP 2.7.4.21 2.7.4.21 2.7.4.24 2.7.4.24 PIK3C3 PKC 3.1.3.36 Endocytosis C=O C=O 2.7.1.151 3.1...
hsa00562 Inositol phosphate metabolism ...PIP5K1C), 8394 (PIP5K1A), 8395 (PIP5K1B) 5289 (PIK3C3) 4534 (MTM1), 55613 (MTMR8), 64419 (MTMR14), 8... 1-Phosphatidyl-1D-myo-inositol-5P 2.7.1.149 1D-myo-Inositol- 1,4,5,6P 3.1.3.36 2.7.1.151 2.7.1.151 3...
hsa01100 Metabolic pathways ...7 (PIK3C2B), 5288 (PIK3C2G) 4534 (MTM1), 5289 (PIK3C3), 55613 (MTMR8), 64419 (MTMR14), 8776 (MTMR1),... Biosynthesis of enediyne antibiotics Flavonoid biosynthesis Toluene degradation Tyrosine metabolism ...
hsa04136 Autophagy - other Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and... ...925 (BECN2), 8678 (BECN1) 30849 (PIK3R4) 5289 (PIK3C3) 285973 (ATG9B), 79065 (ATG9A) 23130 (ATG2A), ... AUTOPHAGY - OTHER Nutrient starvation TORC1 complex Raptor TOR LST8 ATG1 complex ATG1 ATG13 ATG11 ...
hsa04140 Autophagy - animal Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, orga... ...678 (BECN1) 30849 (PIK3R4) 29982 (NRBF2) 5289 (PIK3C3) 22863 (ATG14) 7405 (UVRAG) 51100 (SH3GLB1) 97... PI3P AUTOPHAGY - ANIMAL Nutrient starvation (Amino acids, glucose) mTORC1 complex ER stress Fusion...
hsa04145 Phagosome Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mech... ...GA5), 3688 (ITGB1) 60 (ACTB), 71 (ACTG1) 5289 (PIK3C3) 8411 (EEA1) 5868 (RAB5A), 5869 (RAB5B), 5878 ... PHAGOSOME Fc gamma R-mediated phagocytosis Endocytosis Phagocytic cup pathogen Conventional p...
hsa04371 Apelin signaling pathway Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally d... ...RPS6KB1), 6199 (RPS6KB2) 30849 (PIK3R4), 5289 (PIK3C3) 440738 (MAP1LC3C), 643246 (MAP1LC3B2), 81631 ... APELIN SIGNALING PATHWAY APJ AMPK Sphk1 PAI-1 Gα βγ PI3K Akt MEK1/2 ERK1/2 P70S6K PLCβ IP3 IP3...
hsa05010 Alzheimer disease Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... ...925 (BECN2), 8678 (BECN1) 30849 (PIK3R4) 5289 (PIK3C3) 22863 (ATG14) 5609 (MAP2K7) 1965 (EIF2S1) 468... PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 s...
hsa05014 Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... ...678 (BECN1) 30849 (PIK3R4) 29982 (NRBF2) 5289 (PIK3C3) 22863 (ATG14) 143471 (PSMA8), 5682 (PSMA1), 5... SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell...
hsa05016 Huntington disease Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects m... ...678 (BECN1) 30849 (PIK3R4) 29982 (NRBF2) 5289 (PIK3C3) 22863 (ATG14) 5609 (MAP2K7) 3064 (HTT) 4294 (... HUNTINGTON DISEASE Cx I Cx II Cx III Cx IV Cx V Htt Htt Htt Htt Htt REST REST coREST Sin3A HDACs DN...
hsa05017 Spinocerebellar ataxia The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... ...678 (BECN1) 30849 (PIK3R4) 29982 (NRBF2) 5289 (PIK3C3) 22863 (ATG14) 4287 (ATXN3), 92552 (ATXN3L) 42... Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk...
hsa05022 Pathways of neurodegeneration - multiple diseases Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... ...678 (BECN1) 30849 (PIK3R4) 29982 (NRBF2) 5289 (PIK3C3) 22863 (ATG14) 203228 (C9orf72) 5861 (RAB1A) 5... PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP...
hsa05131 Shigellosis Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... ...925 (BECN2), 8678 (BECN1) 30849 (PIK3R4) 5289 (PIK3C3) 10325 (RRAGB), 10670 (RRAGA), 58528 (RRAGD), ... SHIGELLOSIS Shigella dysenteria Shigella flexneri Shigella boydii Shigella sonnei TNF-R1 TNFα IκB...
hsa05132 Salmonella infection Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid ... ...5868 (RAB5A), 5869 (RAB5B), 5878 (RAB5C) 5289 (PIK3C3) 23207 (PLEKHM2) 8677 (STX10) 9648 (GCC2) 5120... SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 ...
hsa05152 Tuberculosis Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the... ...5868 (RAB5A), 5869 (RAB5B), 5878 (RAB5C) 5289 (PIK3C3) 10312 (TCIRG1), 23545 (ATP6V0A2), 245972 (ATP... SapM TUBERCULOSIS DC-SIGN Raf1 IL-10 Pro-inflammatory cytokines Phagosome maturation arrest Rab5 VPS...
hsa05167 Kaposi sarcoma-associated herpesvirus infection Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most... ...57 (MAP1LC3A) 64422 (ATG3) 22863 (ATG14) 5289 (PIK3C3) 441925 (BECN2), 8678 (BECN1) 8717 (TRADD) 718... IFN-α/β TRAF3 IRF7 IFN-β IFN-α IKK JNK TBK1 IKKε AKT STAT1 IκBα IRF3 TLR3 TRIF KAPOSI SARCO...

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